Digital Commons Network^™

Understanding The Role Of Idh Mutation In Chondrosarcoma, Luyuan Li

Open Access Dissertations

Chondrosarcomas constitute a heterogeneous group of malignant bone tumors that produce hyaline cartilaginous matrix. Chondrosarcomas are generally resistant to conventional chemotherapy and radiotherapy, leaving surgery as the only curative treatment option for most localized tumors. In the absence of effective systemic therapy, metastatic disease is nearly uniformly fatal. Therefore, better therapy for patients with unresectable or metastatic disease is urgently needed. Mutations in isocitrate dehydrogenase 1/2 (IDH1/2) enzymes were recently described in several malignancies including conventional and dedifferentiated chondrosarcomas. These mutations represent a novel genetic abnormality in chondrosarcoma, indicating a potential role for aberrant IDH function in the pathogenesis of …

A Role For The Hypoxia-Inducible Factor 1 Alpha In Murine Gammaherpesvirus 68 (Mhv68) Lytic Replication And Reactivation From Latency, Darlah Michelle López-Rodríguez

Open Access Dissertations

The hypoxia inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV) such as Kaposi' Sarcoma-associated Herpes Virus (KSHV) and Epstein-Barr virus (EBV). However, understanding the role of HIF1α during the virus life cycle and its biological relevance in the context of host pathogenesis has been challenging due to the lack of animal models for human γ HV. To study the role of HIF1α we employed the murine gammaherpesvirus 68 (MHV68), a rodent pathogen that readily infects laboratory mice. We show that MHV68 infection induces HIF1α protein and HIF1α-responsive …

School Of Education Hooding Ceremony & Reception Program, December 2019, Lindenwood University

College of Education: Hooding Ceremony

School of Education Hooding Ceremony & Reception Program, December 2019.

In Search Of Veritas: Kennedy Assassination Conspiracy Theories And The Emergence Of An American Culture Of Suspicion, 1963-1993., Thurman Lee Storing

Theses and Dissertations from 2019

“In Search of Veritas: Kennedy Assassination Conspiracy Theories and the Emergence of an American Culture of Suspicion, 1963-1993” argues that the evolving theories and concepts contained in the literature and media surrounding the Kennedy assassination demonstrate the deteriorating trust in American government institutions that resulted from the political and social climate of the 1960s through the 1980s. The assassination of President John F. Kennedy on November 22, 1963 in Dallas, Texas, marked a pivotal and horrific point in American history. The shocking murder and unanswered questions that surrounded the young president’s death traumatized the nation, leaving a psychological wound that …

Increasing Nursing Policy And Advocacy Engagement, Marketa Houskova

Doctor of Nursing Practice (DNP) Projects

At present, professional nursing does not benefit from strong policy development and advocacy influence in the United States. This project focused on CA nursing policy development and advocacy influence deficit among new members of a statewide professional nursing association. There are nearly 457,000 licensed registered nurses (RNs) in CA (BRN, 2019) and around 3.8 million RNs in the United States (AACN, 2019) making CA RNs twelve percent of the national nursing workforce. Yet only five percent of RNs serve on hospital boards, and legislative efforts to advance important nursing issues such as full practice authority for advanced practice RNs in …

The Impact Of Tourism On The Population Growth In Orlando, Florida, Timothy Mccann

MBA Student Scholarship

Orlando, Florida is currently experiencing one of the fastest population booms in the country. The purpose of this research is to explore possible factors that have acted as a catalyst for this population boom. With tourism, hospitality and events being such an important part of the economy, a qualitative field study will be used to determine whether tourism or hospitality can make an impact on how people are moving. Walt Disney World is one of the largest employers in central Florida and has a strong relationship with the City of Orlando and its residents. The participants in this qualitative field …

Analyzing Discourse Surrounding The George Morris Ban: An Ideological Critique Of Sexual Assault Culture In Sports, Megan Mcloughlin

Senior Honors Projects, 2010-2019

On August 6^th, 2019 one of the biggest names in the equestrian community, George Morris, was barred from the sport for life based on sexual assault allegations. I have conducted a Social Constructionist discourse analysis of the online responses to this case. Overarching themes exposed flaws in the hegemonic ideals of both the sports world and American culture in its entirety. As the case continues to develop every day, I have adapted my research to reflect new findings and have found that Deflection, Bolstering, and Reflection have emerged as the major themes of this discourse. This method allowed …

Theatre As An Intervention For Empathy Development Among Undergraduate Students, Jonathan Stewart

Dissertations, 2014-2019

Empathy is the ability feel into, or put oneself in the place of another. It is the ability to walk in someone else’s shoes. Studies have shown that this ability is decreasing among today’s college students and on the rise as a desired trait for today’s leaders. This dilemma provides an interesting opportunity to explore how institutions of higher education can help develop the leaders of tomorrow by increasing empathy among students. Specifically, this research explores theatre as an intervention for empathy development among college students.

Theatre, as a program of study, is unique within the college experience in that …

2019-12-13, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

2019 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Fall 2019 commencement program. Commencement was on Friday, December 13, 2019.

Offering Medical Providers Capacity And Competence In Caring For Transgender And Non-Binary Patients: Evaluation Of A Pilot Digital Training Program, Lexis Manzara

Master's Projects and Capstones

Purpose: Stigma and discrimination in health care settings contribute to health disparities for transgender and non-binary (TGNB) people. Evidence suggests that a lack of training on the care for transgender and non-binary TGNB patients in medical school curricula has contributed to providers feeling unprepared to provide quality care for this population. Health care providers have the opportunity to play a key role in the reduction of health disparities for TGNB patients.

Methods: Twenty-five health care providers completed the eight-module digital training program. Pre- and post-tests assessed provider knowledge, self-efficacy, preparedness, and behavior. Paired samples t-tests were conducted to compare pre-and …

Collaborative Drama For The Adult Esl Classroom: A Guidebook For Engaging Adult English Language Learners In Their Oral Language Production Through A Television Series, Molly Mccarthy

Master's Projects and Capstones

ABSTRACT

This field project addresses the lack of engagement in oral language production of adult English as a Second Language (ESL) students in the classroom. To address this issue, this project identifies the reasons behind the lack of engagement in oral language production and suggests the ways in which drama techniques can improve engagement of adult ESL students in their oral language production. This project looks specifically at the positive effects that teaching ESL through the use of a television series will have on students’ engagement of oral language production. With a lens on lowering students’ affective filter, increasing collaboration, …

The Museum Of The Infinite Scroll: Assessing The Effectiveness Of Google Arts And Culture As A Virtual Tool For Museum Accessibility, Megan K. Udell

Master's Projects and Capstones

As technology evolves, the concept of the virtual museum continues to come into focus. Google Arts and Culture (formerly the Google Art Project) has been a leading platform in virtual exhibitions and digital collections since 2011. Arts and Culture presents itself as a democratic platform that allows any museum, regardless of size or resources, access to the same new digital technologies. However, its model tends to favor institutions with more staff time to spend on their virtual presence. By analyzing Google Arts and Culture within the context of larger museum trends in virtuality and interviewing museum professionals responsible for their …

Understanding Large Strain Deformation Behavior Of Physically Assembled Triblock [Aba] Copolymer Gels In B-Selective Solvents, Satish Mishra

Theses and Dissertations

Physically assembled gels are widely applicable in the food industry, biomedical devices, drug delivery, and soft robotics due to their tunable mechanical properties and thermoreversibility. The mechanical responses of these gels originate from their microstructure. Therefore, factors affecting the gel microstructure like polymer molecular weight, solvent quality, and polymer concentration play a significant role in determining their mechanical behavior. Gel microstructure also changes during the deformations resulting in a deviation from the structure-property relationship established for the low deformations. During large deformations, other factors like stress relaxation, poroelasticity, and polymer chain entanglement contribute significantly to the gel response. This complexity …

Information Literacy In Place-Based Interdisciplinary Teaching And Learning, Anne E. Leonard

Publications and Research

This chapter explores the role of information literacy in virtual or hybrid place-based interdisciplinary courses. Whether teaching as a guest lecturer or as a co-instructor, I infuse information literacy competencies into assignments, relying on the Framework for Information Literacy for Higher Education. Four of the six frames of the Framework map especially well to interdisciplinary teaching and learning: information has value, authority is contested and contextual, research as inquiry, and searching as strategic exploration. Through searching in special collections and archives and integrating digitized primary sources into research projects students engage in a virtual exploration …

Facts, Not Feelings, Gannon Rush

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

“The world is gonna end in 12 years if we don't address climate change and your biggest issue is how are we gonna pay for it? ” This is a direct quote from Alexandria Ocasio-Cortez, a sitting U.S. congresswoman. In the next few sentences, she also proceeds to say that climate change is “our generations World War II”. 70 million people died in World War II, not only is it doing disrespect to those who gave the ultimate sacrifice, but it is physically impossible to compare war to climate change. What she and others, such as Greta Thunberg and Al …

Multiliteracies In Rural Schools: The “Revuelto Y Mezclada” Of Home And Community Literacy Practices Of Midwestern Emergent Bilingual Families, Trish Morita-Mullaney, Haiyan Li, Jennifer Renn

The Rural Educator

Multiliteracies is a paradigm for language and literacy, in which all languages and literacies are valuable, meaningful, and serve a purpose in meeting the needs of the learner within their social contexts. Multiliteracies are enacted and negotiated through different languages, technologies, and modalities and are represented in homes and communities of English Learners (ELs) or emergent bilinguals (EBs), representing their bi- or multilingual identities. Within rural communities, these family multiliteracies differ from the predominantly English-monolingual contexts found within schools, but have the potential to reshape rural educators’ conceptions of literacies. Redefining literacy holds significance in rural communities where resources, including …

From Sharks To "The Big Ugly", Kristin Rearden, Joy Bertling

The Rural Educator

This longitudinal case study explored one rural elementary art teacher’s praxis for two years after she participated in professional development sessions on place-based education (PBE). These sessions focused specifically on PBE within the discipline of art for K-12 art educators in a geographically-large southeastern school district. Through surveys, observations, interviews, and document analysis of curricular materials, the researchers investigated the teacher’s experiences with PBE as she taught art in a rural area of the district. Her curricular decisions transitioned from a focus on art reflecting her personal knowledge base to art that built on students’ expressions of, experiences in, and …

Consumers Support A Slowing Economy, Eric Thompson

Business in Nebraska

Nebraska will record moderate economic growth during the forecast period but will lag U.S. growth. Like the national economy, growth Nebraska’s goods producing sector will struggle. Farm incomes will be flat from 2020 to 2022 after improving this year. Manufacturing employment also is expected to drop. However, most other sectors will expand, including services, finance and construction. Projected growth rates for 2020 to 2022 are presented in Table 1.

Employment will grow by 0.6% to 0.8% per year, below the national rate. Non-farm income will grow between 3.7% and 3.8% each year. This growth readily exceeds inflation and population growth, …

Beneficial Approaches To Working With Migrant Students, Pete Cade

CUP Ed.D. Dissertations

The migrant student population in the United States continues to rise. This increase in numbers places this unique group of students in thousands of classrooms across the country. Their mobility rates can significantly increase the number of classrooms affected and the number of teachers who must understand their plight. This single qualitative case study explored migrant students’ academic experience, for the purpose of establishing best practices for the educational system to best support them. Using Maslow’s hierarchy of needs and multicultural education as the theoretical framework, the researcher analyzed the perceptions of effective practices from twelve college-educated professionals who were …

English Teachers’ Perceptions And Opinions On The Use Of Instructional Technologies In The Inclusive Classroom, Zachary Caldwell

Departmental Honors & Graduate Capstone Projects

Research has shown that instructional technologies can be harnessed by educators as powerful tools to both create and enhance forms of differentiation in order to provide a more engaging and interactive inclusive classroom for students with and without disabilities. However, these technologies are often under-utilized for students with disabilities in the inclusive classroom and are instead used as simple substitutes for printed assignments. The objective of this study was to learn how English teachers at the secondary level use and understand instructional technologies and how they differentiate instruction in an inclusive classroom. An online survey was conducted to obtain data …

Vaxinsight: An Artificial Intelligence System To Access Large-Scale Public Perceptions Of Vaccination From Social Media, Jingcheng Du

Dissertations and Theses (Open Access)

Vaccination is considered one of the greatest public health achievements of the 20th century. A high vaccination rate is required to reduce the prevalence and incidence of vaccine-preventable diseases. However, in the last two decades, there has been a significant and increasing number of people who refuse or delay getting vaccinated and who prohibit their children from receiving vaccinations. Importantly, under-vaccination is associated with infectious disease outbreaks. A good understanding of public perceptions regarding vaccinations is important if we are to develop effective vaccination promotion strategies. Traditional methods of research, such as surveys, suffer limitations that impede our understanding of …

Burnout, Depression And Suicide Prevention For Nursing Staff In High-Intensity Settings, April Ritchie

Doctor of Nursing Practice (DNP) Projects

Nurses working in high-intensity settings experience burnout at higher rates than in other nursing areas. Burnout in healthcare is a problem estimated as high as 70% by the Agency for Healthcare Research and Quality. Burnout can lead to depressive symptoms, which can lead to suicidal ideation in affected healthcare providers, which makes early identification and treatment of utmost importance to the mental and physical wellbeing of these nurses.

The purpose of this project is to examine burnout in nursing staff working in high-intensity areas of the hospital in order to help identify burnout and/or depressive symptoms before they lead to …

Increasing Utilization Of Motivational Interviewing To Promote Pediatric Oral Health, Ulyses Reamico

Doctor of Nursing Practice (DNP) Projects

Prevalence of early childhood caries (ECC) remains high even in developed countries such as the United States. An interprofessional education (IPE) project between University of San Francisco (USF) School of Nursing and Health Professions and the University of the Pacific (UoP), Arthur A. Dugoni School of Dentistry was initiated four years ago to enhance nurse practitioner (NP) and dental students’ pediatric oral-systemic health assessment and health promotion communication skills. Since then, USF NP students received pediatric oral health assessment training and spent clinical rotations at UoP to provide pediatric oral care alongside dental students. This doctor of nursing (DNP) project …

Nurse Manager Succession Planning: Building A Leadership Pipeline For The Future, Katie Stephens

Doctor of Nursing Practice (DNP) Projects

Problem. This academic medical center was increasing bed-capacity and needed to hire 12 additional nurse managers (NM) to meet these new requirements. Promoting assistant nurse managers (ANM) to the NM role saves time and money, supports leadership and cultural continuity, and demonstrates a strong organizational commitment to internal human capital.

Context. Formal nurse manager succession planning (NMSP) programs have been shown to increase nurse manager competency and retention rates, while also helping to identify and develop new generations of nurse leaders. To mitigate the recent loss of ANMs and strengthen the remaining leadership bench strength, the organization is developing, implementing, …

In The Midst Of The Apocalypse, Artificial Intelligence Can Save Brick And Mortar Retailers, Vrushank Nayak

Capstones

You might have heard that brick and mortar stores are closing by the thousands but I bet you didn't hear that brick and mortar stores are using artificial intelligence and customer data to help them counter closures and stay relevant in the transitioning retail industry.

https://coveringcompanies.journalism.cuny.edu/2020/01/07/in-the-midst-of-the-apocalypse-artificial-intelligence-can-save-brick-and-mortar-retailers/

Feeding The Future Meat Doesn’T Come Cheap, Lukas C. Southard

Capstones

Cultured – or as it is referred to by companies innovating the technology clean – meat is expected to be the next innovation to change the way the world gets its animal protein. Meat from animal cells grown in a lab seems like science fiction but it is around the corner from hitting your supermarket shelves. The technology has been developed but how these companies intend on scaling up their production to meet retail demands remains a mystery. So far companies have relied on seed and early stage investment from venture capital companies and private sources to fund research. Predictions …

Healing The Black Mind, Vanessa Etienne

Capstones

Due to an oppressive history, the African American community is more likely to have issues regarding mental health, but less likely to pursue professional treatment for it. However, as the perception of mental health care in the Black community starts to shift, many are finding unconventional ways to approach healing. http://vanessaetienne.tilda.ws

Getting It Right: New York Can Make Its ‘Inevitable’ Marijuana Industry Accessible Before It’S Too Late, Kelly Zegers

Capstones

New York is inching closer to marijuana legalization. It's often touted as a tax revenue boost for states and a fast-moving industry to be cashed in on. But who gets to have access to those benefits? Advocates are working to make sure that communities hurt by marijuana prohibition have the option and pathway to build businesses in the legal marijuana market. Small farmers are looking to grow marijuana, some hoping to take apply what they've learned about and benefited from, cultivating hemp. What's clear in a quickly evolving industry in other states is that there's no golden standard for accessibility. …

Boys Will Be, Victoria Hoffman

Capstones

SocialJ Presentation

SocialJ Report