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Synthesis And Evaluation Of Novel Silica Hydride-Based Stationary Phases For Bioanalytical Applications, Seiichiro Watanabe

Master's Theses

Most HPLC columns are packed with silanol (Si-OH)-rich type-B silica that often participates in undesired electrostatic interactions with sample solutes and produces a poor analyte peak shape. These silanols are also known to facilitate the surface hydration required for HILIC mode to retain polar analytes. However, the hydrated surface composition can easily fluctuate, which results in poor reproducibility and requires a lengthy equilibration step. In this study, four novel stationary phases have been developed by using the TYPE-C™ silica material, in which up to 95% of the surface silanols have been replaced with Si-H group. One of the advantages of …

Phreatomagmatic Eruption Deposits On The Seafloor Record Cataclysmic Caldera Formation On Axial Seamount, Juan De Fuca Mid-Ocean Ridge, Jacob Danielsen

Master's Theses

The physical and compositional characteristics of a unique ash-rich hydrothermal sediment, hydrothermal muddy tuff (HMT), on Axial Seamount, Juan de Fuca Ridge, suggest that it formed by phreatomagmatic eruptions during caldera formation. Deposit thickness trends away from the seamount summit and the presence of 68% primary volcaniclasts and 32% secondary lithics suggest a source from along caldera ring-faults deep in the crust. Lithic geothermometry indicates that the source was subject to low-temperature (<150 >°C) alteration, consistent with a provenance as deep as 600 – 800 m below the seafloor. At this depth, just above the critical point of seawater, the …

Expressions, Winter 2019, San Jose State University, College Of The Humanities And The Arts

Expressions (College of Humanities and the Arts)

College of Humanities and the Arts Newsletter

Empirical Assessment Of Callous-Unemotional Traits In Preschool: A Comparison Of Confirmatory Factor Analysis And Network Analysis, Pevitr Singh Bansal

Theses and Dissertations--Psychology

Callous – unemotional (CU) traits are a key factor in understanding the persistence and severity of conduct problems. The factor structure of CU traits has been primarily examined through confirmatory factor analysis (CFA) in childhood and adolescent samples, yet little research has examined the structure of CU traits in preschool. Further, current CFA models have yielded poor – to – marginally acceptable fit, suggesting the need for a more nuanced approach in understanding the structure of CU traits in early childhood using an interitem approach (i.e., network analysis). Within a sample of 109 preschool children (M age = 4.77, …

The Effect Of Posttraumatic Stress And Trauma-Focused Disclosure On Experimental Pain Sensitivity Among Trauma-Exposed Women, Caitlyn Olivia Hood

Theses and Dissertations--Psychology

Previous studies evaluating the impact of trauma history and PTSD on pain sensitivity yield inconsistent findings; the presence of trauma-related negative affective states may account for these discrepancies. Therefore, the proposed study aimed to evaluate the effect of trauma-related negative affect and PTSD symptoms on sensory and affective components of pain sensitivity among trauma-exposed women. Adult women (N = 87) with low and high PTSD symptoms underwent an emotional disclosure paradigm, during which they wrote about a traumatic event or a neutral topic. Participants then completed a pain induction procedure. Compared to women with low PTSD symptoms, women with …

Examining The Utility Of Behavioral Economic Demand In Addiction Science, Justin Charles Strickland

Theses and Dissertations--Psychology

The marriage of perspectives from behavioral economic theory and learning theory has the potential to advance an understanding of substance use and substance use disorder. Behavioral economic demand is a central concept to this interdisciplinary approach. Evaluating demand in the laboratory and clinic can improve previous research on the relative reinforcing effects of drugs by accounting for the multi-dimensional nature of reinforcement rather than viewing reinforcement as a unitary construct. Recent advances in the commodity purchase task methodology have further simplified the measurement of demand values in human participants. This dissertation project presents a programmatic series of studies designed to …

Cognition, Repetitive Thought, And Systemic Inflammation In The Midlife In The United States Study, Elana M. Gloger

Theses and Dissertations--Psychology

Segerstrom et al. (2017) found that more repetitive thought (RT) was related to lower interleukin-6 (IL-6), in older adults at average IQ. This study aimed to replicate and extend this finding in midlife adults, with a daily measure of RT, and additional inflammatory biomarkers. 153 participants were drawn from the Midlife in the United States (MIDUS) Refresher project; ages 25-70 (M = 45.07, SD = 10.96), 50.3% female, and 83% Caucasian. Cognition was assessed via the Brief Test of Adult Cognition by Telephone, biological data via fasted blood draw, and RT data were collected as part of the National …

When And Why We Protect Our Honor, Brian Michael Enjaian

Theses and Dissertations--Psychology

Men from a culture of honor often use physical aggression in response to threats as a way of restoring lost honor. Threats can range from being called an offensive name to someone flirting with their romantic partner. On the other hand, women from a culture of honor are expected to be submissive and avoid situations that can result in harm to their reputation. However, a recent meta-analytic review of the literature suggests that women do not always avoid situations that can harm their reputation. Rather, women in a culture of honor also use physical aggression in response to threats. In …

Posttraumatic Stress And Risky Sex In Trauma-Exposed College Students: The Role Of Personality Dispositions Toward Impulsive Behavior, Jessica Flores

Theses and Dissertations--Psychology

Posttraumatic stress disorder (PTSD) has been linked to heightened engagement in risky sexual behavior (RSB) across diverse samples, and impulsivity has been postulated as a potential linkage (Weiss et al., 2012). Limited information has been published on the role that impulsivity can play in strengthening the relationship between PTSD and RSB in college students. The current study examined the moderating role of impulsivity dispositions: negative/positive urgency, (lack of) perseverance, sensation seeking, and (lack of) premeditation on the association between PTSD symptoms and past-year RSB among a sample of 221 undergraduate students (77.4% female) with at least one DSM-5 defined traumatic …

Do Bulimic Behaviors Increase Shame? Toward An Understanding Of Transdiagnostic Risk, Heather A. Davis

Theses and Dissertations--Psychology

Binge eating is a harmful, maladaptive behavior associated with comorbid psychopathology. Theory posits that increases in maladaptive, transdiagnostic emotions following binge eating in individuals with BN may predict the experience of comorbid symptoms. The current study served as a laboratory test of the first part of this theory: whether state increases in maladaptive emotions occur following engagement in binge eating behavior in women with BN compared with healthy controls. Women (n = 51) were recruited from the community if they met DSM-5 criteria for BN or OSFED BN (of low frequency) (n = 21) or were free of lifetime disordered …

Neurobehavioral Measurements Of Natural And Opioid Reward Value, Aaron Paul Smith

Theses and Dissertations--Psychology

In the last decade, (non)prescription opioid abuse, opioid use disorder (OUD) diagnoses, and opioid-related overdoses have risen and represent a significant public health concern. One method of understanding OUD is as a disorder of choice that requires choosing opioid rewards at the expense of other nondrug rewards. The characterization of OUD as a disorder of choice is important as it implicates decision- making processes as therapeutic targets, such as the valuation of opioid rewards. However, reward-value measurement and interpretation are traditionally different in substance abuse research compared to related fields such as economics, animal behavior, and neuroeconomics and may be …

Measuring Glutamate And Oxygen In Brain Reward Circuits In Animal Models Of Cocaine Abuse And Decision-Making, Seth Richard Batten

Theses and Dissertations--Psychology

Drug-specific reward and associated effects on neural signaling are often studied between subjects, where one group self-administers drug and a separate group self-administers a natural reinforcer. However, exposure to drugs of abuse can cause long-term neural adaptations that can affect how an organism responds to drug reward, natural reward, and their reward-associated stimuli. Thus, to isolate drug-specific effects it is important to use models that expose the same organism to all of the aforementioned. Multiple schedules provide a means of dissociating the rewarding effects of a drug from the rewarding effects of food within a single animal. Further, drug users …

Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio

Theses and Dissertations--Psychology

Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers through capitalizing on the commonalities in their mechanisms of action. Towards this goal, several models of concurrent access to EtOH and nicotine were explored as potential preclinical models of co-use using female alcohol-preferring (P) rats. Additionally, potential pharmacotherapeutics for the treatment of EtOH and nicotine co-use disorder were tested using different variations of our model. Treatments tested included (1) varenicline, …

The Moderating Role Of Mindfulness Skills In The Relationship Between Borderline Personality Features And Associated Problematic Behaviors, Carolina A. Caldera

Theses and Dissertations--Psychology

Individuals with borderline personality disorder (BPD) experience intense affect and emotional dyscontrol that may lead them to engage in maladaptive coping strategies and behaviors such as substance use, alcohol use, risky sexual behavior, aggression, and emotional eating. Theory posits that mindfulness, a mental state in which one is attentive, aware, and accepting of the present moment, may lead to increased tolerance of emotional distress. The present study sought to investigate the role of dispositional mindfulness as a moderating factor in the relationship between BPD features and related problematic behaviors using structural equation modeling and regression analyses in cross-sectional and longitudinal …

Ethnoprimatology Of Urban Cebus Yuracus: An Evaluation Of Human-Non-Human Interactions And Local Perceptions In Misahualli, Ecuador, Sofia Castro-Loza

All Master's Theses

Little is known about the group of white-fronted capuchins (Cebus yuracus) coexisting alongside humans in the town of Misahuallí, Tena, Ecuador. This ethnoprimatological study focuses on the human-nonhuman interactions and the perceptions of the local people about the capuchin group. Behavioral interactions were examined using all-occurrence sampling, and the local perceptions of the Misahuallí people were assessed using semi-structured interviews. In total, 2,103 human-capuchin behavioral interactions were recorded. The majority of interactions were positive (55.6%), and 69.6% revolved around food. Overall, the capuchins initiated more negative interactions and in contrast, humans initiated more positive interactions. When interviewed about …

Simultaneity And Solidarity In The Time Of Permanent War, Marie Lo

English Faculty Publications and Presentations

Excerpt in lieu of abstract:

The war that is going on beneath order and peace, the war that undermines our society and divides it in a binary mode is, basically, a race war.
--Michel Foucault, Society Must Be Defended

In their defense of the Muslim travel ban, lawyers for the Trump administration invoked the plenary power doctrine to justify its legality: "The Order was well under the president's authority under Congress' delegation, particularly in an area like immigration, in which the admission to the United States of foreign aliens is subject to plenary control by the political branches." (1) By …

A Residential Camp’S Impact On Youths’ Leadership Skills And Natural Resource Knowledge, Shandra Nicole Frey, Vernon Parent

Extension Research

Learning transcends the classroom. To better understand the natural world around them, it is critical that youth have opportunities to make connections and apply their learning in real-world settings. Improving youths’ perceived skills and knowledge contributes to increased academic motivation and continued leadership development. Multi-day residential natural resource camps have shown the ability to teach ecological concepts and develop land management skills, critical thinking skills, and decision-making skills. We tested the ability of a remotely located residential camp to improve leadership skills and natural resource knowledge, using a pre- and post-camp self-assessment, combined with a pre- and post-camp knowledge test. …

Quantitative Analysis Of The Thrbcrm1-Centered Gene Regulatory Network, Benjamin Souferi, Mark M. Emerson

Publications and Research

Enhancer activity is determined by both the activity and occupancy of transcription factors as well as the specific sequences they bind. Experimental investigation of this dynamic requires the ability to manipulate components of the system, ideally in as close to an in vivo context as possible. Here we use electroporation of plasmid reporters to define critical parameters of a specific cis-regulatory element, ThrbCRM1, during retinal development. ThrbCRM1 is associated with cone photoreceptor genesis and activated in a subset of developing retinal cells that co-express the Otx2 and Onecut1 (OC1) transcription factors. Variation of reporter plasmid concentration was used to generate …

Effects Of Seawater On Carotenoid Production And Lipid Content Of Engineered Saccharomyces Cerevisiae, Yuqi Guo, Shangxian Xie, Joshua Yuan, Katy Kao

Faculty Publications

The use of seawater in fermentation can potentially reduce the freshwater burden in the bio-based production of chemicals and fuels. We previously developed a Saccharomyces cerevisiae carotenoids hyperproducer SM14 capable of accumulating 18 mg g−1 DCW (DCW: dry cell weight) of β-carotene in rich media (YPD). In this work, the impacts of seawater on the carotenoid production of SM14 were investigated. When using nutrient-reduced media (0.1× YNB) in freshwater the β-carotene production of SM14 was 6.51 ± 0.37 mg g−1 DCW; however in synthetic seawater, the production was increased to 8.67 ± 0.62 mg g−1 DCW. We found that this …

Biological Agent Dispersal, Jake Israelsen, Chris Springmeyer, Will Wightman, Camiel Zorn

Mechanical and Aerospace Engineering

BIO-TERRORISM THREAT MITIGATION

Overview

• Understanding the importance understanding how airborne particles behave
• Computer models to describe open air release of Anthrax

Creation of 300 m x 100 m testing facility

• Determine distance traveled based on spore size and wind speed
• Determine important parameters for facility to safely control dispersion

Importance of the problem to society

• Immediate bio-terror-threat response training
• Contamination remediation for first responders
• Future response plans including timely contamination zone determination

This must be researched in order to plan for an undesirable event

University Rover Competition, Nicholas Huld

Mechanical and Aerospace Engineering

The Mar’s Society University Rover Challenge (URC) is a robotics competition held annually in the desert of Southern Utah. The competition tasks the engineers with building a remotely operated rover to accomplish four primary missions:

1. Science mission- The rover must conduct an in-situ analysis to determine the presence of life, either extinct or extant, at designated sights.
2. Extreme retrieval and delivery- The rover must pick up and deliver objects in the field while traversing a wide variety of terrain no further than 1 km.
3. Equipment servicing- The rover must perform operations on an equipment system after traveling …

Threats To The Brazilian Environment And Environmental Policy, Thomas J. Trebat, Laura Nora, Inga Caldwell

Sabin Center for Climate Change Law

The Columbia Global Centers | Rio de Janeiro, in partnership with the Sabin Center for Climate Change Law at Columbia University and the Brazil-American Institute for Law and Environment at Pace University, organized a Workshop on November 13, 2019 in New York City. The Workshop was convened to discuss and raise awareness of the scope and severity of the environmental crisis in Brazil with a focus on the severe threats to the Amazon.

The consequences of the Bolsonaro government´s environmental actions are serious for Brazil and for the world. That is one of the reasons why the Columbia Global Center …

Retrieving And Reimagining Sanctuary And Solidarity: Racial Disparities In Infant Mortality, Alyson Capp

Dissertations

In Milwaukee, Black babies die before their first birthday nearly three times as often as White and Hispanic babies. Prematurity is the major cause of infant mortality, and social determinants of health play a large role. Commitments from within Christian bioethical traditions can critique ethical frameworks commonly in use in US bioethics by calling for the incorporation of analysis of social power dynamics that is necessary for addressing this issue. Original ethnographic fieldwork that listens closely to Black mothers and health professionals uncovers key themes related to women's and infant health at the intersection of race, class, and gender. By …

Structure-Guided T Cell Receptor Mutations That Alter Antigen Specificity, Cross-Reactivity, And Polyfunctional Phenotypes In Gene-Modified T Cells, Kendra Foley

Dissertations

Adoptive cell transfer of T cell receptor (TCR) gene-modified T cells targeting specific tumor antigens is currently in clinical trials for patients with advanced malignancies. Despite the clinical responses, there are still hurdles to be overcome in achieving an effective and safe therapy. One of the limitations in the success of this type of therapy is the potential for cross-reactivity and unanticipated off-target reactivity which could lead to autoimmunity. Adverse events encompassing these "off-target, off-tumor" cross-reactivities leading to autoimmunity have been seen in patients in different clinical trials. Here, we demonstrate a novel approach to improve antigen specific reactivity and …

Membrane Microdomains As Platforms For Extra-Cellular Fusions, Michael Hantak

Dissertations

Life requires biological membranes. Membrane-enclosed compartments separate and unite through dynamic fission and fusion reactions. These are catalyzed processes that are central in organismal biogenesis. This dissertation focuses on extracellular membrane fusions, which are central to several processes. (1) Enveloped viruses enter cells through membrane fusions. (2) Extracellular vesicles (EVs) also deliver molecules into cells through membrane fusions. (3) Entire cells also fuse together, generating fertilized zygotes, skeletal muscles, and giant cell macrophages.Mechanisms of extracellular membrane fusion are poorly understood. This dissertation aimed to further define these mechanisms. We focused on regulatory cofactors, including tetraspanins, transmembrane proteins that cluster into …

Determination Of Transforming Growth Factor-Β Signaling Targets In Activated T Cells, Ramiah Jacks

Dissertations

T lymphocytes are a critical component of the adaptive immune system and their responses in pathogenic and steady state conditions require strict regulation. One mechanism involved in this regulation is Transforming Growth Factor-β (TGF-β) signaling. TGF-β can act on activated T cells to facilitate the differentiation of TGF-β dependent T helper subsets or the suppression of T cell activation and proliferation. However, the molecular mechanism(s) by which TGF-β signaling controls T cell differentiation vs T cell suppression remain poorly understood.TGF-β signaling is propagated by initially binding to the TGF-β type II receptor, which subsequently activates TGF-β type I receptor (TGF-βRI) …

The Social And Contextual Mechanisms Of Children's Learning In Museums, Lindsay R. Maldonado

Dissertations

This study explored the associations between immersive exhibit design, mother-child engagement, conversational interactions, and children's learning. Participants were 41 mothers and their 6-8-year-old children (Mage=7.15, SD=.79). A within-subjects, mixed methods approach was utilized, including naturalistic observations, interview data, and surveys. Mother-child dyads were video and audio-recorded as they visited four different exhibits: two low immersion exhibits and two high immersion exhibits. Interview data was collected from children immediately following the visit to assess learning. Survey data was collected from mothers to assess education, environmental predispositions, and science-related career. In high immersion exhibits, mothers and children spent more time and asked …

Characterization Of The Effects Of Sex And Estrogen Receptor Signaling On Antigen-Specific T Cells For Immunotherapy, Flor Cecilia Navarro Negredo

Dissertations

Adoptive cell transfer (ACT) immunotherapy using antigen (Ag)-specific T cells is partially effective treating several malignancies but numerous challenges remain in order to improve its therapeutic potential. The roles of host factors, such as sex hormone receptor signaling, that can affect the T cell anti-tumor function remain understudied. The work performed in this dissertation characterized the role of estrogen signaling on T cell function in vitro, and during ACT immunotherapy against hepatocellular carcinoma (HCC) in vivo. Estrogen signaling through ERa enhanced the expression and secretion of Type I effector cytokines including IFNg, TNFa, and Granzyme B in male and female …

Protection From Staphylococcus Aureus Bloodstream Infection By Probiotic Exopolysaccharide, Wonbeom Paik

Dissertations

Staphylococcus aureus is known to cause severe systemic infection with high mortality rates. Antibiotics are the only approved therapy for patients, but the widespread prevalence of antibiotic resistant strains limits treatment efficacy, and many patients succumb to the disease. Many probiotic agents are commercially available, but the mechanisms by which they benefit are not known. Understanding these mechanisms will help develop novel therapeutics that can improve healthcare, including systemic infections by S. aureus. Bacillus subtilis is a probiotic bacterium that produces an exopolysaccharide (EPS) that induces anti inflammatory macrophages (MΦ). We tested if EPS could be used for systemic S. …

Behavioral Symptom Clusters, Inflammation, And Quality Of Life In Chronic Low Back Pain Patients, Anitha Saravanan

Dissertations

Chronic low back pain (CLBP) is a prevalent condition, often involving an inflammatory process. Those with CLBP frequently experience behavioral symptoms, including depressed mood, fatigue, and sleep disturbance, which may exacerbate pain and reduce quality of life (QOL). The purpose of this study was to identify behavioral symptom clusters (depressive mood, fatigue, poor sleep) in individuals with CLBP, and to determine whether there are differences in pain, QOL and inflammation (plasma IL-6) based on cluster membership. CLBP patients (N=69; age = 56±13 years) completed measures of pain, depressive mood, fatigue, sleep, and QOL. Blood was obtained for IL-6 measurement. LCA …