Digital Commons Network^™

Board Of Regents Meeting Materials, June 13, 2019, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Board Of Regents Meeting Materials, October 25, 2019, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Board Of Regents Meeting Materials, April 23, 2019, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

The Effects Of In Utero Levothyroxine Exposure On Anterior-Posterior Craniofacial Development In A Mouse Model, Ashley Rogers Albrecht

MUSC Theses and Dissertations

Introduction: The purpose of this study was to investigate the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development in a mouse model. Methods: In order to determine the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development, a study group (n=19) of C57BL6 mice were exposed to high dose (~667ng per day) levothyroxine during fetal development. Mice were sacrificed day 15 post-natal. Skulls were fixed in a solution of 4% paraformaldehyde, then switched to 70% ethanol in preparation for microCT imaging. Scans were loaded into Dolphin Imaging Software and lateral cephalograms were rendered and analyzed. Results: According …

Mechanism Of Action Of Vp1-001 In Cryab(R120g)-Associated And Age-Related Cataracts, Kathleen S. Molnar, Bryan M. Dunyak, Bonnie Su, Yevgeniy Izrayelit, Brittney Mcglasson-Naumann, Paul D. Hamilton, Mingxing Qian, Douglas F. Covey, Jason E. Gestwicki, Leah N. Makley, Usha P. Andley

Open Access Publications

No abstract provided.

Relationships Between The Use Of Pharmacomechanical Catheter-Directed Thrombolysis, Sonographic Findings, And Clinical Outcomes In Patients With Acute Proximal Dvt: Results From The Attract Multicenter Randomized Trial, Ido Weinberg, Suresh Vedantham, Amber Salter, Gail Hadley, Noor Al-Hammadi, Clive Kearon, Jim A. Julian, Mahmood K. Razavi, Heather L. Gornik, Samuel Z. Goldhaber, Anthony J. Comerota, Andrei L. Kindzelski, Robert M. Schainfeld, John F. Angle, Sanjay Misra, Jonathan A. Schor, Darren Hurst, Michael R. Jaff

ICTS Faculty Publications

No abstract provided.

The Invention Secrecy Act: The Uspto As A Gatekeeper Of National Security, Scott Locke

IP Theory

The United States Patent and Trademark Office (“USPTO”) has the privilege of reviewing hundreds of thousands of inventions each year before the public learns about them. Consequently, the USPTO is uniquely positioned as a funnel through which the Government can collect information about new technologies and determine which ones have implications for the safety and welfare of the nation. Under the Invention Secrecy Act, the Commissioner for Patents may order that an invention for which patent protection is sought be kept secret if disclosure of the invention might be detrimental to national security.

In order for the USPTO to review …

Epigenetic Dysregulation Of Enhancers In Neurons Is Associated With Alzheimer’S Disease Pathology And Cognitive Symptoms, Peipei Li, Lee Marshall, Gabriel Oh, Jennifer L. Jakubowski, Daniel Groot, Yu He, Ting Wang, Arturas Petronis, Viviane Labrie

Open Access Publications

No abstract provided.

Comparing Methods For Clinical Investigator Site Inspection Selection: A Comparison Of Site Selection Methods Of Investigators In Clinical Trials, Nicholas Hein, Elena Rantou, Paul Schuette

United States Food and Drug Administration: Publications

Background During the past two decades, the number and complexity of clinical trials have risen dramatically increasing the difficulty of choosing sites for inspection. FDA’s resources are limited and so sites should be chosen with care.

Purpose To determine if data mining techniques and/or unsupervised statistical monitoring can assist with the process of identifying potential clinical sites for inspection.

Methods Five summary-level clinical site datasets from four new drug applications (NDA) and one biologics license application (BLA), where the FDA had performed or had planned site inspections, were used. The num- ber of sites inspected and the results of the …

Response Of Vegetation In Open And Partially Wooded Fens To Prescribed Burning At Seney National Wildlife Refuge, Jane E. Austin, Wesley E. Newton

United States Geological Survey: Publications

The health and function of northern peatlands, particularly for fens, are strongly affected by fire and hydrology. Fens are important to several avian species of conservation interest, notably the yellow rail (Coturnicops noveboracensis). Fire suppression and altered hydrology often result in woody encroachment, altering the plant community and structure. Woody encroachment and its effects on biodiversity have become an increasing concern in the conservation and management of plant communities. This study evaluated the effects of spring and summer prescribed burns on the plant community, cover, and structure in open and partially wooded fens at Seney National Wildlife Refuge, Michigan, using …

Melanism As A Potential Thermal Benefit In Eastern Fox Squirrels (Sciurus Niger), Amanda K. Ciurej, Ashley Oblander, Andrew W. Swift, James A. Wilson

United States Fish and Wildlife Service: Publications

Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas. The selective advantage of melanism is currently unknown, but thermal advantages have been hypothesized, especially in winter. No difference in metabolic response curves were measured between melanistic (black) and rufus (orange) fox squirrels. When exposed to sunny skies, both melanistic and rufus squirrels had higher surface (skin and fur) temperature as ambient temperatures increased. Melanistic squirrel surface temperatures did not differ when squirrels were exposed to sunny or cloudy skies. However, rufus individuals showed significantly lower …

Clinical Outcomes With Neoadjuvant Versus Adjuvant Chemotherapy For Triple Negative Breast Cancer: A Report From The National Cancer Database, Nusayba A Bagegni, Yu Tao, Foluso O Ademuyiwa

Open Access Publications

PURPOSE: Triple negative breast cancer (TNBC) patients frequently receive neoadjuvant chemotherapy (NAC). Only 50% will achieve pathological complete response (pCR). In this retrospective study, we evaluated TNBC outcomes with NAC vs. AC.

METHODS: Patients with stages II and III TNBC treated with NAC or AC between 2010 and 2013 were identified from the National Cancer Database. Baseline characteristics were compared with χ2 and two sample t tests. Kaplan-Meier survival analyses were computed in patients treated with NAC or AC, and log-rank tests used to examine differences. Unadjusted analyses of trends in proportions over time were performed using Cochran-Armitage tests. Log-binomial …

Lncrna Malat1 Gene Polymorphisms In Coronary Artery Disease: A Case-Control Study In A Chinese Population, Weina Hu, Hanxi Ding, An Ouyang, Xiaohong Zhang, Qian Xu, Yunan Han, Xueying Zhang, Yuanzhe Jin

Open Access Publications

No abstract provided.

The Peptide Hormone Adropin Regulates Signal Transduction Pathways Controlling Hepatic Glucose Metabolism In A Mouse Model Of Diet-Induced Obesity, Su Gao, Sarbani Ghoshal, Liyan Zhang, Joseph R. Stevens, Kyle S. Mccommis, Brian N. Finck, Gary D. Lopaschuk, Andrew A. Butler

Open Access Publications

No abstract provided.

Mapping Brain Function During Naturalistic Viewing Using High-Density Diffuse Optical Tomography, Andrew K. Fishell, Tracy M. Burns-Yocum, Karla M. Bergonzi, Adam T. Eggebrecht, Joseph P. Culver

Open Access Publications

No abstract provided.

Serendipity: Decitabine Monotherapy Induced Complete Molecular Response In A 77-Year-Old Patient With Acute Promyelocytic Leukemia, Ramzi Abboud, Se Young Han, Eric J. Duncavage, Amanda F. Cashen, Cara Lunn Shirai, John S. Welch, John F. Dipersio, Camille N. Abboud

Open Access Publications

No abstract provided.

Pain Inhibits Grpr Neurons Via Gabaergic Signaling In The Spinal Cord, Rita Bardoni, Kai-Feng Shen, Hui Li, Joseph Jeffry, Devin M. Barry, Antonella Comitato, Yun-Qing Li, Zhou-Feng Chen

Open Access Publications

No abstract provided.

Adaptation Of Translational Machinery In Malaria Parasites To Accommodate Translation Of Poly-Adenosine Stretches Throughout Its Life Cycle, Jessey Erath, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Open Access Publications

Malaria is caused by unicellular apicomplexan parasites of the genus

Neuroinflammation And White Matter Alterations In Obesity Assessed By Diffusion Basis Spectrum Imaging, Amjad Samara, Tatianna Murphy, Jeremy Strain, Jerrel Rutlin, Peng Sun, Olga Neyman, Nitya Sreevalsan, Joshua S Shimony, Beau M Ances, Sheng-Kwei Song, Tamara Hershey, Sarah A Eisenstein

Open Access Publications

Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in multiple regions, including the hippocampus, and impairments in hippocampal-dependent memory tasks. To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity. We examined diffusion-weighted magnetic resonance imaging (MRI) data in two independent cohorts of obese and non-obese individuals (Cohort 1: 25 obese/21 non-obese; Cohort 2: 18 obese/41 non-obese). We applied Tract-based Spatial Statistics (TBSS) to allow …

Cdek: Clinical Drug Experience Knowledgebase, Rebekah H Griesenauer, Constantino Schillebeeckx, Michael S Kinch

2010-2019 OA Pubs

The Clinical Drug Experience Knowledgebase (CDEK) is a database and web platform of active pharmaceutical ingredients with evidence of clinical testing as well as the organizations involved in their research and development. CDEK was curated by disambiguating intervention and organization names from ClinicalTrials.gov and cross-referencing these entries with other prominent drug databases. Approximately 43% of active pharmaceutical ingredients in the CDEK database were sourced from ClinicalTrials.gov and cannot be found in any other prominent compound-oriented database. The contents of CDEK are structured around three pillars: active pharmaceutical ingredients (n = 22 292), clinical trials (n = 127 223) and organizations …

Quantitative 18f-Av1451 Brain Tau Pet Imaging In Cognitively Normal Older Adults, Mild Cognitive Impairment, And Alzheimer's Disease Patients, Qian Zhao, Min Liu, Lingxia Ha, Yun Zhou, Alzheimer's Disease Neuroimaging Initiative

Open Access Publications

No abstract provided.

The Spectrum Of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms And Interference With Activities, Siobhan Sutcliffe, Tamara Bavendam, Charles Cain, Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Mary K. Townsend, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

Coastal Wetlands: A Synthesis, Charles S. Hopkinson, Eric Wolanski, Mark M. Brinson, Donald R. Cahoon, Gerardo M.E. Perillo

United States Geological Survey: Staff Publications

What are coastal wetland ecosystems, what are their limits of distribution, and where do they exist in the overall coastal landscape? There are several general definitions for wetlands, but the Ramsar definition is likely the most broadly encompassing (http://www.ramsar. org/), whereas others are more focused definitions tailored to country-specific protection and management policies (Mitsch and Gosselink, 2006). We offer a very general approach rather than a precise definition: coastal wetlands are ecosystems that are found within an elevation gradient that ranges between subtidal depths where light penetrates to support photosynthesis of benthic plants to the landward edge where the sea …

Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Mycobacterium avium subspecies paratuberculosis (Map) is the etiologic agent of Johne’s disease in ruminants and has been associated with Crohn’s disease in humans. An effective control of Map by either vaccines or chemoprophylaxis is a paramount need for veterinary and possibly human medicine. Given the importance of fatty acids in the biosynthesis of mycolic acids and the mycobacterial cell wall, we tested novel amphiphilic C₁₀ and C₁₈ cyclobutene and cyclobutane fatty acid derivatives for Map inhibition. Microdilution minimal inhibitory concentrations (MIC) with 5 or 7 week endpoints were measured in Middlebrook 7H9 base broth media. We compared the …

Investigation Of Congestive Heart Failure In Beef Cattle In A Feedyard At A Moderate Altitude In Western Nebraska, Rodney A. Moxley, David R. Smith, Dale M. Grotelueschen, Tom Edwards, David Steffen

School of Veterinary and Biomedical Sciences: Faculty Publications

Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500– 3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8–4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: …

Thymic Expression Of Il-4 And Il-15 After Systemic Inflammatory Or Infectious Th1 Disease Processes Induce The Acquisition Of"Innate" Characteristics During Cd8 + T Cell Development, Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

United States Public Health Resources

Innate CD8 + T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4 and IL-15 for their development. Even though innate CD8 + T cells exist in the thymus of WT mice in low numbers, they are highly enriched in KO mice that lack certain kinases, leading to an increase in IL-4 production by thymic NKT cells. Our work describes that in C57BL/6 WT mice undergoing a Th1 biased infectious disease, …

Whose Voices Count In Biodiversity Conservation? Ecological Democracy In Biodiversity Offsetting, Redd , And Rewilding, David Takacs

Faculty Scholarship

Ecological democracy seeks environmentally sustainable ends through broad, active democratic participation. What happens when laws fostering participation in environmental decision-making and biodiversity preservation lead to differing results? What is best for biodiversity may not be what for local citizens believe is best. I examine conflicts and congruencies in the context of Biodiversity Offsetting, REDD+ (Reducing Emissions from Deforestation and forest Degradation), and the Rewilding movement. I ask questions that are legal (Who has what legal rights to speak for or against programs that enhance biodiversity?), epistemological (Whose expertise and knowledge matters when scientists and non-scientists don’t agree?), axiological (Are some …

Mobile Societies, Mobile Religions: On The Ecological Roots Of Two Religions Deemed Monotheistic, Edward Surman

CGU Theses & Dissertations

How do environments affect the generation and development of religions? The investigation taken up in this dissertation is one attempt to address this question. This work focuses on one comparative case study: the potential causal relationship between agriculturally marginal landscapes and the two oldest religions deemed monotheistic. This dissertation argues that the respective origins (and early development) of communities of worship centered around Ahura Mazda and YHWH were affected by similar environmental contexts. The dearth of literature concerning the effects of environments on religions extends to established theoretical and methodological approaches on the topic. The framework for approaching this research …

Bachelor Of Science In Engineering 2019-2020, Nova Southeastern University

College of Engineering and Computing Course Catalogs

No abstract provided.

Bachelor Of Science-Information Technology 2019-2020, Nova Southeastern University

College of Engineering and Computing Course Catalogs

No abstract provided.