Digital Commons Network^™

The Neurological Development Of Sagittal Craniosynostosis Patients Treated With Whole Vault Cranioplasty, Raysa Cabrejo

Yale Medicine Thesis Digital Library

Objective: In this study we seek to clarify the neurological changes before and after whole vault cranioplasty (WVC) in patients born with sagittal craniosynostosis.

Methods: A case control study design was performed that included forty fMRI scans, from thirty-five individual patients. Functional MRI (fMRI) and diffusion tension imaging (DTI) data were analyzed with BioImageSuite (Yale University, USA). All nine functional brain networks were analyzed with appropriate regions of interest.

Results: Comparing functional MRI the infants after WVC vs. infants before WVC group, the after WVC group demonstrated an increased connectivity in the left frontoparietal (LFPN), secondary (V2) and third (V3) …

Insulin And Non-Insulin Dependent Glut4 Trafficking: Regulation By The Tug Protein, Stephen Devries

Yale Medicine Thesis Digital Library

The body tightly regulates glucose production and disposal despite changing metabolic demands, including large post-prandial and fasting fluctuations. Specifically, under the action of insulin, muscle contraction, ischemia, and poor nutrient availability, cells increase the amount of the glucose transporter type 4 (GLUT4) at the plasma membrane by mobilizing a sequestered pool of transporters. In this work, we demonstrate that the TUG (tether containing a UBX domain for GLUT4) protein mediates both insulin-dependent and insulin-independent pathways to increase GLUT4 at the plasma membrane. In mice fed a high fat diet to induce insulin resistance, the regulation of the endoproteolytic cleavage of …

Ossification Of The Phalanges Of The Foot And Its Relationship To Peak Height Velocity And The Calcaneal System, Mekka Garcia

Yale Medicine Thesis Digital Library

Background: There are multiple skeletal maturity grading systems, but none of them utilizes the phalanges of the foot. To minimize radiation, it would be ideal if one could assess the skeletal maturity of a foot based on bones seen on routine foot x-rays, if guided growth is being considered as a treatment option, as in hallux valgus. We developed a system that in combination with the calcaneal system, can closely predict skeletal maturity and help with the timing of surgical interventions of the foot.

Methods: We selected 94 healthy children from the Bolton-Brush study, each with consecutive radiographs from age …

The Application Of Extracorporeal Photochemotherapy To Head And Neck Squamous Cell Carcinoma, Alp Yurter

Yale Medicine Thesis Digital Library

Extracorporeal Photochemotherapy (ECP) is an FDA-approved immunotherapy that has been treating cutaneous T cell lymphoma (CTCL) for over three decades. ECP’s antitumoral effect is a consequence of its generation of functional, physiologic, inflammatory monocyte-derived dendritic cells (MoDCs) and apoptotic, patient-derived tumor, which collectively, stimulate the adaptive immune system. Thus, in CTCL, ECP serves as a therapeutic dendritic cell vaccine against patient-specific neoantigens. This mechanism of action suggests ECP’s potential application to other solid tumors. We tested ECP’s applicability to head and neck squamous cell carcinoma (HNSCC) using a trackable antigen system involving the constitutively expressed HPV16 E7 oncoprotein. We hypothesized …

Medicine@Yale February/March 2019 Volume 15, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale November/December 2019 Volume 15, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Artificial Intelligence In The Aviation Manufacturing Process For Complex Assemblies And Components, Elena Vishnevskaya, Ian Mcandrew, Michael Johnson

Publications

Aviation manufacturing is at the leading edge of technology with materials, designs and processes where automation is not only integral; but complex systems require more advanced systems to produce and verify processes. Critical Infrastructure theory is now used to protect systems and equipment from external software infections and cybersecurity techniques add an extra layer of protection. In this research, it is argued that Artificial Intelligence can reduce these risks and allow complex processes to be less exposed to the threat of external problems, internal errors or mistakes in operation.

Analysis Of Gene Transcription Changes Following Chlamydia Pneumoniae Infection Of Thpl Monocytes May Have Relevance To Alzheimer's Disease, Desiré Guthier

PCOM Biomedical Studies Student Scholarship

There is increasing evidence that neuroinflammation caused by infectious agents is an important etiologic factor in neurodegenerative diseases including Alzheimer's disease (AD). One infectious agent that has been associated with AD is Chlamydia pneumoniae (Cpn). Cpn DNA can be detected within peripherally circulating mononuclear cells and there is evidence that infected mononuclear cells could be involved in chronic infection and contribute to inflammation at numerous anatomical sites, including the brain. Understanding Cpn genetic changes progressing from an acute to a chronic infection within monocytes may help to further elucidate. the role of Cpn infected monocytes with regard to …

Test 2216: Kubota M7-172, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Test 2214: Kubota M7-132, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Paging Dr. Robot: Applying An Outdated, Regulated Scheme To Robotic Medicine, Talya Van Embden

Nova Law Review

No abstract provided.

Undergraduate Catalogue 2019-2020, Seton Hall University

Undergraduate Catalogues

No abstract provided.

Growing Up In America's Segregated South: Reminiscences And Regrets, Mark R. Elliott

The Asbury Journal

In this personal essay, originally given as an address delivered at the Sakharov Center, a human rights NGO in Moscow, Russia, on June 2, 2017, the author contemplates a lifetime of experience in the Southern United States and the prejudices and racism that he saw during that time. He relates these experiences to similar issues in Russia today, adding a Christian plea for equality and fair treatment for all people by the Christian community, and also calling on the Church to stand in opposition to racism and anti-Semitism wherever it appears.

Chemical Synthesis, Characterization And Biological Evaluation Of Methylation And Glycation Dna Adducts, Qi Tang

Open Access Dissertations

The integrity of genomic DNA is constantly challenged by endogenous and environmental agents with the formation of DNA adducts. Some of these adducts are toxic and mutagenic to replication, thus potentially leading to cancer and other genetic diseases. To counteract the undesired DNA modifications from damaging agents, cells have evolved a number of repair pathways, such as base-excision repair, nucleotide-excision repair, mismatch repair, and direct reversal repair, to restore the intact DNA. However, DNA repair is not always efficient, there are many interfering factors, such as inherited deficiency in DNA repair pathways, or the abnormal uptake of substance with inhibitory …

Self-Monitoring Heart Rate Biofeedback: A Secondary Prevention Strategy For Managing Anxiety In College Students, Louis William Turchetta

Open Access Dissertations

Intro: Anxiety is often a chronic condition that will affect approximately 29% of individuals during their lifetimes (Dennis & O’Toole, 2014). Unfortunately, numerous barriers to treatment exist, especially when treating children (Dennis & O’Toole, 2014). Wearable technology, particularly utilizing heart rate monitoring, can potentially aid in the treatment of anxiety, allowing for greater recognition of symptoms and interventions in any setting.

Hypothesis: Hypothesis one: College students with "mild to moderate" levels of anxiety will be able to utilize self-monitoring heart rate biofeedback (SMHRB) consistently (e.g., respond to at least 70% of Maximum HR alerts utilizing relaxation breathing). Hypothesis …

Dietary Polyphenols And Their Gut Microbiota Metabolites As Potential Treatments For Alzheimer's Disease, Kenneth N. Rose

Open Access Dissertations

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that has no cure, no therapies to stop the disease progression, and limited palliative care options. As the 6th leading cause of death in the United States, it is necessary to discover therapeutics which can alter disease progression to alleviate the burden on patients, caregivers, and healthcare systems. In the search of therapeutics for AD, dietary polyphenols have become the topic of research as epidemiological evidence suggests that exposure to dietary polyphenols, such as a Mediterranean diet, over one’s life, reduces the risk of dying from AD. Additionally, evidence from rodent models …

The Development Of The Self-Efficacy During Exposure – Child (See-C) Measure: A Pilot Study, Mary Kathryn M. Cancilliere

Open Access Dissertations

Cognitive-behavioral therapy (CBT) with exposure is an effective treatment for anxiety disorders but involves acute discomfort, rendering treatment engagement a challenge. Willingness to engage in exposure is of interest, because a child has to willingly approach a feared stimulus. This preliminary study investigated child engagement during exposures in CBT for anxiety disorders, with the development, validation, and field testing of a measure of self-efficacy over three time points. The measure, Self-Efficacy During Exposure-Child (SEE-C), is a 9-item, self-report measure of self-efficacy during exposure for youth 8-17 years old. A sample of eight reviewers at least 2-years post licensure (M = …

Development Of An E-Textile Debugging Module To Increase Computational Thinking Among Graduate Education Students, Victoria Herbst Kim

Theses and Dissertations

The increased presence of technology in all aspects of daily life makes computational thinking a necessary skill. Predictions say that the rising need for computational thinkers will be unmet by computer science graduates. An e-textile learning module, based on principles of constructionism, was designed as a method to develop computation thinking skills and encourage interest and confidence in the computing fields in both male and female graduate education students. The module leveraged the affordances of the LilyPad Arduino, a technology that allows for the creation of projects that integrate textiles and electronics without soldering. The creation of the learning module …

Oyster-Associated Microbial Community Dynamics, Rebecca Jean Stevick

Open Access Dissertations

Oysters are keystone species in the coastal environment, providing ecological, economic, and cultural services. A significant ecosystem service is their ability to improve water quality by filtration and denitrification. These ecological functions are made possible by oyster-associated microbes, but may also be threatened by microbial pathogens. This positions the oyster as a model system for the study of marine host-associated microbial diversity and function. However, studies of microbial diversity and function in shellfish are lacking, particularly in response to environmental perturbations. As coastal ecosystems change due to anthropogenic impacts and climate variability, it is important to understand how the oyster …

An ‘Omics Approach To Diet & Structure Impact On Perfluoroalkyl Substance Induced Liver Disease, Marisa Pfohl

Open Access Dissertations

Perfluoroalkyl substances (PFAS), a family of environmental toxicants, are ubiquitous in the environment and the human population. PFAS are manmade chemicals that have been widely used in manufacturing since the 1940s. PFAS are extremely resistant to degradation leading to their accumulation within the environment and the general population. The most concentrated PFAS member present in the general population, perfluorooctanesulfonic acid (PFOS), has been linked to suppressed vaccine response, high serum cholesterol, low fetal birth weight, thyroid disease, increased markers of liver injury, and even certain types of cancers. PFOS was voluntarily phased out of manufacturing due to its bioaccumulutive and …

Constructing Transgression: Criminality In Experimental Literature, Charles Kell

Open Access Dissertations

This dissertation examines integral, challenging contemporary poetry and fiction, and its relationship to notions of the criminal in multiple guises. The present focus on “criminal” excavates not only its literal meaning - the nature of crime, and its specific relation to penal law - but also brings to light how the “criminal” affects the construction of fiction and poetry, and the lives of various individuals (speakers) within the chosen texts. Intricately tied with the criminal are practices that transgress, and this study will also locate specific creations where poets and novelists construct transgressions that challenge contemporary ideas of narrative and …

Nanoparticle-Cell Membrane Interactions: Adsorption Kinetics And The Monolayer Response, Nasim Ganji

Open Access Dissertations

The fast-growing production and utilization of nanomaterials in diverse applications will undoubtedly lead to the release of these materials into the environment. As nanomaterials enter the environment, determining their interaction with biological systems is a key aspect to understanding their impact on environmental health and safety. It has been shown that engineered nanoparticles (ENPs) can interact with cell membranes by adhering onto their surface and compromising their integrity, permeability, and function. The interfacial and biophysical forces that drive these processes can be examined using lipid monolayers or bilayers as model cell membranes.

Interfacial interactions between NPs and cell membranes have …

Microplastic Prevalence In Two Fish Species In Two U.S. Reservoirs, William Perry, Catherine M. O'Reilly, Raven Hurt

Faculty Publications – Biological Sciences

No abstract provided.

Identifying Dopamine Receptor Genes And Transcription Marbled Crayfish, Wolfgang Stein, Saisupritha Talasu

Faculty Publications – Biological Sciences

Modulatory transmitters are major contributors to nervous system plasticity and behavioral flexibility, they determine motivational states and are involved in psychiatric and neurological disorders. Neuromodulators act through a variety of distinct receptors and due to the diversity in receptor subtypes and distribution, a single neuromodulator can exert many different actions. A prerequisite to understand the ways modulators work is thus to identify which receptors are expressed in an animal.

I studied which Dopamine receptors are present in the Procambarus virginalis, a highly invasive species of all female genetic clones with high quality genome and transcriptomes. Their broad behavioral repertoire makes …

Degradation Kinetics Of Cold Plasma-Treated Antibiotics And Their Antimicrobial Activity, Chaitanya Sarangapani, Dana Ziuzina, Patrice Behan, Daniela Boehm, Brendan F. Gilmore, Patrick J. Cullen, Paula Bourke

Articles

Antibiotics, such as ofloxacin (OFX) and ciprofloxacin (CFX), are often detected in considerable concentrations in both wastewater effluents and surface water. This poses a risk to non-target organisms and to human health. The aim of this work was to study atmospheric cold plasma (ACP) degradation of antibiotics in water and meat effluent and to explore any residual antimicrobial activity of samples submitted to the plasma process. The results revealed that ACP successfully degraded the studied antibiotics and that the reaction mechanism is principally related to attack by hydroxyl radicals and ozone. According to the disk diffusion assay, the activity of …

Cost-Efficient And Easy To Perform Pcr-Based Assay To Identify Met Exon 14 Skipping In Formalin-Fixed Paraffin-Embedded (Ffpe) Non-Small Cell Lung Cancer (Nsclc) Samples, Odharnaith O'Brien, Mark C. Wright, Cathal O'Brien, Orla Geoghegan, Niamh Leonard, Siobhan Nicolson, Sinead Cuffe, Aurelie Fabre, Wolfram Jochum, Markus Joerger, Steven G. Gray, Stephen P. Finn

Articles

MET is a receptor tyrosine kinase (RTK) that plays important roles in carcinogenesis. Despite being frequently overexpressed in cancer, clinical responses to targeting this receptor have been limited. Recently novel splicing mutations involving the loss of exon 14 (called METex14 skipping) have emerged as potential biomarkers to predict for responsiveness to targeted therapies with Met inhibitors in non-small cell lung cancer (NSCLC). Currently, the diverse genomic alterations responsible for METex14 skipping pose a challenge for routine clinical diagnostic testing. In this report, we examine three different methodologies to detect METex14 and assess their potential utility for use as a diagnostic …

Ultrasound/Elastography Techniques, Lipidomic And Blood Markers Compared To Magnetic Resonance Imaging In Non-Alcoholic Fatty Liver Disease Adults, Irene Cantero, Mariana Elorz, Itziar Abete, Bertha Araceli Marin, Jose Ignacio Herrero, Jose Ignacio Monreal, Alberto Benito, Jorge Quiroga, Ana Martínez, Pilar Huarte, Juan Isidro Uriz-Otano, Josep Antoni Tur, John Kearney, J. Alfredo Martinez, M. Angeles Zulet

Articles

Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations. Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease. Materials and methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Body composition (DXA), hepatic related biochemical measurements as well as the Fatty …

Effect Of Neoadjuvant Chemoradiation On Preoperative Pulmonary Physiology, Postoperative Respiratory Complications And Quality Of Life In Patients With Oesophageal Cancer, J. A. Elliott, L. O'Byrne, G. Foley, C. F. Murphy, Suzanne Doyle, S. King, E. M. Guinan, N. Ravi, V. Reynolds

Articles

Background: It remains controversial whether neoadjuvant chemoradiation (nCRT) for oesophageal cancer influences operative morbidity, in particular pulmonary, and quality of life. This study combined clinical outcome data with systematic evaluation of pulmonary physiology to determine the impact of nCRT on pulmonary physiology and clinical outcomes in locally advanced oesophageal cancer.

Methods: Consecutive patients treated between 2010 and 2016 were included. Three-dimensional conformal radiation was standard, with a lung dose–volume histogram of V20 less than 25 per cent, and total radiation between 40 and 41⋅4Gy. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and diffusion capacity …

A Web-Based Dietary Intervention In Early Pregnancy And Neonatal Outcomes: A Randomized Controlled Trial, Rachel Ak Kennedy, C.M.E. Reynolds, Shona Cawley, E. O'Malley, D.M. Mccartney, M.J. Turner

Articles

Background Maternal nutrition is a determinant of pregnancy outcomes. Few studies have evaluated the potential of online nutrition resources to modify behaviour. This randomized controlled trial aimed to determine whether access to a customized evidence-based nutrition website in pregnancy improved neonatal outcomes.

Methods Women < 18 weeks gestation were recruited at their convenience. The control group received standard care. In addition to standard care, the intervention group received access to an evidence-based nutrition website, customized to the preferences of pregnant women.

Results Of the 250 women, there were no differences in characteristics between the two groups. Of the women, 91.0% reported they make a conscious effort currently to eat a healthy diet. However, only 19.6% met dietary requirements for calcium, 13.2% for iron, 2.7% for folate and 2.3% for iodine. The most popular website section was pregnancy …

The Effect Of Atmospheric Cold Plasma On Bacterial Stress Responses And Virulence Using Listeria Monocytogenes Knockout Mutants, Apurva Patange, Conor O'Byrne, Daniela Boehm, Patrick J. Cullen, Kevin Keener, Paula Bourke

Articles

Listeria monocytogenes is an opportunistic intracellular pathogen commonly associated with serious 16 infections and multiple food-borne outbreaks. In this study, we investigated the influence of 17 atmospheric cold plasma (80 kV, 50 Hz) on L. monocytogenes (EGD-e) and its knockout mutants of 18 sigB, rsbR, prfA, gadD and lmo0799 genes at different treatment time intervals. Further, to ascertain if 19 sub-lethal environmental stress conditions could influence L. monocytogenes survival and growth 20 responses, atmospheric cold plasma (ACP) resistance was evaluated for the cultures exposed to cold 21 (4°C) or acid (pH 4) stress for 1 h. The results demonstrate that …