Digital Commons Network^™

Data Exclusivities And The Limits To Trips Harmonization, Peter K. Yu

Faculty Scholarship

2019 marks the silver anniversary of the WTO TRIPS Agreement. Policymakers and commentators remain deeply divided about the strengths and limitations of this agreement. On the one hand, they marvel at its success in establishing international minimum standards for the protection and enforcement of intellectual property rights. On the other hand, they widely criticize the agreement for imposing high "one size fits all" standards upon developing countries.

Regardless of one's perspective, the harmonization project advanced by the TRIPS Agreement, and continued through TRIPS-plus bilateral, regional and plurilateral agreements, has been at the forefront of the international intellectual property debate. While …

Heart Failure Symptom Biology In Response To Ventricular Assist Device Implantation., Christopher S Lee, James O Mudd, Karen S Lyons, Quin E Denfeld, Corrine Y Jurgens, Bradley E Aouizerat, Jill M Gelow, Christopher V Chien, Emily Aarons, Kathleen L Grady

Articles, Abstracts, and Reports

BACKGROUND: We have a limited understanding of the biological underpinnings of symptoms in heart failure (HF), particularly in response to left ventricular assist device (LVAD) implantation.

OBJECTIVE: The aim of this study was to quantify the degree to which symptoms and biomarkers change in parallel from before implantation through the first 6 months after LVAD implantation in advanced HF.

METHODS: This was a prospective cohort study of 101 patients receiving an LVAD for the management of advanced HF. Data on symptoms (dyspnea, early and subtle symptoms [HF Somatic Perception Scale], pain severity [Brief Pain Inventory], wake disturbance [Epworth Sleepiness Scale], …

Neoantigen Screening Identifies Broad Tp53 Mutant Immunogenicity In Patients With Epithelial Cancers., Parisa Malekzadeh, Anna Pasetto, Paul F Robbins, Maria R Parkhurst, Biman C Paria, Li Jia, Jared J Gartner, Victoria Hill, Zhiya Yu, Nicholas P Restifo, Abraham Sachs, Eric Tran, Winifred Lo, Robert Pt Somerville, Steven A Rosenberg, Drew C Deniger

Articles, Abstracts, and Reports

No abstract provided.

Report Of An Inferior Rectal Nerve Variant Arising From The S3 Ventral Ramus., Graham Dupont, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

In surgical approaches to the perineum in general and anal region specifically, considering the possible variations of the inferior rectal nerve is important for the surgeon. Normally, the inferior rectal nerve originates as a branch of the pudendal nerve. However, during routine dissection, a variant of the inferior rectal nerve was found where it arose directly from the third sacral nerve ventral ramus (S3). Many cases have described the inferior rectal nerve arising independently from the sacral plexus, most commonly from the fourth sacral nerve root (S4); however, few cases have reported the inferior rectal nerve arising from S3. Herein, …

Interactions Between The Organellar Pol1a, Pol1b, And Twinkle Dna Replication Proteins And Their Role In Plant Organelle Dna Replication, Stewart Anthony Morley

Theses and Dissertations

Plants maintain organelle genomes that are descended from ancient microbes. Ages ago, these ancient microbes were engulfed by larger cells, beginning a process of co-evolution we now call the endo-symbiotic theory. Over time, DNA from the engulfed microbe was transferred to the genome of the larger engulfing cell, eventually losing the ability to be free-living, and establishing a permanent residency in the larger cell. Similarly, the larger cell came to rely so much on the microbe it had engulfed, that it too lost its ability to survive without it. Thus, mitochondria and plastids were born. Nearly all multicellular eukaryotes possess …

It All Started With Columbo: Teaching Law With Popular Culture, Christine A. Corcos

Journal of Legal Education

No abstract provided.

Effect Of 10-Valent Pneumococcal Conjugate Vaccine On The Incidence Of Radiologically-Confirmed Pneumonia And Clinically-Defined Pneumonia In Kenyan Children: An Interrupted Time-Series Analysis, Micah Silaba, Michael Ooko, Christian Bottomley, Joyce Sande, Rachel Benamore, Kate Park, James Ignas, Kathryn Maitland, Neema Mturi, Anne Makumi

Imaging & Diagnostic Radiology, East Africa

Background: Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of pneumococcal disease in low-income and middle-income countries is dominated by pneumonia, most of which is non-bacteraemic. We examined the effect of 10-valent PCV on the incidence of pneumonia in Kenya.

Methods: We linked prospective hospital surveillance for clinically-defined WHO severe or very severe pneumonia at Kilifi County Hospital, Kenya, from 2002 to 2015, to population surveillance at Kilifi Health and Demographic Surveillance System, comprising 45000 children younger than 5 years. Chest radiographs were read according to a WHO standard. A …

An Atypical Presentation Of A Rare Disease, Elizabeth Schoenberg, Kathleen P. Mcguinn, Deirdre Connolly, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

A 76-year-old white woman presented for evaluation of asymptomatic skin lesions on her right shin, right buttock, and left arm. All lesions initially underwent slow growth and plateaued and then remained stable in size. A complete review of systems revealed normal results. She had 3 well-demarcated erythematous round plaques ranging from 1.5 to 3 cm, all with a central depression, yellow hue, and prominent telangiectasias (Figs 1 and 2). An excisional biopsy was performed. Histologically, there were palisading granulomas within the papillary and reticular dermis, predominantly composed of a histiocytic cell population with multiple large giant cells (S100^-; …

Prevalence And Determinants Of Unprotected Sex In Intimate Partnerships Of Men Who Inject Drugs: Findings From A Prospective Intervention Study, Vartika Sharma, Waimar Tun, Avina Sarna, Lopamudra R. Saraswati, Minh D. Pham, Ibou Thior, Stanley Luchters

Population Health, East Africa

Unprotected sex, common among people who inject drugs, puts them and their partners at risk of sexually transmitted infections including human immunodeficiency virus (HIV). This analysis assesses the changes in sexual risk behavior with regular female partners (RFPs), among married men who inject drugs, before and after implementation of a HIV prevention intervention, and identifies correlates of unprotected sex. People who inject drugs (PWID) were assessed at three points: baseline, preintervention follow-up visit (FV)1, and postintervention FV2. Descriptive analysis was used for reporting changes in sexual behavior over time. Generalized estimating equation assessed the population-averaged change in self-reported unprotected sex …

Root Canal Treatment In Elderly Patients: A Review And Clinical Considerations, Mothanna K. Alrahabi

Saudi Medical Journal

Life expectancy has increased as a result of advancements in health care services; thus, maintaining healthy dentition is an important factor in overall health. Furthermore, the growing desire of elderly patients to maintain their teeth has led to an increased need for the performance of complex dental treatment in elderly patients. Root canal therapy is an essential phase of such treatments. Elderly patients may exhibit one or more systemic conditions that require special care, in addition to other changes that occur within the dentition and oral mucosa as a result of aging. These make root canal treatment in elderly patients …

Bibliography Of The Published Works Of Stephen L. Williams, Suzanne Boyer Mclaren, Catharine A. Hawks, Hugh H. Genoways

University of Nebraska State Museum: Mammalogy Papers

Bibliography of the published works of Stephen Lory Williams (1948-2018).

The Extensive And Intensive Margins Of Time Investments On The Skill Development Of Children And Adolescents, Yi Rachel Tan

Dissertations and Theses Collection (Open Access)

The literature on time investments and skill development has focused on estimating the intensive margins of time investments; This study explores whether including extensive margins might provide additional insights. The extensive and intensive margins of maternal time investments and child time investments (or child self-investments) in three categories of activities (educational, structured and unstructured) on the cognitive and non-cognitive skill development of children (6 to 10 years) and adolescents (11 to 15 years) are quantified by fitting skill production functions with ordinary least squares and family fixed effects specifications. Cognitive skills are assessed by three achievement test scores which indicate …

Epithelioid Glioblastoma Presenting As Aphasia In A Young Adult With Ovarian Cancer: A Case Report, Megan M. Finneran, Joseph Georges, Michael Kakareka, Ryan Moncman, Miriam Enriquez, Todd Siegal, Gregory Kubicek, Alan Turtz, Steven S. Yocom, H Warren Goldman

PCOM Scholarly Works

Our patient's clinical history and preoperative radiographic evaluation suggested central nervous system (CNS) metastatic disease. Ultimately, final pathology revealed epithelioid glioblastoma (eGBM), a newly classified CNS primary tumor. This reinforces the importance of direct tissue sampling and including eGBM on the differential for young patients with histories of systemic cancer presenting with new CNS lesions.

Transformation Of Tfb2 Overexpression Plasmid Into Hyperthermophile Pyrococcus Furiosus Com1, Brent Marsonette

University Honors Theses

Pyrococcus furiosus is an exceptional model organism for studies of life in extreme environments. Being a hyperthermophile, this archaeal species thrives at temperatures nearing that of boiling water. The underlying machinery for transcription in most archaeal species is poorly studied, and data concerning transcriptional regulation is limited. Transcription Factor B Subunit II (TFB2), a non-standard component of the transcription preinitiation complex in P. furiosus, is poorly understood regarding its function and mechanism. One hypothesis is that TFB2 is important for cellular response to oxidative stress. To test this, a plasmid that over-expresses the TFB2 protein was successfully transformed into …

Human Security In The Arctic: Implications For The United States Army, C. Anthony Pfaff

The US Army War College Quarterly: Parameters

No abstract provided.

Hydrological Drought Persistence And Recovery Over The Conus: A Multi-Stage Framework Considering Water Quantity And Quality, Behzad Ahmadi, Ali Ahmadalipour, Hamid Moradkhani

Civil and Environmental Engineering Faculty Publications and Presentations

Hydrological droughts have considerable negative impacts on water quantity and quality, and understanding their regional characteristics is of crucial importance. This study presents a multi-stage framework to detect and characterize hydrological droughts considering both streamflow and water quality changes. Hydrological droughts are categorized into three stages of growth, persistence, retreat, and water quality variables (i.e., water temperature, dissolved oxygen concentration, and turbidity) are utilized to further investigate drought recovery. The framework is applied to 400 streamflow gauges across the Contiguous United States (CONUS) over the study period of 1950–2016. The method is illustrated for the 2012 US drought, which affected …

Perturbation Based Decomposition Of Semg Signals, Rachel Huettinger

Master's Theses

Surface electromyography records the motor unit action potential signals in the vicinity of the electrode to reveal information on muscle activation. Decomposition of sEMG signals for characterization of constituent motor unit action potentials in terms of amplitude and firing times is useful for clinical research as well as diagnosis of neurological disorders. Successful decomposition of sEMG signals would allow for pertinent motor unit action potential information to be acquired without discomfort to the subject or the need for a well-trained operator (compared with intramuscular EMG). To determine amplitudes and firing times for motor unit action potentials in an sEMG recording, …

The Impact Of Sexual Assault Training And Gender On Rape Attitudes, Monica Krolnik Campos

Electronic Theses, Projects, and Dissertations

Sexual assault is a growing concern across college campuses in the United States. According to the Sexual Victimization of College Women study, the victimization rate is 27.7 rapes per 1,000 ­­­­women students (Fisher, Cullen, & Turner, 2000). In response to the high prevalence of sexual assault, college campuses are now mandated to implement various forms of sexual assault prevention programming. Sexual assault prevention programming is intended to promote awareness of sexual assault and reduce the prevalence of sexual assault on college campuses. Numerous studies have examined the short term effectiveness of sexual assault prevention programs (e.g., Anderson & Whiston, 2005). …

Cancer, Sexual Quality Of Life, And The Dyad: A Qualitative Study, Gabriela E. Gutierrez

Loma Linda University Electronic Theses, Dissertations & Projects

As the rate of survivorship continues to increase within oncological care (White, 2007), more attention is being focused on the quality of life and long-term outcomes of cancer survivors (American Cancer Society, 2014). Sexual quality of life (SQOL), which includes both sex and intimacy, have been identified as primary sources of stress among patients and their partners across cancer types (Manne & Badr, 2008; 2010; Manne, Badr, & Kashy, 2012); however, reproductively related cancers, such as breast and gynecologic cancers have especially posed unique challenges to both patients and their partners (Jonsdottir, et al., 2016). It is widely known that …

Sensory Processing Sensitivity In The Context Of Environmental Sensitivity: A Critical Review And Development Of Research Agenda, Cu Greven, F Lionetti, C Booth, En Aron, Et Al

School of Psychology

Sensory Processing Sensitivity (SPS) is a common, heritable and evolutionarily conserved trait describing inter-individual differences in sensitivity to both negative and positive environments. Despite societal interest in SPS, scientific knowledge is lagging behind. Here, we critically discuss how SPS relates to other theories, how to measure SPS, whether SPS is a continuous vs categorical trait, its relation to other temperament and personality traits, the underlying aetiology and neurobiological mechanisms, and relations to both typical and atypical development, including mental and sensory disorders. Drawing on the diverse expertise of the authors, we set an agenda for future research to stimulate the …

Fungi In The Marine Environment: Open Questions And Unsolved Problems, Anthony Amend, Gaetan Burgaud, Michael Cunliffe, Virginia P. Edgcomb, Cassandra L. Ettinger, M. H. Gutiérrez, Joseph Heitman, Erik F.Y. Hom, Giuseppe Ianiri, Adam C. Jones, Maiko Kagami, Kathryn T. Picard, C. Alisha Quandt, Seshagiri Raghukumar, Mertixell Riquelme, Jason Stajich, José Vargas-Muñiz, Allison K. Walker, Oded Yarden, Amy S. Gladfelter

Faculty and Student Publications

© 2019 Amend et al. Terrestrial fungi play critical roles in nutrient cycling and food webs and can shape macroorganism communities as parasites and mutualists. Although estimates for the number of fungal species on the planet range from 1.5 to over 5 million, likely fewer than 10% of fungi have been identified so far. To date, a relatively small percentage of described species are associated with marine environments, with ~1,100 species retrieved exclusively from the marine environment. Nevertheless, fungi have been found in nearly every marine habitat explored, from the surface of the ocean to kilometers below ocean sediments. Fungi …

The Patent Option, Daniel J. Gervais

Vanderbilt Law School Faculty Publications

There is a shift in the shape of intellectual property (IP) tools used to strengthen and lengthen the right of pharmaceutical companies to exclude others from making and marketing their products. Patents have traditionally been the tool of choice. Over the past two decades, however, pharmaceutical companies have increased their degree of reliance on a right known as “data exclusivity.” This right, which now exists in most major jurisdictions, is the right to prevent third parties from relying on the clinical trial data submitted by another pharmaceutical company to obtain marketing approval for a bioequivalent or biosimilar product. The right …

Pharmacological Studies On Ceftiofur In Sheep, Nourhan Lutfi, Reham El-Shafe, Mohamed El- Diasty, Mohamed El-Sayed

Mansoura Veterinary Medical Journal

This work was done on twenty young male and female lambs (15-60 days old) in a special sheep grazing herds in Dakahlia governorate. Lambs were divided into two groups; each one has ten animals .The first group non-vaccinated, kept as a control group without any interference by any medication. The second group lamb was injected with ceftiofur (2mg/kg B.W) s/c at posterior aspect in the middle third of ear as single dose. Results revealed a significant decrease in total erythrocytic count, hemoglobin content, total leukocytic count, lymphocyte count, monocyte count, eosinophil count, globulin, ALT, total protein, Albumin ;creatinine and urea …

The Effect Of Dexamethasone On Mucosal Immunity Of Uterine Tissue During Pregnancy In Rat, Fahim Wehaish, Elseady Youssef, Nada Hashem

Mansoura Veterinary Medical Journal

Disturbances in early pregnancy immunity affect embryo development, endometrial receptivity, placental development, fetal growth and lead to subfertility, dexamethasone is a synthetic glucocorticoid used for treatment of various complications. Immune cells and cytokines were examined during the early pregnancy in twenty-four female rats and six male rats for mating. Rats were grouped into two group control and dexamethasone treated by a dose of 50µgm/kgm body weight daily starting from one week before mating and persisted for one week after pregnancy. Blood samples were collected from each rat at 5hrs and at 1,3,7 day of pregnancy. Extracted RNA was subjected to …

Revisiting The Miller-Kanazawa Debate: Should Asia Be Afforded More Attention From Evolutionary Psychologists?, Sean Teck Hao Lee

Research Collection School of Social Sciences

A decade ago, Dr. Satoshi Kanazawa and Dr. Geoffrey Miller, two renowned evolutionary psychologists, participated in a debate on whether evolutionary psychologists should focus on Asia in their quest to establish a stronghold in the general field of psychology. Despite painstaking efforts to foster greater receptiveness among Western psychologists toward an evolutionary perspective of psychological phenomena, most still seem to be critically reserved toward it; favoring instead proximate sociocultural explanations of psychological phenomena as stipulated by the standard social science model. Facing such an inertia, Miller suggested that it may perhaps be wise to re-direct the field's efforts on the …

The Odd Log-Logistic Gompertz Lifetime Distribution: Properties And Applications, Morad Alizadeh, Saeid Tahmasebi, Mohammad Reza Kazemi, Hamideh Siyamar Arabi Nejad, Gholamhossein G. Hamedani

Mathematical and Statistical Science Faculty Research and Publications

In this paper, we introduce a new three-parameter generalized version of the Gompertz model called the odd log-logistic Gompertz (OLLGo) distribution. It includes some well-known lifetime distributions such as Gompertz (Go) and odd log-logistic exponential (OLLE) as special sub-models. This new distribution is quite flexible and can be used effectively in modeling survival data and reliability problems. It can have a decreasing, increasing and bathtub-shaped failure rate function depending on its parameters. Some mathematical properties of the new distribution, such as closed-form expressions for the density, cumulative distribution, hazard rate function, the kth order moment, moment generating function and …

Overcoming Impediments To Shellfish Aquaculture Through Legal Research And Outreach: Case Studies, National Sea Grant College Program, Catherine Janasie, Amanda Nichols, Read Porter, Mitchell Ramic, Jordan Viana, Joseph Bingaman, Elizabeth Andrews, Angela King, Danielle Goshen, Shana Jones, Lisa Schiavinato, Catherine Courtier, Danielle Goshen

Virginia Coastal Policy Center

More than half of the population of the continental United States resides in coastal communities, which are increasingly home to commercial shellfish aquaculture operations. Consequently, a variety of user conflicts can arise as states seek to encourage the development or expansion of shellfish aquaculture. Each of these conflicts creates the potential for opposition and legal challenges to the industry.

An understanding of the legal and regulatory context governing shellfish aquaculture can assist in managing conflicts related to the industry. Laws and regulations in some cases create or can be perceived as impediments to the growth or success of the aquaculture …

The MOlecular EDucation And REsearch COnsortium In UNdergraduate Computational ChemistRy (Mercury): Twenty Years Of Exceptional Success Supporting Undergraduate Research And Inclusive Excellence, George C. Shields

Chemistry Department Faculty Citations

The author discusses the history of the Molecular Education and Research Consortium in Undergraduate Computational Chemistry (MERCURY), which has made significant contributions benefiting science faculty and undergraduates. The peer review publication rate of 1.7 for MERCURY faculty is 3.4 times the average rate for physical science faculty at primarily undergraduate institutions. Since 2001, 888 students have worked on research projects; 75 percent of them have come from underrepresented populations, such as female students or students of color. Approximately half of all graduates have pursued advanced degrees in STEM fields; two-thirds of this group have been female and/or students of color. …

Orientation Dependent Elastic Stress Concentration At Tips Of Slender Objects Translating In Viscoelastic Fluids, Chuanbin Li, Becca Thomases, Robert D. Guy

Mathematics Sciences: Faculty Publications

Elastic stress concentration at the tips of long slender objects moving in viscoelastic fluids has been observed in numerical simulations, but despite the prevalence of flagellated motion in complex fluids in many biological functions, the physics of stress accumulation near the tips has not been analyzed. Here, we theoretically investigate elastic stress development at the tips of slender objects by computing the leading-order viscoelastic correction to the equilibrium viscous flow around long cylinders, using the weak-coupling limit. In this limit, nonlinearities in the fluid are retained, allowing us to study the biologically relevant parameter regime of high Weissenberg number. We …

Differences In Coping Between Parents Of Mentally Handicapped Children And Parents Of Non Handicapped Children, Cynthia Chatham

Dissertations

The purpose of this study was to ascertain if there was a difference in perceived effectiveness of coping behaviors between mothers and fathers of a mentally handicapped child and mothers and fathers of a non handicapped child. The conceptual framework was derived from the work of Lazarus (1961) and Pearl in and Schooler (1978). Utilizing a descriptive design, 64 parents (28 parents of a mentally handicapped child and 36 parents of a non handicapped child) were surveyed using the Family Coping Inventory (FCI). Twenty-eight parents of a mentally handicapped child completed an additional instrument, the Coping Health Inventory for Parents …