Digital Commons Network^™

Novel Algorithms For Ldd Motif Search, Peng Xiao, Martin Schiller, Sanguthevar Rajasekaran

Life Sciences Faculty Research

Background: Motifs are crucial patterns that have numerous applications including the identification of transcription factors and their binding sites, composite regulatory patterns, similarity between families of proteins, etc. Several motif models have been proposed in the literature. The (l,d)-motif model is one of these that has been studied widely. However, this model will sometimes report too many spurious motifs than expected. We interpret a motif as a biologically significant entity that is evolutionarily preserved within some distance. It may be highly improbable that the motif undergoes the same number of changes in each of the species. To address this issue, …

Muscular Apoptosis But Not Oxidative Stress Increases With Old Age In A Long-Lived Diver, The Weddell Seal, Kaitlin N. Allen, Jose Pablo Vazquez-Medina, John M. Lawler, Jo-Ann E. Mellish, Markus Horning, Allyson G. Hindle

Life Sciences Faculty Research

Seals experience repeated bouts of ischemia–reperfusion while diving, potentially exposing their tissues to increased oxidant generation and thus oxidative damage and accelerated aging. We contrasted markers of oxidative damage with antioxidant profiles across age and sex for propulsive (longissismus dorsi) and maneuvering (pectoralis) muscles of Weddell seals to determine whether previously observed morphological senescence is associated with oxidative stress. In longissismus dorsi, old (age 17–26 years) seals exhibited a nearly 2-fold increase in apoptosis over young (age 9–16 years) seals. There was no evidence of age-associated changes in lipid peroxidation or enzymatic antioxidant profiles. In pectoralis, 4-hydroxynonenal-Lys (4-HNE-Lys) levels increased …

Illinois Wesleyan Announces 2019 Eckley Scholars, University Communications

News and Events (Discontinued Series)

No abstract provided.

"We Are Strong Women": A Focused Ethnography Of The Reproductive Lives Of Women In Belize, Carrie S. Klima

Dissertations

Belize is a small country in Central America with a unique heritage. The cultural pluralism found in Belize provides an opportunity to explore the cultures of the Maya, Mestizo and the Caribbean. Women in Belize share this cultural heritage as well as the reproductive health issues common to women throughout the developing world. The experiences of unintended pregnancy, contraceptive use and abortion were explored with women using a feminist ethnographic framework. Key informants, participant observations, secondary data sources and individual interviews provided rich sources of data to examine the impact of culture in Belize upon the reproductive lives of women.

The Personal Experience Of Developing Sexuality In Middle Childhood, Marie Winn

Dissertations

The purpose of this study was to investigate the personal experience of developing sexuality in middle childhood.

Adaptable Xerogel-Layered Amperometric Biosensor Platforms On Wire Electrodes For Clinically Relevant Measurements, Lillian B. Hughes, Najwa Labban, Grace E. Conway, Julie A. Pollock, Michael C. Leopold

Chemistry Faculty Publications

Biosensing strategies that employ readily adaptable materials for different analytes, can be miniaturized into needle electrode form, and function in bodily fluids represent a significant step toward the development of clinically relevant in vitro and in vivo sensors. In this work, a general scheme for 1st generation amperometric biosensors involving layer-by-layer electrode modification with enzyme-doped xerogels, electrochemically-deposited polymer, and polyurethane semi-permeable membranes is shown to achieve these goals. With minor modifications to these materials, sensors representing potential point-of-care medical tools are demonstrated to be sensitive and selective for a number of conditions. The potential for bedside measurements or continuous monitoring …

Trends In Health, Stress, And Migration In The Pre-Contact Southwest United States, Alexis O'Donnell

Anthropology ETDs

The major goal of this dissertation was to examine migration and its impacts on health through use of dental morphological and paleopathological data. The case study is the Southwest United States between A.D. 1200-1400s. The second chapter, written with Corey Ragsdale, Biological Distance and the Fate of the Gallina in the American Southwest, examines where the Gallina people may have gone upon abandoning their homes in the late A.D. 1200s. We used dental data for 492 individuals and mean measure of divergence (biodistance) analysis to examine several hypotheses regarding where the Gallina went. We find that the Gallina may have …

Employees Create Sustainability Network Across Campus, Haley Herfurth

Browse All News

No abstract provided.

Scenes From The Swale: Investigating Spatial And Temporal Dimensions Of Nitrogen Cycling In Urban Stormwater Bioretention Facilities, Erin Nicole Looper

Dissertations and Theses

Urban development is transforming landscapes at unprecedented rates. Human activities and landscape modifications associated with urbanization extensively increase hydrologic demands and modify natural hydrologic systems; consequently, population growth occurring in urban areas increases pressure on water resources. Urban aquatic ecosystems are vulnerable to impacts associated with increased connectivity with urban surfaces and hydrologic changes that initiate long-term changes in receiving waterbodies. Nitrogen (N) loading from urban and suburban catchments to receiving surface waters can lead to impairment of aquatic ecosystems and is a concern in many cities with water quality issues. To improve urban water quality, cities are increasingly adopting …

Rare Earth Geochemistry Of Apatitic Fossils From The Middle-Upper Ordovician Southern Margin Of Laurentia, Rafael Adrian Villanueva

LSU Master's Theses

Widespread deposition of phosphate and a transition from tropical to cool water carbonates is seen throughout Middle-Upper Ordovician Nashville Dome area spanning the M4/M5 sequence boundary. Hypotheses explaining the onset of these lithologic changes have included the onset of glaciation, drawdown of CO₂ related to the Guttenburg Isotope Carbon Excursion (GICE), and siliciclastic weathering, yet none of these studies have provided definitive evidence that shows any of these are the sole factor driving paleoenvironmental changes across the M4/M5 boundary. In order to test whether rapid subsidence along the southeastern margin of Laurentia may have caused an influx of phosphate …

Atmospheric Deposition Of Nitrogen And Sulfur In China: Current Status And Future Changes, Cheng Shi

LSU Master's Theses

Dry and wet deposition of nitrogen (N) and sulfur (S) has detrimental impacts on the health of both human and ecosystems. Intensive human activities are responsible for elevating emissions and deposition of N and S species. Large population and fast industrial development led China to one of the countries with highest acid deposition. The large fluxes of N and S deposition have caused acidification of surface water and soil, which damages plant growth and biodiversity in China. N and S deposition has been investigated using ground-based monitoring networks and satellite-based sensors. The limitation of location of monitoring sites and performance …

Evaluation Of Post-Harvest Procedures For Quality Enhancement In The Louisiana Commercial Shrimp Industry, Nicholas Alan Haddad

LSU Master's Theses

The Louisiana commercial shrimp fishery has faced numerous challenges and is declining at an alarming rate. The opportunity may exist to add value to the industry by creating a superior product through optimal operating procedures. Post-harvest processes of plate freezing were analyzed to develop a high-quality shrimp product capable of fostering economic growth for fishermen. Quantifiable data was collected via overnight trips onboard plate freezing boats and at plate freezing docks. Sulfite-free melanosis prevention testing occurred by exploring the use of 4-hexylresorcinol treatments, in combination with vacuum packaging and modified atmosphere packaging, to delay the onset of black spot. Physical …

Resilience And Post-Traumatic Growth In Parents Of Children With Special Needs, Elizabeth A. Sidener

OSRI Journal of Student Research and Innovation

From the day their child is diagnosed, parents of children with special needs are traveling on a journey of extremes. The stress parents experience can lead down many paths filled with stress, worries, and concerns as their constant companion. These conditions exert extreme pressure on parents and can lead to life-altering changes. Parents who are resilient and able to cope with continuous change will ultimately weave through the unknown to a place of positive growth known as post-traumatic growth. The research project was based on qualitative data obtained from interviews with eleven parents of children with special needs.

One of …

Protecting The Nation’S Spaceport Kennedy Space Center, Wayne Kee

Space Congress® Proceedings

No abstract provided.

Culture-Based Analysis Of ‘Cave Silver’ Biofilms On Rocks In The Former Homestake Mine In South Dakota, Usa, Amanpreet K. Brar, David Bergmann

International Journal of Speleology

Tunnels in a warm, humid area of the 1478 m level of the Sanford Underground Research Facility (SURF), located in a former gold mine in South Dakota, USA, host irregular, thin whitish, iridescent biofilms, which appear superficially similar to ‘cave silver’ biofilms described from limestone and lava tube caves, despite the higher rock temperature (32°C) and differing rock surface (phyllite) present at SURF. In this study, we investigated the diversity of cultivable bacteria constituting the cave silver by using several media: CN agar, CN gellan gum and 0.1X R2A agar. The highest colony count (CFU/g of sample) was observed on …

Oneweb Satellites, Christopher Winslett

Space Congress® Proceedings

No abstract provided.

Explore: Moon Lights The Way, Mark D. Wiese

Space Congress® Proceedings

No abstract provided.

Are Marine National Monuments "Situated On Lands Owned Or Controlled By The Government Of The United States?", Tyler C. Costello

Ocean and Coastal Law Journal

The ocean offers what may seem like endless supply of natural resources, ecosystem services, or for some, simple enjoyment. Yet, in the face of climate change and overexploitation, many of these unique ecosystems and their inhabitants face an uphill battle. A president's use of the Antiquities Act establishing a national monument is an efficient and effective method of protecting these diverse ecosystems, as long as the area to be protected satisfies one of the Act's limitations that the monument be "situated on land owned or controlled by the federal government." Prior to a 2017 lawsuit concerning President Obama's use of …

Defining Fishing, The Slippery Seaweed Slope, Ross V. Acadian Seaplants Ltd., Rebecca P. Totten

Ocean and Coastal Law Journal

In Maine, the intertidal zone has seen many disputes over its use, access, and property rights. Recently, in Ross v. Acadian Seaplants, Ltd., the Maine Supreme Judicial Court, sitting as the Law Court, held that rockweed seaweed in the intertidal zone is owned by the upland landowner and is not part of a public easement under the public trust doctrine. The Court held harvesting rockweed is not fishing. This case will impact private and public rights and also the balance between the State's environmental and economic interests. This Comment addresses the following points: first, the characteristics of rockweed and the …

The Role Of State Planning Law In The Regulation And Protection Of Ocean Resources, Edward J. Sullivan

Ocean and Coastal Law Journal

While land use planning is pervasive in the United States, legal structures for the planning and management of ocean resources are less well known or studied. The passage of the federal Coastal Zone Management Act in 1972 provided federal funds for state planning and regulation of coastal areas, with the incentive of binding federal agencies to state and regulations plans certified by the Secretary of Commerce. Most of the focus of CZMA study has been on estuaries and coastal shorelands; much less focus has been on coastal waters. Regarding coastal waters, more attention is given to the three mile ocean …

Sleeping With The Enemy: Demystifying Faculty-Librarian Relationships, Pam Dennis, Natalie Bishop

Dover Library Faculty Professional Development Activities

Too often campus culture adopts an Us vs. Them attitude. In reali- ty, we are all in the fight together, dealing with a new generation of students, rising textbook costs, and budget crises that arise on a seemingly daily basis. In our presentation, we will look at collabo- rative efforts where librarians partner with faculty in financing pur- chase agreements, tenure and promotion strategies, digital reposi- tory efforts, embedding strategies, and alignment between library instruction and university initiatives such as writing intensive cours- es. Embrace the faculty. They are not the enemy – they are your comrades in arms!

Effects Of Land Use, Topography, Climate And Socio-Economic Factors On Geographical Variation Pattern Of Inland Surface Water Quality In China, Qinghui You, Na Fang, Lingling Liu, Wenjing Yang, Li Zhang, Yeqiao Wang

Natural Resources Science Faculty Publications

The deterioration of water quality has become a primary environmental concern worldwide. Understanding the status of water quality and identifying the influencing factors are important for water resources management. However, reported analyses have mostly been conducted in small and focused areas. It is still unclear if factors driving spatial variation in water quality would be different in extended spatial scales. In this paper, we analyzed spatial pattern of inland surface water quality in China using a dataset with four water quality parameters (i.e., pH, DO, NH₄⁺-N and COD_Mn) and the water quality level. We tested …

Cyclin C Regulated Oxidative Stress Responsive Transcriptome In Mus Musculus Embryonic Fibroblasts, David C Stieg, Kai-Ti Chang, Katrina F Cooper, Randy Strich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway. Cyclin C-Cdk8 is a conserved kinase that associates with the RNA polymerase II Mediator complex that stimulates or represses transcription depending on the locus. In response to oxidative stress, cyclin C, but not Cdk8, displays partial translocation into the cytoplasm. These findings open the possibility that cyclin C relocalization is a regulatory mechanism governing oxidative stress-induced transcriptional changes. In the present study, the cyclin C-dependent transcriptome was determined and compared to transcriptional changes occurring in oxidatively …

Vesicular Glutamatergic Transmission In Noise-Induced Loss And Repair Of Cochlear Ribbon Synapses, Kyunghee X. Kim, Shelby Payne, Aizhen Yang-Hood, Song-Zhe Li, Bethany Davis, Jason Carlquist, Babak V-Ghaffari, Jay A. Gantz, Dorina Kallogjeri, James A.J. Fitzpatrick, Kevin K. Ohlemiller, Keiko Hirose, Mark A. Rutherford

Open Access Publications

Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner hair cells in mice lacking the vesicular glutamate transporter-3 (

Meta-Analysis Of Yield Response Of Foliar Fungicide-Treated Hybrid Corn In The United States And Ontario, Canada, Kiersten A. Wise, Damon Smith, Anna Freije, Daren S. Mueller, Yuba Kandel, Tom Allen, Carl A. Bradley, Emmanuel Byamukama, Martin Chilvers, Travis Faske, Andrew Friskop, Clayton Hollier, Tamra Jackson-Ziems, Heather Kelly, Bob Kemerait, Paul Price Iii, Alison Robertson, Albert Tenuta

Department of Plant Pathology: Faculty Publications

Foliar fungicide applications to corn (Zea mays L.) occur at one or more application timings ranging from early vegetative growth stages to mid-reproductive stages. Previous studies indicated that fungicide applications are profitable under high disease pressure when applied during the tasseling to silking growth stages. Few comprehensive studies in corn have examined the impact of fungicide applications at an early vegetative growth stage (V6) compared to late application timings (VT) for yield response and return on fungicide investment (ROI) across multiple locations.

Extreme Events Reveal An Alimentary Limit On Sustained Maximal Human Energy Expenditure, Caitlin Thurber, Lara R. Dugas, Cara Ocobock, Bryce Carlson, John R. Speakman, Herman Pontzer

Publications and Research

The limits on maximum sustained energy expenditure are unclear but are of interest because they constrain reproduction, thermoregulation, and physical activity. Here, we show that sustained expenditure in humans, measured as maximum sustained metabolic scope (SusMS), is a function of event duration. We compiled measurements of total energy expenditure (TEE) and basal metabolic rate (BMR) from human endurance events and added new data from adults running ~250 km/week for 20 weeks in a transcontinental race. For events lasting 0.5 to 250+ days, SusMS decreases curvilinearly with event duration, plateauing below 3× BMR. This relationship differs from that of shorter events …

Mitochondrial Activity And Skeletal Muscle Insulin Resistance In Kidney Disease, Jane E. Carré, C Affourtit

School of Biomedical Sciences

Insulin resistance is a key feature of the metabolic syndrome, a cluster of medical disorders that together increase the chance of developing type 2 diabetes and cardiovascular disease. In turn, type 2 diabetes may cause complications such as diabetic kidney disease (DKD). Obesity is a major risk factor for developing systemic insulin resistance, and skeletal muscle is the first tissue in susceptible individuals to lose its insulin responsiveness. Interestingly, lean individuals are not immune to insulin resistance either. Non-obese, non-diabetic subjects with chronic kidney disease (CKD), for example, exhibit insulin resistance at the very onset of CKD, even before clinical …

Geographic Biases In Bee Research Limits Understanding Of Species Distribution And Response To Anthropogenic Disturbance, Mary A. Jamieson, Adrian L. Carper, Caleb J. Wilson, Virginia L. Scott, Jason Gibbs

Entomology Faculty Publications

Habitat loss and degradation due to agricultural intensification and urbanization are key threats facing wild pollinators, especially bees. However, data on the distribution and abundance of most of the world's 20,000+ bee species is lacking, making it difficult to assess the effects of anthropogenic disturbance through time. Moreover, there are geographic biases in the study of bees creating gaps in our understanding of species distributions and regional patterns of diversity. Research efforts are often focused around cities or field stations associated with universities and other research institutions. In this perspectives paper, we provide examples of geographic bias in knowledge regarding …

Faculty Awarded Nearly $58,000 From John C. Baker Fund (June 5, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Meta-Analysis Of Yield Response Of Foliar Fungicide-Treated Hybrid Corn In The United States And Ontario, Canada, Kiersten A. Wise, Damon Smith, Anna Freije, Daren S. Mueller, Yuba Kandel, Tom Allen, Carl A. Bradley, Emmanuel Byamukama, Martin Chilvers, Travis Faske, Andrew Friskop, Clayton Hollier, Tamra A. Jackson-Ziems, Heather Kelly, Bob Kemerait, Paul Price Iii, Alison Robertson, Albert Tenuta

Plant Pathology Faculty Publications

Background

Foliar fungicide applications to corn (Zea mays L.) occur at one or more application timings ranging from early vegetative growth stages to mid-reproductive stages. Previous studies indicated that fungicide applications are profitable under high disease pressure when applied during the tasseling to silking growth stages. Few comprehensive studies in corn have examined the impact of fungicide applications at an early vegetative growth stage (V6) compared to late application timings (VT) for yield response and return on fungicide investment (ROI) across multiple locations.

Objective

Compare yield response of fungicide application timing across multiple fungicide classes and calculate the probability …