Digital Commons Network^™

Evaluating The Effectiveness Of Counter-Narrative Tactics In Preventing Radicalization, Ellen Berman

Walden Dissertations and Doctoral Studies

The U.S. Department of State disseminates counter-radicalization information through social media but has been unable to reach users due to an inability to create engaging posts due to a lack of understanding of the interests of the general population. The purpose of this quantitative study was to assess the utility of data analytics when administering counter-radicalization social media campaigns. The population for this study were social media posts published on the Quilliam Facebook page between 1 January 2018 and 31 December 2018. The nonexperimental quantitative descriptive research design sought to examine the correlation between the independent variables (topic of a …

Built Environments And Childhood Obesity Epidemic In The Immigrant Population, Monique M. Nurse

Walden Dissertations and Doctoral Studies

A lack of adequately built environments can negatively affect obesity rates among adolescents. The purpose of this quantitative cross-sectional study was to determine if there is a relationship between the presence of built environments and childhood obesity among the immigrant population living in Cobb County Georgia. The social ecological model was used to explain how environmental factors may influence behavior. The research questions addressed whether walkability and elements of built environments such as to healthy foods and access to parks and recreational areas of census tracts affect childhood obesity when adjusting for race/ethnicity and immigrant population in Cobb County. Data …

The Lived Experiences Of Male Victims Of Intimate Partner Violence, Arielle Chieko Woodyard

Walden Dissertations and Doctoral Studies

This qualitative study explored the lived experiences of male victims of intimate partner violence (IPV). Few studies exist about the experiences of men who are victims of female-perpetrated IPV and there are not many studies about these men's experiences in seeking and receiving psychological help. Maslow's hierarchy of needs and Peck's gender role strain paradigm guided this study to understand victimology and perceptions of gender roles. Research questions attempted to understand the lived experiences of male IPV victims of female-perpetrated IPV, accessing supportive and psychological services, and their experiences of these services. Seven male individuals were recruited through flyers in …

High School Science Teachers' Perspectives On Their Technology Knowledge, Content, And Pedagogy, Mentor Mentor Jr.

Walden Dissertations and Doctoral Studies

In a southeastern U.S. school district, it was unknown how teachers integrated technology into their classroom teaching in the science, technology, engineering, and mathematics (STEM) curriculum. Teachers should be knowledgeable of their content, pedagogy of the content, and delivery instruction to improve students' learning outcomes. The purpose of this bounded qualitative case study was to examine how teachers integrated technology into their teaching to improve science students' learning outcomes. Mishra and Koehler's and Shulman's theories of technology, pedagogy, and content knowledge served as the conceptual framework. Purposeful sampling was used to select 12 certified science teachers, with at least 1 …

Understanding Nonoffending Caregiver Protection In Child Sexual Abuse, Christina Lynn Sally

Walden Dissertations and Doctoral Studies

Child sexual abuse is a global issue that has affected children, families, and communities for centuries regardless of socioeconomic, religious, ethnic, race, or multicultural factors and distinctions. Sexually abused children may be reluctant to disclose sexual abuse due to perceptions or realities that their nonoffending caregiver (NOC) will not believe their reports and may fail to provide adequate protection. The purpose of this quantitative study was to assess if child demographics (i.e., age, sex, and race/ethnicity); type of sexual offense (i.e., contact or noncontact); and perpetrator relationship to the child (i.e., familial or extrafamilial) predict a NOC's response (i.e., protection …

Near-Field Electrospinning Of A Polymer/Bioactive Glass Composite To Fabricate 3d Biomimetic Structures, Krishna C. R. Kolan, Jie Li, Sonya Roberts, Julie A. Semon, Jonghyun Park, D. E. Day, Ming-Chuan Leu

Biological Sciences Faculty Research & Creative Works

Bioactive glasses have recently gained attention in tissue engineering and three-dimensional (3D) bioprinting because of their ability to enhance angiogenesis. Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues. In this study, we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning (NFES). An overall controlled 3D scaffold with pores, containing random fibers, is created and aimed to provide superior cell proliferation. Highly angiogenic borate bioactive glass (13-93B3) in 20 wt.% is added to polycaprolactone (PCL) to fabricate scaffolds using the NFES technique. …

Modeling Cell Line-Specific Recruitment Of Signaling Proteins To The Insulin-Like Growth Factor 1 Receptor, Keesha E. Erickson, Dipak Barua, For Full List Of Authors, See Publisher's Website.

Chemical and Biochemical Engineering Faculty Research & Creative Works

Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation sites can recruit downstream signaling proteins containing Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which recognize phosphotyrosine-containing short linear motifs (SLiMs). These domains and SLiMs have polyspecific or promiscuous binding activities. Thus, multiple signaling proteins may compete for binding to a common SLiM and vice versa. To investigate the effects of competition on RTK signaling, we used a rule-based modeling approach to develop and analyze models for ligand-induced recruitment of SH2/PTB domain-containing proteins to autophosphorylation sites in the insulin-like growth factor 1 …

Flavin Oxidation In Flavin-Dependent N-Monooxygenases, Reeder M. Robinson, Catherine A. Klancher, Pedro J. Rodriguez, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Siderophore A (SidA) from Aspergillus fumigatus is a flavin-containing monooxygenase that hydroxylates ornithine (Orn) at the amino group of the side chain. Lysine (Lys) also binds to the active site of SidA; however, hydroxylation is not efficient and H₂O₂ is the main product. The effect of pH on steady-state kinetic parameters was measured and the results were consistent with Orn binding with the side chain amino group in the neutral form. From the pH dependence on flavin oxidation in the absence of Orn, a pKa value >9 was determined and assigned to the FAD-N5 atom. In the …

Dynamical Interference In The Vibronic Bond Breaking Reaction Of Hco, Shanyu Han, Xianfeng Zheng, Steve A. Ndengue, Yu Song, Richard Dawes, For Full List Of Authors, See Publisher's Website.

Chemistry Faculty Research & Creative Works

First-principles treatments of quantum molecular reaction dynamics have reached the level of quantitative accuracy even in cases with strong non-Born-Oppenheimer effects. This achievement permits the interpretation of puzzling experimental phenomena related to dynamics governed by multiple coupled potential energy surfaces. We present a combined experimental and theoretical study of the photodissociation of formyl radical (HCO). Oscillations observed in the distribution of product states are found to arise from the interference of matter waves-a manifestation analogous to Young's double-slit experiment.

Deep Learning Of Human Apparent Age For The Detection Of Sexually Exploitative Imagery Of Children, Jared Rondeau

Open Access Master's Theses

Over the last decade, advancements in deep learning and computer vision have led to a tremendous growth in performance at the tasks of automated human age estimation and nudity detection. Modern machine learning models can predict whether or not an image contains nudity or the presence of a minor with startling accuracy. When used in conjunction, these technological advancements can be used to identify new instances of child pornography without ever coming into contact with the illicit material during model training.

In this thesis, a label distribution learning framework for modeling human apparent age is proposed. Instead of directly modeling …

Coculture Of Probiotic Bacteria In Algal Feedstocks For Disease Management In Bivalve Hatcheries, Samuel Hughes

Open Access Master's Theses

Bivalve hatcheries include microalgae culture operations as a food source for stock, and these algae cultures harbor dynamic bacterial communities. Because algae from these cultures and their commensal microbiota are distributed to stock larval tanks daily upon feeding, the presence of pathogenic Vibrio spp. in hatchery microalgae cultures is a threat to stock health and survival. This study investigates the algal/bacterial and bacterial/bacterial interaction between four popular species of microalgae feedstock, a Vibrio sp. of known pathogenicity to bivalves (V. coralliilyticus RE22 [RE22]), a probiotic marine bacterium with demonstrated effectiveness in reducing larval shellfish mortality in culture operations …

Correlations Of The Fear Of Missing Out & Interpersonal Stress With Female College Students’ Sleep, Victoria Elizabeth Russo

Open Access Master's Theses

Insomnia has been correlated with several negative mental and physical health outcomes in female undergraduate students, a population with increasing interest when considering those suffering with insomnia. Considering the increased vulnerability reported by college students, and the poor outcomes of insomnia, it is important to determine correlates of insomnia and which factors differentially impact college students’ development of insomnia. This study examined whether interpersonal stress or the fear of missing out (i.e. FoMO) was more highly correlated with insomnia in a population of female undergraduate students at the University of Rhode Island. This study also examined whether levels of interpersonal …

Platform For Hadal Autonomy And General Experimentation (Phage), Lillian Muir

Open Access Master's Theses

Due to the harsh environment and inaccessibility of the deep-sea, most oceanographic equipment is rated to sample above the hadal region (6000 meters and below). A few deep-sea landers and piloted vehicles have ventured into deep ocean trenches to sample at the ocean floor, but the hadal water column remains under-sampled. A full ocean depth profile and hadal samples can provide information on ocean circulation, deep-water mixing, trench overturning rates, and the ocean environment.

The Platform for Hadal Autonomy and General Experimentation (PHAGE) is a full ocean depth profiler rated to 11 km. Designed around a 24 bottle CTD rosette, …

Plastic Perceptions: Surveying Public Opinion Of Plastic Pollution In Rhode Island, Sabrina Pereira

Open Access Master's Theses

This research surveyed 200 coastal and noncoastal Rhode Island residents to determine their perceptions of marine plastic debris and their support for plastic and paper bag legislation. The results suggest that one’s residency, or geographic distance from the coast, has no bearing on plastic and paper bag policy support and that most participants, 77%, classify plastic pollution as a serious threat to various types of wildlife, the marine environment, human health, and Rhode Island’s economy. The data also seems to suggest support for a statewide plastic bag ban and a statewide fee of 10 cents on paper bags as a …

The Copy Number Variation Landscape Of Congenital Anomalies Of The Kidney And Urinary Tract., Miguel Verbitsky, Rik Westland, Alejandra Perez, Krzysztof Kiryluk, Qingxue Liu, Priya Krithivasan, Adele Mitrotti, David A. Fasel, Ekaterina Batourina, Matthew G. Sampson, Monica Bodria, Max Werth, Charlly Kao, Jeremiah Martino, Valentina P. Capone, Asaf Vivante, Shirlee Shril, Byum Hee Kil, Maddalena Marasà, Jun Y. Zhang, Young-Ji Na, Tze Y. Lim, Dina Ahram, Patricia L. Weng, Erin L. Heinzen, Alba Carrea, Giorgio Piaggio, Loreto Gesualdo, Valeria Manca, Giuseppe Masnata, Maddalena Gigante, Daniele Cusi, Claudia Izzi, Francesco Scolari, Joanna A E Van Wijk, Marijan Saraga, Domenico Santoro, Giovanni Conti, Pasquale Zamboli, Hope White, Dorota Drozdz, Katarzyna Zachwieja, Monika Miklaszewska, Marcin Tkaczyk, Daria Tomczyk, Anna Krakowska, Przemyslaw Sikora, Tomasz Jarmoliński, Maria K. Borszewska-Kornacka, Robert Pawluch, Maria Szczepanska, Piotr Adamczyk, Malgorzata Mizerska-Wasiak, Grazyna Krzemien, Agnieszka Szmigielska, Marcin Zaniew, Mark G. Dobson, John M. Darlow, Prem Puri, David E. Barton, Susan L. Furth, Bradley A. Warady, Zoran Gucev, Vladimir J. Lozanovski, Velibor Tasic, Isabella Pisani, Landino Allegri, Lida M. Rodas, Josep M. Campistol, Cécile Jeanpierre, Shumyle Alam, Pasquale Casale, Craig S. Wong, Fangming Lin, Débora M. Miranda, Eduardo A. Oliveira, Ana Cristina Simões-E-Silva, Jonathan M. Barasch, Brynn Levy, Nan Wu, Friedhelm Hildebrandt, Gian Marco Ghiggeri, Anna Latos-Bielenska, Anna Materna-Kiryluk, Feng Zhang, Hakon Hakonarson, Virginia E. Papaioannou, Cathy L. Mendelsohn, Ali G. Gharavi, Simone Sanna-Cherchi

Manuscripts, Articles, Book Chapters and Other Papers

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in 2,824 cases and 21,498 controls. Affected individuals carried a significant burden of rare exonic (that is, affecting coding regions) CNVs and were enriched for known genomic disorders (GD). Kidney anomaly (KA) cases were most enriched for exonic CNVs, encompassing GD-CNVs and novel deletions; obstructive uropathy (OU) had a lower CNV burden and an intermediate prevalence of GD-CNVs; and vesicoureteral reflux (VUR) had the fewest GD-CNVs but was enriched for novel exonic CNVs, …

Research Clinics: An Alternative Model For Large-Scale Information Literacy Instruction, Glenn Koelling, Lori Townsend

Communications in Information Literacy

This article describes the pilot year of a new model for information literacy instruction in first-year composition classes at the University of New Mexico. The flipped classroom model, the Association of College and Research Libraries Framework for Information Literacy in Higher Education, and challenges to library staffing sparked the implementation of research clinics, which are a blend of a flipped classroom and a research/reference consultation. These clinics are designed to meet students at their point of need for research projects and allow students to choose what sort of library help will be the most beneficial at that moment. At …

Inflammatory Serine Proteases Play A Critical Role In The Early Pathogenesis Of Diabetic Cardiomyopathy., Mikhail A Kolpakov, Kunal Sikder, Amrita Sarkar, Shaswati Chaki, Sanket K Shukla, Xinji Guo, Zhao Qi, Carlos Barbery, Abdelkarim Sabri, Khadija Rafiq

Center for Translational Medicine Faculty Papers

BACKGROUND/AIMS: Diabetic cardiomyopathy (DCM) is characterized by structural and functional alterations that can lead to heart failure. Several mechanisms are known to be involved in the pathogenesis of DCM, however, the molecular mechanism that links inflammation to DCM is incompletely understood. To learn about this mechanism, we investigated the role of inflammatory serine proteases (ISPs) during the development of DCM.

METHODS: Eight weeks old mice with deletion of dipeptidyl peptidase I (DPPI), an enzyme involved in the maturation of major ISPs, and wild type (WT) mice controls were injected with streptozotocin (50 mg/kg for 5 days intraperitoneally) and studied after …

Point Spread Function Determination In The Scanning Electron Microscope And Its Application In Restoring Images Acquired At Low Voltage, Mandy C. Nevins

Theses

Electron microscopes have the capability to examine specimens at much finer detail than a traditional light microscope. Higher electron beam voltages correspond to higher resolution, but some specimens are sensitive to beam damage and charging at high voltages. In the scanning electron microscope (SEM), low voltage imaging is beneficial for viewing biological, electronic, and other beam-sensitive specimens. However, image quality suffers at low voltage from reduced resolution, lower signal-to-noise, and increased visibility of beam-induced contamination. Most solutions for improving low voltage SEM imaging require specialty hardware, which can be costly or system-specific. Point spread function (PSF) deconvolution for image restoration …

Gender Disparities In Awards To Neuroscience Researchers, David Melnikoff, Virginia Valian

Publications and Research

Women in academia receive fewer prestigious awards than their male counterparts. Why this gender gap emerges, however, remains poorly understood. Thus, we tested multiple hypotheses about the proximate cause of the gender gap in award prestige. Our findings suggest that the gender gap in award prestige may emerge in part from gender schemas that portray women as warmer and less competent than men. Specifically, our results are consistent with the hypothesis that gender schemas lead to women’s papers receiving fewer citations than men’s papers, which in turn results in more prestigious awards for men than for women. Additionally, our results …

Clinic-Based Delivery Of The Young Men’S Health Project (Ymhp) Targeting Hiv Risk Reduction And Substance Use Among Young Men Who Have Sex With Men: Protocol For A Type 2, Hybrid Implementation-Effectiveness Trial, Jeffrey T. Parsons, Tyrel Starks, Sitaji Gurung, Demetria Cain, Jonathan Marmo, Sylvie Naar

Publications and Research

Background: Young men who have sex with men (YMSM) are disproportionately at risk for HIV and sexually transmitted infections. Adapting and testing the effectiveness of the Young Men’s Health Project (YMHP), an efficacious intervention designed to reduce substance use and condomless anal sex (CAS) among YMSM, at clinics in Miami, Detroit, and Philadelphia has the potential to reduce HIV and STI disparities among urban YMSM.

Objective: This study (Adolescent Medicine Trials Network for HIV/AIDS Interventions [ATN] 145 YMHP) aims to adapt YMHP for clinic and remote delivery by existing clinic staff and compare their effectiveness in real-world adolescent HIV clinics. …

Identification Of 15 Phthalate Esters In Commercial Cheese Powder Via Cyclodextrin-Promoted Fluorescence Detection, Benjamin B. Cromwell

Open Access Master's Theses

Human exposure to toxicants such as environmental pollutants, carcinogens, and endocrine disruptors occurs via a variety of mechanisms, including through the use of commercial products that contain these toxicants. Among such commercial products, many classes of food products have been found to contain toxicants, including phthalate and phthalate esters, which have traditionally been detected using mass spectrometry-based techniques. Reported herein is the use of gas chromatography mass spectrometry and cyclodextrin-promoted fluorescence detection to accomplish the sensitive (0.124µM limits of detection) detection of 15 phthalate esters in commercial cheese powder used in macaroni and cheese products. These results highlight the versatility …

Anthelmintic Efficacy Of Pelleted Cranberry Vine Against Gastrointestinal Nematodes Of Sheep, Bailey Chalut

Open Access Master's Theses

Gastrointestinal nematodes (GIN) represent a major health concern in small ruminants as well as a constraint for producers. The prevalence of anthelmintic resistance in small ruminant GIN has increased rapidly worldwide, creating the need for alternative control methods to address the issue. The discovery that plant secondary compounds, including proanthocyanidins (PAC), suppress GIN infections has provided promise for alternative methods of GIN control. Although the mechanism is not well understood, studies have shown in vitro and in vivo evidence of anti-parasitic effects of bioactive plants. Recently a study from our laboratory provided in vitro evidence of anthelmintic activity of cranberry …

Dredging For Environmental Benefit: Models Of Circulation And Flushing Dynamics In The Providence River Estuary, Grace Elizabeth Medley

Open Access Master's Theses

In estuarine dynamics, circulation in the form of mixing and exchange have a direct link to the water quality. Edgewood Shoals is a highly anthropogenically impacted region of the Providence River bordered by three cities, and receives the outfall from six wastewater treatment facilities. Edgewood Shoals also has low dissolved oxygen levels during the summer months. The Shoal is classified as a circulation-restricted zone, where hydrodynamic exchange is limited due to the steep bathymetric gradient created by an adjacent federal shipping channel. The US Army Corps of Engineers (USACE) is in the process of determining if there are options for …

Performance Comparison Of Self-Organizing Maps Based On Different Autoencoders, Boren Zheng

Open Access Master's Theses

The Autoencoder (AE) is a kind of artificial neural network, which is widely used for dimensionality reduction and feature extraction in unsupervised learning tasks. Analogously, the Self-Organizing Map (SOM) is an unsupervised learning algorithm to represent the high-dimensional data by a 2D grid map, thus achieving dimensionality reduction. Some recent work has shown improvement in performance by combining the AEs with the SOMs. Knowing which variations of AEs work best and finding out whether the selection of AEs is data-depended or not is the purpose of this research.

Five types of AEs are implemented in this research; three different data …

Optimizing Recommendations For Clustering Algorithms Using Meta-Learning, Adam Jilling

Open Access Master's Theses

The field of machine learning (ML) has seen explosive growth over the past decade, largely due to increases in technology and improvements of implementations. As powerful as ML solutions can be, they are still reliant on human input to select the optimal algorithms and parameters. This process is typically done by trial and error, as researchers will select a number of algorithms and choose whichever provides the most desirable result.

This study will use a process called meta-learning to evaluate and analyze datasets and extract a series of meta-features. These features can then be used to intelligently recommend an optimal …

The Relationship Between Personality Of Students In An Intergenerational Program And Attitudes Toward Older Adults, Maryam Marzban

Open Access Master's Theses

With the rapid aging of the population as well as increasing diversity in United State, research on ageism and intergenerational relationships is increasingly warranted. Ageism, or the prejudicial attitudes towards older adults, is seen as one of the most prevalent preconceived judgments that can cause poor treatment, and may even decrease levels of confidence, happiness, and health for older adults (Bishop, 2016). Intergenerational programs can provide many benefits for both younger and older adults, including developing positive changes in attitude towards aging (Wescott & Healy, 2011). Currently, the University of Rhode Island (URI) Engaging Generations: Cyber-Seniors program was developed to …

Growth Of Saccharina Latissima In Aquaculture Systems Modeled Using Dynamic Energy Budget Theory, Celeste T. Venolia

Open Access Master's Theses

Aquaculture is an industry with the capacity for further growth that can sustainably feed an increasing human population. Sugar kelp (Saccharina latissima) is of particular interest for farmers as a fast-growing species that benefits ecosystems. However, as a new industry in the U.S., farmers interested in growing S. latissima lack data on growth dynamics. To address this gap, we calibrated a Dynamic Energy Budget (DEB) model to data from the literature and a 2-year growth experiment in Rhode Island (U.S.). Environmental variables forcing model dynamics included temperature, irradiance, dissolved inorganic carbon (DIC) concentration, and nitrate and ammonium concentration. …

Global Patterns Of Net Respiration In Subseafloor Sediment, Victoria Madison Fulfer

Open Access Master's Theses

Microbial life is abundant in subseafloor sediment. Rates of respiration in subseafloor sediment appear to be very slow, but are generally poorly constrained. This thesis aims to address this problem by quantifying respiration rates in subseafloor sediment at sites across the globe and determining geographic patterns of depth-integrated respiration rates and average per-cell respiration rates. First, we compiled pore water profiles and descriptive data from scientific coring and drilling sediment cores deposited in publicly accessible databases. Using these profiles, we quantified the global distribution of net respiration rates in subseafloor sediment (>1.5 meters below seafloor) using (i) a reaction-transport …

Rhode Island’S Agricultural Production And Climate Change: Practices, Perceptions, And Limitations, Mishreky N. Lawandy

Open Access Master's Theses

Climate change is projected to have significant impacts on the productivity and sustainability of agricultural production in coming years. In order to safeguard agricultural productivity and strengthen the resilience of regional food systems, farmers and other agricultural stakeholders will need to explore and adopt on-farm practices that are adaptive and/or mitigative. Understanding how farmers perceive and respond to climate change on their farms is essential to resilience building efforts.

The goal of this research is to address the lack of information on the concerns and response strategies of food-producing specialty crop growers in the U.S. Northeast, specifically the state of …

Development Of Bayesian And Non-Bayesian Melphalan Pharmacokinetic Model From Literature-Generated Data, Enoch Cobbina

Open Access Master's Theses

Published articles constitute a huge repository of population pharmacokinetic (Pop PK) models that can be repurposed to answer dose-related questions. We present a Simulation-Informed-Statistically-Aided (SISA) method that can be used to select population pharmacokinetic models from literature for repurposing.

Seven published melphalan PK models, and 1 reference model from FDA NDA submission documents were selected. A 30 minute IV infusion of 140 mg/m² of melphalan was simulated using each of the 7 models. The predictive performance of each of the models were evaluated using a proposed method called modified standard normal deviate (mSND). Five models, M1, M3, M4, M5 …