Digital Commons Network^™

Dispersal As A Buffer Against Zooplankton Community Change In Response To Fluctuating Salinity Levels On The Great Plains, Mercedes Huynh

Theses and Dissertations (Comprehensive)

The North American Great Plains is home to thousands of closed-basin lakes that are sensitive to changes in hydrology. Climate change models predict increased aridity in this region over the coming century, which is expected to lead to higher salinity levels in many freshwater lakes. Increases in salinity levels may impact zooplankton communities, as laboratory experiments show that many freshwater species have a low tolerance for elevated salinity levels, and field data demonstrate that salinity is the primary factor structuring aquatic communities on the Great Plains. Changes to zooplankton communities could lead to a trophic cascade based on their important …

Policy, Plans And Processes For Developing And Improving The Use Of Hazard Maps In Climate Change Adaptation For Yukon Communities, Stephanie Pike

Theses and Dissertations (Comprehensive)

Climate change has quickly become one of the most commonly discussed topics in northern Canada. Communities located in Canada’s north are facing impacts to every aspect of life. Hazard mapping is one of the tools used to predict risk from climate change impacts and thus assist communities in adaptation planning. The Northern Climate ExChange in Yukon has developed hazard maps for seven communities across Yukon. While hazard maps are a useful tool, in order for them to reach their maximum potential, users need to be well educated and trained to use them. Capacity and communication are arguably the most significant …

Nanoscale Building Blocks: Bridging The Gap Between Potential And Realized Applications, Nicole Ritter

Theses and Dissertations (Comprehensive)

The vast potential of nanoparticles and nanotechnology remains largely untapped; the crucial bottleneck being the knowledge gap between making and using nanoparticles (NPs). This PhD work bridges this gap by focusing on synthesizing nanoparticles with applications at the forefront. Four peer-reviewed publications are presented in Chapters 3-6, a safety and toxicological perspective is given in Chapter 7, and current work and future progress are summarized in Appendix 1. Bimorphic silver nanoparticles were prepared, presenting an innovative method to synthesize diverse nanostructures using polymeric surface blocking to break symmetry in seeded regrowth (Chapter 3).¹ Silver stars with D_5h symmetry …

Characterizing The Cellulose-Modifying Enzyme Bcsg From Escherichia Coli, Alexander Anderson, Joel T. Weadge

Theses and Dissertations (Comprehensive)

Microbial biofilms are communities of microorganisms that exhibit co-operative behaviour, producing a matrix of exopolysaccharide that enmeshes the community. The well-studied human pathogens Escherichia coli and Salmonella entericaproduce a biofilm matrix comprised chiefly of the biopolymer cellulose, along with amyloid protein fibers termed curli. This biofilm matrix confers surface adherence and acts as a protective barrier to disinfectants, antimicrobials, environmental stressors, and host immune responses. Pertaining to this research, the bcsEFG operon, conserved in the Enterobacteriaceae, encodes an inner membrane-spanning complex responsible for the addition of a phosphoethanolamine (pEtN) modification to microbial cellulose, essential for extracellular matrix assembly and …

Parents Who Kill: Media Constructions Of Male And Female Filicide Cases, Mary Mccluskey

Theses and Dissertations (Comprehensive)

Often, mothers who murder their children are portrayed as “bad mothers”, as “the news media creates monsters out of [those] who transgress what is considered appropriate maternal behavior” (Goc, 2009, p. 42). This is especially important, as the media has created portrayals of females as murderers which are different from portrayals of males who murder their children. Previous research has addressed the association of motherhood in female offenders, however, there is a lack of research that compares the portrayals of females and males who murder their children, formally known as filicide. Using a social constructionist lens, this research analyzes filicide …

Heterogeneous Chemistry Of Iron At The Liquid/Solid And Air/Solid Interfaces, Mohammad Aminur Rahman

Theses and Dissertations (Comprehensive)

Hematite is one of the common and stable phases of iron oxide that is ubiquitous in nature. It is involved in many heterogeneous reactions through liquid-solid and gas-solid interfacial interactions in aquatic geochemical systems. Moreover, the interfacial chemistry of metal-oxide and organic matter plays a significant role in the mobility and bioavailability of iron and other components such as arsenic in the soil and aquatic systems. The interactions of organic matter with metal oxide surfaces occur through several mechanisms in aquatic environment. Chapter 2 of this thesis describes the interactions of low molecular weight model organics that include citric acid …

Does Perceived Ecological Integrity Affect Restorative Health Outcomes? An Examination Of Visitor Experiences In Diverse Environments In An Ontario Protected Area, Catherine E. Reining

Theses and Dissertations (Comprehensive)

The human health and well-being benefits associated with nature contact is well established. Parks and other forms of protected areas contribute significantly to these benefits by providing access to nature. However, limited research has been done on how different environments within protected areas (e.g., forests, coasts, areas being restored) and the perceived quality (i.e., ecological integrity) of these environments affect the health and well-being outcomes of visitors. This study builds on previous work to better understand how visitor experiences provided by diverse natural and built environments in Pinery Provincial Park affect perceived restorative outcomes as one aspect of health and …

Temperature-Dependent Kinetic Studies Of Arsenicals Adsorption From Solution To Hematite Nanoparticles, Sara Soldoozy

Theses and Dissertations (Comprehensive)

Surface chemistry is the study of the chemical and physical phenomena that transpire at interfaces such as liquid-solid, solid-gas, liquid-gas, and liquid-liquid. To study the reactions occurred at the surfaces, surface sensitive techniques come to play. Adsorption of arsenical compounds (liquid adsorbate), particularly arsenate (iAs) and dimethylarsinic acid (DMA), to the surface of iron bearing materials (solid adsorbent) that frequently are found in geosorbents such as hematite (Fe₂O₃) has been studied in this thesis. Arsenical compounds can pollute the environment through natural sources and anthropogenic activities, and ultimately contaminate water. Absorbing these pollutants to a material …

Environmental Factors Associated With Benthic Macroinvertebrate Communities In Arctic Lakes, Northwest Territories, Rachel Cohen

Theses and Dissertations (Comprehensive)

Lake water quality and the macroinvertebrate communities in Arctic regions are threatened by increased development and climate change. In order to understand how macroinvertebrate communities may respond to their changing environment, I performed a biological and water quality survey of 46 Arctic lakes located in the Gwich’in Settlement Area and the Inuvialuit Settlement Region of the Northwest Territories. Using these survey data, I performed two interrelated studies that asked: 1) how artificial pit lakes associated with gravel extraction for road development compared with natural lakes in terms of their water quality, morphometry, and macroinvertebrate communities; and 2) how water quality …

Exploring The Personhood And Citizenship Of Persons With Disabilities Among Konkombas In Rural Ghana, Festus Moasun

Theses and Dissertations (Comprehensive)

Persons with disabilities (PWDs) are susceptible to various forms of mistreatments, particularly in the developing world, such that their personhoods are called to question. It was for this purpose that I set out to explore the personhood and citizenship of PWDs in rural Ghana. I used the constructivist paradigm in addition to the personhood and critical disability theories to guide the study which was conducted using an interpretive phenomenological research approach. To make the findings of the study participant driven, semi-structured interviews were held with PWDs. The findings revealed personhood to be perceived in a rank order of three semi-fluid …

Looking For Maize Genes Involved In Cold Response: Producing Knockouts For Arabidopsis Homologs Of Maize Candidate Genes Using A Crispr/Cas9 Approach, Katie Hillmann

Departmental Honors Projects

Most of today’s maize is cultivated outside its original climate zone, where yields are constrained by the changes in climate. Maize is especially vulnerable to high temperatures and drought stress, both of which negatively affect corn yields. An important strategy to combat this is early sowing, which avoids the effects of summer droughts and high temperatures in many places around the globe. However, maize is a cold sensitive species (Sanghera et al., 2011), making improvement to cold stress crucial for its adaption. The relatively new system CRISPR (Clustered regularly-interspaced short palindromic repeats)/Cas9 offers the potential to study cold-stress related …

Influence Of Ligand Complexation On Nickel Toxicity, Speciation And Bioavailability In Marine Waters, Samantha Sherman

Theses and Dissertations (Comprehensive)

Currently there are no site-specific bioavailability-based prediction models for assessing the impacts of nickel (Ni) in marine environments although there are indications that these may be warranted. The aim of this research was to characterize the complexation of Ni in relation to toxicity and speciation. Various complexing ligands were used, and it was predicted that the binding affinity (logKf) of ligands would be inversely correlated to toxicity based on dissolved Ni concentrations ([NiD]) but that on a free ion concentration ([Ni2+]) basis, toxicity would not vary. A two-phased approach was used; the first was a proof of principle where synthetic …

Genomic Prediction Of Relapse In Recipients Of Allogeneic Haematopoietic Stem Cell Transplantation., J Ritari, K Hyvärinen, S Koskela, M Itälä-Remes, R Niittyvuopio, A Nihtinen, U Salmenniemi, M Putkonen, L Volin, T Kwan, T Pastinen, J Partanen

Manuscripts, Articles, Book Chapters and Other Papers

Allogeneic haematopoietic stem cell transplantation currently represents the primary potentially curative treatment for cancers of the blood and bone marrow. While relapse occurs in approximately 30% of patients, few risk-modifying genetic variants have been identified. The present study evaluates the predictive potential of patient genetics on relapse risk in a genome-wide manner. We studied 151 graft recipients with HLA-matched sibling donors by sequencing the whole-exome, active immunoregulatory regions, and the full MHC region. To assess the predictive capability and contributions of SNPs and INDELs, we employed machine learning and a feature selection approach in a cross-validation framework to discover the …

The Children's Oncology Group: Organizational Structure, Membership, And Institutional Characteristics., Janice S. Withycombe, Todd A. Alonzo, Michele A. Wilkins-Sanchez, Maxine Hetherington, Peter C. Adamson, Wendy Landier

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The Children's Oncology Group (COG) is the only organization within the National Cancer Institute's National Clinical Trials Network dedicated exclusively to pediatric cancer research. The purpose of this article is to provide an overview of COG's organizational structure, to characterize its institutional and individual membership, and to summarize enrollments onto COG clinical trials.

METHOD: Data from 2013 to 2015 were compiled from sources internal (Network Operations, Statistics and Data Center, Chair's Office) and external (American Hospital Association, American Nurses Credentialing Center) to COG, to present a comprehensive overview of COG's structure, individual and institutional membership, and group operations.

RESULTS: …

Patent Eligibility Of Predictive Algorithm In Second Generation Personalized Medicine, Jerry I-H Hsiao

SMU Science and Technology Law Review

No abstract provided.

Driverless Cars And Resource Allocation, Jeff Daniel Clark

SMU Science and Technology Law Review

No abstract provided.

Corporate Genealogists: The New Homicide Detectives, Morgan Crider

SMU Science and Technology Law Review

No abstract provided.

Gotta Catch ‘Em All! The Rise Of Esports And The Evolution Of Its Regulations, Elizabeth Chung

SMU Science and Technology Law Review

No abstract provided.

Biomaterials Evaluation: Conceptual Refinements And Practical Reforms, Reza Masaeli, Kavosh Zandsalimi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Regarding the widespread and ever-increasing applications of biomaterials in different medical fields, their accurate assessment is of great importance. Hence the safety and efficacy of biomaterials is confirmed only through the evaluation process, the way it is done has direct effects on public health. Although every biomaterial undergoes rigorous premarket evaluation, the regulatory agencies receive a considerable number of complications and adverse event reports annually. The main factors that challenge the process of biomaterials evaluation are dissimilar regulations, asynchrony of biomaterials evaluation and biomaterials development, inherent biases of postmarketing data, and cost and timing issues. Several pieces of evidence indicate …

Edta-Modified Mesoporous Silica As Supra Absorbent Of Copper Ions With Novel Approach As An Antidote Agent In Copper Toxicity, Elham Rafiee Taqanaki, Reza Heidari, Mohammad Monfared, Lobat Tayebi, Amir Azadi, Fatemeh Farjadian

School of Dentistry Faculty Research and Publications

Purpose: Mesoporous silica (MS) have been considered as a biocompatible compound and found to have various pharmaceutical applications. Recently, novel approaches in applications of MS as antidote agents were introduced. In this study, the capacity of ethylenediaminetetraacetic acid modified mesoporous silica (MS-EDTA) was evaluated in in vitro and in vivo adsorption of copper (Cu). Methods: The MS-EDTA was characterized by fourier transform infrared (FT-IR) and X-ray diffraction, while surface area was determined by N₂ adsorption–desorption technique. Morphological studies were observed by high resolution-transmission electron microscopy and field emission-scanning electron microscopy and the sizes were determined by dynamic light scattering. …

Microfluidic Synthesis Of Plga/Carbon Quantum Dot Microspheres For Vascular Endothelial Growth Factor Delivery, Meisam Omidi, Mohadeseh Hashemi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide-co-glycolide) (PLGA) – carbon quantum dot microspheres were produced using microfluidic platforms. The microcapsules were fabricated in flow-focusing geometry with a biphasic flow to generate solid/oil/water (s–o–w) droplets. To avoid any damage to protein functional and structural stability during the encapsulation process, the VEGF was PEGylated. The produced microspheres were intact and highly monodisperse in size (CV < 5%). Furthermore, microspheres in a size range of 16–36 µm were achieved by adjusting the flow ratio parameter. The encapsulation efficiency, release profile, and bioactivity of the produced microparticles were also studied. The loading efficiency of PEGylated VEGF in the microparticles was varied from 51–69% and more than 90% of PEGylated VEGF was released within 28 days. Furthermore, the release of VEGF was indirectly monitored by carbon quantum dots. The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications.

Influence Of Apical Preparation Size On Effective Conventional Irrigation In The Apical Third: A Scanning Electron Microscopic Study, Seth Butcher, Abeer Mansour, Mohamed Ibrahim

School of Dentistry Faculty Research and Publications

Objective: This study aimed to investigate the relationship between final apical preparation size and smear layer removal in the apical third using conventional irrigation in mandibular bicuspids.

Methods: A total of 66 extracted human mandibular bicuspids with comparable root canal morphology were equally divided into five experimental groups and a control group (n=11). Based on their experimental group, samples were instrumented up to size 25, 30, 35, 40, or 45 with 0.04 taper using 2.5% sodium hypochlorite (NaOCl) as the irrigant. Final irrigation was performed with 17% EDTA followed by 2.5% NaOCl. The control group was instrumented up to size …

An Emerging Theory Of The Persistence Of Social Class Microaggressions: An Interpretative Phenomenological Study, Jennifer M. Cook, Caroline O'Hara

College of Education Faculty Research and Publications

Eleven counselor education doctoral students participated in an Interpretive Phenomenological Analysis study aimed to understand their social class microaggressions (SCMs) experiences. A tentative theory emerged from the data that SCMs persist to preserve homeostasis. The super-ordinate theme, Unequal, Embedded, Societal Structures is corroborated by the subordinate themes, Social Class Invisibility, Intersecting Identities, Perceptions and Assumptions about Social Class, Privilege and Unawareness about Social Class, and SCM Manifestations. Together, the superordinate theme and subsequent subordinate themes culminate in the preservation of homeostasis. We offer a data driven model to depict the theory, present participant data with extensive quotes, counseling …

Social And Psychological Factors Affecting Coping With And Adjusting To Disability, Alie Kriofske Mainella, Susan Miller Smedema

College of Education Faculty Research and Publications

This chapter provides an overview of the social and psychological factors contributing to coping with and adjusting to disability by summarizing models; clinical implications, evidence-based practice, and measurement issues; and empirical research related to the process of coping with and adjustment to disability. While the models are useful for understanding a portion of the experience of people with disabilities and their coping and adjustment process, these reactions are not universal and not always experienced in an orderly sequence. Both coping and adaptation are multidimensional, complex processes affected by many factors and influenced by the person with the disability, the stress …

Justice For Nature, Haydn Washington

Animal Sentience

Eight points are made in this commentary: (1) Ecocentrism is the preferable term. (2) Indigenous societies have long used a kinship ethics. (3) Earth jurisprudence and ecodemocracy should be considered. (4) Assumptions can be better defined. (5) Ethical pluralism is open to question. (6) The ethics of individuals vs. ecosystems needs further discussion. (7) Including justice for nature within social justice may be a serious mistake. (8) Trustees need to be ethically sophisticated.

Just Policy Paralysis?, Clare Palmer, Bob Fischer

Animal Sentience

Treves et al. (2019) argue that policy making should include the interests and well-being of present and future generations of humans and nonhumans. There are deep and abiding conflicts of interest both between and within these groups. Trying to factor in so many considerations is likely to generate political gridlock. The authors need to explain how to avoid this.

Futurity, Selves And Further Organisms, Robin Attfield

Animal Sentience

Most aspects of Treves et al.’s target article are commendable, but I would suggest: explicitly including (1) Singer’s ‘equal interests’ principle; adjusting (2) Mathews’s principle of ‘bioproportionality’; and clarifying the implications of (3) Parfit’s Non-Identity Problem, (4) the limits of present predictions of future needs, and (5) the application of the concept of selves to biotic individuals. There is also a problem about (6) how plants are to be individuated.

Just Preservation: From Vision To Reality, Rupu Gupta

Animal Sentience

Treves et al. propose a tangible shift in current discourse and practice related to the human relationship with other forms of nature. They aim to instill an ethical stance in human perspectives on nature, advocating the idea of trustees as advocates for non-human nature in consensus-building scenarios. This commentary raises questions about the practicality of a wide-scale culture shift in values towards non-human nature, and the power dynamics that are inevitable in multi-stakeholder settings.

Granting Political Representation To Non-Humans, Joe Gray

Animal Sentience

This commentary discusses the representation of individuals versus populations — human and nonhuman, present and future — in Treves et al.’s proposed trusteeship for futurity. Terminological questions are also discussed.

Reconciling Just Preservation, Shelley M. Alexander

Animal Sentience

Treves et al.’s target article can play an important role in reconciling the needs of future generations and non-human animals in conservation. Human capacities are adequate for interpreting and defining many non-human animal needs. Worldviews are more complex, however, and conservation science, like the target article itself, suffers from a lack of diversity and inclusiveness. This may pose practical impediments to realizing just preservation.