Molecular Insights Into Major Peripheral T-Cell Lymphoma Entities With Advances In A Representative Model System, Tayla B. Heavican

Theses & Dissertations

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Genomic copy number analysis and targeted sequencing revealed unique genomic abnormalities and oncogenic pathways, indicating distinct oncogenic evolution. PTCL-GATA3 exhibited higher genomic complexity characterized by frequent loss or mutation of tumor suppressor genes targeting the CDKN2A/B-TP53 axis and PTEN-PI3K pathways. …

Mechanism Of Bax/Bak Activation In Apoptotic Signaling, Kai Huang

Theses & Dissertations

The Bcl-2 family proteins, including the anti-apoptotic members, pro-apoptotic effectors Bax/Bak, and the BH3-only proteins, are key components of the mitochondrial apoptotic pathway. The BH3-only protein Bid is critical for the mitochondrial pathway of apoptosis after TRAIL-induced death receptor activation. However, the mechanism of Bid activation during TRAIL-induced apoptosis is unclear. By putting back wild-type and mutants of Bid in Bid deficient (Bid KO) and Bid/Bax/Bak TKO colon cancer cells, we demonstrated that cleavage by caspase 8 and mitochondrial targeting are critical events for Bid activation. One of the biggest mysteries in apoptosis is how Bax/Bak was activated by BH3-only …

Brca1 & Ctdp1 Brct Domainomics In The Dna Damage Response, Kimiko L. Krieger

Theses & Dissertations

Genomic instability is one of the enabling characteristics of cancer. DNA damage response pathways are important for genomic integrity and cell cycle progression. Defects in DNA damage repair can often lead to cell cycle arrest, cell death, or tumorigenesis. The activation of the DNA damage response includes tightly regulated signaling cascades that involve kinase phosphorylation and modular domains that scaffold phosphorylated motifs to coordinate recruitment of DNA repair proteins. Modular domains are conserved tertiary structures of a protein that can fold, function, and evolve independently from an intact protein. One of the most common modular domains involved in DNA damage …

Cholesterol Biosynthesis In The Nervous System With An Emphasis On Desmosterolosis, Luke Allen

Theses & Dissertations

Cholesterol biosynthesis is integral to proper neurodevelopment due to the reliance on de novo synthesis of cholesterol in the brain. Disruptions in this process have devastating outcomes for human life characterized by several phenotypic manifestations concomitant with developmental delay. The cholesterol biosynthesis disorder desmosterolosis is an extremely rare disorder with a severe clinical phenotype, however, the models used to study this disease are not well characterized. In addition to genetic disruptions in cholesterol biosynthesis, pharmacological perturbation is an understudied side effect of many commonly prescribed drugs. Here we present a characterization of the sterol profile of the mouse model of …

Defining The Role Of Tyrosine Phosphorylation In The Regulation Of Connexin43 In Cardiac Diseases, Li Zheng

Theses & Dissertations

Connexins are integral membrane proteins that oligomerize to form gap junction channels. Ions and small molecules diffuse intercellularly through these channels, allowing individual cellular events to synchronize into the functional response of an entire organ. Gap junction channels composed of Connexin43 (Cx43) mediate electrical coupling and impulse propagation in the normal working myocardium. In the failing heart, Cx43 remodeling (decreased expression, altered phosphorylation state, loss at intercalated discs, and increased presence at lateral membranes) contributes to rhythm disturbances and contractile dysfunction. While there is considerable information regarding key interactions of Cx43 in the regulation of gap junction channels, unfortunately, the …

Two Clamped Pipe Support Connections For Oil And Gas Brownfield Projects, Helen M. Claycomb

LSU New Orleans Theses and Dissertations

In the oil and gas industry, brownfield projects focus on the modification of or addition to an existing production facility that is fully operational and operating. Welding is typically avoided on these projects. The drilling of holes in existing primary structural elements is also prohibited. Clamped connections are often used when adding additional services in a brownfield project. There are different types of clamped connections utilized when a new structural support must be attached to an existing vertical structural pipe. The short bolt clamped connection is a well-established connection and typically used on offshore projects. The U-bolt clamped connection is …

Working Memory Deficits Are Associated With Altered Regional Brain Volume And Structural Connectivity In Children With Chromosome 22q11.2 Deletion Syndrome., Diana Hobbs

LSU New Orleans Theses and Dissertations

Background: Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit nonverbal learning disability that may manifest in part because of working memory (WM) deficits. 22q11.2DS is a complex developmental disorder with serious physical, learning, cognitive, and psychiatric symptoms including a risk of developing schizophrenia 30 times that of the general population. WM impairment likely contributes to and exacerbates learning difficulties, school problems, existing neuropsychological disorders such as attention deficit hyperactivity disorder (ADHD); and a poor WM may be a biological risk marker for future mental illness. WM impairment is established in this population, but less is known about its neurological origins. …

Teachers' Perceptions Of How The Teacher Evaluation Process Impacts Classroom Instruction In Three High Poverty School Districts, Zina R. Jones Ms

LSU New Orleans Theses and Dissertations

Abstract

Improving the educational system for students and teachers is of the upmost importance. Educational leaders have realized that the best way to improve student success is by improving teachers’ instructional practices and measuring their effectiveness (Mathers, Oliva, & Laine, 2008). Because of this awareness, educators have realized the importance of connecting student achievement with instructional practices and instructional practices with teacher effectiveness. Evaluation tools are used to measure how effective teachers are in their classrooms. Evaluations are crucial in assisting our teachers in their professional growth. When evaluations are utilized as supportive tools, they help teachers and administrators identify …

Evaluating The Effectiveness Of A Community-Based Youth Non-Profit Organization At Increasing Prosocial Behavior And Decreasing Antisocial Behavior Among Young Boys: A Pilot Study, Molly A. Miller

LSU New Orleans Theses and Dissertations

Community-based youth non-profit organizations (NPOs) have become increasingly popular for the provision of youth prevention and intervention services, yet many youth NPOs lack the resources to undergo formal evaluation. Further, most existing program evaluations do not consider individual characteristics of the child or the child’s exposure to stressors. The current pilot study sought to evaluate the extent to which boys participated in 1:1 mentoring and other program activities at the Son of a Saint (SOAS) NPO, an organization seeking to provide positive male role models for fatherless young boys. In addition, the current study examined the effects of program involvement …

Seismic Communication, Anna Tatelman

LSU New Orleans Theses and Dissertations

No abstract provided.

Weathering The Storm: Black Maternal Mortality, Resistance, And Power In Richard Wright’S “Down By The Riverside,” Zora Neale Hurston’S Their Eyes Were Watching God, And Jesmyn Ward’S Salvage The Bones, Renee Vincent

LSU New Orleans Theses and Dissertations

Representations of natural disasters in Black Southern literature identify social location as the greatest indicator of risk vulnerability. Moreover, they can expose the precarious subjectivity of the Black female reproductive body, as addressed through characters Lulu in Richard Wright’s “Down by the Riverside,” Janie in Zora Neale Hurston’s Their Eyes Were Watching God, and Jesmyn Ward’s Esch in Salvage the Bones. Together, these female characters share a legacy of social marginalization and Black female resistance that is (re)shaped through their experiences with ecological catastrophe. This thesis considers these three texts together as an ongoing testimony and as a …

Reliability Sensitivity Analysis Of Dropped Objects Hitting On The Pipeline At Seabed, Hanqi Yu

LSU New Orleans Theses and Dissertations

Nowadays, as oil industry gradually moves towards deep sea fields with water depth more than 1000 meters, they are subjected to several threats which can cause failure of the pipeline, of which the accidentally-dropped objects have become the leading external risk factor for subsea developments. In this thesis, a sample field layout introduced in Det Norske Veritas (DNV) guide rules is selected as the study case with 100 m water depth. Six different groups of dropped objects are used in this paper. The conditional hit probability for long/flat shaped objects will be calculated with the methods from both DNV rules …

The Ethical Justification Of Increasing Awareness Of Preventive Medicine Among Healthcare Professionals, Patients And The General Public In The United States, Karishma Ether Moazzam

Electronic Theses and Dissertations

While practiced for centuries, preventive medicine has received increased attention during the recent times. Preventive medicine has a distinct mission to protect, promote, and maintain health as well as to prevent diseases, disabilities, and premature deaths. It aims to fulfill its mission through the combined form of clinical intervention and health promotion. In the recent years, preventive medicine has begun to lean more towards the clinical interventions, taking away from the health promotion. This imbalance has caused preventive medicine to lose its effectiveness in fulfilling its mission. One of the leading causes for such imbalance is the lack of proper …

God, Land, Identity: Divine Fluidity And A Spatial Ecclesiology In West Africa, Clement Kanu

Electronic Theses and Dissertations

African theology is burdened with a major problem of identity, which stems from the lack of African history and memory in African theology. African theologians in the face of the delicate dilemma of creating a theology that is both African and Christian, have fallen into the epistemological compulsion to impose western Christian theological categories as foundational to African theology. Inculturation thus presupposes the already alien space on which the structures of the present ecclesiology is anchored. The result is a peripheral inculturation, a consumer ecclesiology, always seeking to solve its local pastoral problems in accordance with alien incongruous codes and …

The Mediating Role Of Differentiation In The Relationship Between Mindfulness And Working Alliance, Caleb P. Thompson

Electronic Theses and Dissertations

This study involved a mediation analysis exploring the relationship of counselor’s perceptions of mindfulness and working alliance through differentiation of self. Sample data (N=80) was collected and analyzed using the PROCESS mediation model to quantitatively determine the indirect effect of counselor’s perceptions of mindfulness and their perceptions of working alliance through the variable of differentiation of self. This indirect effect was not statistically significant, b = .08, 95% CI [-.11, .25], therefore no mediating effect was demonstrated for differentiation. A follow-up moderation analysis was also conducted on these same three variables. Results revealed that at low levels of …

Ud In The News Dec. 14-20, University Of Dayton

News Releases

Two of the nation's top outlets covering higher education, a pair of iconic American magazines, the top U.S. Catholic news wire service, The Associated Press, The Conversation and the daily newsletter of the American Society for Engineering Education featured the University's programs, curriculum, students and faculty expertise.

State V. Robles Respondent's Brief Dckt. 47063

Not Reported

No abstract provided.

Determining Levers Of Cost-Effectiveness For Screening Infants At High Risk For Peanut Sensitization Before Early Peanut Introduction, Matthew Greenhawt, Marcus Shaker

Dartmouth Scholarship

Importance Early peanut introduction reduces the risk of developing peanut allergy, especially in high-risk infants. Current US recommendations endorse screening but are not cost-effective relative to other international strategies.

Objective To identify scenarios in which current early peanut introduction guidelines would be cost-effective.

Design, Setting, and Participants This simulation/cohort economic evaluation used microsimulations and cohort analyses in a Markov model to evaluate the cost-effectiveness of early peanut introduction with and without peanut skin prick test (SPT) screening in high-risk infants during an 80-year horizon from a societal perspective. Data were analyzed from April to May 2019.

Exposures High-risk infants with …

The Cost Of Secrecy Isn't Worth It For The Lds Church, Nathan B. Oman

Popular Media

No abstract provided.

Lindenwood Digest, December 20, 2019, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

The Role Of Occupational Therapy For Survivors Of Human Trafficking, Margaux Mariano

Student Capstone Papers

Human trafficking involves sex trafficking, labor trafficking, and trafficking of children. The needs of survivors of human trafficking are widespread due to the traumatic experiences they face. Concerns that may arise include decreased participation in meaningful activities in an individual's life, possibly due to anxiety, depression, suicidal ideation, memory loss, posttraumatic stress disorder, and social isolation. Individuals who have been subjected to human trafficking often experience occupational deprivation and occupational therapy has yet to establish its role in the recovery process for survivors. This capstone project consists of the process towards the development of an occupation-based, trauma-informed, evidence-based, and survivor-centered …

Intrapersonal And Organizational Predictors Of Burnout Among School Counselors, Kathryn Theresa Kozak

Dissertations - ALL

This study utilized hierarchical regression to examine the impact of practicing school counselors’ years of professional experience, master’s-level training, and work environment characteristics on their levels of occupational burnout. The specific training program variables under consideration included the number of school counseling courses completed, number of courses taught by faculty members with a school counseling identity, and degree of congruence between what was taught about the school counselor’s role during master’s-level training and participants’ actual practice. Work environment characteristics explored included caseload size, level of principal support, and assignment of non-counseling duties. Participants’ (n = 236) burnout levels were measured …

Rival Brands’ Response Strategies To Mitigate The Negative Spillover Effects During A Brand Crisis, Jan-Juba Y. Arway

Theses - ALL

Effectively managing a crisis is highly essential to any company to protect or restore its reputation, including consumer faith and loyalty to the brand, after the crisis has occurred, especially to competing brands. It is also essential that the rival brand approaches the situation with the correct response strategy (Veil, Dillingham, & Sloan, 2016). Extending Rohem and Tybout's (2016) research about the Negative Spillover Effect (NSE), this study’s purpose is to examine the effective communication strategy a rival brand can employ to lessen and or prevent negative spillover from competing brand scandal and or crisis. Furthermore, exploring differentiation and bolstering …

The Third Wave Of Graduate Labor Unions, Anthony Walker

Theses - ALL

A 2016 NLRB decision that made graduate labor unions legal has contributed significantly to a wave of graduate organizing, continuing a 50-year history of graduate unions. This research investigates this contemporary wave of graduate unionization using two papers, which take a theoretical and an empirical approach respectively. The first paper uses a Marxist analysis to connect the narrow antagonism between graduates and management with larger-scale phenomena that involves other workers too, such as the growing population of contingent academic workers. It describes how corporate interests have influenced higher education and administrators have become managers of workers in order to help …

“Everybody Is Scared To Eat The Food”: Exploring Food Sovereignty Applications In A Refugee Agricultural Program, Cheyenne Rose Schoen

Theses - ALL

This research documents some of the goals and challenges of refugee farmers and gardeners who participated in an organized agriculture project in Syracuse, New York. During the 2018 harvest season I observed and interviewed nine refugee farmers from Somalia, Bhutan, Nepal, and Democratic Republic of Congo, as well as four organizational staff members who were recruited through their affiliation with the Syracuse Refugee Agricultural Partnership Program (SyRAPP) and the Refugee and Immigrants Self-Empowerment (RISE) organization. Refugee farmers expressed distrust of the conventional food system, they valued control over the food supply through farming, and many desired to live at or …

Bradykinesia Is Driven By Cumulative Beta Power During Continuous Movement And Alleviated By Gabaergic Modulation In Parkinson’S Disease., Emma J. Prokic, Gavin L. Woodhall, Adrian C. Williams, Ian M. Stanford, Stephen D. Hall

School of Psychology

No abstract provided.

Implementing Ethics Into Artificial Intelligence: A Contribution, From A Legal Perspective, To The Development Of An Ai Governance Regime, Axel Walz, Kay Firth-Butterfield

Duke Law & Technology Review

The increasing use of AI and autonomous systems will have revolutionary impacts on society. Despite many benefits, AI and autonomous systems involve considerable risks that need to be managed. Minimizing these risks will emphasize the respective benefits while at the same time protecting the ethical values defined by fundamental rights and basic constitutional principles, thereby preserving a human centric society. This Article advocates for the need to conduct in-depth risk-benefit-assessments with regard to the use of AI and autonomous systems. This Article points out major concerns in relation to AI and autonomous systems such as likely job losses, causation of …

Critical Genocide And Atrocity Prevention Studies, Andrew Woolford, Alexander Hinton

Genocide Studies and Prevention: An International Journal

An introductory essay for the special issue on "Critical Approaches to Genocide and Atrocity Prevention."

Moving Beyond The State: An Imperative For Genocide Prediction, Hollie Nyseth Brehm

Genocide Studies and Prevention: An International Journal

Studies of the onset of genocide and accompanying early warning and forecasting efforts have focused almost exclusively on states. This article suggests that genocide prediction must move beyond a purely state-centric approach. Specifically, I suggest three major avenues that will refine and complement existing research and related prediction efforts. These include 1) theorizing and analyzing non-state actors who commit genocide, 2) engaging in conflict-centered approaches, and 3) addressing the onset and triggers of genocide within subnational spaces. I conclude with a discussion of how these three avenues can be pursued simultaneously to inform more robust genocide prevention endeavors.

Human Rights? What A Good Idea! From Universal Jurisdiction To Crime Prevention, Daniel Feierstein

Genocide Studies and Prevention: An International Journal

Over the last decades, Genocide Studies has entered in a “comfort zone.” With fellowships and support from governments or NGOs, we have developed a very comfortable environment in which the knowledge we produce about genocide prevention is neither critical nor useful. We have become trapped by assumptions we have never checked against reality and many of us have chosen to work inside the circle of those assumptions: genocide and mass violence are horrible acts committed by horrible people; we cannot stand by and do nothing; we have the responsibility to protect civilian populations and that responsibility takes the form, as …