Digital Commons Network^™

The Role Of Protein O-Glcnacylation In Regulating Mitochondrial Function, Jalessa Nicole Wright

All ETDs from UAB

The attachment of O-linked-N-acetylglucosamine (O-GlcNAc) to the serine/threonine residues of proteins has emerged as an important regulatory mechanism in transcriptional regulation, protein activation as well as cell survival. Several studies have reported that elevated O-GlcNAc levels have adverse effects on mitochondrial function. These negative effects have been linked to O-GlcNAc modification of mitochondrial proteins that are integral across multiple metabolic cell processes i.e. VDAC, NDUFA9 and DRP-1. Mitochondrial complexes I, III and IV all contain subunit proteins that are O-GlcNAc modified and increased O-GlcNAcylation of these proteins is associated with deficits in oxidative phosphorylation in these models. Conversely, it has …

Self-Tracking Practices: The Roles Of Social Contexts And Chronic Conditions, Aowen Zhu

All ETDs from UAB

The rapid development of mobile health (mHealth) technologies is propelled by the culture of disease prevention and management. Smartphone applications and wearable devices provide valuable personal data for self enhancement. In addition to health promotion, people with chronic conditions are using apps and devices to monitor symptoms and behaviors. There is great potential for self-tracking practices to reduce health care cost and improve population health. However, the emphasis on personal responsibility of individuals’ health may hinder the long-term effectiveness of self-tracking practices. The purpose of the study is to examine the associations between social contexts and self-tracking practices, chronic health …

Examining Naloxone Access: A Spatial Asessment Of Opioid Use In Urban And Rural Contexts, Keith Chichester

All ETDs from UAB

Background: Elements of the physical environment have been shown to influence health behaviors including drug use and overdose mortality. Throughout the opioid epidemic in the United States, rural regions have been disproportionately affected by opioid overdose. Although the relationship between the urban built environment and opioid overdose has been established, little is known as to how trends may differ in rural areas. Methods: Risk terrain modeling was used as a spatial analytical approach to assess environmental features that significantly increase the risk of opioid overdose in Jefferson County, Alabama. Spatial risk assessments were conducted for urban and rural regions as …

Exposure Assessment Of Ultrafine Particles And Hazardous Chemicals In Electronic Cigarettes, Oluwabunmi Magret Dada

All ETDs from UAB

The widespread use of electronic cigarettes (e-cig) among youths and adolescents is a growing public health problem due to exposures to harmful byproducts formed during heating. These byproducts include particulate matter, benzene, and toluene. However, the mechanisms and variables governing their formation including the chemical content of e-cig liquid (e-liquid) are not fully understood. This study aimed to assess exposures to particulate matter, benzene, and toluene in e-cig vapors (e-vapors) and their coupling to e-liquid chemical content. A novel nuclear magnetic resonance spectroscopy method was developed to characterize e-liquids (propylene glycol, glycerol, and nicotine) and the functional content of flavorings. …

Low-Cost Wastewater Treatment Using Agricultural Waste Materials, Seyma Demirci

All ETDs from UAB

Wastewater generated from human activities is one of the biggest problems polluting in the world. Currently, in order to reduce pollution and to limit the effects on the environment, researchers are investigating new methods and innovative materials for use in wastewater treatment. A goal of environmental engineers is to lower the coagulant cost and to improve the characteristics of the produced purification. This presented work investigates the role of agricultural materials (woodchips, banana fibers, and straw) to use in the treatment of municipal wastewater and to study their physicochemical characteristics (pH, COD, BOD, TSS, Conductivity, Turbidity, and Fecal Coliforms) of …

Examining Teacher Perceptions Of Professional Learning Teams And Teacher Professionalism, Rebecca Thomas Stripling

All ETDs from UAB

EXAMINING TEACHER PERCEPTIONS OF PROFESSIONAL LEARNING TEAMS AND TEACHER PROFESSIONALISM This study explores the perceptions of teachers’ professionalism as they participate in professional learning teams. Through a qualitative lens, teacher perceptions of how their own professionalism (as indicated by the Professionalism Index by McMahon & Hoy, 2009) is influenced or affected as a result of their participation in a PLT were examined from the perspective of teachers that fell into three categories, those teachers that scored high on the Professionalism Index, those teachers that scored low on the Professionalism Index and those teachers that had a medium score on the …

Dysregulation In The Central Nervous System Upon Mcmv Infection In Newborn Mice, Cathy Yea Won Sung

All ETDs from UAB

Human cytomegalovirus (HCMV) infection is a major cause of morbidity in infants and children throughout the world. Between 0.2-1.2% of all live births is infected with HCMV in the United States. Approximately 5-15% of these newborn babies will develop long-term neurological damage resulting in motor disorders, mental retardation, and sensorineural hearing loss. Although the neurological sequelae associated with congenital HCMV infections are well characterized, little is known about the pathogenesis of the damage to the central nervous system (CNS). To study the pathogenesis of congenital HCMV infection, we have developed a mouse model in which newborn mice are infected intraperitoneally …

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson

All ETDs from UAB

Objective: Unintentional childhood injury is a significant global health burden particularly in low and middle income countries (LMIC). Effective supervision can reduce risk of injury to supervisees. Frequently, older siblings assist in supervising younger siblings, but may not be as effective as adult caregivers at preventing supervisee injury. The current investigation had three primary objectives: 1) Assess Ugandan adult caregivers’ self-reported expectations for children to provide sibling supervision; 2) Assess sixth-grade students’ self-reported experiences providing supervision; 3) Determine whether students’ supervision knowledge and skill improve through participation in the Super Siblings program, a novel classroom-based, culturally-adapted intervention. Methods: Adult caregivers …

Teachers’ Experiences Of Change From Traditional Teaching Methods To Active Participatory Learning Approaches Within The Alabama P-3 Pilot Program: A Case Study, Shushan Vardanyan

All ETDs from UAB

This case study explored teachers’ experiences with the implementation of the Alabama P-3 initiative to move away from traditional teaching methods to active participatory learning (APL) approaches. Semi-structured interviews were conducted with nine teachers from four schools who taught kindergarten (K), first, or second grade. The data were analyzed through comparison of K and primary (P) teachers’ experiences of the implementation of the initiative using Lewin’s (1951) change theory as an a priori theory. The data were organized into two a priori themes: the process of change and forces influencing the change. The process of change theme was presented in …

Novel Biomarkers For Parkinson Disease, Shijie Wang

All ETDs from UAB

Parkinson disease (PD) is the second most common neurodegenerative disorder with no reliable biochemical biomarkers for disease prediction or progression, nor disease-modifying treatments to slow the relentless progression. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are known to increase LRRK2 kinase activity and increase the risk for late-onset PD. In this thesis, I discovered that LRRK2 is secreted into exosomes in urine and CSF, where LRRK2 kinase activity, reflected by autophosphorylation at pS1292 site, is preserved and reflective of cytosolic LRRK2 levels. In a cohort of biosamples from LRRK2 mutation carriers and matched controls, with and without PD, …

The Anti-Tumor Effects Of Hur Inhibition In Glioblastoma, Jiping Wang

All ETDs from UAB

Glioblastomas (GBMs) are the most malignant primary brain tumor. GBMs represent 14.7% of total primary CNS tumors and 47.7% of malignant CNS tumors. The median survival of GBM is 18-20 months, while five-year survival rate is only 5.6%. GBMs are maintained by glioma stem cells (GSCs), and poor treatment outcomes are linked to the high resistance of GSCs to radiation and chemotherapy, and the immunosuppressive tumor microenvironment. The mRNA binding protein HuR is a key regulator of tumor growth and development based upon the fact that HuR targets mRNAs that are broadly involved in tumorigenesis. We have previously shown that …

Examining Web-Based Lifestyle Interventions For Cancer Survivors, Victoria Williams

All ETDs from UAB

Diet, physical activity, and body weight status are important modifiable risk factors for many health outcomes among cancer survivors, including cancer recurrence. Face-to-face, print, and mailed lifestyle interventions have been used to promote behavior change in cancer survivors successfully. However, such approaches are costly and have limited reach. Web-based lifestyle interventions represent a promising solution to this public health concern. Therefore, this project involved first reviewing and identifying gaps in the existing literature in this area and then developing and pilot testing a web-based lifestyle intervention for cancer survivors. For this three-part dissertation, study 1 was a narrative review of …

Weight Loss And Weight Gain Among Participants In A Community-Based Weight Loss Challenge, Merrill D. Funk, Minjae Lee, Michelle L. Vidoni, Belinda M. Reininger

Health & Human Performance Faculty Publications

Background

To describe the characteristics of participants who registered for multiple annual offerings of a community-based weight loss program called The Challenge, and to determine participant characteristics associated with weight change over multiple offerings of The Challenge occurring during the years 2010–2016.

Methods

Multivariable linear mixed effects analyses were conducted to describe percent weight change within and between offerings of The Challenge by participant characteristics.

Results

There were 669 and 575 participants included in the within and between analyses, respectively, for offerings of The Challenge. Among the 434 participants who lost weight in their first attempt at The Challenge and …

​Youth Smoking In Europe. Strategies For Prevention And Reduction, Joan Hanafin, Luke Clancy

Books / book chapters

No abstract provided.

Atmospheric Cold Plasma Interactions With Microbiological Risks In Fresh Food Processing, Apurva Patange

Doctoral

Atmospheric cold plasma (ACP) is a novel emerging non-thermal technology that has attracted attention as a decontamination tool in several industrial, food and healthcare sectors. This study investigated the anti-microbial efficacy of ACP against microbiological risks associated with fresh foods. Treatment was performed using in-package ‘dry’ ACP technology and plasma functionalised liquid to decontaminate microorganisms, exploring the responses to real and challenging microbiological risks pertinent to both fresh foods themselves as well as the effluents generated from food processing industry. A range of critical control process parameters were investigated with respect to key pathogenic and spoilage microorganisms commonly implicated in …

Modelling Anti-Phishing Authentication Ceremonies, Edina Hatunic-Webster

Doctoral

No abstract provided.

Synthesis And Novel Applications Of Cerium Dioxide, Rafaela Cristina De Carvalho

Doctoral

Cerium dioxide nanoparticles (NPs) were synthesised using a novel precipitation procedure and their function explored in a range of applications. The impact of different factors on CeO2 NPs synthesis including temperature and reactant concentration were evaluated experimentally and optimised. The resulting nanoparticles (with an average size of 35 nm) was then characterised by a range of physical and spectroscopic techniques including dynamic light scattering, scanning electron microscopy in conjunction with energy dispersive spectrometry, X-ray diffractometry,Brunauer–Emmett–Teller isotherm measurement, Raman spectroscopy, UV-visible spectroscopy and X-ray photoelectron spectroscopy. A new nanoparticle synthetic route, the “frozen NH4(OH) cubes method”, was developed, resulting in a …

Screening Of Human Serum/Plasma Using Vibrational Spectroscopy For Early Disease Diagnostics And Therapeutic Drug Monitoring, Drishya Rajan Parachalil [Thesis]

Doctoral

Analysis of analytes present in the blood stream can potentially deliver crucial information on patient health and indicate the presence of numerous pathologies. Existing clinical techniques for this analysis can, however, be costly and time-consuming. The potential of Raman spectroscopic analysis of human plasma and/or serum for diagnostic purposes has been widely investigated and, increasingly, its feasibility for clinical translation has been explored. However, as the concentration of many analytes in plasma/serum is relatively low, to date such analysis has commonly been performed on air-dried drops deposited on substrates, leading to inhomogeneity and inconsistencies. This study explores the potential of …

Distance,Time And Terms In First Story Detection, Fei Wang

Doctoral

First Story Detection (FSD) is an important application of online novelty detection within Natural Language Processing (NLP). Given a stream of documents, or stories, about news events in a chronological order, the goal of FSD is to identify the very first story for each event. While a variety of NLP techniques have been applied to the task, FSD remains challenging because it is still not clear what is the most crucial factor in defining the “story novelty”. Giventhesechallenges,thethesisaddressedinthisdissertationisthat the notion of novelty in FSD is multi-dimensional. To address this, the work presented has adopted a three dimensional analysis of the …

The Use Of Fluid Haemodynamics In The Diagnosis Of Cardiovascular Disease, Andrew Malone

Doctoral

Currently the diagnostic methods used to detect cardiovascular disease largely rely on the inference of the presence of arterial stenosis. There is a clinical interest in the development of a diagnostic screening technique which can indicate the risk of developing cardiovascular disease at an early stage so that non-surgical treatments can be applied. The goal of this work was to develop and validate a diagnostic screening technique for cardiovascular disease using the mechanical biomarker wall shear stress. Improvements in wall shear stress measurements were made by using a 2D Fourier transform to extract additional spectral information from the ultrasound pulse …

'Elle T'Aime Trop, Et Moi, Pas Assez': Jacques Feyder's Melodramatic Mise En Scène Of Female Desire In Pension Mimosas (1935), Barry Nevin

Articles

Extract

Melodrama ‘à la française’: Feyder and French cinema of the 1930s

By the end of 1934, Jacques Feyder had led a distinguished career in French silent cinema, had directed a critically acclaimed adaptation of Émile Zola’s Thérèse Raquin (1928) in Berlin, had returned from a three-year contract in Hollywood, had brought Le Grand Jeu to the screen (the greatest box-office success of the 1933–34 season), and appeared to be virtually unstoppable as he proceeded to direct his next film, Pension Mimosas. The film was described by one critic as ‘sans aucun doute l’une des œuvres les plus attendues …

Identifying Associated Risk With Exposure Ti Weapon Carrying Among Emerging Adults Living In Disadvantaged Urban Areas In Birmingham, Tolulope Aduroja

All ETDs from UAB

IDENTIFYING ASSOCIATED RISK WITH EXPOSURE TO WEAPON CARRYING AMONG EMERGING ADULTS LIVING IN DISADVANTAGED URBAN AREAS IN BIRMINGHAM TOLULOPE ADUROJA HEALTH EDUCATION/HEALTH PROMOTION ABSTRACT Weapon carrying is a public health concern due to its association with a serious injury, disability or death, and adverse health-related outcomes. Weapon carrying among youth is associated with both intrinsic or internalizing and extrinsic or externalizing factors (Stayton, 2011). Violence in youth and young adults is the 2nd leading cause of death (homicide) in Alabama. Health behavior theories posit that health-relevant attitudes, beliefs, and behavioral skills drive subsequent actions people take to protect themselves from …

Religion, Psychological Distress, And Discrimination Among Arab Americans, Najwa Alharbi

All ETDs from UAB

A growing body of research has focused on the experiences of Arab Americans post-9/11. These studies have been conducted to investigate the relationship between ethnic discrimination and mental health among Arab Americans. However, these studies show some gaps. Specifically, no study has explored the differences between Muslim and Christian Arabs after the 9/11 attacks in terms of religion, including how religious attendance influences the levels of psychological distress and discrimination among the two religious groups. This paper is dedicated to exploring religion (religious affiliation and religious attendance) as a key factor to understand the different levels of psychological distress and …

Towards Safeguarding Users Against Phishing And Ransomware Attacks, Arsh Arora

All ETDs from UAB

Over the past decade, malicious software (malware) attacks have skyrocketed and increased at a considerably faster pace than predicted. The variety in the number of malware categories is one of the contributing factors to this rapid insurgence. According to Microsoft statistics, a range of 300,000-400,000 malware binaries is observed on average per day. With this increase, there is an unmet need for innovative approaches to detect new malware, as current nomenclature is not equipped to handle the prevention against continuous growth. Developing appropriate preventive measures to stop these malware attacks has been an ongoing struggle for security experts. The most …

Exhaustion In The Service Of Progress, Ofer Tur-Sinai

Cardozo Arts & Entertainment Law Journal

Under the doctrine of patent exhaustion, an authorized sale of a patented item exhausts the patentee's rights with respect to that item, leaving the purchaser and subsequent owners free to use or resell it without fear of an infringement lawsuit. In 2017, the U.S. Supreme Court issued its landmark decision in Impression Products v. Lexmark International, which strengthened the exhaustion doctrine in various significant ways. The Court held that an authorized sale of a patented item exhausts all patent rights with respect to that item, regardless of any restrictions on use or resale the patentee purports to impose. The Court …

Panel 2: Art Law And Blockchain, Tonya M. Evans, Derek Fincham, Katya Fisher, Jeanne Schroeder

Cardozo Arts & Entertainment Law Journal

No abstract provided.

Assessing The Viability Of Blockchain To Impact The Antiquities Trade, Derek Fincham

Cardozo Arts & Entertainment Law Journal

Blockchain, the technology underpinning Bitcoin and other digital currencies, offers promise to shift the gathering and sharing of information in profound ways. It could help form a new kind offinancial system that limits current inefficiencies, or even radically change how parties enter into contract, or monitor supply chains. The technology's distributed ledger allows users in a network to monitor and access peer-to-peer digital transactions in real time. This digital ledger allows users to maintain this information securely by encrypting and allowing access only to those who have permission, given by cryptographic keys.

For the art market, blockchain offers a tantalizing …

The Peculiar Case Of State Network Neutrality Regulation, Thomas B. Nachbar

Cardozo Arts & Entertainment Law Journal

In the wake of the FCC's recent decision to rescind federal network neutrality rules, several states have implemented their own network neutrality regulations, some in the form of procurement conditions on state contracts and others affirmative mandates requiring broadband Internet service providers to observe neutrality in providing service. The federal government and industry trade associations have challenged the state network neutrality laws as both preempted and unconstitutional under the "dormant Commerce Clause" doctrine.

This paper analyzes those state restrictions as a matter of constitutional law. The Court has recently changed dormant Commerce Clause law, liberalizing those limits with regard to …

Changes In The Children's Television Marketplace, The Children's Television Act, And The First Amendment, Joel Timmer

Cardozo Arts & Entertainment Law Journal

Since the passage of the Children's Television Act of 1990, broadcast television stations have been required to provide educational programming for children as a condition for license renewal. Since 1996, broadcasters can fulfill this obligation by providing three hours of such programming according to the Federal Communications Commission's (FCC) guidelines. These requirements were later extended to broadcasters' multicast channels. With more children's programming available today than ever before from a wide variety of sources, and with changes in the ways children consume programming, the FCC has proposed to revise its rules to reflect these changes. This Article considers the constitutionality …

Is It Reasonable To Block Unreasonable Advertisements? An Examination Of The Legality Of Ad-Blockers, Andrew Steele

Cardozo Arts & Entertainment Law Journal

No abstract provided.