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Analysis Of Atlantic And Northern Gulf Coast Wetland Bacterial Extracellular Enzyme Activity, Noah Kippenbrock

Honors Theses

Sea-level rise is projected to cause saltwater marshes to migrate landward replacing brackish and freshwater marshes. Coastal wetlands are important sinks of carbon, phosphorous, and nitrogen, so it is important to understand the function of their microbial communities. This study aims to categorize the difference in function between different spatially distinct wetland marsh types in advance of the expected alteration of the wetland ecosystems. Extracellular microbial enzymatic activity was measured to understand organic matter decomposition and nutrient mineralization in different marsh types. We measured the activities of the extracellular enzymes β-glucosidase, NAGase, peroxidase, phenol oxidase, and phosphatase across sites along …

Exploration Of Thiol-Michael Addition Bioconjugation To Extend Polymers Of A Protein-Based Hydrogel, Elaine Wallin Smith

Honors Theses

Hydrogels have been explored for many biomedical applications, including targeted, in situ drug delivery to avoid the negative side effects associated with systemic delivery. In our work, we are exploiting the high affinity, calcium-dependent binding between calmodulin and its target peptides to create a biomaterial for in situ, extracellular drug delivery. Genes were engineered to make two protomers, Calmodulin Collagen-Like Protein (CCLP) and Peptide Collagen-Like Protein (PCLP), that will spontaneously self-assemble in situ due to the high Ca2+ concentration in the extracellular space and provide tunable, targeted drug delivery in a biocompatible hydrogel. One important factor that would dictate the …

It's Not Just "Skin Deep": Social Anxiety And Anxiety Sensitivity In Adults With Psychodermatological Disorders, Lauren E. Ellison

Honors Theses

Anxiety contributes to dermatological conditions and, due to the visible nature of skin conditions, social anxiety is particularly salient to dermatology patients. Although many dermatology outpatients report clinically significant social anxiety symptoms, there is little understanding of social anxiety among dermatology patients. Anxiety sensitivity (AS), or the fear of the consequences of anxiety, has been implicated in both social anxiety and dermatological symptoms. To this end, this study aimed to further elucidate the relation of social anxiety and AS among skin disease in two separate samples of individuals with psychodermatological conditions. We hypothesized that AS social, but not physical or …

Preparation Of A Perylenebisimide Acceptor With Serinol And Nonadecyl-Swallowtail Imides For Use In Molecular Rectification, Tarrah Frederick

Honors Theses

Several attempts were made to add 2-amino-1,3-propanediol to the acceptor perylene monoanhydride (PMA). The theoretical product, N-(10-nonadecyl)-N'-(1,3-dihydroxypropan-2-yl)perylene-3,4,9,10-bis(dicarboximide), is intended for use in unimolecular rectification because the perylenebisimide core is classified as a good acceptor due to its high electron affinity. Rectification usually utilizes donor-σ-acceptor molecules, whose localized orbitals permit electron transfer when placed between metal electrodes of asymmetric voltages. However, according to an “asymmetric rectification” analysis, an electron can pass from one electrode, through the LUMO of the acceptor, and then to the other electrode when said electrodes are held at certain voltages, and result in rectification if the acceptor …

Design And Development Of Chemically And Biologically Stable Salvinorin-Based Ligands For Opioid Receptors, Tanner Neilson

Honors Theses

The number of opioid prescriptions as a method in pain management increased dramatically in the mid 1990’s following Dr. James Campbell’s 1995 Presidential address to the American Pain Society, where he called for patient pain to be included as a vital sign. The rapid increase in prescriptions in the early 2000’s coupled with a massive effort by pharmaceutical companies to downplay the addictiveness of these drugs has led to a consistent increase in opioid-related drug overdoses, with 47,600 of 70,237 drug related deaths involving opioids in 2017. Opioid analgesics most commonly act upon the mu-opioid receptor (MOR), which is one …

The Wise Women Of Oxford, Jaz Brisack

Honors Theses

In Fall 2015, a group of women began meeting for lunch. The first meeting was nearly spontaneous: a woman named Eunice Benton emailed a few of her friends, saying that she would prefer to go out to eat with them at one o’clock on a Friday instead of eating alone. From there, the email list Eunice had created began growing and incorporating many new women from a variety of backgrounds, some of whom Eunice knew and then, increasingly, some she didn’t. The list spiked tremendously after the 2016 presidential election, as the group provided comfort to women who were extremely …

Carbon Dioxide Reduction Using Redox-Active Macrocyclic Catalysts, Dawson Kendall Buettner

Honors Theses

The current energy crisis experienced by society today is in desperate need of a solution. Through carbon dioxide (CO2) reduction, we can reduce the amount of greenhouse gas that is warming our planet as well as create a source of renewable energy. Significant challenges currently inhibit the reduction of CO2 to more desirable products. Current limitations can be addressed through the design and synthesis of more efficient catalysts that are selective, durable, and operate close to the target thermodynamic potential of CO2 reduction. In this work, three redox-active macrocyclic ligands have been synthesized and studied for the development of potential …

Compositional Differences In Bacterial Communities In Fresh And Saltwater Wetlands Of The Gulf Coast, Mary Grace Bass

Honors Theses

Wetlands are important reservoirs for biodiversity and ecosystem services such as nutrient cycling. However, the anthropogenic stressors of sea-level rise and eutrophication threaten these habitats. In this study, I examined the bacterial communities at six locations along the US Gulf Coast between Louisiana and Florida, focusing on how these communities were affected by salinity, depth, and site location. At each of six locations, five 30cm-deep soil cores were taken from a tidal fresh marsh and either a tidal brackish marsh or tidal saltmarsh. Bacterial DNA was extracted from both the surface layer and the root layer of each soil core. …

Feedback-Related Neuronal Processing During Motor Learning, Rosemary Marguerite Marquez

Honors Theses

Motor learning has been widely examined using electroencephalography (EEG) to record event related potentials (ERP). ERPs occur in response to given stimuli and represent underlying neural processes that are either modifying or being modified by motor learning. This study seeks to examine how movement feedback changes neural activity (i.e. ERPs) in the motor cortex, and more specifically, if feedback-related neuronal activity is modified by motor learning and visual feedback. A novel visuomotor rotation task was employed in which participants adapted their movement to a 30- degree counter-clockwise rotation. Feedback was given through the presence or absence of the trajectory line …

To Sleep Or Not To Sleep, That Is The Question: Sleep, Anxiety And Depressive Symptoms In Pregnancy, Alexis B. Miller

Honors Theses

Pregnancy is a time associated with many changes in a woman’s body including hormonal, metabolic, physical, and physiological changes (Miller, 2004; Okun, Kiewra, Luther, Wisniewski, & Wisner, 2011). A related concern is pregnant women and the impact of disturbed sleep. According to the Centers for Disease Control and Prevention (CDC), over 36% of the population in Mississippi experience an insufficient amount of sleep (CDC, 2014). Moreover, sleep disturbances in pregnancy are significantly associated with antenatal depressive and anxiety symptoms (Volkovich, Tikotzky, & Manber, 2015; Yu et al., 2017). The present study assessed potential relations between sleep disturbances, anxiety, depressive symptoms …

“Nosotras Como Mujeres”: The Environmental Activism Of Indigenous Women Of The Ecuadorian Amazon, Leta Rowan

Honors Theses

Across Latin America, indigenous organizations have mobilized against environmental destruction inflicted upon their communities. Environmental destruction brought about by climate change and extractive industries has been especially devastating in the Western Amazon- the most biologically diverse region of the Amazon and home to a diversity of indigenous populations. The efforts of indigenous organizations in the Western Amazon, notably the Ecuadorian Amazon, have been successful in affecting progressive environmental policies as a means to protect their natural environments and standards of living. Indigenous women specifically have played a significant role in addressing the climate injustices affecting their communities and have employed …

Ferritin: An Iron Deficiency Biomarker In Collegiate Female Distance Runners, Ty Bigelow

Graduate Theses, Dissertations, and Problem Reports (ETD)

Context: Iron deficiency is a concern in distance runners due to the implications that hemoglobin production becomes impaired limiting oxygen uptake and tissue oxidation in the body. Ferritin is a biomarker used to diagnose iron deficiency. The related signs and symptoms of iron deficiency are associated with decreased performance and prolonged recovery. Objective: The purpose of this study was to investigate whether the change in ferritin levels affect measures of performance, measures of recovery, and rate of perceived exertion in female endurance runners. Design: The study was a descriptive longitudinal study. Setting: The study was conducted at a Mid-Atlantic Division …

The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Matthew John Myers

Graduate Theses, Dissertations, and Problem Reports (ETD)

Human skeletal muscle is a highly metabolic tissue necessary for mobility and coordination. Responsible for approximately one-fifth of the resting human metabolism, skeletal muscle is also an important regulator of metabolites like glucose and contributes to the regulation of body temperature. Although there is a gradual decline in muscle mass associated with aging, a certain percentage of the population suffer from severe muscle mass and strength deterioration, classified as sarcopenia (5-13% for people aged 60-70 years old, 11-50% for those 80 or older). Sarcopenia is linked to increased morbidity and mortality rates in the elderly population, while annual healthcare costs …

Stakeholder Perspectives On Teacher Attrition In Private Early Childhood Schools In India, Swathi Sandesh Menon

Walden Dissertations and Doctoral Studies

Teacher attrition is a problem that has consequences for children and schools in many countries; children are affected negatively both emotionally and intellectually, while schools suffer setbacks, such as financial stress and disruption of the learning environment. This multiple case study explored the perspectives of stakeholders in India regarding how teacher attrition in private early childhood schools influenced students, teachers, parents, school leaders, and schools, as well as the factors that stakeholders identified as important for teacher retention in private early childhood education. The conceptual framework was Bronfenbrenner's ecological systems theory. Data were collected through interviews with teachers and school …

Predictors Of Poor Pregnancy Outcomes Among Pregnant Women In Island Maternity, Nigeria, Letam Nwi-Ue

Walden Dissertations and Doctoral Studies

Pregnancy outcomes have improved tremendously in developed countries. Notwithstanding, it is still a huge challenge in developing countries, especially Sub-Saharan Africa. In 2015 in Nigeria, about 145 women died daily from pregnancy-related causes. Similarly, nearly 2,300 children under 5 years were lost in the same year. Nigeria consistently underperformed in some of the critical pregnancy indicators such as maternal and neonatal mortality, second worst only to India in the world. Studies on poor pregnancy outcomes are scarce in Nigeria. The purpose of this quantitative, retrospective cross-sectional study was to use local evidence to ascertain the risk factors that predict poor …

Examining The Lived Experiences Of Divorce Among Hispanic Parents, Maria Rosa Perez

Walden Dissertations and Doctoral Studies

Parental divorce does not have the same effect on all children, and the cultural background of families may have an impact on children's experience of divorce. The purpose of this research was to investigate the lived experiences of Hispanic parents of school-aged children who are divorced or are going through the divorce process in order to examine how their children adjust to this family change. Crisis theory and critical race theory were used as theoretical frameworks, and a phenomenological approach was used to collect data from 13 parents through semi-structured interviews. Twenty-seven themes (six minor, five major, 14 subthemes, and …

Risk Factors Associated With The Contraction Of Ebola Virus Disease In Liberia, Beyan Yancy Sana

Walden Dissertations and Doctoral Studies

Ebola virus disease (EVD) is a highly transmittable disease with high mortality rate. The purpose of this study was to examine risk factors associated with the contraction of EVD in Liberia. A retrospective cross-sectional design was used to analyze secondary data collected on 1,658 patients admitted to Ebola treatment units in Liberia, using the social ecological model as a theoretical framework. Descriptive statistics and the chi-square test for association and logistic regression were used to analyze the data. The findings of this study revealed that funeral attendance, exposure to body fluids, and contact with a living sick person were associated …

Evaluating The Effects Of Counterterrorism Strategies On Insurgency In Nigeria, Bowie Sonnie Bowei

Walden Dissertations and Doctoral Studies

With the evolving problems of terrorism in Nigeria and the formation of numerous new terrorist groups, insurgency in Nigeria has escalated, making it one of the most terrorized countries in sub-Saharan Africa. This study looked critically at the effects of the strategies applied in the attempt to fight terrorism and how these strategies have affected insurgency in Nigeria. The background of the study gives an insight on the evolution of terrorist groups in Nigeria, their mode of operation, effects on citizens and the Nigerian economy, as well as the operations of counterterrorist agencies. The qualitative research method was used for …

Safe Chemical Handling By Agrochemical Users In Plateau State, Nigeria, Adaobi Ifeoma Ekwempu

Walden Dissertations and Doctoral Studies

Agrochemical use has been increasing in both developing and the developed nations. The unsafe handling and use of agrochemicals can lead to accumulation of hazardous chemicals in the body, causing adverse effects on health. This quantitative cross sectional study sought to understand the level of awareness, practices, and perceptions of safe chemical handling by agrochemical using the Theory of Planned Behavior. This study was conducted among 260 farmers in Plateau State, Nigeria. Data on background knowledge and practices of safe agrochemical handling by farmers were collected using a structured paper based, interviewer-€administered questionnaire. Descriptive statistics revealed that the most practiced …

Randomized Trial Of Polychromatic Blue-Enriched Light For Circadian Phase Shifting, Melatonin Suppression, And Alerting Responses., J. P. Hanifin, S. W. Lockley, K. Cecil, K. West, M. Jablonski, B. Warfield, M. James, M. Ayers, B. Byrne, E. Gerner, C. Pineda, M. Rollag, G. C. Brainard

Department of Neurology Faculty Papers

Wavelength comparisons have indicated that circadian phase-shifting and enhancement of subjective and EEG-correlates of alertness have a higher sensitivity to short wavelength visible light. The aim of the current study was to test whether polychromatic light enriched in the blue portion of the spectrum (17,000 K) has increased efficacy for melatonin suppression, circadian phase-shifting, and alertness as compared to an equal photon density exposure to a standard white polychromatic light (4000 K). Twenty healthy participants were studied in a time-free environment for 7 days. The protocol included two baseline days followed by a 26-h constant routine (CR1) to assess initial …

Adherence To Art Among Hiv Infected Female Sex Workers In Nigeria, Abass Babatunde Yusuf

Walden Dissertations and Doctoral Studies

A lack of adherence to antiretroviral therapy (ART) increases the risk of onward human immunodeficiency virus (HIV) transmission and mortality. The purpose of this cross-sectional study based on Andersen's conceptual framework was to test the associations between age, marital status, job/occupational status, education, membership in a peer support group, community, and facility ARV drug refill and alcohol and substance use, and adherence to ART among female sex workers (FSWs) who are 15 years and older in Rivers and Cross Rivers states Nigeria. Data were abstracted from existing program data collected between January 2015 and December 2017 by Heartland Alliance International, …

Assessment Of Tuberculosis Underreporting By Level Of Reporting System In Lagos, Nigeria, Mustapha Gidado

Walden Dissertations and Doctoral Studies

Abstract

Tuberculosis (TB) is the leading cause of death from a single infectious disease. Unfortunately, 4.1 million cases were missed in 2017 globally, and Nigeria contributes 9% of the missing TB cases. At least 73% of the estimated TB cases in Nigeria were not reported in 2017 to the National TB Program (NTP); therefore, the true burden of TB was not certain, and this affected planning for prevention and control of TB. This quantitative secondary data analysis (NTP Lagos TB Inventory study database) guided by the integrated behavioral model assessed TB underreporting based on the TB reporting process in Nigeria. …

Probation Officers And Parole Agents' Perceptions Of Institutional Obstacles To Reducing Recidivism In A Midwestern State, Gertha Lee Lusby

Walden Dissertations and Doctoral Studies

Prison management and key stakeholders lack an understanding of how institutional obstacles interfere with probation officers and parole agents' ability in managing offenders to reduce recidivism in a Midwestern state. In 2014, 1 out of 52 adults in the U.S. were under the supervision of probation officers or parole agents. The purpose of this descriptive phenomenological study was to identify the institutional obstacles that exist for probation officers and parole agents in terms of their lived experiences in their jobs. The participants were 5 probation officers and 6 parole agents from a municipal district in a county in a Midwestern …

Preconception Health And Preterm Birth Differences Among U.S.-Born And Foreign-Born Black Women, Sheree Holmes Keitt

Walden Dissertations and Doctoral Studies

Foreign-born Black women giving birth in the United States have superior preterm birth outcomes compared to their U.S-born Black peers. Many studies have focused on tobacco use and medical risk factors, but few have focused solely on preconception health. The purpose of this study was to examine preconception health and preterm birth differences among U.S.-born and foreign-born Black women. Three theoretical frameworks guided this study: the life course theory, healthy migrant theory/immigrant paradox, and weathering theory. Primary research questions assessed (a) if there were an association between chronic preconception risk factors, prepregnancy obesity, diabetes, and hypertension, in U.S.-born and foreign-born …

"Exploring Telehealth Feasibility For Hiv Status In Individuals Aged 17 To 34 In Southwestern Nigeria", Michael Funso Olaniyi

Walden Dissertations and Doctoral Studies

Abstract

The use of smart phones among young people in Southwestern Nigeria has grown since the early 1990'€™s while traditional healthcare access had continued to deteriorate. HIV care centers have been concentrated in large cities, but earlier studies had shown higher prevalence of HIV in rural areas that constituted a larger portion of the population. However, existing studies had not adequately explored the use of mobile phones to supplement traditional healthcare access. The purpose of this study was to assess the feasibility of telehealth for healthcare access among individuals aged 17-34 with positive HIV status and those at high risk …

Can Online Media-Literacy Education Mitigate The Effects Of A Toxic Media?, Patricia Tefo

Walden Dissertations and Doctoral Studies

Media-literacy education provides a way for people to assess and critically evaluate media images. Traditional media literacy programs have mitigated the negative effects of idealized media imagery such as reduced self-esteem, eating-disordered attitudes, and low body-satisfaction among women. Although education is moving increasingly to online platforms, the potential of media literacy education delivered online has not been evaluated. Based on social comparison and objectification theories, the purpose of this study was to quantitatively assess the comparative efficacy of online and face-to-face media literacy education programs. A quasi-experimental design using pre- and post-media literacy education program questionnaires was used. A mixed-method …

Cultural Competence Of Public Health Nurses Who Care For Diverse Populations, Althea Michelle Otuata

Walden Dissertations and Doctoral Studies

Despite advances in health, science, and technology, U.S. healthcare lags in providing access to care and quality care to racial and ethnic minorities. Cultural competence has been noted as a strategy to improve access and quality. The purpose of this project was to assess public health nurses' cultural competence before and after participating in cultural competence informational modules. Two conceptual models were used in this project for theoretical guidance: Leininger's cultural care diversity and universality theory and Campinha-Bacote's process of cultural competence. To assess the nurses' cultural competence, the Cultural Competence Self-Assessment Checklist questionnaire was e-mailed to 57 public health …

Unconventional Oil And Gas Energy Systems: An Unidentified Hotspot Of Antimicrobial Resistance?, Maria Fernanda Campa, Amy K Wolfe, Stephen Techtmann, Ann-Marie Harik, Terry C Hazen

Michigan Tech Publications, Part 1

Biocides used in unconventional oil and gas (UOG) practices, such as hydraulic fracturing, control microbial growth. Unwanted microbial growth can cause gas souring, pipeline clogging, and microbial-induced corrosion of equipment and transportation pipes. However, optimizing biocide use has not been a priority. Moreover, biocide efficacy has been questioned because microbial surveys show an active microbial community in hydraulic fracturing produced and flowback water. Hydraulic fracturing produced and flowback water increases risks to surface aquifers and rivers/lakes near the UOG operations compared with conventional oil and gas operations. While some biocides and biocide degradation products have been highlighted as chemicals of …

The Effects Of A Multicultural Overseas Community On Military Adolescents, Nicole Hayes

Walden Dissertations and Doctoral Studies

Several reserachers have identified the challenges faced by military adolescent dependents. However, scholarly literature provides little evidence regarding examples of the impact of military adolescents' transition and adjustment to residing in a multicultural community overseas. A qualitative case study was conducted of 6 former military adolescents between the ages of 18 and 25, regarding their perceptions of the experiences and challenges they encountered while residing in a multicultural overseas community as a military dependent between grades 8-12. Benet's polarities of democracy served as the theoretical framework. All data were inductively coded and subjected to a thematic analysis from which 5 …

Effects Of Neighborhood Membership And Hypertensive Disorders In Pregnancy On Adverse Birth Outcomes, Chinyere Onyebuchi

Walden Dissertations and Doctoral Studies

Infant mortality (IM) rates in the United States remains high. The higher rates of IM among specific groups in the United States is believed to be fueled by the high rates of adverse birth outcomes including low birthweight (LBW) and preterm births (PTB) among these groups. Adverse birth outcomes have also been linked to the presence of hypertensive disorders during pregnancy. The purpose of this cross-sectional study was to explore the association between hypertensive disorders during pregnancy and adverse birth outcomes and the impact of the residential neighborhood of expectant mothers on this association. The life course health development theory …