Digital Commons Network^™

Bridging The Gaps: Team 6 Hotspotting Experience, Sean O'Sullivan, Rebecca Schuck, Sean Tonnesen, Gabrielle Sallade, Emily Osisek, Avninder Ubhi

JCIPE Posters

Healthcare spending in the U.S. reached $3.5 trillion in 20171. Half of this spending was due to only 5% of patients. Hotspotting is the practice of identifying high-utilizing patients and providing them ancillary care. Supporting such patients with nutrition information, care coordination, clinician communication, health education, and treatment adherence coaching benefits the patients, clinicians, and healthcare system. The Jefferson Interprofessional Student Hotspotting Program places students of different educational programs into teams to identify high-utilizing patients and provide them individualized and holistic care. It is an intimate longitudinal clinical experience for students and an opportunity to improve the health of complex …

Consumption Of Black Raspberries Altered The Composition Of The Fecal Microbiome In Mice Fed A Western Type Diet (Or04-01-19), Abby D. Benninghoff, Sumira Phatak, Korry Hintze

Chemistry and Biochemistry Faculty Publications

Dietary strategies to reduce colonic inflammation and promote gut homeostasis may markedly reduce the risk of colitis-associated colorectal cancer. Previously, we showed that dietary supplementation with black raspberries significantly suppressed colitis and colon tumorigenesis promoted by the consumption a Western type diet in mice. In this study, our goal was to assess the impact of consumption of the TWD with and without black raspberry supplementation on the composition of the fecal microbiome over the course of disease development.

Dietary Intervention With Black Raspberries To Reduce Colitis Symptoms In Mice Fed Either Standard Ain93g Diet Or The Total Western Diet (P05-021-19), Daphne Michelle Rodriguez Jimenez, Michaela Brubaker, Elizabeth Park, Canyon Neal, Korry Hintze, Abby D. Benninghoff

Chemistry and Biochemistry Faculty Publications

Approximately 1.4 million people suffer from inflammatory bowel disease, which is a major risk factor for developing colitis associated colorectal cancer (CAC). Dietary interventions with the goal to reduce colon inflammation and encourage gut microbiome homeostasis may be a strategy to reduce the risk of CAC. The antioxidants and anti-inflammatory compounds present in black raspberries (BRB) have demonstrated protective effects in the colon epithelium and may alter the composition of the gut microbiome. Previously, we showed that dietary supplementation with black raspberries significantly suppressed colitis and colon tumorigenesis promoted by the consumption of a Western type diet in mice. The …

Phospho Tensin Homolog In Human And Lipid Peroxides In Peripheral Blood Mononuclear Cells Following Exposure To Flavonoids, William Y. Boadi, Elbert L. Myles, Alekzander S. Garcia

Biology Faculty Research

Objectives: Studies have shown that human and peripheral blood mononuclear cells (PBMCs) are mostly used for research purposes to study several biochemical endpoints. The effects of the flavonoids, genistein, kaempferol, and quercetin on phospho tensin homolog (PTEN) levels in cancer cells (i.e., breast [BT549], lung [A549]), human embryonic kidney cells (HEK293), and the levels of lipid peroxides (LP) in PBMCs were respectively investigated.

Materials and methods: Cancer, kidney, and PBMCs from several donors were each exposed to each of the flavonoids at concentrations of 0, 5, 10, 15, 20, and 25 µM. Our hypotheses were that exposure of cancer and …

Relationship Between Sepsis And Timing Achievement Of Peristaltic Function In Congenital Duodenal Obstruction, Sastiono Sastiono, Juwita Cresti Rahmaania

The New Ropanasuri Journal of Surgery

Introduction. Intestinal obstruction has been shown to induce bacterial translocation and in turn, would be associated with an increased risk of sepsis. Such a condition would be affecting the achievement of peristaltic and ultimately increased morbidity and mortality. In addition, nosocomial infections that threaten neonates cause sepsis also will affect the achievement of a peristaltic. Thus, the aim of this study was to investigate the relationship between sepsis with timing achievement of peristaltic postoperatively. Method. This is a cross-sectional study with data obtained from medical records of patients with duodenal obstruction without congenital abnormalities (gastroschisis, omphalocele, and another intestinal atresia) …

Hospital Malnutrition In Pediatric Surgery At Dr. Cipto Mangunkusumo General Hospital 2015 And Its Associated Factors, Novi Kurnia Cendrawan, Iskandar R. Budianto

The New Ropanasuri Journal of Surgery

Introduction. Hospital malnutrition is known to increase the length of stays, mortality, and morbidity, however, the factors associated with the development of hospital malnutrition, especially in pediatric surgery patient population, has not been recognized. Method. This study was done to evaluate the occurrence of hospital malnutrition in pediatric surgery population and to identify the factors associated with hospital malnutrition. Primary data was gathered from pediatric surgery patients hospitalized in the pediatric surgery ward of Dr. Cipto Mangunkusumo General Hospital within July–December 2015. Data on age, diagnosis, nutrition status at admission, whether any procedure was done during a hospital stay, fasting …

Fish Performance, Nutrient Digestibilities, And Hepatic And Intestinal Morphologies In Grouper Epinephelus Fuscoguttatus Fed Fermented Copra Meal, Roger Edward P. Mamauag, Janice A. Ragaza, Trisha J. Nacionales

Biology Faculty Publications

Protein enhanced copra meal (PECM®) is an alternative, cheap, and sustainable source of plant protein for the aquafeed industry, albeit its use on carnivorous fish species has been very limited. A 70-day feeding trial using grouper Epinephelus fuscoguttatus (initial mean body weight of 1.86 ± 0.19 g) tested fermented copra meal as feed ingredient. Six isonitrogenous (crude protein of 45%) and iso-lipidic (crude fat of 11%) diets consisted of PECM®: a control diet at 0% soybean meal replacement (C); four diets replacing soybean meal at 25% (FC25), 50% (FC50), 75% (FC75), 100% (FC100) – all with methionine and lysine supplementation; …

Integrated Analysis Of Clinical And Microbiome Risk Factors Associated With The Development Of Oral Candidiasis During Cancer Chemotherapy., Patricia I Diaz, Bo-Young Hong, Amanda K Dupuy, Linda Choquette, Angela Thompson, Andrew L Salner, Peter K Schauer, Upendra Hegde, Joseph A Burleson, Linda D Strausbaugh, Douglas E Peterson, Anna Dongari-Bagtzoglou

Faculty Research 2019

Oral candidiasis is a common side effect of cancer chemotherapy. To better understand predisposing factors, we followed forty-five subjects who received 5-fluorouracil- or doxorubicin-based treatment, during one chemotherapy cycle. Subjects were evaluated at baseline, prior to the first infusion, and at three additional visits within a two-week window. We assessed the demographic, medical and oral health parameters, neutrophil surveillance, and characterized the salivary bacteriome and mycobiome communities through amplicon high throughput sequencing. Twenty percent of all subjects developed oral candidiasis. Using multivariate statistics, we identified smoking, amount of dental plaque, low bacteriome and mycobiome alpha-diversity, and the proportions of specific …

An Integrative Cross-Omics Analysis Of Dna Methylation Sites Of Glucose And Insulin Homeostasis, Jun Liu, Elena Carnero-Montoro, Jenny Van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. De Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christian Herder, Bertha A. Hidalgo, Toshiko Tanaka, Ann Zenobia Moore, Rozenn N. Lemaitre, Min A. Jhun, Jennifer A. Smith, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation …

New Faculty/Staff/Administrative Appointments, Andrews University

Andrews Agenda: Campus News

No abstract provided.

Dietary Inflammatory Index And Sleep Quality In Southern Italian Adults, Justyna Godos, Raffaele Ferri, Filippo Caraci, Filomena I. I. Cosentino, Sabrina Castellano, Nitin Shivappa, James R. Hébert, Fabio Galvano, Giuseppe Grosso

Faculty Publications

Background: Current evidence supports the central role of a subclinical, low-grade inflammation in a number of chronic illnesses and mental disorders; however, studies on sleep quality are scarce. The aim of this study was to test the association between the inflammatory potential of the diet and sleep quality in a cohort of Italian adults. Methods: A cross-sectional analysis of baseline data of the Mediterranean healthy Eating, Aging, and Lifestyle (MEAL) study was conducted on 1936 individuals recruited in the urban area of Catania during 2014-2015 through random sampling. A food frequency questionnaire and other validated instruments were used to calculate …

Parent Bmi Increase 2 To 5 Years Post-Study Related To Change In Age But Independent Of Other Sociodemographics, Health Behavior, And Study Engagement (P16-001-19), Brenda Abu, Barbara A. Lohse, Leslie Cunningham-Sabo

Articles

Objectives Characterize parent (P) weight change 2-5 y post participation in Fuel for Fun (FFF) a controlled trial of a school and family intervention focused on culinary and physical activity experiences for 4th grade youth. Methods P who had participated with their 4th grader in FFF were recruited via email to enroll in a follow-up (FFFFU) assessment. FFF-FU survey set included measures from the original study and new items pertinent to P of adolescents. Physical activity was measured with the IPAQ; low income was denoted as using an income-based program or worry about money for food. Height, weight, age in …

Multifocal Assessment Reveals Anemia-Related Program Gaps And Implementation Challenges In Ghana (P10-088-19), Brenda Abu, Rachel Stefanic, Olivia Garror, Nicole Buttner, Kingsley Pereko, Adam Sandow

Articles

Objectives: Despite existing program efforts in Ghana, incidence of childhood anemia remain high. This study describes existing childhood anemia prevention and treatment strategies and assessed implementation gaps. Methods: A cross-sectional study using purposive sampling/snowballing technique identified organizations implementing childhood anemia prevention and treatment programs. Interview guides constructed around UNICEF's conceptual framework of malnutrition identified programs addressing each cause of anemia. Interviews were administered via in-person and phone in August 2018. Interviews were audio-recorded, transcribed, and coded/analyzed using Dedoose software version 8.1.8. Results: Twenty-five officials from Universities (n = 2), local non-governmental (n = 4), government departments (n = 6) and …

Cardiovascular Factors Moderate The Association Of Infection Burden With Cognitive Function In Young To Middle-Aged U.S. Adults, Bruce L. Brown, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges, Andrew N. Berrett, Evan L. Thacker

Faculty Publications

Background: Infectious diseases might affect cognitive aging and dementia risk, possibly via neuroinflammation. Similarly, risk factors for cardiovascular and cerebrovascular diseases are associated with cognitive function and dementia. We hypothesized that cardiovascular risk factors moderate the association of exposure to infectious diseases with cognitive function.

Methods: We studied 5662 participants aged 20 to 59 years from the third National Health and Nutrition Examination Survey (1988–1994) in the United States. We used linear regression to investigate whether the Framingham general cardiovascular risk index moderated the association of infection burden based on exposure to eight different infectious diseases with cognitive functioning as …

Insulin Signal Transduction Mediates Ethanol-Induced Feeding Dysfunction In A Fly Model Of Fetal Alcohol Spectrum Disorder, Manae Matsubara

McNair Research Journal SJSU

Fetal alcohol spectrum disorder (FASD) is the leading cause of congenital intellectual disabilities in the Western World, with a worldwide prevalence of 2-11% of all births. FASD is preventable but recent epidemiological studies suggest that public awareness campaigns have reached the limits of their effectiveness. Therefore, research is shifting from prevention to treatment and mitigation of symptoms. No biological treatments for FASD exist, due in part to the fact the cellular mechanisms of alcohol toxicity are not well-understood. Developmental alcohol exposure (DAE) causes a variety of deleterious effects in both vertebrates and invertebrates, including increased mortality, slow growth, learning and …

Nutrient Pollution In Casco Bay, Maine: State Of The Science And Recommendations For Action, Curtis Bohlen Phd, Marti Blair, Victoria Boundy

Publications

The Casco Bay Nutrient Council, a group with wide representation including local and state government, wastewater treatment and stormwater management professionals, researchers, community development organizations, and water quality advocacy organizations, was convened in 2017 to develop recommendations to policymakers, regulators, and funders on how best to assess, understand, convey and reduce the negative impacts of nutrients on Casco Bay.

While in common usage “nutrients” are things that make food nutritious or healthy, nutrients in Casco Bay refers to nitrogen, phosphorus, and silica. These chemical elements boost plant growth in aquatic ecosystems and such effects can lead to negative impact on …

Perspectives On Micrornas And Phased Small Interfering Rnas In Maize (Zea Mays L.): Functions And Big Impact On Agronomic Traits Enhancement, Zhanhui Zhang, Sachin Teotia, Jihua Tang, Guiliang Tang

Department of Biological Sciences Publications

Small RNA (sRNA) population in plants comprises of primarily micro RNAs (miRNAs) and small interfering RNAs (siRNAs). MiRNAs play important roles in plant growth and development. The miRNA-derived secondary siRNAs are usually known as phased siRNAs, including phasiRNAs and tasiRNAs. The miRNA and phased siRNA biogenesis mechanisms are highly conserved in plants. However, their functional conservation and diversification may differ in maize. In the past two decades, lots of miRNAs and phased siRNAs have been functionally identified for curbing important maize agronomic traits, such as those related to developmental timing, plant architecture, sex determination, reproductive development, leaf morphogenesis, root development …

Whey Protein Supplementation Post Resistance Exercise In Elderly Men Induces Changes In Muscle Mirna's Compared To Resistance Exercise Alone, Randall F. D'Souza, Nina Zeng, James F. Markworth, Vandre C. Figueiredo, Christopher P. Hedges, Aaron C Petersen, Paul A Della Gatta, David Cameron-Smith, Cameron J. Mitchell

Center for Muscle Biology Faculty Publications

Progressive muscle loss with aging results in decreased physical function, frailty, and impaired metabolic health. Deficits in anabolic signaling contribute to an impaired ability for aged skeletal muscle to adapt in response to exercise and protein feeding. One potential contributing mechanism could be exerted by dysregulation of microRNAs (miRNAs). Therefore, the aim of this study was to determine if graded protein doses consumed after resistance exercise altered muscle miRNA expression in elderly men. Twenty-three senior men (67.9 ± 0.9 years) performed a bout of resistance exercise and were randomized to consume either a placebo, 20 or 40 g of whey …

The Significance Of Air Circulation And Hearth Location At Paleolithic Cave Sites, Yafit Kedar, Ran Barkai

KIP Articles

No abstract provided.

Perceptions Of Academic Success And Quality Of Life Issues Among Undergraduate University Students, Susan Sunden

CUP Ed.D. Dissertations

The purpose of this qualitative study was to gain an understanding about the experiences of undergraduate students regarding quality of life and academic success at a midsized Midwestern university. Two research questions drove the study: How do university students perceive quality of life issues as they relate to academic success, and what life experiences are identified as influencing college student’s perception of a positive or negative quality of life? Purposeful sampling was used and 11 students volunteered for the study. All were undergraduates in a college of health professions. The data collection instruments were semistructured interviews, secondary semi structured interviews …

Meat Analogs From Different Protein Sources: A Comparison Of Their Sustainability And Nutritional Content, Ujué Fresán, Maximino Alfredo Mejia, Winston J. Craig, Karen Jaceldo-Siegl, Joan Sabaté

Faculty Publications

© 2018 by the authors. Meat analogs are processed foods designed to mimic meat products. Their popularity is increasing among people seeking foods that are healthy and sustainable. Animal-sourced protein products differ in both their environmental impact and nutritional composition. The protein sources to produce meat analogs come from different plants. There is a lack of published research data assessing differences in these two aspects of meat analogs according to the plant protein source. This study compared the greenhouse gas (GHG) emissions of different types of meat analogs according to their main source of protein (wheat, soy, wheat and soy, …

Caloric Restriction Alters Postprandial Responses Of Essential Brain Metabolites In Young Adult Mice, Lucille M. Yanckello, Lyndsay E. A. Young, Jared D. Hoffman, Robert P. Mohney, Mignon A. Keaton, Erin L. Abner, Ai-Ling Lin

Sanders-Brown Center on Aging Faculty Publications

Caloric restriction (CR) has been shown to extend longevity and protect brain function in aging. However, the effects of CR in young adult mice remain largely unexplored. In addition to the fundamental, long-term changes, recent studies demonstrate that CR has a significant impact on transient, postprandial metabolic flexibility and turnover compared to control groups. The goal of this study was to identify the brain metabolic changes at a transient (2 h) and steady (6 h) postprandial state in young mice (5–6 months of age) fed with CR or ad libitum (AL; free eating). Using metabolomics profiling, we show that CR …

Design Of An Urban Garden Aquaponics System, Riley Albright-Borden, James Wang, Sydney Thompson

Interdisciplinary Design Senior Theses

The project objective is to create a durable, off-the-grid, large-scale aquaponics system consisting of over 90 sq. ft of growing space, a 650-gallon fishpond, and four types of sensors to transmit water quality data to the internet for remote water quality monitoring. The end goal of the project is to supplement produce grown in the garden to further increase fresh, nutritional options available in meals cooked and distributed by Loaves and Fishes Family Kitchen to combat food insecurity in San Jose. This report presents the need for a system, details the various subsystems, and the rationale for the designs. It …

Nash-Wo-Numa (Childhood Growth & Development) Study Protocol: Factors That Impact Linear Growth In Children 9 To 15 Years Of Age In Matiari, Pakistan, Susan C. Campisi, Yaqub Wasan, Sajid Bashir Soofi, Suneeta Monga, Daphne J. Korczak, Wendy Lou, Olle Soder, Ashley Vandermorris, Khadija N Humayun, Ayesha Mian, Peter Szatmari, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Introduction: Adolescence is a time of significant physical and emotional change, and there is emerging concern that adolescents living in low- and middle-income countries (LMIC) may face substantial challenges in relation to linear growth and mental health. Data on the global burden of stunting after 5 years of age are limited, but estimates suggest up to 50 per cent of all adolescents in some LMIC are stunted. Additionally, many LMIC lack robust mental health care delivery systems. Pakistan has one of the world's largest populations of adolescents (10 to 19 years) at approximately 40 million. The Nash-wo-Numa study's primary objective …

2019 June 11 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Unh Research Finds Uneven Distribution Of Retail Food And Food Support Sites Across The State, Erika Mantz

Media Relations

No abstract provided.

Lactic Acid Threshold Stimulator, Justin Brackett, Karen Carreon, Fernando Guerra, Malyna Sanchez

Interdisciplinary Design Senior Theses

As a person works out, the threshold of lactic acid will build causing anywhere from discomfort to pain. Reducing the discomfort caused by lactic acid could greatly improve an individual’s performance while working out. Reducing this discomfort may be done through Electrical Muscle Stimulation (EMS), which is the procedure of contracting muscles through sending electrical signals. Our team’s goal is to create LATS, a wearable and mobile application that alleviates discomfort and aids muscle recovery during the intense parts of a workout. The system consists of a heart rate monitor to measure lactic acid levels, a garment that is worn …

Mapping The Food Landscape In New Hampshire, Jess Carson

Carsey Publications

In this brief, Jess Carson explores the food landscape of New Hampshire, documenting where lower incomes and low population density might lead to food insecurity, and mapping the locations of various food sources. Much of the northern and western parts of the state have high proportions of low-income residents and low population density, compared with more southern parts of the state. In terms of food sources, retail locations roughly mirror the state’s population distribution, with many options throughout the southern tier of the state and concentration around the Interstate 93 corridor into Northern New Hampshire. While many food support sites, …

Packed Red Blood Cell Transfusion Associates With Acute Kidney Injury After Transcatheter Aortic Valve Replacement, Akeel M. Merchant, Javier A. Neyra, Abu Minhajuddin, Lauren E. Wehrmann, Richard A. Mills, Sarah K. Gualano, Dharam J. Kumbhani, Lynn C. Huffman, Michael E. Jessen, Amanda A. Fox

Internal Medicine Faculty Publications

Background: Acute kidney injury after cardiac surgery significantly associates with morbidity and mortality. Despite not requiring cardiopulmonary bypass, transcatheter aortic valve replacement patients have an incidence of post-procedural acute kidney injury similar to patients who undergo open surgical aortic valve replacement. Packed red blood cell transfusion has been associated with morbidity and mortality after cardiac surgery. We hypothesized that packed red blood cell transfusion independently associates with acute kidney injury after transcatheter aortic valve replacement, after accounting for other risk factors.

Methods: This is a single-center retrospective cohort study of 116 patients undergoing transcatheter aortic valve replacement. Post-transcatheter aortic valve …

Food Assistance May Help Families Prevent Emergency Department Visits For Child Asthma, Colleen Heflin

Population Health Research Brief Series

Childhood asthma is the leading cause of emergency department visits for children under the age of 15 in the U.S. Food insecurity may increase a child’s risk for developing asthma. This research brief shows that higher SNAP benefits are associated with fewer asthma –related emergency department visits.