Digital Commons Network^™

Characterization Of A Phosphomimetic Mutant Of The Als Associated Protein Tdp-43, Nicole Toro

Electronic Theses and Dissertations

Trans-activation response (TAR) DNA-binding protein 43 (TDP-43) is a natively dimeric 414-residue protein that is encoded by the human TARDBP gene that has important implications in the pathogenesis of the neurodegenerative disorders ALS, FTD, and CTE. TDP-43 has been found hyperphosphorylated and ubiquitinated in the aggregates of the affected neurons of these diseases. The discovery of the presence of TDP-43 positive inclusions in brain matter of patients with CTE has made repetitive brain injury a possible environmental stimulus for aggregation in TDP-43 proteinopathies. We expand upon the hypothesis that TDP-43 readily aggregates under agitation conditions and that the addition of …

Deer Management In Tennessee, 2019-2023, Tennessee. Wildlife Resources Agency

Deer Management in Tennessee 2019-2023

This document includes a long-term strategy for the management of white-tailed deer in Tennessee.

Academics: The Newsletter Of The Swosu College Of Arts And Sciences, Peter Grant

aCAdemicS: The Newsletter of the SWOSU College of Arts & Sciences

No abstract provided.

Optimization Of Isolation Of O-Linked Glycopeptides, Juwan Lee, Earnest James, Victoria Rich

Undergraduate Research Posters 2019

Mucin type O-glycosylation is a common modification of proteins in higher organisms found on cell surfaces and secreted proteins. O-glycosylation is important in a variety of biological processes from development, the control of serum phosphate levels, and playing role in vascular and heart diseases and cancer. A family of 20 transferases (GalNAc-Ts) initiate mucin type O-glycosylation in humans by adding the sugar GalNAc onto Ser or Thr residues on targeted proteins. Since several diseases and cancers are specifically linked to the expression of individual GalNAc-T isoforms, there is a need to fully understand and characterize their specificities and determine what …

Possible Pathologic Effect Of Hmgb1 On P. Gingivalis Induced Inflammatory Response By Macrophages, Michelle Marie Torres Santos

Student Theses, Dissertations and Capstones

BACKGROUND: Periodontitis is an inflammatory disease caused by poly-microbial infection that leads to destruction of connective tissue and alveolar bone. It is well documented that bacteria-derived virulent factors that can act on Toll-like receptors (TLRs), represented by Lipopolysaccharides (LPS), are engaged in the initiation of inflammatory responses. However, while LPS is also produced by the bacteria colonized in the healthy periodontal tissue, inflammation is not induced by LPS in those periodontal healthy subjects, suggesting the requirement of additional factor to upregulate the LPS-mediated inflammatory response in periodontal tissue. Recent studies revealed that novel class of endogenous proinflammatory mediator, high mobility …

Philippine-Based Filipino Women And Breast Cancer, Elizabeth S. Azutillo

Student Theses, Dissertations and Capstones

Background. The rate of breast cancer incidence in the Philippines has increased in recent years. Three out of 100 Filipino women will contract breast cancer before age 75; one out of 100 will die before age 75. Purpose. The study was used to determine the level of knowledge of the respondents about breast cancer and breast cancer screening modalities, the relationship of the level of knowledge and frequency of breast self-examination (BSE) performance; the predictive ability of their health perceptions; modifying variables for their intent to perform BSE, submit to screening mammography, and engage in clinical breast exam (CBE); their …

Enhancing The Sublingual Permeability Of Atropine Sulfate: Effect Of Ph And Penetration Enhancers, Rawan Saeed Bafail

Student Theses, Dissertations and Capstones

Atropine Sulfate (AS) auto-injector (AtroPen®) is being used as an effective and safe antidote for the treatment of organophosphate (OP) pesticides or nerve gas poisoning. The use of AtroPen® is associated with several drawbacks including: bulky size, availability, affordability, invasiveness, and administration errors. Previously, AS fast disintegrating sublingual tablets (FDSTs) were developed and the feasibility of AS sublingual permeability were demonstrated. However, AS permeability was delayed due to the negative impact of higher doses of AS on FDST’s physical characteristics. Therefore, the aim in this research project was to optimize the previously developed AS FDSTs. It was hypothesized that optimizing …

Master Of Science In Anesthesia-Tampa, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physician Assistant Jacksonville, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physician Assistant Orlando, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Analyzing Brain Sample Via Hplc Method, Neethu Mathew

BIO4950: Internship in Biology

This paper aims to investigate the principle methodology behind extraction and detection of an anti-cancer drug from brain samples via the high performance liquid chromatography (HPLC) method. In order to assess the efficiency of the methodology carried out in the Rumbaugh-Goodwin Institute of Cancer Research (RGI), numerous peer-reviewed journals and articles were analyzed over the duration of this internship. They were filtered on the basis of inclusion of keywords, date written, peer-reviewed credibility, and similarity to RGI’s research. The literature that has been chosen to be reviewed includes studies that present similar methodologies or test drugs with similar functions. From …

Brush-Arm Star Polymer Imaging Agents And Uses Thereof, Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca

Department of Chemistry: Faculty Publications

Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitrox-ide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field ¹H MRI techniques.

Indole Reverses Intrinsic Antibiotic Resistance By Activating A Novel Dual-Function Importer, Yan Wang, Tian Tian, Jingjing Zhang, Xin Jin, Huan Yue, Xiao-Hua Zhang, Liangcheng Du, Fan Bai

Department of Chemistry: Faculty Publications

Bacterial antibiotic resistance modulation by small signaling molecules is an emerging mechanism that has been increasingly reported in recent years. Several studies indicate that indole, an interkingdom signaling molecule, increases bacterial antibiotic resistance. However, the mechanism through which indole reduces antibiotic resistance is largely unknown. In this study, we demonstrated a novel mechanism for indole-mediated reversal of intrinsic antibiotic resistance in Lysobacter. This reversal was facilitated by a novel BtuD-associated dual-function importer that can transfer both vitamin B₁₂ and antibiotics. Indole stimulated btuD overexpression and promoted efficient absorption of extracellular vitamin B₁₂; meanwhile, the weak selectivity …

Idiot Science For A Blue Humanities: Shakespeare's The Comedy Of Errors And Deleuze's Mad Cogito, Steven Swarbrick

Publications and Research

Can we imagine a Blue Humanities that takes the non-relation as a starting point for ecological thought? I believe we can. Following Shakespeare and Deleuze, this essay engages in a thought experiment that, if it is not too absurd, might, like the ship of fools of medieval times, unmoor the Blue Humanities from its current safe harbor by putting the thought of ‘our’ world under erasure. This is not a matter of turning thought around, such that, by turning to the sea, we turn thought away from calculation and instrumental reason and rediscover our true nature. Rather, the image of …

Transgenerational Effects Of Maternal Age On Offspring Fitness In Crickets, Jacob D. Wilson

Electronic Theses and Dissertations

Advanced parental age is an important aspect of parental condition that can have both positive and negative effects on offspring fitness, and thus, parental age can be considered a parental effect. As a parental effect, parental age may affect a variety of offspring traits and may cascade to influence several generations of offspring. Given the complexities of studying both paternal and maternal age, we studied the effects of maternal age only. Using the Pacific field cricket, Teleogryllus oceanicus, we asked 1) does maternal age have influences over several generations of offspring and 2) does maternal age influence the reproductive …

Exploring The Lived Religious Experiences Of Gay And Lesbian Ordained Clergy In The United Methodist Church, Tracy Allen Temple

Electronic Theses and Dissertations

The United Methodist Church (UMC) as an institution has strict language against lesbian and gay people and against the ordination of the lesbian and gay people. Prior research has focused on how denominations and congregations discuss issues around sexuality, how attitudes have shifted around issues of sexuality, and how to provide spiritual care for the LGBTQ+ community. This qualitative study interviewed lesbian and gay ordained elders in the UMC to learn about their experiences of serving as clergy people in the UMC even though there are prohibitive statements in church documents. Firstly, the interviews revealed that the participants feel loved …

Rapid-Scan Epr And Imaging, Yilin Shi

Electronic Theses and Dissertations

EPR imaging at low frequency is a powerful tool to obtain important biological information in vivo in a non-invasive way. Properties of nitroxide and trityl radical imaging reagents have been studied. Developments in rapid scan imaging techniques are reported that improve efficiency of experiments and user-friendliness of software.

Relaxation and signal-to-noise ratio (S/N) in pulse experiments on trityl radicals were measured at frequencies between 400 MHz and 1.5 GHz. Relaxation time increases as the frequency increases and the radical concentration decreases. Since relaxation time is a sensitive and accurate measure of oxygen pressure, this study provides criteria for the selection …

Taking A “Hard Look”: The Legality And Policy Implications Surrounding The Polymet Mine Land Transfer, Kyle Hoffmeister

Mitchell Hamline Law Journal of Public Policy and Practice

No abstract provided.

Ms Environmental Biology Capstone Project, Jessica Ann Policarpio Aquino

Regis University Student Publications (comprehensive collection)

MS Environmental Biology Capstone Project

Ms Environmental Biology Capstone Project, Ryan Lee

Regis University Student Publications (comprehensive collection)

MS Environmental Biology Capstone Project

Step Model For Managing Chronic, Non-Malignant Pain In Primary Care, Melissa J. Smith

Regis University Student Publications (comprehensive collection)

Oftentimes, primary care providers lack the knowledge, confidence, and time to monitor chronic pain patients closely resulting in possible inappropriate prescribing of opioids. Purpose: The project aim was to improve primary care provider knowledge and confidence in managing chronic pain patients in the primary care setting using a step model that was developed based on the Centers for Disease Control (CDC) guidelines as well as online education modules produced by the CDC. Methods: The project design was a quantitative pretest-posttest design. The primary outcome was to provide training on the CDC guidelines for prescribing opioids for chronic pain as well …

Ms Environmental Biology Capstone Project, Chris Scott

Regis University Student Publications (comprehensive collection)

MS Environmental Biology Capstone Project

Structure/Function Analysis Of Fega And Fhua In Bradyrhizobium Sp., Alexander James Herd

Senior Honors Projects, 2010-2019

Bradyrhizobium japonicum is a Gram-negative soil bacterium commonly known for its agriculturally significant mutualistic relationship with soybean. In this symbiosis, the bacteria and plant undergo complex molecular signaling characterized by sent and received signals resulting in the formation of infection threads and root nodules. This research aimed to compare two related bacterial outer membrane proteins, FegA and FhuA, associated with the molecular signaling between the bacteria and plant. Previous work has led to the hypothesis that the N-terminal domain (NTD) of FegA in B. japonicum is needed for a functional symbiosis to occur. Recombinant bacterial strains expressing altered FegA proteins …

Birds In The Urban Landscape, Center For Urban Resilience

Module 10: Garden Ecology

No abstract provided.

Cognitive Rigidity In Patients With Anorexia Nervosa, Miriam Sheynblyum

The Science Journal of the Lander College of Arts and Sciences

Anorexia Nervosa (AN) is a psychiatric disorder characterized by significantly low body weight and over-evaluation of weight and shape in self-identity. The complex etiology of Anorexia Nervosa renders many current treatments ineffective, thereby prolonging the course of the illness. Among the many psychological and behavioral features of AN, cognitive features like obsessiveness, rigidity, and perfectionism are often described. Patients hold firm beliefs about an ideal body weight and find it difficult to alter their thinking patterns. Recent studies have identified a pathway to understanding this disorder through characterization of it’s cognitive features. With this research, advances have been made in …

Punishing Families For Being Poor: How Child Protection Interventions Threaten The Right To Parent While Impoverished, David Pimentel

Articles

No abstract provided.

In-Quest Of Biomarkers For Alzheimer’S Disease And Pharmacokinetic Profile Of Anticancer Agents Using Lc-Ms In Human Plasma, Chandana Mannem

ETD Archive

In this dissertation work, a semi-quantitative assay using a lipidomics approach and an absolute quantitative assay using liquid chromatography-mass spectrometry techniques were developed (LC-MS). In the lipidomics approach, ultra-high pressure liquid chromatography in tandem with quadrupole time of flight (UHPLC-QTOF) mass spectrometry was used to profile, compare and quantitate the human plasma lipids in Alzheimer’s disease subjects (AD) and normal cognitive controls (NCCs). The purpose of this study is to identify potential plasma lipid markers of AD and to explore the relationships between AD and lipid pathways in humans by using bioinformatic tools. The plasma samples of study subjects were …

Language Policy And Practice In Almost-Bilingual Classrooms, Elaine Allard, S. Apt, Isabel M. Sacks , '15

Educational Studies Faculty Works

This study explores language policies in “almost-bilingual” classrooms, in which most but not all students share a home language. Teachers who are bilingual face a dilemma in these settings. Should they draw on shared linguistic expertise to benefit the majority while excluding a few, or should they forego significant benefits for most in the interest of equity? This qualitative study examines the classroom language policies and practices of one English-as-a second-language (ESL) teacher at a majority-Latino high school. Drawing on field notes, interviews, and systematic teacher reflection, the authors identify a collection of multilingual practices across ESL and sheltered content …

General Undergraduate Catalog, 2019-2020, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Undergraduate Course Catalog for the 2019-2020 academic year.

Graduate Catalog, 2019-2020, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Graduate Course Catalog for the 2019-2020 academic year.