Digital Commons Network^™

A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe

Dissertations and Theses

Cardiovascular disease is the leading cause of death worldwide. Coronary Artery Disease (CAD) accounts for the majority of those deaths. Observational studies have identified risk factors that have been helpful in lowering the death rate, including hypertension, high cholesterol, diabetes, smoking, physical inactivity and poor diet. The effects of these risk factors on CAD remain unclear. To clarify the effect of three amino acids, alanine, glutamine, and glycine on CAD I applied a two sample Mendelian randomization analysis to extensively genotyped observational data. In a sample with up to 184,000 individuals and approximately 60,000 controls, SNPs that reached genome wide …

Basal Ganglia Involvement In The Playfulness Of Juvenile Rats, Stephen M. Siviy

Psychology Faculty Publications

Play is an important part of normal childhood development and can be readily studied in the laboratory rat in the form of rough‐and‐tumble play. Given the robust nature of rough‐and‐tumble play, it has often been assumed that the basal ganglia would have a prominent role in modulating this behavior. Recent work using c‐fos expression as a metabolic marker for neural activity combined with temporary inactivation of relevant corticostriatal regions and pharmacological manipulations of opioid, cannabinoid, and dopamine systems has led to a better understanding of how basal ganglia circuitry may be involved in modulating social play in the juvenile rat. …

Review Of Chagas Disease And Treatment Obstacles To Eradication, Emily Sherman

Senior Honors Theses

The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries. The agent of the disease is a single-celled protozoan parasite, Trypanosoma cruzi, and common modes of transmission include infected feces of a triatomine bug, crossing the placental barrier, and blood products. The two phases of infection are acute and chronic, and the three most affected body systems are cardiovascular, digestive, and nervous. Although research has led to several advances in the knowledge of CD, there are gaps in treatment and epidemiological …

Alterations In Cortical Activation Among Individuals With Chronic Ankle Instability During Single-Limb Postural Control, Adam Rosen, Jennifer M. Yentes, Melanie L. Mcgrath, Arthur C. Maerlender, Sara A. Myers, Mukul Mukherjee

Journal Articles

Context

Chronic ankle instability (CAI) is characterized by repetitive ankle sprains and perceived instability. Whereas the underlying cause of CAI is disputed, alterations in cortical motor functioning may contribute to the perceived dysfunction.

Objective

To assess differences in cortical activity during single-limb stance among control, coper, and CAI groups.

Design

Cross-sectional study.

Setting

Biomechanics laboratory.

Patients or Other Participants

A total of 31 individuals (10 men, 21 women; age = 22.3 ± 2.4 years, height = 169.6 ± 9.7 cm, mass = 70.6 ± 11.6 kg), who were classified into control (n = 13), coper (n = 7), and CAI …

Social Clustering In Epidemic Spread On Coevolving Networks, Hsuan-Wei Lee, Nishant Malik, Feng Shi, Peter J. Mucha

Articles

Even though transitivity is a central structural feature of social networks, its influence on epidemic spread on coevolving networks has remained relatively unexplored. Here we introduce and study an adaptive susceptible- infected-susceptible (SIS) epidemic model wherein the infection and network coevolve with nontrivial proba- bility to close triangles during edge rewiring, leading to substantial reinforcement of network transitivity. This model provides an opportunity to study the role of transitivity in altering the SIS dynamics on a coevolving network. Using numerical simulations and approximate master equations (AMEs), we identify and examine a rich set of dynamical features in the model. In …

Heatwaves And Novel Host Consumption Increase Overwinter Mortality Of An Imperiled Wetland Butterfly, Mariana Abarca, Elise A. Larsen, Leslie Ries

Biological Sciences: Faculty Publications

Disruptive effects of climate change include range shifts, phenological mismatches among consumers and producers, and population declines. While these biological alterations have been widely documented, studies identifying specific mechanisms linking climate change to population declines are scarce. Extreme events, such as heatwaves can have devastating effects on living organisms and are increasing in frequency as Earth warms. Hence, understanding the effects of heatwaves on insects is necessary to inform conservation efforts and to develop predictions of population dynamics under future climate scenarios. Here, we experimentally evaluated the effects of heatwaves on the survival and phenology of the Baltimore Checkerspot (Euphydryas …

The Association Of Higher Carbon Dioxide Levels And Teachers’ Perceived Air Quality And Well Being In New York City Elementary Schools, Leon Levine

Dissertations and Theses

Introduction:

Several recent studies have investigated the direct effects of carbon dioxide (CO₂) at concentrations typically found in office buildings on occupant cognitive functioning. These studies have reported a significant association between (impaired) decision making ability and exposure to increased levels of CO₂ (600 ppm versus 1500 ppm). The findings have serious implications in a classroom setting since the objective of schools is to provide an optimal environment for learning. If CO₂ levels in schools are elevated, the teachers’ health and the students’ learning environment will be compromised. Higher CO₂ levels could impact teachers’ and …

The Xfp (17-Bm) Beamline For X-Ray Footprinting At Nsls-Ii, Awuri Asuru, Erik R. Farquhar, Michael Sullivan, Donald Abel, John Toomey, Mark R. Chance, Jen Bohon

Faculty Scholarship

Hydroxyl-radical mediated synchrotron X-ray footprinting (XF) is a powerful solution-state technique in structural biology for the study of macromolecular structure and dynamics of proteins and nucleic acids, with several synchrotron resources available to serve the XF community worldwide. The XFP (Biological X-ray Footprinting) beamline at the NSLS-II was constructed on a three-pole wiggler source at 17-BM to serve as the premier beamline for performing this technique, providing an unparalleled combination of high flux density broadband beam, flexibility in beam morphology, and sample handling capabilities specifically designed for XF experiments. The details of beamline design, beam measurements, and science commissioning results …

2019 Staff Presidential Award Of Excellence, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Academic Senate - Agenda, 6/04/2019, Academic Senate

Academic Senate Agendas

No abstract provided.

Immunomodulatory Role Of Non-Neuronal Cholinergic Signaling In Myocardial Injury, Cibele Rocha-Resende, Carla Weinheimer, Geetika Bajpai, Luigi Adamo, Scot J. Matkovich, Joel Schilling, Philip M. Barger, Kory J. Lavine, Douglas L. Mann

Open Access Publications

Whereas prior studies have demonstrated an important immunomodulatory role for the neuronal cholinergic system in the heart, the role of the non-neuronal cholinergic system is not well understood. To address the immunomodulatory role of the non-neuronal cholinergic system in the heart we used a previously validated diphtheria toxin (DT)-induced cardiomyocyte ablation model (Rosa26-DTMlc2v-Cre mice). DT-injected Rosa26-DTMlc2v-Cre mice were treated with diluent or Pyridostigmine Bromide (PYR), a reversible cholinesterase inhibitor. PYR treatment resulted in increased survival and decreased numbers of MHC-IIlowCCR2+ macrophages in DT-injected Rosa26-DTMlc2v-Cre mice compared to diluent treated Rosa26-DTMlc2v-Cre mice. Importantly, the expression of CCL2/7 mRNA and protein was …

Impact Of High Volume Energy Drink Consumption On Electrocardiographic And Blood Pressure Parameters: A Randomized Trial, Sachin A. Shah, Andy H. Szeto, Raechel Farewell, Allen Shek, Dorothy Fan, Kathy N. Quach, Mouchumi Bhattacharyya, Jasmine Elmiari, Winny Chan, Kate O'Dell, Nancy Nguyen, Tracey J. Mcgaughey, Javed M. Nasir, Sanjay Kaul

School of Pharmacy Faculty Articles

Background Energy drinks have been linked to an increase in emergency room visits and deaths. We aim to determine the impact of energy drinks on electrocardiographic and hemodynamic parameters in young healthy volunteers. Methods and Results A randomized, double-masked, placebo-controlled, crossover study was conducted in healthy volunteers. Participants consumed 32 oz of either energy drink A, energy drink B, or placebo within 60 minutes on 3 study days with a 6-day washout period in between. The primary end point of QT c interval and secondary end points of QT interval, PR interval, QRS duration, heart rate, and brachial and central …

Mapping Modeled Exposure Of Wildland Fire Smoke For Human Health Studies In California, Patricia Koman, Michael Billmire, Kirk Baker, Ricardo De Majo, Frank Anderson, Sumi Hoshiko, Brian Thelen, Nancy H. F. French

Michigan Tech Publications, Part 1

Wildland fire smoke exposure affects a broad proportion of the U.S. population and is increasing due to climate change, settlement patterns and fire seclusion. Significant public health questions surrounding its effects remain, including the impact on cardiovascular disease and maternal health. Using atmospheric chemical transport modeling, we examined general air quality with and without wildland fire smoke PM_2.5. The 24-h average concentration of PM_2.5 from all sources in 12-km gridded output from all sources in California (2007–2013) was 4.91 μg/m³. The average concentration of fire-PM_2.5 in California by year was 1.22 μg/m³ (~25% …

Interfacial Amino Acids Support Spa47 Oligomerization And Shigella Type Three Secretion System Activation, Hannah J. Demler, Heather B. Case, Yalemi Morales, Abram R. Bernard, Sean J. Johnson, Nicholas E. Dickenson

Chemistry and Biochemistry Faculty Publications

Like many Gram-negative pathogens, Shigella rely on a type three secretion system (T3SS) for injection of effector proteins directly into eukaryotic host cells to initiate and sustain infection. Protein secretion through the needle-like type three secretion apparatus (T3SA) requires ATP hydrolysis by the T3SS ATPase Spa47, making it a likely target for in vivo regulation of T3SS activity and an attractive target for small molecule therapeutics against shigellosis. Here, we developed a model of an activated Spa47 homo-hexamer, identifying two distinct regions at each protomer interface that we hypothesized to provide intermolecular interactions supportingSpa47 oligomerization and enzymatic activation. Mutational analysis …

Risk Factors Of Asthma Among Teens, Lina G. Nouwayhed

DNP and Student Works

Asthma is a chronic disease caused by many risk factors. Many factors were assessed among this survey including age, gender, heredity, smoking, and environmental pollutants. Three schools of a total of one thousand one hundred students were selected to conduct the study. Fifty-one students were diagnosed asthmatics and fifty-one students were taken as control group. Same questionnaire was distributed to both cases and control as the method for this study. Results showed a greater prevalence among age group fifteen to eighteen years. No gender difference was discovered. 80% of the cases had one of their family members asthmatics. Molds and …

Seafloor Mapping – The Challenge Of A Truly Global Ocean Bathymetry, Anne-Cathrin Wölfl, Helen Snaith, Sam Amirebrahimi, Colin W. Devey, Boris Dorschel, Vicki L. Ferrini, Veerle A. I. Huvenne, Martin Jakobsson, Jennifer Jencks, Gordon Johnston, Geoffroy Lamarche, Larry A. Mayer, David Millar, Terje Haga Pedersen, Kim Picard, Anja Reitz, Thierry Schmitt, Martin Visbeck, Pauline Weatherall, Rochelle Wigley

Center for Coastal and Ocean Mapping

Detailed knowledge of the shape of the seafloor is crucial to humankind. Bathymetry data is critical for safety of navigation and is used for many other applications. In an era of ongoing environmental degradation worldwide, bathymetry data (and the knowledge derived from it) play a pivotal role in using and managing the world’s oceans in a way that is in accordance with the United Nations Sustainable Development Goal 14 – conserve and sustainably use the oceans, seas and marine resources for sustainable development. However, the vast majority of our oceans is still virtually unmapped, unobserved, and unexplored. Only a small …

"You Can't Go Back To Holding Hands." Reading Judy Blume's Forever In The #Metoo Era, Jenna Spiering, Kate Kedley

Faculty Publications

Judy Blume’s Forever is a cultural artifact that gives readers a historical look at society’s attitudes about sex and sexuality at the time of publication in 1975. However, in the #MeToo era, Blume’s text is poised for new analysis in light of important conversations and concerns about sex, sexuality, and consent. In this article, Critical Youth Studies and Queer Theory are used to explore the ways in which young readers can critically engage with Blume’s novel and questions about virginity, sex, sexuality, and consent associated with the #MeToo movement.

Highlights From The American Heart Association's Epi|Lifestyle 2019 Scientific Sessions, Alvaro Alonso, Madison D. Anderson, Michael P. Bancks, Sherry Ann Brown, Melissa C. Caughey, Alex R. Chang, Erin Delker, Kathryn Foti, Véronique Gingras, Michael G. Nanna, Alexander C. Razavi, Jewel Scott Phd, Rn, Fnp-C, Elizabeth Selvin, Catherine Tcheandjieu, Alvin G. Thomas, Ruth Alma N. Turkson-Ocran, Allison Webel, Deborah R. Young, Bailey M. Debarmore

Faculty Publications

No abstract provided.

Highlights From The American Heart Association's Epi|Lifestyle 2019 Scientific Sessions, Alvaro Alonso, Madison D. Anderson, Michael P. Bancks, Sherry Ann Brown, Melissa C. Caughey, Alex R. Chang, Erin Delker, Kathryn Foti, Véronique Gingras, Michael G. Nanna, Alexander C. Razavi, Jewel Scott Phd, Rn, Fnp-C, Elizabeth Selvin, Catherine Tcheandjieu, Alvin G. Thomas, Ruth Alma N. Turkson-Ocran, Allison Webel, Deborah R. Young, Bailey M. Debarmore

Faculty Publications

No abstract provided.

Disentangling The Impact Of Poor Sleep From Depressive Symptoms On Emotion Regulation, Kimberly O'Leary

USF Tampa Graduate Theses and Dissertations

Depressive symptoms and sleep are both strongly associated with deficits in emotional functioning (Durmer & Dinges, 2005; van der Helm & Walker, 2010). Although sleep and depression are tightly intertwined, understanding their independent and conjoint impact on emotional functioning is imperative. Given the limitations of previous designs, the primary goal of this study was to examine the separate impact of poor sleep quality and depressive symptoms on emotion regulation. In order to accomplish this goal, we preselected groups on the basis of their sleep and depression profiles: individuals with mainly sleep problems (N = 30), individuals with mainly depressive symptoms …

Next Generation Science Standards And Physics First: A Case Study Of High School Teachers' Beliefs And Practices, Stephen Godfrey Scannell

Dissertations and Theses

This dissertation is a case study of a school district in the Pacific Northwest that developed three-year high school science curricula using a Physics First course sequence (Physics, Chemistry, Biology), with the crosscutting concept Patterns as the central theme of the courses. The purpose of the study was to examine the impact of the implementation of the 9th grade course, Patterns Physics, on teacher practice and beliefs about science teaching and determine whether this new approach facilitated teacher classroom practices and beliefs congruent with those expressed in A Framework for K-12 Science Education (NRC, 2012) and the Next Generation Science …

"It's All Because I Like The Person That's Teaching Me": Masculinities, Engagement, And Caring Relationships In Secondary Schools, Cristy Lauren Weggelaar

Dissertations and Theses

U.S. schools face a well-documented gender gap within some important educational and social indicators. In the United States, boys and young men are significantly more likely than girls and young women to be diagnosed with a learning disability, leave high school without a diploma, receive failing grades in core classes, and be suspended or expelled from school. This study uses an interpretive research framework to investigate the relationship between this gender gap in education and constructions of masculinity, social and cultural capital, agency, caring and resistance in secondary schools. Data collected through interviews with young men who engaged in acts …

Peripheral Synucleinopathy In A Dj1 Patient With Parkinson Disease, Cataracts, And Hearing Loss, Derek P. Narendra, Risa Isonaka, Diana Nguyen, Alice B. Schindler, Angela D. Kokkinis, Debra Ehrlich, Tanya M. Bardakjian, David S. Goldstein, Tsao-Wei Liang, Pedro Gonzalez-Alegre

Department of Neurology Faculty Papers

No abstract provided.

Evaluating The Utility Of Theories Of Social Integration In Understanding Areal Suicide Rates In The United States, Nathan Finch Parsons

Dissertations and Theses

Despite over a century's worth of study, areal variations in suicide rate remain largely unexplained. In order to better understand these regional differences, this analysis aggregates county-level National Center for Health Statistics Multiple Cause of Death data with data from the US Census, the Association of Statisticians of American Religious Bodies, and the Penn State Northeast Regional Center for Rural Development to test the three leading conceptualizations of social integration (i.e. demographic, compositional, ecological) against US suicide rates. Results of negative binomial regression models indicate that an ecological measure, social capital, is substantially associated with suicide rate, while demographic and …

Aquatic Invasive Species Change Ecosystem Services From The World's Largest Wild Sockeye Salmon Fisheries In Alaska, Tobias Schwoerer, Joseph M. Little, Milo D. Adkison

Journal of Ocean and Coastal Economics

This study combines a multi-method approach to structured expert judgment with market valuation to forecast fisheries damages from introduced invasive species. The method is applied to a case study of Alaska’s first submersed aquatic invasive plant, Elodea spp., threatening Alaska’s salmon fisheries. Assuming that Elodea spp. remains unmanaged, estimated mean damages to commercial sockeye fisheries aggregated across Alaska amount to a potential $159 million annually with a 5% chance of exceeding $577 million annually ($2015 USD). The associated mean loss of natural capital amounts to $5.1 billion cumulatively over the next 100 years reaching $400 million after 10 years. …

A Low-Cost Experimental Testbed For Multi-Agent System Coordination Control, Victor Fernandez-Kim

LSU Master's Theses

A multi-agent system can be defined as a coordinated network of mobile, physical agents that execute complex tasks beyond their individual capabilities. Observations of biological multi-agent systems in nature reveal that these ``super-organisms” accomplish large scale tasks by leveraging the inherent advantages of a coordinated group. With this in mind, such systems have the potential to positively impact a wide variety of engineering applications (e.g. surveillance, self-driving cars, and mobile sensor networks). The current state of research in the area of multi-agent systems is quickly evolving from the theoretical development of coordination control algorithms and their computer simulations to experimental …

Interpreting Reality In The Anthropocene, Jake Philip Hamill

LSU Master's Theses

In this paper, I would like to propose that abundant beautification techniques in contemporary nature documentaries are counterproductive when attempting to address humans’ impact on our planet. By utilizing technology there could be a new way to educate ourselves about the Anthropocene on platforms such as Google Earth where one can view nature, statistics, and art by location. With limited data, learning about our effects on nature in its entirety is close to impossible but art can allow us to try and reveal new hidden connections.

Maximizing And Modeling Malonyl-Coa Production In Escherichia Coli, Tatiana Thompson Silveira Mello

LSU Master's Theses

In E. coli, fatty acid synthesis is catalyzed by the enzyme acetyl-CoA carboxylase (ACC), which converts acetyl-CoA into malonyl-CoA. Malonyl-CoA is a major building block for numerous of bioproducts. Multiple parameters regulate the homeostatic cellular concentration of malonyl-CoA, keeping it at a very low level. Understanding how these parameters affect the bacterial production of malonyl-CoA is fundamental to maximizing it and its bioproducts. To this end, competing pathways consuming malonyl-CoA can be eliminated, and optimal nutritional and environmental conditions can be provided to the fermentation broth. Most previous studies utilized genetic modifications, expensive consumables, and high-cost quantification methods, making …

Reproductive Parameters And Methodologies For The Culture Of Golden Topminnows (Fundulus Chrysotus) And Bluenose Shiners (Pteronotropis Welaka), Jacob A. Fetterman

LSU Master's Theses

The global ornamental fish trade has expanded over the past 20 years, requiring captive rearing methods to be improved or developed for species of interest. Aquaculture of desirable species is preferable over wild harvest to conserve natural habitats and biodiversity. This thesis focused on improving culture methods for Golden Topminnows Fundulus chrysotus and developing culture methods for Bluenose Shiners Pteronotropis welaka, both native fishes of the southeastern United States with ornamental demand. A combination of reproductive metric analyses, examination of historical collections, and captive spawning trials were employed to target specific objectives for each species. In female Golden Topminnows, …

Contributor Biographies, Editors Of Suurj

SUURJ: Seattle University Undergraduate Research Journal

No abstract provided.