Digital Commons Network^™

Sphingosine-1-Phosphate Receptor 1 Activation In Astrocytes Contributes To Neuropathic Pain, Zhoumou Chen, Timothy M. Doyle, Livio Luongo, Tally M. Largent-Milnes, Luigino Antonio Giancotti, Grant Kolar, Silvia Squillace, Serena Boccella, John K. Walker, Alexander Pendleton, Sarah Spiegel, William L. Neumann, Todd W. Vanderah, Daniela Salvemini

Biological Sciences Faculty Research & Creative Works

Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing. However, the neuropharmacology of sphingolipid signaling in the central nervous system in the context of chronic pain remains largely unexplored and controversial. We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes. Accordingly, genetic and pharmacological inhibition of S1PR1 with multiple antagonists in distinct chemical …

Hilton M. Briggs Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

University Archives

Hilton M. Briggs was president at South Dakota State University from 1958 to 1975. The collection is composed of material related to his retirement, recognition, and his life after retirement. Included are biographical materials, clippings, correspondence, writings, photographs, and scrapbooks.

Contracting Around Gender Constructs: Transgender Men At Women's Colleges, Elizabeth A. Heise

Michigan Journal of Gender & Law

As the transgender community gains increasing visibility in society, women’s colleges have begun to address new questions about who is eligible to attend. One such question is whether students who come out as transgender men after matriculation are eligible to remain enrolled and graduate from these institutions. The main claims relevant to this discussion are (1) colleges’ right to retain their identity as all-women’s institutions; (2) the parallel rights of cisgender female students who explicitly choose to attend an all-women’s institution, and (3) transgender students’ competing right to avoid arbitrary or capricious dismissal based on gender identity. This Note posits …

Southern Register. 2019.1 (Winter 2019), University Of Mississippi. Center For The Study Of Southern Culture

Southern Register

No abstract provided.

The University Of Texas Permian Basin Undergraduate Catalog 2019-2020, The University Of Texas Permian Basin

Course Catalogs

No abstract provided.

Eco-Psychological And Phenomenological Approach To Sustainability, Larry Riggs, Sandra Hellyer-Riggs

Modern Languages, Literatures & Cultures

Our purpose is to show the value of eco-psychology and phenomenology for a cognitive paradigm fostering sustainable development. Our hypothesis is that those fields help lay the groundwork for truly sustainable development. Our method is a review of scholarly and theoretical work on the origins of the modern paradigm that has governed conceptions of development, and on eco-psychology, phenomenology, cognitive science, and sustainable development. Our contribution is a fully informed understanding of psychological and socio-cultural issues relevant to sustainability. The prevailing conception of development derives from the origins of modern science in seventeenth-century Europe. Francis Bacon and René Descartes elaborated …

Baltimore, Darryl Francis

Word Ways

A list of various transdeletions using the word Baltimore.

Aspirin Use Following Preeclampsia To Prevent Future Adverse Cardiovascular Outcomes, Kristi Bohlig

Physician Assistant Scholarly Project Posters

• Introduction: Preeclampsia during pregnancy warrants therapy with low dose aspirin. The purpose of this review is to investigate if these women are at increased future risk for cardiovascular morbidity and mortality, and if aspirin therapy prevents future cardiovascular events.

• Research Questions: Do women who had preeclampsia during pregnancy have increased future cardiovascular morbidity and mortality? • Does continued aspirin use in postpartum women, who had preeclampsia during pregnancy; decrease future cardiovascular morbidity and mortality?

• Research Methods: Literature review was conducted utilizing CINAHL, Dynamed plus and PubMed databases.

• Discussion: Many studies have found that preeclampsia does increase …

Examining Predictor Measures For Students' Testing In The International Baccalaureate Diploma Programme, Shannon Siebe

Ed.D. Dissertations

The purpose of this study was to explore the relationships between both student achievement and growth in 9th and 10th grade English and math courses and achievement on International Baccalaureate English and math exams. The researcher examined student end-of-course exam scores, student growth values, and International Baccalaureate English and math exam scores from an International Baccalaureate World School across 4 graduating cohorts, including 305 students. The researcher concluded that while 9th grade math end-of-course exam achievement does not significantly predict International Baccalaureate math exam scores, student growth in 9th grade math does. The researcher also concluded that Advanced Placement Language …

Increasing The Concentration Of Linolenic Acid In Diets Fed To Jersey Cows In Late Lactation Does Not Affect Methane Production, J. V. Judy, G. C. Bachman, T. M. Brown-Brandl, S. C. Fernando, K. E. Hales, K. J. Harvatine, P. S. Miller, P. J. Kononoff

Department of Animal Science: Faculty Publications

Although the inclusion of fat has reduced methane production in ruminants, relatively little research has been conducted comparing the effects of source and profile of fatty acids on methane production in lactating dairy cows. A study using 8 multiparous (325 ± 17 DIM; mean ± SD) lactating Jersey cows was conducted to determine effects of feeding canola meal and lard versus extruded byproduct containing flaxseed as a high-C18:3 fat source on methane production and diet digestibility in late-lactation dairy cows. A crossover design with 32-d periods (28-d adaptation and 4-d collections) was used to compare 2 different fat sources. Diets …

Approximate Kernel Reconstruction For Time-Varying Networks, Gregory Ditzler, Nidhal Carla Bouaynaya, Roman Shterenberg, Hassan Fathaliah-Shaykh

Henry M. Rowan College of Engineering Departmental Research

Most existing algorithms for modeling and analyzing molecular networks assume a static or time-invariant network topology. Such view, however, does not render the temporal evolution of the underlying biological process as molecular networks are typically “re-wired” over time in response to cellular development and environmental changes. In our previous work, we formulated the inference of time-varying or dynamic networks as a tracking problem, where the target state is the ensemble of edges in the network. We used the Kalman filter to track the network topology over time. Unfortunately, the output of the Kalman filter does not reflect known properties of …

Variation In Righting Times Of Holothuria Atra, Stichopus Chloronotus, And Holothuria Edulis In Response To Increased Seawater Temperatures On Heron Reef In The Southern Gbr, Elizabeth Buccheri, Matthias W. Foellmer, Beth A. Christensen, Paul Langi, Stefani Ritter, Esther Wolf, Aaren S. Freeman

School of Earth & Environment Departmental Research

Sea cucumbers can mitigate some impacts of climate change through digestion of benthic sands and production of calcium carbonate. The projected ecological benefits of sea cucumbers in warmer, more acidic oceans are contingent on the capacities of individuals to acclimate and populations to adapt to climatic changes. The goal of this experiment was to evaluate the degree to which warming waters would impact three abundant species of sea cucumbers on the Heron Reef in Queensland, Australia. We conducted a behavioral assay using three species of sea cucumbers, Holothuria atra, Stichopus chloronotus, and Holothuria edulis. Individuals from each species were subjected …

Prebiotics, Probiotics, And Bacterial Infections, Christina C. Tam, Kirkwood M. Land, Luisa W. Cheng

College of the Pacific Faculty Books and Book Chapters

Bacterial pathogens have developed exquisite virulence mechanisms to survive in the host cells. These virulence mechanisms help them bind and internalize into host cells, replicate, and evade the host immune response. The mammalian host itself has developed its own repertoire of weapons to prevent this from happening. One important component of host response in preventing infections in the gut lumen is the diverse commensal microbiota present. Dysbiosis of the gut microbiota has been implicated in the development of many gastrointestinal diseases. A potential therapeutic pathway to solve these diseases would be by providing probiotics and/or prebiotics to help stimulate growth …

Probability Of Streamflow Permanence Model (Prosper): A Spatially Continuous Model Of Annual Streamflow Permanence Throughout The Pacific Northwest, K. E. Kaiser

Geosciences Faculty Publications and Presentations

The U.S. Geological Survey (USGS) has developed the PRObability of Streamflow PERmanence (PROSPER) model, a GIS raster-based empirical model that provides streamflow permanence probabilities (probabilistic predictions) of a stream channel having year-round flow for any unregulated and minimallyimpaired stream channel in the Pacific Northwest region, U.S. The model provides annual predictions for 2004–2016 at a 30-m spatial resolution based on monthly or annually updated values of climatic conditions and static physiographic variables associated with the upstream basin. Predictions correspond to any pixel on the channel network consistent with the medium resolution National Hydrography Dataset channel network stream grid. Total annual …

Late Permian And Early Triassic Conchostracans From The Babii Kamen Section (Kuznetsk Coal Basin), V. I. Davydov, V. V. Zharinova, V. V. Silantiev

Geosciences Faculty Publications and Presentations

The Late Permian and Early Triassic conchostracans from the Babii Kamen section (Western Siberia) were studied. The conchostracans were collected from the section during the field work in 2015–2018. It was found that the conchostracans from the Babii Kamen section are characterized by a rather high taxonomical diversity: we identified five Late Permian conchostracan species (Pseudestheria novacastrensis (Mitchell, 1927), Cornia papillaria (Lutkevich, 1937), Megasitum harmonicum Novojilov, 1970, Megasitum lopokolense Novojilov, 1970, and Echinolimnadia mattoxi Novojilov, 1965) and two Early Triassic species (Concherisma tomensis Novojilov, 1958, Cyclotunguzites gutta (Lutkevich, 1938). The discovered conchostracan species occur frequently in the …

Influence Of Applied Potential And Metal Ion Concentraion On Metal Electrodeposition At Micron Gap Gold Electrodes, Krista Michel Riggins

Online Theses and Dissertations

Zamborini and Coworkers developed, a simple, low cost, and highly parallel electrochemical approach for fabricating nano-scale (metal/metal) or molecular (metal/polymer or self-assembled monolayer (SAM)/metal) junctions that should be useful in preparing working sensors and molecular electronic devices. The fabrication of metal/metal junctions involves metal deposition on one set of electrodes (E1), where the metal grows and becomes connected to a second set of electrodes (E2) of an Au interdigitated array of electrodes with a 5 µm separation. However, when different metals were deposited, they deposited in different fashions. Ag grew in the form of wires and Palladium deposited in the …

Reviews Of Two Books Of Robert E. Bieder, Roger L. Nichols, Juliet Clutton-Brock

Swiss American Historical Society Review

No abstract provided.

Ecosystem Functional Consequences Of Top Predator Mortality Due To The Invasive Shrub, Lonicera Maackii, Josey Lee-Anne Berta

Online Theses and Dissertations

Lonicera maackii (Amur Honeysuckle) is an invasive woody plant species that is present across the United States. Previous studies have assessed the biotic effects of honeysuckle, as well as abiotic effects such as changes in soil chemistry, ground level light, and forest floor temperature. Although directs effects of L. maackii on native terrestrial plant communities are well studied, little is known about its indirect effects, especially in aquatic ecosystems. Based on limited prior studies, I predicted addition of L. maackii leaves to aquatic systems would increase mortality of a top amphibian predator due to the release of phenolic compounds that …

Out With The Old, In With Revitalized Grammar Through Style-Based Composition Pedagogy, Courtney Forester

Online Theses and Dissertations

Composition theory has grappled with innumerable pedagogical approaches to grammar studies in the past, many of which yielded questionable results regarding improved clarity and effectiveness of student writing. Grammar is a primary component of spoken and written language; however, its teaching is often overlooked in many first-year writing classrooms. Composition instructors, then, are challenged to design an improved curriculum inclusive of grammar study through its reconciliation with style (Rankin, Amare), which would allow students to explore and experiment with a variety of rhetorical techniques in their compositions with significantly less severe mental detriments to their composing processes and attitudes. Facilitating …

Truth 2018-2019, University Center For The Humanities

University Center for the Humanities Events

The truth is easy. Tell me it’s raining outside, or not. But we know the truth is easy only until it’s not. When it really matters, and when matters are complex, the truth is in question, contested, open to interpretation, subject to doubt, even strategically denied. On the big questions, truth functions as a fragile, even suspect ideal. For this reason, truth has long been a central theme of the humanities. What should we believe, whom should we trust, how can we capture and face deep truths about ourselves, our social lives, the fundamental conditions of life and well-being? This …

Evaluating Shallow Mixing Protocols As Application Methods For Microbial Induced Calcite Precipitation Targeting Expansive Soil Treatment, Bhaskar C. S. Chittoori, Tasria Rahman, Malcolm Burbank, Arif Ali Baig Moghal

Civil Engineering Faculty Publications and Presentations

Expansive soils, also known as swell-shrink soils, undergo substantial volumetric changes due to moisture fluctuations from seasonal variations. These volumetric changes cause millions of dollars in damages annually. Microbial Induced Calcite Precipitation (MICP) is a promising soil improvement technique, which uses urease producing bacteria to precipitate calcium carbonate. In this study, a stabilization alternative for expansive soils was studied using MICP. Specifically, indigenous bacteria were stimulated by mixing enrichment and cementation solutions with expansive natural soils to precipitate calcium carbonate and make soil stronger and less expansive. This study examined three expansive soils with varying plasticity and mineralogical characteristics. Two …

Research And Innovation, January 2019, Office Of Vice President For Research

Research and Discovery News

• The Office of Human Research Protections has set Jan. 21 for the Implementation of the Final Rule on the "Federal Policy for the Protection of Human Subjects" (Common Rule)
• Undergraduate Award for Research and Creative Scholarship Excellence Recipients Named
• Changes in FY19 to NIH Academic Research Enhancement Award (AREA)/R15 Program
• The Center for the Study of Ethics Speaker Series to feature talks on the Opioid Crisis and Addiction Prevention
• NSF CAREER Workshop Feb. 15
• Feb. 19 Discovery Acceleration Workshop
• Reminder of Internal Funding Deadlines for Spring 2019
• Federal Agencies Impacted by the Partial Government Shutdown
• Kay Mortellaro Selected as Research …

Immigration Unilateralism And American Ethnonationalism, Robert L. Tsai

Loyola University Chicago Law Journal

This essay places the Trump administration’s immigration and refugee policy in the context of a resurgent ethnonationalist movement in America as well as the constitutional politics of the past. In particular, it argues that Trumpism’s suspicion of foreigners who are Hispanic or Muslim, its move toward indefinite detention and separation of families, and its disdain for so-called “chain migration” are best understood as part of an assault on the political settlement of the 1960s. These efforts at demographic control are being pursued unilaterally, however, without sufficient evidence there is a broad and lasting desire on the part of the people …

Santa Clara Magazine, Volume 61 Number 1, Winter 2019, Santa Clara University

Santa Clara Magazine

14 - IN THE BEGINNING An interview with Santa Clara University President Kevin O’Brien, S.J. on what's next and noticing what we swim in. Matt Morgan

22 - ADAM, EVE, AND THE APPLE If making—and appreciating—art makes us human, what happens when we get help making a masterpiece from something unhuman? Lauren Loftus.

28 - BEDROCK When faced with tough decisions, Santa Clara values stand as good guides, says Leon Panetta ’60, J.D. ’63. Leslie Griffy.

A Systematic Review Of Genetic Influence On Psychological Resilience, Kosuke Niitsu, Michael J. Rice, Julia F. Houfek, Scott F. Stoltenberg, Kevin A. Kupzyk, Cecilia R. Barron

Department of Psychology: Faculty Publications

When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well, described as resilience. Resilience is a complex biopsychosocial phenomenon conceptualized as adaptation to adversity influenced by an individual’s genetic variants, epistasis, epigenetics, and gene-by-environment interactions. Studies on psychological resilience have focused on behavioral and psychosocial variables with far less examination of the genetic contributions. The purpose of this review is to identify specific genetic variants contributing to the biological capacity for psychological resilience. PubMed and PsycINFO were searched using the following key words: psychological resilience AND genotype …

Ecological Drivers Of Species Distributions And Niche Overlap For Three Subterranean Termite Species In The Southern Appalachian Mountains, Usa, Chaz Hyseni, Ryan C. Garrick

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. In both managed and unmanaged forests, termites are functionally important members of the dead-wood-associated (saproxylic) insect community. However, little is known about regional-scale environmental drivers of geographic distributions of termite species, and how these environmental factors impact co-occurrence among congeneric species. Here we focus on the southern Appalachian Mountains-a well-known center of endemism for forest biota-and use Ecological Niche Modeling (ENM) to examine the distributions of three species of Reticulitermes termites (i.e., R. flavipes, R. virginicus, and R. malletei). To overcome deficiencies in public databases, ENMs were underpinned by field-collected high-resolution …

Rollins Magazine, Summer 2019, Rollins College Office Of Marketing And Communications

Rollins Magazine

No abstract provided.

January 2019, Lori Gwyn, Cj Smith

The Source

No abstract provided.

Ovalbumin-Sensitized Mice Have Altered Airway Inflammation To Agriculture Organic Dust, Kristi J. Warren, John D. Dickinson, Amy J. Nelson, Todd A. Wyatt, Debra J. Romberger, Jill A. Poole

Journal Articles: Environmental, Agricultural & Occupational Health

Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases. The objective of this study was to investigate the airway inflammatory response to organic dust extract (ODE) in mice with established ovalbumin (OVA)-induced experimental asthma. C57BL/6 mice were either OVA sensitized/aerosol-exposed or saline (Sal) sensitized/aerosol-challenged. Both groups were then subsequently challenged once with intranasal saline or swine confinement ODE to obtain 4 treatment groups of Sal-Sal, Sal-ODE, OVA-Sal, and OVA-ODE. Airway hyper-responsiveness (AHR) to methacholine, bronchiolar lavage fluid, lung tissues, …

Assessing The Role Of Polyphenols As A Vascular Protectant Against Drug Induced Vascular Injury, Anson Jacob Oommen

Browse all Theses and Dissertations

Vascular injury is identified during pre-clinical toxicity testing within certain pharmacological classes of drug candidates and induces degenerative and hyperplastic changes in endothelial (ECs) and vascular smooth muscle (VSMCs) cells. This drug-induced vascular injury has been show as a side-effect caused by various classes of drugs, including, antibacterial (e.g., azithromycin), anti-malarial (e.g., quinoline), anti-viral (e.g., anti-hepatitis C virus interferons) and nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), and affects normal cardiovascular function and can further lead to various cardiovascular conditions like arrhythmia, cardiac arrest, high blood pressure, and even heart attack. The search for agents capable of reducing vascular injury side-effects by …