Digital Commons Network^™

Patients With Flt3-Mutant Aml Needed To Enroll On Flt3-Targeted Therapeutic Clinical Trials, Taylor Bucy, John M. Zoscak, Motomi Mori, Uma Borate

OHSU-PSU School of Public Health Faculty Publications and Presentations

We sought to identify the total number of therapeutic trials targeting FLT3-mutant acute myeloid leukemia (AML) to estimate the number of patients needed to satisfy recruitment when compared with the incidence of this mutation in the US AML population. A systematic review of all therapeutic clinical trials focusing on adult FLT3-mutated AML was conducted from 2000 to 2017. An updated search was performed using ClinicalTrials.gov for trials added between October 2017 and December 2018. Analysis was performed for ClinicalTrials.gov search results from 2000 to 2017 to provide descriptive estimates of discrepancies between anticipated clinical trial enrollment using consistently cited rates …

Barriers And Facilitators To Recruitment And Enrollment Of Hiv-Infected Individuals With Opioid Use Disorder In A Clinical Trial, Kim Hoffman, Robin Baker, Lynn Elizabeth Kunkel, Elizabeth Needham Waddell, Paula J. Lum, Dennis Mccarty, P. Todd Korthuis

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background

The CTN-0067 CHOICES trial tests implementation of extended-release naltrexone (XR-NTX) versus treatment-as-usual (TAU) for opioid use disorders (OUD) in HIV clinics to improve HIV viral suppression. The study team investigated recruitment strategies to elucidate the barriers and facilitators to recruitment and enrollment in the study.

Main text

Methods: Semi-structured, in-depth, digitally recorded interviews were completed with study recruitment-related staff and medical providers (n = 26) from six participating HIV clinics in the fall of 2018. Interviews probed 1) factors that might prevent prospective participants from engaging in study recruitment and enrollment procedures and 2) strategies used by study …

Trace Amine-Associated Receptor Gene Polymorphism Increases Drug Craving In Individuals With Methamphetamine Dependence, Jennifer M. Loftis, Michael Lasarev, Xiao Shi, Jodi Lapidus, Aaron Janowsky, William Hoffman, Marilyn Huckans

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence.

Methods: Participants (n = 106) with active MA dependence (MA-ACT), in remission from MA dependence (MA-REM), with active polysubstance dependence, in remission from polysubstance dependence, and with no history of substance dependence completed neuropsychiatric symptom questionnaires and provided blood samples. In vitro expression and function of CV and wild type TAAR1 receptors were also measured.

Results: The V288V polymorphism …

Cardiovascular Risk Factors Associated With Venous Thromboembolism, John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Carlos J. Crespo, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Importance It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).

Objective To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.

Design, Setting, and Participants This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February …

Telebehavioral Health Program Needs Assessment Conducted At Aurora Mental Health Center, Iwei Wang

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The purpose of this project was to conduct a needs assessment for a Telebehavioral Health Program at Aurora Mental Health Center (AuMHC) to determine how telebehavioral health aligns with the organization’s interests, needs, services, target population, and readiness for telebehavioral health services. This investigator used survey and content analysis methods to conduct this investigation. Findings of this assessment showed that both literature and existing programs at AuMHC were supportive of moving forward with telebehavioral health services. Considerations of AuMHC’s contextual conditions and recommendations for successful implementation are provided.

Adverse Childhood Experiences, Neuroadaptation, And Resilience: Does Trauma Focused Cognitive Behavioral Therapy Go Far Enough?, Tracie Abbott

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Adverse childhood experiences (ACEs) pose a significant public health risk. Current literature suggests ACEs have the potential to significantly disrupt sensitive periods of neurodevelopment. These neuroadaptations can result in social, emotional, and cognitive impairments that place a child at a significantly greater risk for adopting health risk behaviors and lifestyle factors that lead to the major causes of disease, disability, social problems, and early death in adults. Mental health clinicians have a unique opportunity to intervene by working with families to alter the trajectories of the child’s health risk behaviors and lifestyle factors. Trauma Focused Cognitive Behavioral Therapy (TF-CBT), a …

Was Yosef On The Spectrum? Understanding Joseph Through Torah, Midrash, And Classical Jewish Sources (Introduction), Samuel J. Levine

Scholarly Works

The story of Yosef (Joseph) presents some of the most challenging questions of all biblical narratives. Yosef’s behavior, interpersonal relationships, and personal journey and development are often difficult to understand, and at times seem to defy explanation. Leading commentators are repeatedly puzzled both by Yosef’s actions and by the events that surround him. This book attempts to achieve a coherent and cohesive reading of the story that offers a plausible understanding of Yosef’s behaviors toward others and those of others toward him, while at the same time accounting for both his successes and his failures. Toward that goal, the book …

The Constitution As Poetry, Samuel J. Levine

Scholarly Works

Building upon a body of scholarship that compares constitutional interpretation to biblical and literary interpretation, and relying on an insight from a prominent nineteenth century rabbinic scholar, this Article briefly explores similarities in the interpretation of the Torah—the text of the Five Books of Moses—and the United States Constitution. Specifically, this Article draws upon Rabbi Naftali Zvi Yehudah Berlin’s (“Netziv”) intriguing suggestion that the interpretation of the text of the Torah parallels the interpretation of poetry. According to Netziv, this parallel accounts for the practice of interpreting the Torah expansively in ways that derive substantive legal rules and principles far …

Disciplinary Regulation Of Prosecutorial Discretion: What Would A Rule Look Like?, Samuel J. Levine

Scholarly Works

This Essay is the third part of a larger project examining the potential role of professional discipline in the regulation and supervision of prosecutors’ charging decisions. The first two parts of the project argued that courts have both the authority and the ability to exercise effective disciplinary review of charging decisions through the adoption of ethics rules and their enforcement in the disciplinary process. This Essay takes the next step in the project, considering the nature of rules that courts might adopt, by exploring potential rules targeting two improprieties: arbitrary and capricious charging decisions, and discriminatory charging decisions.

Introduction: Singapore Convention Reference Book, Harold Abramson

Scholarly Works

No abstract provided.

The New Singapore Mediation Convention: The Process And Key Choices, Harold Abramson

Scholarly Works

No abstract provided.

Singapore Mediation Convention Reference Book, Harold Abramson (Faculty Editor)

Scholarly Works

No abstract provided.

Advanced Artificial Intelligence And Contract, John Linarelli

Scholarly Works

The aim of this article is to inquire whether contract law can operate in a state of affairs in which artificial general intelligence (AGI) exists and has the cognitive abilities to interact with humans to exchange promises or otherwise engage in the sorts of exchanges typically governed by contract law. AGI is a long way off but its emergence may be sudden and come in the lifetimes of some people alive today. How might contract law adapt to a situation in which at least one of the contract parties could, from the standpoint of capacity to engage in promising and …

On Burr Iii Marshal Olkin Family: Development, Properties, Characterizations And Applications, Fiaz Ahmad Bhatti, Gholamhossein G. Hamedani, Mustafa Ç. Korkmaz, Gauss M. Cordeiro, Haitham M. Yousof, Munir Ahmad

Mathematical and Statistical Science Faculty Research and Publications

In this paper, a flexible family of distributions with unimodel, bimodal, increasing, increasing and decreasing, inverted bathtub and modified bathtub hazard rate called Burr III-Marshal Olkin-G (BIIIMO-G) family is developed on the basis of the T-X family technique. The density function of the BIIIMO-G family is arc, exponential, left- skewed, right-skewed and symmetrical shaped. Descriptive measures such as quantiles, moments, incomplete moments, inequality measures and reliability measures are theoretically established. The BIIIMO-G family is characterized via different techniques. Parameters of the BIIIMO-G family are estimated using maximum likelihood method. A simulation study is performed to illustrate the performance of the …

On Burr Iii-Pareto Distribution: Development, Properties, Characterizations And Applications, Fiaz Ahmad Bhatti, Gholamhossein G. Hamedani, Mustafa Ç. Korkmaz, Munir Ahmad

Mathematical and Statistical Science Faculty Research and Publications

In this paper, a new four parameter lifetime model with increasing, decreasing, increasing-decreasing, decreasing-increasing-decreasing, modified bathtub, bathtub and inverted bathtub hazard rate function called Burr III-Pareto (BIII-Pareto) is developed on the basis of the T-X family technique. The BIII-Pareto density function is arc, J-shape, reverse J-shape, positively, negatively skewed and symmetrical. Some structural and mathematical properties including moments, moments of order statistics, inequality measures and reliability measures are theoretically established. The BIII-Pareto distribution is characterized via different techniques. Parameters of the BIII-Pareto distribution are estimated using maximum likelihood method. The simulation study for performance of the maximum likelihood estimates (MLEs) …

On The Modified Burr Xii-Power Distribution: Development, Properties, Characterizations And Applications, Fiaz Ahmad Bhatti, Gholamhossein G. Hamedani, Mustafa Ç. Korkmaz, Munir Ahmad

Mathematical and Statistical Science Faculty Research and Publications

In this paper, a flexible lifetime distribution with increasing, decreasing and bathtub hazard rate called the Modified Burr XII-Power (MBXII-Power) is developed on the basis of the T-X family technique. The density function of the MBXII-Power is arc, exponential, left-skewed, right-skewed, J, reverse-J and symmetrical shaped. Descriptive measures such as moments, moments of order statistics, incomplete moments, inequality measures, residual life functions and reliability measures are theoretically established. The MBXII-Power distribution is characterized via different techniques. Parameters of the MBXII-Power distribution are estimated using maximum likelihood method. The simulation study is performed on the basis of graphical results to see …

Recent Developments In Distribution Theory: A Brief Survey And Some New Generalized Classes Of Distributions, Zubair Ahmad, Gholamhossein G. Hamedani, Nadeem Shafique Butt

Mathematical and Statistical Science Faculty Research and Publications

The generalization of the classical distributions is an old practice and has been considered as precious as many other practical problems in statistics. These generalizations started with the introduction of the additional location, scale or shape parameters. In the last couple of years, this branch of statistics has received a great deal of attention and quite a few new generalized classes of distributions have been introduced. We present a brief survey of this branch and introduce several new families as well.

Relationships And Ethics In The Land Use Game, Patricia E. Salkin, Thomas Brown, Aisha Scholes

Scholarly Works

Ethical considerations in the land use decision making process can be organized into a number of categories, including, first and foremost, the broad subject of conflicts of interest.1 Players in the land use game can find themselves in real or perceived conflicts situations based on personal financial interests resulting from investments, including businesses and real estate holdings (such as the location of their property vis-à-vis the location of the subject property before the Board), employment for themselves or members of their immediate family, and memberships in nonprofit organizations that may be either passive or active (e.g., simply dues paying member …

The Extended Alpha Power Transformed Family Of Distributions: Properties And Applications, Zubair Ahmad, Muhammad Ilyas, Gholamhossein G. Hamedani

Mathematical and Statistical Science Faculty Research and Publications

In this article, a new family of lifetime distributions by adding an additional parameter to the existing distributions is introduced. The new family is called, the extended alpha power transformed family of distributions. For the proposed family, explicit expressions for some mathematical properties along with estimation of parameters through Maximum likelihood Method are discussed. A special sub-model, called the extended alpha power transformed Weibull distribution is considered in detail. The proposed model is very flexible and can be used to model data with increasing, decreasing or bathtub shaped hazard rates. To access the behavior of the model parameters, a small …

A Euclid Dissent, Michael Lewyn

Scholarly Works

In Euclid v. Ambler Realty, the Supreme Court upheld the constitutionality of zoning, including zoning that excluded apartment houses and retail businesses. Although the decision was not unanimous, the Euclid minority did not write a formal dissent. The purpose of this article is to show what such a dissent should have looked like.

Foreword To Latcrit 2017 Symposium: What’S Next? Resistance Resilience And Community In The Trump Era, Jorge R. Roig, Saru M. Matambanadzo, Sheila I. Vélez-Martínez

Scholarly Works

In this Foreword, we strive to contextualize “LatCrit XXI: What’s Next?” against the backdrop of two crises: the current political crisis in the United States and the continuing crisis of scarcity that impacts the legal academy. Through an examination of these crises, we will reveal how LatCrit scholars, in their efforts to build community and in their commitment to critical outsider scholarship, are part of the constellations of resistance that struggle against el mundo malo. We will argue that LatCrit has become a necessary institution for those seeking to engage in persistent resistance and dissent in the critical and progressive …

Redefining The Reasonable Person In Police Encounters: The Impact Of The Mainstream News Media’S Portrayal Of Modern Police Conduct, Taurus Myhand

Scholarly Works

Who is the “reasonable person”? There is little doubt that every competent legal professional, both in law practice and in the academic setting, has spent a great deal of time attempting to define the reasonable person. “Reasonableness is largely a matter of common sense.” In police encounters, the definition is certainly important to the outcome of questionable police conduct. How the reasonable person is defined often determines whether a police officer has infringed on an individual’s Fourth Amendment guarantee to be secure in their person against unreasonable searches and seizures. As the narratives of the news media shape how some …

Law, Religion, And Secular Order, Zachary R. Calo

Scholarly Works

This article compares the law and religion jurisprudence of the US Supreme Court and the European Court of Human Rights across three legal areas: religious symbols and religion-state relations, individual religious freedom, and institutional religious freedom or freedom of the church. Particular focus is given to the manner in which this jurisprudence reveals the underlying structure and meaning of the secular. Although there continues to be significant jurisprudential diversity between these two courts and across these legal areas, there is also emerging a shared accounting of religion, secularity, and moral order in the late modern West.

Operative Subsidiary And Municipal Authority: The Case Of Toronto's Ward Boundary Review, Alexandra Flynn

All Faculty Publications

This paper analyzes what the principle of subsidiarity means for municipalities, arguing in favour of “operative subsidiarity” in the design of provincial legislation. First, I outline the meaning and origins of subsidiarity, including critiques in the potential of its application. Second, I discuss the judicial treatment of municipal authority in Canada over the last twenty years. I advance that municipal authority as interpreted by the SCC has increasingly made room for municipalities as governments deserving of deference, unless the action breaches fairness or human rights. However, despite this judicial evolution, provinces have not drafted legislation with the principle of subsidiarity …

Rural-Urban Variation In Weight Loss Recommendations Among Us Older Adults With Arthritis And Obesity, Mary L. Greaney, Steven Cohen, Christie L. Ward-Ritacco, Deborah Riebe

Public Health Faculty Publications

Purpose: Weight loss is advantageous for individuals with obesity and arthritis. Therefore, this study was conducted to determine if there are differences by rural-urban status among older adults with these conditions who reported being advised by a health care provider to lose weight for arthritis or to ameliorate arthritis symptoms. Methods: A cross-sectional analysis of 2011 Behavioral Risk Factor Surveillance System (BRFSS) data. Respondents reported if they had been diagnosed with arthritis and if they received a provider weight loss recommendation (WLR). The analytic sample was limited to older adults aged 60–79 living in the five states that …

Being Missional, Becoming Missional : A Biblical-Theological Study Of The Missional Conversion Of The Church, Banseok Cho

ATS Dissertations

No abstract provided.

Affirmative Action, David Oppenheimer, Angela Onwuachi-Willig, Nancy Leong

Faculty Scholarship

There are consistent messages to people of color about their proper place in
/="/">society, which has always been a really important tool for maintaining and
/="/">advancing white supremacy. Referring back to what Professor Haney-Lopez
/="/">asserted earlier today, in today’s post-civil rights society, few people would
/="/">argue in favor of segregation in racial terms explicitly so. And few people would
/="/">assert that Blacks, for example, do not belong in certain places. However,
/="/">opponents of affirmative action have begun to articulate a form of these
/="/">arguments as an add-on to the mismatch theory. In the …

Revisionist History? Responding To Gun Violence Under Historical Limitations, Michael Ulrich

Faculty Scholarship

In the D.C. Circuit case Heller v. District of Columbia (Heller II), Judge Kavanaugh wrote that “Heller and McDonald leave little doubt that courts are to assess gun bans and regulations based on text, history, and tradition, not by a balancing test such as strict or intermediate scrutiny.” Now Justice Kavanaugh, will he find support on the highest court for what was then a dissenting view? Chief Justice Roberts, during oral arguments for Heller I, asked “Isn’t it enough to…look at the various regulations that were available at the time…and determine how these—how this restriction and the scope of this …

Byrd V United States: Unauthorized Drivers Of Rental Cars Have Fourth Amendment Rights? Not As Evident As It Seems, Tracey Maclin

Faculty Scholarship

No discerning student of the Supreme Court would contend that Justice Anthony Kennedy broadly interpreted the Fourth Amendment during his thirty years on the Court. His majority opinions in Maryland v. King, Drayton v. United States and his willingness to join the three key sections of Justice Scalia’s opinion in Hudson v. Maryland, which held that suppression is never a remedy for knock-and-announce violations, are just a few examples of Justice Kennedy’s narrow view of the Fourth Amendment.

In light of his previous votes in search and seizure cases, surprisingly Justice Kennedy, in what would be his final Fourth Amendment …

Digital Platforms And Antitrust Law, Keith N. Hylton

Faculty Scholarship

This Article is about "big data" and antitrust law. Big data, for my purposes, refers to digital platforms that enable the discovery and sharing of information by consumers, and the harvesting and analysis of consumer data by the platform. The obvious example of such a platform is Google. The big platforms owe their market dominance not to anticompetitive conduct, but to economies of scale. This Article discusses three types of anticompetitive conduct associated with digital platforms: kill zone expropriation, acquisition of nascent rivals, and denial of access to data. There is nothing so unusual about digital platforms that would require …