Digital Commons Network^™

Characterizing And Quantifying Regulatory Changes In Cancer, Lizhong Ding

All-Inclusive List of Electronic Theses and Dissertations

This study is to characterize and quantify regulatory changes in the cancer regulatory network, which includes factors such as alternative splicing (AS) and miRNA-mRNA interaction. To achieve this goal, we compare, develop, and evaluate tools to identify AS splicing junction. We also develop pipelines to characterize, cluster, and visualize miRNA-mRNA pairs in tumor tissues compared to normal tissues. With the tools or pipelines, researchers can characterize and quantify molecular level changes in the tumorous tissues compared to normal tissues in different cancer types. This study provides new hallmarks of cancer types, potential diagnostic biomarkers, and therapeutic targets in cancer and …

Patients With Flt3-Mutant Aml Needed To Enroll On Flt3-Targeted Therapeutic Clinical Trials, Taylor Bucy, John M. Zoscak, Motomi Mori, Uma Borate

OHSU-PSU School of Public Health Faculty Publications and Presentations

We sought to identify the total number of therapeutic trials targeting FLT3-mutant acute myeloid leukemia (AML) to estimate the number of patients needed to satisfy recruitment when compared with the incidence of this mutation in the US AML population. A systematic review of all therapeutic clinical trials focusing on adult FLT3-mutated AML was conducted from 2000 to 2017. An updated search was performed using ClinicalTrials.gov for trials added between October 2017 and December 2018. Analysis was performed for ClinicalTrials.gov search results from 2000 to 2017 to provide descriptive estimates of discrepancies between anticipated clinical trial enrollment using consistently cited rates …

Women Into Advanced Manufacturing: Can Community College Open This Door?, Carissa Bradley Schutzman

Theses and Dissertations--Educational Policy Studies and Evaluation

Women still rarely choose to seek employment in advanced manufacturing. Lack of familiarity with manufacturing jobs and education programs, lack of role models, and too few experiential opportunities contribute to women not choosing manufacturing jobs as well as other jobs traditionally held by men (Reha, Lufkin, & Harrison, 2009; St. Rose & Hill, 2013; Starobin & Laanan, 2008). Nontraditional jobs for women often provide higher wages and more opportunity for advancement than traditional jobs for women. This study is a qualitative thematic narrative analysis of factors that influenced women who chose an advanced manufacturing program at a community college to …

A Partial Simulation Study Of Phantom Effects In Multilevel Analysis Of School Effects: The Case Of School Socioeconomic Composition, Hao Zhou

Theses and Dissertations--Education Sciences

Socioeconomic status (SES) affects students’ academic achievement at different levels of an educational system. However, misspecified Hierarchical Linear Model (HLM) may bias school SES estimation. In this study, a partial simulation study was conducted to examine how misspecified HLM model bias school and student SES estimation.

The result of this study can be summarized by four important points. First, based on partial simulation procedure, phantom effects of school SES and student SES are real. Second, characteristics of phantom effects are generalized. The stronger the correlation between prior science achievement measure and present science achievement measure, the greater the decrease in …

Assessing The Model Fit Of Multidimensional Item Response Theory Models With Polytomous Responses Using Limited-Information Statistics, Caihong Rosina Li

Theses and Dissertations--Education Sciences

Under item response theory, three types of limited information goodness-of-fit test statistics – M₂, M_ord, and C₂ – have been proposed to assess model-data fit when data are sparse. However, the evaluation of the performance of these GOF statistics under multidimensional item response theory (MIRT) models with polytomous data is limited. The current study showed that M₂ and C₂ were well-calibrated under true model conditions and were powerful under misspecified model conditions. M_ord were not well-calibrated when the number of response categories was more than three. RMSEA₂ and RMSEA_C2 are …

The Effect Of Increased Physical Activity On Academic Performance, Lauren Michelle Willis

Theses and Dissertations--Education Sciences

Increased levels of obesity, particularly among American youth, have consistently been cause for concern over the last few decades. Additionally, the amount of time youth spend being active throughout the day has consistently decreased. Physical activity levels among school-aged children in America are effected by any number of reasons, but this study points to the possibility of time spent being physically active during the school day having the greatest effect on a student’s overall level of physical activity. Increased pressures from different entities on local schools to improve student performance on standardized test scores have contributed to a decline in …

Walking With A Robotic Exoskeleton Does Not Mimic Natural Gait: A Within-Subjects Study, Chad Swank, Sharon Wang-Price, Fan Gao, Sattam Almutairi

Kinesiology and Health Promotion Faculty Publications

Background: Robotic exoskeleton devices enable individuals with lower extremity weakness to stand up and walk over ground with full weight-bearing and reciprocal gait. Limited information is available on how a robotic exoskeleton affects gait characteristics.

Objective: The purpose of this study was to examine whether wearing a robotic exoskeleton affects temporospatial parameters, kinematics, and muscle activity during gait.

Methods: The study was completed by 15 healthy adults (mean age 26.2 [SD 8.3] years; 6 males, 9 females). Each participant performed walking under 2 conditions: with and without wearing a robotic exoskeleton (EKSO). A 10-camera motion analysis system synchronized with 6 …

Endowments Of Higher Education Institutions And Individual Income Tax Policy: Wealth Erosion From A Loss In Charitable Contributions, Jennifer W. Siebenthaler

Theses and Dissertations--Educational Policy Studies and Evaluation

The most significant tax overhaul bill in over thirty years was enacted in 2017 and expected to have wide-ranging effects. The Tax Cuts and Jobs Act includes numerous policies that directly and indirectly impact the higher education sector and the effect to endowments was not addressed in the public debate leading up to enactment. Unlike expendable gifts, a reduction in endowment contributions has a cumulative effect because a gift to an endowment can benefit all subsequent years. Each year following a contribution, investment income earned on the original gift is available for spending and benefits escalate over time in amount, …

Soft Skills: Old & New, Kevin Wayne Beardmore

Theses and Dissertations--Educational Policy Studies and Evaluation

The problem of a prepared workforce is perennial. Part of the challenge is one of supply and demand, as education systems attempt to produce graduates with the technical competencies required for the current jobs available. In the new service- and knowledge-based economy, however, soft skills are cited as a greater need by today’s employers. Increasingly sought across all industry sectors, these skills allow employees to work independently and interdependently, respond rapidly to customer needs, and adjust to changing market conditions. As a result, institutions of higher education are being called upon to infuse soft skills into their curricula. In this …

Believing In Achieving: Examining African American Women’S Doctoral Attainment, Reshanta Camea Hazelbaker

Theses and Dissertations--Educational, School, and Counseling Psychology

This research explored the intersectionality of race, class, and gender within the sources of self-efficacy (Bandura, 1997) underlying the socialization messages influencing African American women’s doctoral attainment beliefs. Twenty African American female/woman doctoral achievers completed an online survey, consisting of open-ended and multiple-choice response items, designed to identify and explore the sources of self-efficacy influencing African American women’s doctoral attainment beliefs. Eleven participants participated in focus interviews to expand upon and clarify initial survey responses.

Thematic analysis (Braun & Clarke, 2006) and tenets of critical race theory (Ladson-Billings & Tate, 1995; McCoy & Rodricks, 2015) were used to analyze the …

The Stakeholder Gap Lens: Teacher And Parental Perceptions Of The Achievement Gap In Kentucky's Public Schools, Heather Renee Brown Chapman

Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education

The research around the achievement gap is extensive. However, regardless that the term “achievement gap” is so widely used in academia today, there is often confusion surrounding what the achievement gap is. This study seeks to answer three research questions: (1) To what extent does an achievement gap exist among different subgroups of students in Kentucky’s K-12 public schools? (2) How do the perceptions of parents and teachers interact with decision-making? (3) How do the ideas of parents and teachers regarding closing the achievement gap compare?

This research examines perceptions of the existence of an achievement gap in Kentucky’s public …

A Quasi-Experimental Study Of Middle Level Student Engineering Understanding Pre-And Post-Treatment, Emily Driessen

Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education

This qualitative quasi-experimental study analyzed middle-level students’ understanding of engineering before and after instruction. Students from four teachers were examined. Before and after instruction, all students completed the Draw an Engineer Test (DAET) and the Views of Nature of Engineering (VNOE) survey. Additionally, sixteen students (eight girls and eight boys) from each group (Treatment and Comparison) were interviewed before and after instruction. Findings revealed that after instruction (1) many students viewed engineers as makers/builders/workers (just as they did pre-instruction), however, the percentage of students who listed engineers as inventors, designers, and creators increased; (2) fewer students from both groups noted …

The Influence Of Access To Informal Stem Learning Experiences On Middle School Students’ Self-Efficacy And Interest In Stem, Soledad G. Yao

Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education

Informal learning experiences have become increasingly effective in enhancing self-efficacy and interest in the fields of science, technology, engineering, and mathematics (STEM).This study investigated the impact of access to informal STEM learning experiences on student self-efficacy and interest in STEM before and after participating in the 2018 See Blue See STEM Summer Experience. Pre-survey results indicated that middle school students who had previous access to informal STEM learning experiences are 3.21 times as likely to demonstrate high self-efficacy in STEM as those who had no previous access. After engaging in the 2018 summer experience, post-survey results showed a statistically significant …

Improving Undergraduate Statistics Education: Educational Lessons From Two Pedagogical Experiments, Anushka Karkelanova

Theses and Dissertations--Curriculum and Instruction

The ultimate goal of statistics education is to create a statistically literate society in which people can appropriately use statistical thinking. Although the need to improve the teaching of introductory statistics courses is not a new one, with increased demand on these courses, there has been constant effort to seek out better ways of teaching these courses. The University of Kentucky (UK) began a reform of its general education program in November 2005. Thinking and reasoning are the central themes of this well-designed general education curriculum.

The main goal of this dissertation is to fill in some gaps in the …

Principal Behaviors That Foster Collective Efficacy Among Teachers In Rural Secondary Schools In Kentucky, Tanya Jo Jury

Theses and Dissertations--Educational Leadership Studies

The purpose of this study was to examine principal behaviors, identified by teachers and principals, which foster collective efficacy among teachers. As instructional leaders of a school, principals are expected to lead their schools. Behaviors exhibited by the principal can either help or hinder the success of the school and teachers and students in that school. This study will assist principals, aspiring principals, and instructors of principal preparation programs in knowing what behaviors are necessary to foster collective efficacy in their schools, leading to greater success for that school.

Collective efficacy is a shared belief that by working together, “we …

Targeting Mitochondria In Cancer Therapy Could Provide A Basis For The Selective Anticancer Activity, Dmitri Rozanov, Anton Cheltsov, Aaron Nilsen, Christopher Boniface, Isaac Forquer, James Korkola, Joe Gray, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

To determine the target of the recently identified lead compound NSC130362 that is responsible for its selective anti-cancer efficacy and safety in normal cells, structure-activity relationship (SAR) studies were conducted. First, NSC13062 was validated as a starting compound for the described SAR studies in a variety of cell-based viability assays. Then, a small library of 1,4-naphthoquinines (1,4-NQs) and quinoline-5,8-diones was tested in cell viability assays using pancreatic cancer MIA PaCa-2 cells and normal human hepatocytes. The obtained data allowed us to select a set of both non-toxic compounds that preferentially induced apoptosis in cancer cells and toxic compounds that induced …

Glacial Deposits, Vol. 44, 2019, Department Of Geography, Geology, And The Environment

Glacial Deposits

Newsletter of the Department of Geography, Geology, and the Environment

The Regressive Effect Of Legal Uncertainty, Uri Weiss

Journal of Dispute Resolution

No abstract provided.

Towards Optimal Enforcement, Kent Barnett

Vanderbilt Law Review

No abstract provided.

Campus Sustainability Office Annual Report, 2018-2019, Campus Sustainability Office

Campus Sustainability Office Publications, Reports and Presentations

The Campus Sustainability Office 2018-2019 annual report.

Stars Annual Report, 2019, Campus Sustainability Office

Campus Sustainability Office Publications, Reports and Presentations

The Campus Sustainability Office (CSO) compiles information from departments across campus annually to complete the STARS Report. The score is based on the number of points received across five categories: Academics, Engagement, Operations, and Planning & Administration, and Innovation & Leadership. PSU has maintained a Gold rating since the institution began reporting in 2011 and is within the top 40 of over 400 reporting institutions. This summary includes improvement opportunities to assist our efforts to eventually become a STARS Platinum institution. For more information on improvement opportunities please contact Amanda Wolf at [email protected]

Despite Similar Perceptions And Attitudes, Postbaccalaureate Students Outperform In Introductory Biology And Chemistry Courses, Erin E. Shortlidge, Liz Rain-Griffith, Chloe Shelby, Gwen Shusterman, Jack Barbera

Biology Faculty Publications and Presentations

Embedding active learning is a common mechanism for meeting science, technology, engineering, and mathematics (STEM) education reform goals. Researchers have identified student benefits from such strategies, yet these benefits may not be universal for all students. We sought to identify how students at a nontraditional university perceive introductory biology and chemistry courses, and whether perceptions relate to course type, performance, or student status. We surveyed students (n = 601) using open-ended prompts regarding their perceptions of factors that impact their learning and interest, and about specific learning strategies. Generally, students did not differ in what influenced their learning or …

Art Adherence And Viral Suppression Are High Among Most Non-Pregnant Individuals With Early-Stage, Asymptomatic Hiv Infection: An Observational Study From Uganda And South Africa, Jessica E. Haberer, Bosco M. Bwana, Catherine Orrell, Stephen Asiimwe, Gideon Amanyire, Nicholas Musinguzi, Mark J. Siedner, Lynn T. Matthews, Alexander Tsai, Ingrid T. Katz, Kathleen Bell, Annet Kembabazi, Stephen Mugisha, Victoria Kibirige, Anna Cross, Nicola Kelly, Bethany Hedt-Gauthie, David R. Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction

The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS‐free generation depend on high adherence in individuals initiating ART during early‐stage HIV infection; however, adherence may be difficult in the absence of illness and associated support.

Methods

From March 2015 to October 2017, we prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non‐pregnant women with early‐stage HIV infection (CD4 > 350 cells/μL), pregnant women with early‐stage HIV infection and men and non‐pregnant women with late‐stage HIV infection (CD4 < 200 cells/μL). Socio‐behavioural questionnaires were administered and viral loads were performed at 0, 6 and 12 months. Adherence was monitored electronically.

Results

Adherence data were available for 869 participants: 322 (37%) early/non‐pregnant, …

Counting And Coloring Sudoku Graphs, Kyle Oddson

Mathematics and Statistics Dissertations, Theses, and Final Project Papers

A sudoku puzzle is most commonly a 9 × 9 grid of 3 × 3 boxes wherein the puzzle player writes the numbers 1 - 9 with no repetition in any row, column, or box. We generalize the notion of the n² × n² sudoku grid for all n ∈ ℤ^≥2 and codify the empty sudoku board as a graph. In the main section of this paper we prove that sudoku boards and sudoku graphs exist for all such n; we prove the equivalence of [3]'s construction using unions and products of graphs to the definition of …

Predicting Spawning Habitat For Coho Salmon (Oncorhynchus Kisutch), Chinook Salmon (Oncorhynchus Tshawytscha), And Steelhead (Oncorhynchus Mykiss) Using Geospatially Constructed Stream Morphology From High-Resolution Lidar-Derived Digital Elevation Model And Field Survey Data In The Indian Creek Watershed, Mendocino County, California, Justin Patrick Bissell Mr.

Cal Poly Humboldt theses and projects

Restoration of anadromous salmonid habitat is of primary importance to the economic, historical, and cultural geography of the Pacific Northwest. Derivation and use of geospatial habitat models as guides to pinpoint key areas where limited restoration funding can be cost-effectively employed is of great importance. To this purpose, 1 meter resolution lidar-derived Digital Elevation Model data was acquired for the Indian Creek and neighboring watersheds in Mendocino County, California, and used together with field-acquired geomorphic stream data to geospatially model stream widths, depths, and streambank morphology. These geospatial covariates were field-verified in selected locations and then used in conjunction with …

Effects Of Thinning And Prescribed Burning On Tree Resistance To Extreme Drought In A Sierra Nevada Mixed-Conifer Forest, California Usa, Chance C. Callahan

Cal Poly Humboldt theses and projects

Drought-induced tree mortality can drastically alter forest composition, structure, carbon dynamics, and ecosystem function. Increasingly, forest policy and management focuses on how to improve forest resistance and resilience to drought stress. This study used tree ring data at Teakettle Experimental Forest (TEF), a historically frequent fire mixed-conifer forest in the California Sierra Nevada, to quantify how prescribed fire and mechanical thinning conducted in 2001-2002 influenced stand and tree-level growth responses to the extreme California drought of 2012-2016. Overstory thinning and understory thinning significantly enhanced growth responses to treatments alone and treatments during the drought at the stand-level. In each year …

Mechanisms And Spatial Patterns Of Bark Beetle-Associated Mortality Following Variable Density Thinning Treatments In A Sierra Mixed-Conifer Forest, Alexis Bernal

Cal Poly Humboldt theses and projects

Long-term trends of tree mortality have increased over the last several decades, coinciding with above-average temperatures, high climatic water deficits, and bark beetle outbreaks. With the anticipation that drought and bark beetles may increase with climate change, uncertainty exists over the appropriate treatments that could ensure the future sustainability of forest resources and the ecosystem services that forests provide. Conventional thinning treatments are used to reduce stand density, with the assumption that reductions in competition can alleviate drought stress and enable trees to resist bark beetle attack. Alternative thinning treatments may also reduce stand density, but have a greater focus …

Distribution And Habitat Use Of A Recently Discovered Population Of Humboldt Martens In California, Holly E. Gamblin

Cal Poly Humboldt theses and projects

The Humboldt marten (Martes caurina humboldtensis) has declined from over 95% of its historic range in California, with only two populations remaining. In response to the forthcoming listing of the Humboldt marten a conservation assessment and strategy was developed to address the most important conservation needs for this species. This assessment identified an area near the California – Oregon border as the second extant population area in California based on a small number of recent detections. However little else was known of this population, and this prompted my investigation to determine 1) the distribution and potential population size …

Student Movements In The United States And Mexico: A Testimony, Roberto M. De Anda

Chicano/Latino Studies Faculty Publications and Presentations

The author reflects on his experiences teaching and going to graduate school in Mexico City in the late 1970s and early 1980s. I discuss my participation in Chicano Movement organizations before moving to Mexico, and the reasons that propelled me to go to graduate school there. I highlight lessons learned teaching as a volunteer at a normal popular, or people’s teachers college, and as a professor at the Universidad Autónoma Chapingo (UACh). I also describe my graduate studies at the Universidad Nacional Autónoma de México (UNAM). The conclusion focuses on the impact that these experiences had on the author’s professional …

Conceptual And Procedural Knowledge: A Framework For Analyzing Point-Of-Need Information Literacy Instruction, Amy Vanscoy

Communications in Information Literacy

The information literacy instruction (ILI) that occurs during a spontaneous information interaction, such as at the reference desk, is not clearly defined and not extensively researched. It differs, however, from classroom ILI, with its lesson plans, carefully considered learning outcomes, and planned learning activities. This paper uses the framework of conceptual and procedural knowledge, drawn from education research, to analyze point-of-need ILI. Digital reference transcripts were analyzed using this framework, and examples of ILI from the transcripts were categorized to make sense of how conceptual and procedural knowledge manifest in point-of-need ILI. This conceptual/procedural focus acknowledges the unique context of …