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J Mich Dent Assoc Jan 2019

The Journal of the Michigan Dental Association

Archival issues of the Journal of the Michigan Dental Association may include reports on the activities of the association and its members, clinical articles, information on legal and ethical practice considerations, and perspectives of interest to MDA members and those in the oral health profession.

Biomaterials Evaluation: Conceptual Refinements And Practical Reforms, Reza Masaeli, Kavosh Zandsalimi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Regarding the widespread and ever-increasing applications of biomaterials in different medical fields, their accurate assessment is of great importance. Hence the safety and efficacy of biomaterials is confirmed only through the evaluation process, the way it is done has direct effects on public health. Although every biomaterial undergoes rigorous premarket evaluation, the regulatory agencies receive a considerable number of complications and adverse event reports annually. The main factors that challenge the process of biomaterials evaluation are dissimilar regulations, asynchrony of biomaterials evaluation and biomaterials development, inherent biases of postmarketing data, and cost and timing issues. Several pieces of evidence indicate …

Edta-Modified Mesoporous Silica As Supra Absorbent Of Copper Ions With Novel Approach As An Antidote Agent In Copper Toxicity, Elham Rafiee Taqanaki, Reza Heidari, Mohammad Monfared, Lobat Tayebi, Amir Azadi, Fatemeh Farjadian

School of Dentistry Faculty Research and Publications

Purpose: Mesoporous silica (MS) have been considered as a biocompatible compound and found to have various pharmaceutical applications. Recently, novel approaches in applications of MS as antidote agents were introduced. In this study, the capacity of ethylenediaminetetraacetic acid modified mesoporous silica (MS-EDTA) was evaluated in in vitro and in vivo adsorption of copper (Cu). Methods: The MS-EDTA was characterized by fourier transform infrared (FT-IR) and X-ray diffraction, while surface area was determined by N₂ adsorption–desorption technique. Morphological studies were observed by high resolution-transmission electron microscopy and field emission-scanning electron microscopy and the sizes were determined by dynamic light scattering. …

Applications Of 3d Printing On Craniofacial Bone Repair: A Systematic Review, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren

School of Dentistry Faculty Research and Publications

Objectives

Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.

Data & sources

A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.

Study selection

43 …

Microfluidic Synthesis Of Plga/Carbon Quantum Dot Microspheres For Vascular Endothelial Growth Factor Delivery, Meisam Omidi, Mohadeseh Hashemi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide-co-glycolide) (PLGA) – carbon quantum dot microspheres were produced using microfluidic platforms. The microcapsules were fabricated in flow-focusing geometry with a biphasic flow to generate solid/oil/water (s–o–w) droplets. To avoid any damage to protein functional and structural stability during the encapsulation process, the VEGF was PEGylated. The produced microspheres were intact and highly monodisperse in size (CV < 5%). Furthermore, microspheres in a size range of 16–36 µm were achieved by adjusting the flow ratio parameter. The encapsulation efficiency, release profile, and bioactivity of the produced microparticles were also studied. The loading efficiency of PEGylated VEGF in the microparticles was varied from 51–69% and more than 90% of PEGylated VEGF was released within 28 days. Furthermore, the release of VEGF was indirectly monitored by carbon quantum dots. The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications.

Influence Of Apical Preparation Size On Effective Conventional Irrigation In The Apical Third: A Scanning Electron Microscopic Study, Seth Butcher, Abeer Mansour, Mohamed Ibrahim

School of Dentistry Faculty Research and Publications

Objective: This study aimed to investigate the relationship between final apical preparation size and smear layer removal in the apical third using conventional irrigation in mandibular bicuspids.

Methods: A total of 66 extracted human mandibular bicuspids with comparable root canal morphology were equally divided into five experimental groups and a control group (n=11). Based on their experimental group, samples were instrumented up to size 25, 30, 35, 40, or 45 with 0.04 taper using 2.5% sodium hypochlorite (NaOCl) as the irrigant. Final irrigation was performed with 17% EDTA followed by 2.5% NaOCl. The control group was instrumented up to size …

Effect Of Strength On Velocity And Power During Back Squat Exercise In Resistance-Trained Men And Women, Andrew T. Askow, Justin J. Merrigan, Jonathan M. Neddo, Jonathan M. Oliver, Jason D. Stone, Andrew R. Jagim, Margaret T. Jones

Faculty Scholarship

The purpose was to examine load-velocity and load-power relationships of back squat in resistance-trained men (n = 20, 21.3 ± 1.4 years, 183.0 ± 8.0 cm, 82.6 ± 8.0 kg, 11.5 ± 5.0% total body fat) and women (n = 18; 20.0 ± 1.0 years; 166.5 ± 6.9 cm; 63.9 ± 7.9 kg, 20.3 ± 5.0% body fat). Body composition testing was performed followed by determination of back squat 1 repetition maximum (1RM). After at least 72 hours of recovery, subjects returned to the laboratory and completed 2 repetitions at each of 7 separate loads (30, 40, 50, …

Proprietary Milk Protein Concentrate Reduces Joint Discomfort While Improving Exercise Performance In Non-Osteoarthritic Individuals, Tim N. Ziegenfuss, Chad M. Kerksick, A. William Kedia, Jennifer Sandrock, Betsy Raub, Hector L. Lopez

Faculty Scholarship

Milk and dairy products are known to contain various bioactives with potential anti-inflammatory and immune modulating effects. Previous research has indicated that milk produced from hyperimmunized cows provided meaningful health benefits to individuals suffering from varying degrees of osteoarthritis and rheumatoid arthritis. PURPOSE: To examine the impact of a proprietary milk protein concentrate on joint discomfort and physical function, exercise performance, quality of life and various measures of affect. METHODS: Non-osteoarthritic men (42.5 ± 8.9 years, 176.7 ± 6.7 cm, 89.9 ± 11.5 kg, 28.8 ± 3.5 kg/m2, n = 30) and women (46.4 ± 9.6 years, 163.1 ± 8.2 …

A Proof-Of-Mechanism Study To Test Effects Of The Nmda Receptor Antagonist Lanicemine On Behavioral Sensitization In Individuals With Symptoms Of Ptsd, Marijn Lijffijt, Charles E Green, Nicholas Balderston, Tabish Iqbal, Megan Atkinson, Brittany Vo-Le, Bylinda Vo-Le, Brittany O'Brien, Christian Grillon, Alan C Swann, Sanjay J Mathew

Faculty, Staff and Students Publications

Background: Individuals with post-traumatic stress disorder (PTSD) have a heightened sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of behavioral sensitization. N-methyl-D-aspartate receptors (NMDARs) are involved in the establishment and activation of sensitized behavior.

Objective: We describe a protocol of a randomized placebo-controlled Phase 1b proof-of-mechanism trial to examine target engagement, safety, tolerability, and possible efficacy of the NMDAR antagonist lanicemine in individuals with symptoms of PTSD (Clinician Administered PTSD Scale [CAPS-5] score ≥ 25) and evidence of behavioral sensitization measured as enhanced anxiety-potentiated startle (APS; T-score ≥ 2.8).

Methods: Subjects (n = 24; age range 21–65) …

Chronic Stress And Ovarian Function In Female Childhood Cancer Survivors, Theresa Marie Hardy, Mauricio Garnier-Villarreal, Jennifer M. Ohlendorf, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Objectives: To explore the relationships among perceived stress, biomarkers of hypothalamic–pituitary–adrenal (HPA) activity, gonadotropin levels, and anti-Müllerian hormone (AMH) in female childhood cancer survivors (CCSs).

Sample & Setting: 24 female CCSs from the Royal Hospital for Sick Children in Edinburgh, Scotland, were included in the study.

Methods & Variables: Perceived stress was measured using the Perceived Stress Scale. HPA activity was measured using salivary cortisol and hair cortisol. Ovarian function was measured using serum gonadotropin levels and serum AMH levels. Latent growth curve modeling was used to determine diurnal cortisol slope and intercept. Bayesian structural equation modeling was used to …

The Orphan Drug Act At 35: Observations And An Outlook For The Twenty-First Century, Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite

Articles

On the thirty-fifth anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new orphan drugs appears to be greater today than it was in 1983. All else equal, this should reduce the threshold for research and development (R&D) investment in an economically viable product. Further, the small size of patient populations for orphan drugs, together with the increasing prevalence of biologics among orphan drugs, have created a set …

Clown Eggs, Dave Fagundes, Aaron Perzanowski

Articles

Since 1946, many clowns have recorded their makeup by having it painted on eggs that are kept in a central registry in Wookey Hole, England. This tradition, which continues today, has been referred to alternately as a form of informal copyright registration and a means of protecting clowns’ property in their personae. This Article explores the Clown Egg Register and its surrounding practices from the perspective of law and social norms. In so doing, it makes several contributions. First, it contributes another chapter to the growing literature on the norms-based governance of intellectual property, showing how clowns—like comedians, roller derby …

Generating Genome Browsers To Facilitate Undergraduate-Driven Collaborative Genome Annotation, Luke Sargent, Yating Liu, Wilson Leung, Nathan Mortimer, David Lopatto, Jeremy Goecks, Sarah C.R. Elgin

Biology Faculty Research

Scientists are sequencing new genomes at an increasing rate with the goal of associating genome contents with phenotypic traits. After a new genome is sequenced and assembled, structural gene annotation is often the first step in analysis. Despite advances in computational gene prediction algorithms, most eukaryotic genomes still benefit from manual gene annotation. Undergraduates can become skilled annotators, and in the process learn both about genes/genomes and about how to utilize large datasets. Data visualizations provided by a genome browser are essential for manual gene annotation, enabling annotators to quickly evaluate multiple lines of evidence (e.g., sequence similarity, RNA-Seq, gene …

"One Crowded Hour Of Glorious Life": Growing Up And Growing Old In The Awkward Age, Sarah Wadsworth

English Faculty Research and Publications

No abstract provided.

Eden, Just Not Ours Yet: On Parable Of The Trickster And Utopia, Gerry Canavan

English Faculty Research and Publications

No abstract provided.

Ellen Robinson Epstein '69-Joan Hosmer Smith '69, Ellen Epstein, Joan Smith

Alumni Oral History Project

No abstract provided.

Benjamin Panciera-Platt Townsend Arnold '64, Benjamin Panciera, Platt Arnold

Alumni Oral History Project

No abstract provided.

Identifying Key Topics Bearing Negative Sentiment On Twitter: Insights Concerning The 2015-2016 Zika Epidemic, Ravali Mamidi, Michele Miller, Tanvi Banerjee, William Romine, Amit Sheth

Publications

Background To understand the public sentiment regarding the Zika virus, social media can be leveraged to understand how positive, negative, and neutral sentiments are expressed in society. Specifically, understanding the characteristics of negative sentiment could help inform federal disease control agencies’ efforts to disseminate relevant information to the public about Zika-related issues.

Objective The purpose of this study was to analyze the public sentiment concerning Zika using posts on Twitter and determine the qualitative characteristics of positive, negative, and neutral sentiments expressed.

Methods Machine learning techniques and algorithms were used to analyze the sentiment of tweets concerning Zika. A supervised …

Factors Influencing Parent-Teacher Discrepancies In Ratings Of Child Externalizing Behavior, Erin F. Mctiernan

All-Inclusive List of Electronic Theses and Dissertations

Informants tend to provide discrepant ratings of child behavior, which can complicate the process of assessing behavior problems in children. The present study evaluated parent and teacher ratings of child externalizing behavior problems, as well as ratings of attention problems, hyperactivity, and aggression, to understand the degree of influence that various factors have on these ratings. A variety of demographic factors (i.e., child age, family income, child ethnicity, parent mental health), parenting and parent-child relationship variables (i.e., attachment, involvement, relational frustration, parenting stress) and school-related factors (i.e., length of time the teacher has known the child, child academic performance) were …

The Role Of Optimism In Goal Adjustment Behavior And Subjective Well-Being, Emily R. Fink

All-Inclusive List of Electronic Theses and Dissertations

Research suggests that the experience of striving towards blocked goals negatively impacts subjective well-being, through decreased self-esteem and increased rumination and intrusive thoughts (Klinger, 1977; Mathews & Wells, 2004). Self-regulation theories propose that individuals may avoid these negative outcomes by engaging in goal adjustment processes comprised of goal disengagement (i.e., withdrawal of effort and resources from a desired goal) and goal reengagement (i.e., psychological and motivation commitment towards a new goal; Wrosch, Scheier, Carver & Schulz, 2003). While self-regulation theorists generally agree that optimism is likely to be linked with goal adjustment processes, there is significant disagreement as to the …

Using Species Distribution Models And Connectivity Analyses To Predict Habitat Suitability For Three Bat Species, James Howard Cox Iii

All-Inclusive List of Electronic Theses and Dissertations

Forests are the most important and universally threatened habitats for bats. Habitat loss and fragmentation are leading causes of damage to forest ecosystem integrity. Critically, most bats need forests: over half of the 45 species of bats in North America use forests for roosting or foraging. Much research to date has been done to identify roosting and foraging patches of bats, but few have attempted to investigate how these patches are connected across a landscape. By understanding how to maintain connectivity across even fragmented landscapes, we may be able to mitigate the effects of forest habitat loss. In this thesis, …

Lipoprotein Sub-Fractions By Ion-Mobility Analysis And Its Association With Subclinical Coronary Atherosclerosis In High-Risk Individuals, Emeka Osondu, Theodore Feldman, Emir Veledar

All Publications

AIMS:

There is limited knowledge about the association of lipoprotein particles and markers of coronary atherosclerosis such as coronary artery calcification (CAC) in relatively young high-risk persons. This study examines the association of lipoprotein subfractions and CAC in high cardiometabolic risk individuals.

METHODS:

The study presents analysis from baseline data of a randomized trial targeted at high-risk workers. Employees of Baptist Health South Florida with metabolic syndrome or diabetes were recruited. At baseline, all 182 participants had lipoprotein subfraction analysis using the ion mobility technique and participants above 35 years (N=170) had CAC test done. Principal components (PC) were computed …

Blind Spot: The Attention Economy And The Law, Tim Wu

Faculty Scholarship

Human attention, valuable and limited in supply, is a resource. It has become commonplace, especially in the media and technology industries, to speak of an "attention economy" and of competition in "attention markets.” There is even an attentional currency, the "basic attention token," which purports to serve as a medium of exchange for user attention. Firms like Facebook and Google, which have emerged as two of the most important firms in the global economy, depend nearly exclusively on attention markets as a business model.

Yet despite the well-recognized commercial importance of attention markets, antitrust and consumer protection authorities have struggled …

Improving Stem Recruitment Through A Theme-Based Summer Residential Camp Focused On Sea Level Rise, Vukica M. Jovanović, Balša Terzić, Mujde Erten-Unal, Victoria Hill, George Mcleod, Michelle Covi, David Burdige, Jenifer Alonzo, Justin Mason, Tysha Batts, Cynthia Tomovic

Engineering Technology Faculty Publications

In this paper, the authors present an enrichment program that focuses on Science, Technology, Engineering, and Math (STEM) concepts. The program is named Building Leaders to Advance Science and Technology (BLAST) and is held each summer at three universities across the Commonwealth of Virginia: Old Dominion University, the University of Virginia, and the Virginia Polytechnic Institute. BLAST is sponsored in partnership among these three universities and the Virginia Space Grant Consortium (VSGC), and is funded by the General Assembly of Commonwealth of Virginia. Its main purpose is to expose high school students to topics related to different STEM fields through …

Associations Of Ambivalent Leadership With Distress And Cortisol Secretion, Wendy C. Birmingham, Raphael M. Herr, Frenk Van Harreveld, Bert N. Uchino, Adrian Loerbroks, Joachim E. Fischer, Jos A. Bosch

Faculty Publications

Ambivalent social ties, i.e., whereby a relationship is evaluated simultaneously in positive and negative terms, are a potential source of distress and can perturb health-relevant biological functions. Social interactions at the workplace, in particular with supervisors, are often described in ambivalent terms, but the psychological and psychobiological impact of such interactions has received little scientific attention. The current study examined associations between ambivalent attitudes towards one’s supervisor, perceived distress (general and work-related), and diurnal dynamics of the stress hormone cortisol. 613 employees evaluated their supervisor in terms of positive and negative behaviors, which was combined into an ambivalent index. Higher …

Midwest Vegetable Trial Report For 2018, Elizabeth Maynard, Petrus Langenhoven, Wenjing Guan, Brad R. Bergefurd

Midwest Vegetable Trial Reports

This is a compilation of 15 research trial reports from four land-grant universities in the Midwestern United States. Crops include cantaloupe, pickling cucumber, pepper, potato, pumpkin, summer squash and zucchini, sweet corn, tomato, and watermelon. Somecrops were evaluated in high tunnels or hoophouses. Most trials evaluated different cultivars or varieties. One report addressed plant spacing for sweet corn and one addressed soil block for production of tomato seedlings. A list of vegetable seed sources and a list of other online sources of vegetable trial reports are also included.

Overcoming Impediments To Offshore Co2 Storage: Legal Issues In The U.S. And Canada, Romany M. Webb, Michael B. Gerrard

Faculty Scholarship

Limiting future temperature increases and associated climate change requires immediate action to prevent additional carbon dioxide being released into the atmosphere and to lower the existing atmospheric carbon dioxide load. This could be advanced through carbon capture and storage (CCS), which involves collecting carbon dioxide that would otherwise be released by power plants or similar facilities and injecting it into underground geologic formations, where it will remain permanently sequestered. The techniques developed for CCS can also be used to sequester carbon dioxide that has been removed from the atmosphere using direct air capture or other negative emission technologies. Past CCS …

Nebraska’S Natural Resource District System: Collaborative Approaches To Adaptive Groundwater Quality Governance, Gregory N. Sixt, Laurens Klerkx, J. David Aiken, Timothy S. Griffin

Department of Agricultural Economics: Faculty Publications

Nonpoint source pollution of groundwater by nitrates from agricultural activity is a persistent problem for which developing effective policy approaches has proven difficult. There is little empirical information on forms of governance or regime attributes that effectively and sustainably address agricultural nonpoint source pollution of groundwater. Nebraska’s Natural Resource District (NRD) system is a rare example of a groundwater governance regime that is putting programmes in place that are likely to generate sustainable groundwater quality outcomes. We focus on three groundwater nitrate management programmes in the state that collectively represent the broader NRD system. The research shows that four elements …

Fiduciary Principles In Family Law, Elizabeth S. Scott, Ben Chen

Faculty Scholarship

Family members bear primary responsibility for the care of dependent and vulnerable individuals in our society, and therefore family relationships are infused with fiduciary obligation. Most importantly, the legal relationship between parents and their minor children is best understood as one that is regulated by fiduciary principles. Husbands and wives relate to one another as equals under contemporary law, but this relationship as well is subject to duties of care and loyalty when either spouse is in a condition of dependency. Finally, if an adult is severely intellectually disabled or becomes incapacitated and in need of a guardian, a family …

Compact Srf Linac For High Brilliance Inverse Compton Scattering Light Source, Kirsten E. Deitrick, Jean R. Delayen, Geoffrey A. Krafft, Balša Terzić

Physics Faculty Publications

New designs for compact SRF linacs can produce micron-size electron beams. These can can be used for inverse Compton scattering light sources of exceptional flux and brilliance.