Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2019

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 2161 - 2190 of 26982

Full-Text Articles in Entire DC Network

Educators’ Practices Involving Deaf Multilingual Learners: A Single Case Study, Mary Christine Thomas Dec 2019

Educators’ Practices Involving Deaf Multilingual Learners: A Single Case Study, Mary Christine Thomas

Doctoral Dissertations and Projects

The purpose of this single case study was to identify instructional strategies, that takes into account language and culture, used by professionals and educators involved in the instructional process of DMLs at an elementary school in the southeast. The central research question for this study was: What educational assessments and instructional strategies, that takes language and culture into consideration, are used in the education of DMLs? The theory that guided this study was Vygotsky’s sociocultural theory (Vygotsky, 1978, 2012) as it incorporates students’ culture and social interactions with peers and teachers into the learning process. This was a qualitative single …


Causal-Comparative Study: Differences In Academic Achievement By Levels Of Social-Emotional Skills In Grade Five Students, David Frederick Salvatelli Dec 2019

Causal-Comparative Study: Differences In Academic Achievement By Levels Of Social-Emotional Skills In Grade Five Students, David Frederick Salvatelli

Doctoral Dissertations and Projects

Students’ social-emotional skills contribute to academic achievement and life success. This causal-comparative study examined differences in mathematics and English Language Arts (ELA) achievement test scores among grade five students by their levels of proficiency (low, moderate, or high) in particular social and emotional skills, namely, academic self-efficacy, persistence, self-control, mastery orientation, and social competence. Participants were 115 grade five students from Title I schools in a metropolitan school district in south Florida. Each social and emotional skill was assessed using the Child Trends Social and Emotional Skills Survey battery. Multivariate Analysis of Variance, Analysis of Variance, and post hoc tests …


Perceptual Differences In School Climate Between Administrators And Teachers Within Christian Schools, Cheryl Turner Cavanaugh Dec 2019

Perceptual Differences In School Climate Between Administrators And Teachers Within Christian Schools, Cheryl Turner Cavanaugh

Doctoral Dissertations and Projects

School climate has been researched for the past 100 years. However, there is a lack of school climate research focused on perceptual differences between school leaders and teachers. It is important to evaluate stakeholder differences, as principals are tasked with forming the climate of the school and teachers are responsible for relaying that climate to students. Furthermore, there is a lack of school climate studies conducted in private Christian schools. Christian school leaders need school climate data to help sustain and improve Christian education. The purpose of this causal comparative study is to evaluate perceptual differences between administrators and teachers …


¡No Me Juzguez! Latino Parent Perceptions Of The Lived Experience Of Participation In Their Child's Education: A Transcendental Phenomenological Study, Trinidad Y. Sierra Dec 2019

¡No Me Juzguez! Latino Parent Perceptions Of The Lived Experience Of Participation In Their Child's Education: A Transcendental Phenomenological Study, Trinidad Y. Sierra

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand Latino parent perceptions of the lived experience of participation in their middle school child’s education. Participants were chosen through convenience and snowball sampling with the criterion that each participant was a Latino parent of a child who attended a middle school in Lehigh Valley, Pennsylvania. “Lehigh Valley” is the pseudonym used for the school district and the area in which the study was conducted. Theories that guided this study and the research questions were parental involvement theory and cultural capital theory. The central question for this study was focused on Latino …


Perfecting Singapore’S System Of Political Governance: Privileging Elites In The Quest For Good Governance, Tan K. B. Eugene Dec 2019

Perfecting Singapore’S System Of Political Governance: Privileging Elites In The Quest For Good Governance, Tan K. B. Eugene

Research Collection Yong Pung How School Of Law

This chapter argues that the office of the Elected President is best understood as an elite institution with eligibility restricted to a select group by a stringent set of criteria for hopefuls from the public and private sectors. The Singapore Constitution provides the Elected President with executive and legislative powers. Since independence in 1965, Singapore has sought to constitutionally engineer a political system that meets its unique needs and aspirations. Any theory of responsible government, undergirded by the separation of powers, will entail some measure of both conflict and cooperation, whether one or the other dominates. Given the particularistic neo-Confucian …


Online And Clicker Quizzing On Jargon Terms Enhances Definition-Focused But Not Conceptually Focused Biology Exam Performance, Steven C. Pan, James Cooke, Jeri L. Little, Mark A. Mcdaniel, Erin R. Foster, Lisa Tabor Connor, Timothy C. Rickard Dec 2019

Online And Clicker Quizzing On Jargon Terms Enhances Definition-Focused But Not Conceptually Focused Biology Exam Performance, Steven C. Pan, James Cooke, Jeri L. Little, Mark A. Mcdaniel, Erin R. Foster, Lisa Tabor Connor, Timothy C. Rickard

Open Access Publications

Mastery of jargon terms is an important part of student learning in biology and other science, technology, engineering, and mathematics domains. In two experiments, we investigated whether prelecture quizzes enhance memory for jargon terms, and whether that enhanced familiarity can facilitate learning of related concepts that are encountered during subsequent lectures and readings. Undergraduate students enrolled in neuroanatomy and physiology courses completed 10-minute low-stakes quizzes with feedback on jargon terms either online (experiment 1) or using in-class clickers (experiment 2). Quizzes occurred before conventional course instruction in which the terms were used. On exams occurring up to 12 weeks later, …


Comparison Of Naïve Bayes Algorithm And Decision Tree C4.5for Hospital Readmission Diabetes Patientsusing Hba1c Measurement, Utomo Pujianto, Asa Luki Setiawan, Harits Ar Rosyid, Ali M. Mohammad Salah Dec 2019

Comparison Of Naïve Bayes Algorithm And Decision Tree C4.5for Hospital Readmission Diabetes Patientsusing Hba1c Measurement, Utomo Pujianto, Asa Luki Setiawan, Harits Ar Rosyid, Ali M. Mohammad Salah

Knowledge Engineering and Data Science

Diabetes is a metabolic disorder disease in which the pancreas does not produce enough insulin or the body cannot use insulin produced effectively. The HbA1c examination, which measures the average glucose level of patients during the last 2-3 months, has become an important step to determine the condition of diabetic patients. Knowledge of the patient's condition can help medical staff to predict the possibility of patient readmissions, namely the occurrence of a patient requiring hospitalization services back at the hospital. The ability to predict patient readmissions will ultimately help the hospital to calculate and manage the quality of patient care. …


Handwriting Character Recognition Usingvector Quantization Technique, Haviluddin Haviluddin, Rayner Alfred, Ni’Mah Moham, Herman Santoso Pakpahan, Islamiyah Islamiyah, Hario Jati Setyadi Dec 2019

Handwriting Character Recognition Usingvector Quantization Technique, Haviluddin Haviluddin, Rayner Alfred, Ni’Mah Moham, Herman Santoso Pakpahan, Islamiyah Islamiyah, Hario Jati Setyadi

Knowledge Engineering and Data Science

This paper seeks to explore Learning Vector Quantization (LVQ) processing stage to recognize The Buginese Lontara script from Makassar as well as explaining its accuracy. The testing results of LVQ obtained an accuracy degree of 66.66 %. The most optimal variant of network architecture in the recognition process is a variation of learning rate of 0.02, a maximum epoch of 5000 and a hidden layer of 90 neurons which was the result of recognition based on feature 8. Based on these variations, the obtained performance with a mean square error (MSE) of 0.0306 and the time required during the learning …


Missouri S&T Magazine Fall/Winter 2019, Missouri S&T Marketing And Communications Department, Miner Alumni Association Dec 2019

Missouri S&T Magazine Fall/Winter 2019, Missouri S&T Marketing And Communications Department, Miner Alumni Association

Missouri S&T Magazine

No abstract provided.


Novel Cyber Fault Prognosis And Resilience Control For Cyber-Physical Systems, Shanshan Bi, Tianchen Wang, Lei Wang, Maciej Zawodniok Dec 2019

Novel Cyber Fault Prognosis And Resilience Control For Cyber-Physical Systems, Shanshan Bi, Tianchen Wang, Lei Wang, Maciej Zawodniok

Electrical and Computer Engineering Faculty Research & Creative Works

Cyber-physical systems (CPSs) consist of a network, computation, and physical process. Embedded networks, which deliver control and sensing signal, can potentially affect CPSs performance. However, the degradation of physical system performance caused by the embedded networks is frequently oversimplified with strong assumptions. The proposed scheme effectively relaxes those assumptions in the existing works that network delays are bounded in a specific range, or its distribution is time invariant. Most of the existing works on fault diagnosis and prognosis addressed the physical system fault detection and isolation and ignore cyber network faults. A novel cyber network fault prognosis scheme is proposed …


Enhanced Label Noise Filtering With Multiple Voting, Donghai Guan, Maqbool Hussain, Weiwei Yuan, Asad Masood Khattak, Muhammad Fahim, Wajahat Ali Khan Dec 2019

Enhanced Label Noise Filtering With Multiple Voting, Donghai Guan, Maqbool Hussain, Weiwei Yuan, Asad Masood Khattak, Muhammad Fahim, Wajahat Ali Khan

All Works

© 2019 by the authors. Label noises exist in many applications, and their presence can degrade learning performance. Researchers usually use filters to identify and eliminate them prior to training. The ensemble learning based filter (EnFilter) is the most widely used filter. According to the voting mechanism, EnFilter is mainly divided into two types: single-voting based (SVFilter) and multiple-voting based (MVFilter). In general, MVFilter is more often preferred because multiple-voting could address the intrinsic limitations of single-voting. However, the most important unsolved issue in MVFilter is how to determine the optimal decision point (ODP). Conceptually, the decision point is a …


Predicting The Daily Return Direction Of The Stock Market Using Hybrid Machine Learning Algorithms, X. Zhong, David Lee Enke Dec 2019

Predicting The Daily Return Direction Of The Stock Market Using Hybrid Machine Learning Algorithms, X. Zhong, David Lee Enke

Engineering Management and Systems Engineering Faculty Research & Creative Works

Big data analytic techniques associated with machine learning algorithms are playing an increasingly important role in various application fields, including stock market investment. However, few studies have focused on forecasting daily stock market returns, especially when using powerful machine learning techniques, such as deep neural networks (DNNs), to perform the analyses. DNNs employ various deep learning algorithms based on the combination of network structure, activation function, and model parameters, with their performance depending on the format of the data representation. This paper presents a comprehensive big data analytics process to predict the daily return direction of the SPDR S&P 500 …


Hedge Fund Replication Using Strategy Specific Factors, Sujit Subhash, David Lee Enke Dec 2019

Hedge Fund Replication Using Strategy Specific Factors, Sujit Subhash, David Lee Enke

Engineering Management and Systems Engineering Faculty Research & Creative Works

Hedge funds have traditionally served wealthy individuals and institutional investors with the promise of delivering protection of capital and uncorrelated positive returns irrespective of market direction, allowing them to better manage portfolio risk. However, the financial crisis of 2008 has heightened investor sensitivity to the high fees, illiquidity, lack of transparency, and lockup periods typically associated with hedge funds. Hedge fund replication products, or clones, seek to answer these challenges by providing daily liquidity, transparency, and immediate exposure to a desired hedge fund strategy. Nonetheless, although lowering cost and adding simplicity by using a common set of factors, traditional replication …


Dynamics Considerations Dedicated To Study Bodies In High-Altitude Free Fall, Michelle Carolina Rodriguez Dec 2019

Dynamics Considerations Dedicated To Study Bodies In High-Altitude Free Fall, Michelle Carolina Rodriguez

Theses and Dissertations

The objective of this thesis is to develop a simulation model to study the dynamics of a rigid body in free fall. A set of 6 degrees of freedom (DOF) equations is developed to reflect the dynamic and trajectory characteristics over time. The simulation models a body dropped at different altitudes ranging from 30,480 – 39,624 m (100,000 – 130,000 ft). The trajectory of the body is analyzed using a mathematical nonlinear dynamics model. The mathematical model was developed in MATLAB and Simulink which can be modified for different geometries and conditions. The model was validated by testing that the …


Effects Of Resampled Data On Time Series Forecasting Accuracy, Jennifer Garland Dec 2019

Effects Of Resampled Data On Time Series Forecasting Accuracy, Jennifer Garland

Theses and Dissertations

This thesis will look at time series forecasting of the air pollutants in Beijing, China and the power consumption of an individual household located in Sceaux, France. The forecast will be taken from two classical methods, the Holt-Winters’ methods and the Seasonal Autoregressive Integrated Moving Average (SARIMA) method. The Holt-Winters’ method will be looked at from the additive, multiplicative and damped methods. The SARIMA model will be looked at as a uni-variate model. In this thesis, it will be shown that less complex algorithms, such as the Holt-Winters’ methods can process larger data sets without the need of resampling, and …


Communications And Methodologies In Crime Geography: Contemporary Approaches To Disseminating Criminal Incidence And Research, Mitchell Ogden Dec 2019

Communications And Methodologies In Crime Geography: Contemporary Approaches To Disseminating Criminal Incidence And Research, Mitchell Ogden

Electronic Theses and Dissertations

Many tools exist to assist law enforcement agencies in mitigating criminal activity. For centuries, academics used statistics in the study of crime and criminals, and more recently, police departments make use of spatial statistics and geographic information systems in that pursuit. Clustering and hot spot methods of analysis are popular in this application for their relative simplicity of interpretation and ease of process. With recent advancements in geospatial technology, it is easier than ever to publicly share data through visual communication tools like web applications and dashboards. Sharing data and results of analyses boosts transparency and the public image of …


Function Space Tensor Decomposition And Its Application In Sports Analytics, Justin Reising Dec 2019

Function Space Tensor Decomposition And Its Application In Sports Analytics, Justin Reising

Electronic Theses and Dissertations

Recent advancements in sports information and technology systems have ushered in a new age of applications of both supervised and unsupervised analytical techniques in the sports domain. These automated systems capture large volumes of data points about competitors during live competition. As a result, multi-relational analyses are gaining popularity in the field of Sports Analytics. We review two case studies of dimensionality reduction with Principal Component Analysis and latent factor analysis with Non-Negative Matrix Factorization applied in sports. Also, we provide a review of a framework for extending these techniques for higher order data structures. The primary scope of this …


Extracting Social Network From Literary Prose, Tarana Tasmin Bipasha Dec 2019

Extracting Social Network From Literary Prose, Tarana Tasmin Bipasha

Graduate Theses and Dissertations

This thesis develops an approach to extract social networks from literary prose, namely, Jane Austen’s published novels from eighteenth- and nineteenth- century. Dialogue interaction plays a key role while we derive the networks, thus our technique relies upon our ability to determine when two characters are in conversation. Our process involves encoding plain literary text into the Text Encoding Initiative’s (TEI) XML format, character name identification, conversation and co-occurrence detection, and social network construction. Previous work in social network construction for literature have focused on drama, specifically manually TEI-encoded Shakespearean plays in which character interactions are much easier to track …


Characterizing Hydrothermal System Groundwater Dynamics Using Conservative And Non-Conservative Tracers: Insights And Implications Drawn From Study At The Taupo Volcanic Zone (New Zealand) And Valles Caldera (Usa), Joshua Michael Blackstock Dec 2019

Characterizing Hydrothermal System Groundwater Dynamics Using Conservative And Non-Conservative Tracers: Insights And Implications Drawn From Study At The Taupo Volcanic Zone (New Zealand) And Valles Caldera (Usa), Joshua Michael Blackstock

Graduate Theses and Dissertations

Hydrothermal systems constitute an important component of heat and mass transport within Earth’s crust having direct and indirect impacts to society. Investigating contemporary hydrochemical differences and change are critical to evaluating and deconvolving factors that influence geothermal systems through time. In this dissertation, groundwater mixing approaches were used to study hydrochemical differences in two globally significant hydrothermal areas, which included fabrication of a low-cost dissolved CO2 monitoring for dissolved inorganic carbon (DIC). In the Taupo Volcanic Zone (New Zealand), empirical spatial relations were used to derive low-temperature groundwater end-members of Cl and Cl/Br for end-member mixing analysis (EMMA). Using EMMA, …


Rotational Tuning Of Transmembrane Helix Properties Based On The Precise Placements Of Aromatic And Charged Residues, Matthew J. Mckay Dec 2019

Rotational Tuning Of Transmembrane Helix Properties Based On The Precise Placements Of Aromatic And Charged Residues, Matthew J. Mckay

Graduate Theses and Dissertations

Designed model transmembrane peptides and oriented 2H and 15N solid-state nuclear magnetic resonance (NMR) spectroscopy were used to analyze how simple sequence modifications can influence peptide structure, behavior and dynamics as well as for determining the pKa of glutamic acid at the membrane interface. The GW5,19ALP23 (acetyl-GGALW(LA)6LWLAGA-amide) peptide framework adopts a well-defined tilted orientation in lipid bilayers (DLPC, DMPC and DOPC) and undergoes low amounts of dynamic motion. The sequence was initially modified by moving the Trp residues outwards to positions 4 and 20. This new sequence GW4,20ALP23 (acetyl-GGAW(AL)7AWAGA-amide) displays high amounts of signal averaging of NMR observables caused by …


The Feedback-Related Negativity Is A Time-Dependent Brain Mechanism That Facilitates Aversive Learning: Implications For The Reinforcement Learning Frn Hypothesis, Eric Rawls Dec 2019

The Feedback-Related Negativity Is A Time-Dependent Brain Mechanism That Facilitates Aversive Learning: Implications For The Reinforcement Learning Frn Hypothesis, Eric Rawls

Graduate Theses and Dissertations

Organisms encode rewarding and aversive experiences through reinforcement learning, capitalizing on prediction errors (PEs), which adapt action strategies over time. Computational theories are explicit that PE signals should update action weights continuously over the course of a behavioral task, an important time-dependent variation that is eschewed in traditional neuroscience studies that average over large numbers of trials. I examined variation in reaction times and feedback-locked cortical activity over time as a function of PE to critically examine theories indicating that PE signals drive time-dependent learning. We recorded EEG while participants completed a novel reinforcement task that varied prediction error on …


Interfacial Contact With Noble Metal - Noble Metal And Noble Metal - 2d Semiconductor Nanostructures Enhance Optical Activity, Ricardo Raphael Lopez Romo Dec 2019

Interfacial Contact With Noble Metal - Noble Metal And Noble Metal - 2d Semiconductor Nanostructures Enhance Optical Activity, Ricardo Raphael Lopez Romo

Graduate Theses and Dissertations

Noble metal nanoparticles and two-dimensional (2D) transition metal dichalcogenide (TMD) crystals offer unique optical and electronic properties that include strong exciton binding, spin-orbital coupling, and localized surface plasmon resonance. Controlling these properties at high spatiotemporal resolution can support emerging optoelectronic coupling and enhanced optical features. Excitation dynamics of these optical properties on physicochemically bonded mono- and few-layer TMD crystals with metal nanocrystals and two overlapping spherical metal nanocrystals were examined by concurrently (i) DDA simulations and (ii) far-field optical transmission UV-vis spectroscopic measurements. Initially, a novel and scalable method to unsettle van der Waals bonds in bulk TMDs to prepare …


Understanding And Controlling Lithium Microstructure During Electroplating For Energy Applications, Yang Tian Dec 2019

Understanding And Controlling Lithium Microstructure During Electroplating For Energy Applications, Yang Tian

Graduate Theses and Dissertations

Lithium-ion batteries are reaching the specific theoretical capacity limit, while lithium metal batteries are regarded as the ideal energy storage system for the next generation “beyond lithium-ion” battery systems. The lithium metal anode is considered as the “Holy grail” of anodes due to its relatively low electrochemical potential (-3.04 V vs SHE) and high theoretical capacity (3860 mAh g-1). However, the application of lithium metal anodes is hindered because of significant reaction between metallic lithium and electrolytes, as well as uneven electro-plating, which leads to dendrite formation, causing safety problems.

The kinetic parameters of Li ions such as diffusion coefficient …


Surface Modification Of Pvdf Membranes For Treating Produced Waters By Direct Contact Membrane Distillation, Zahra Anari Dec 2019

Surface Modification Of Pvdf Membranes For Treating Produced Waters By Direct Contact Membrane Distillation, Zahra Anari

Graduate Theses and Dissertations

Direct contact membrane distillation is a promising unit operation for treating hydraulic fracturing flow back and produced water. However, while a hydrophobic membrane is essential to prevent the passage of water from the feed to the permeate side, fouling by dissolved organic species can compromise membrane performance and result in wetting of the membrane pores. Here four monomers, hydroxyethylmethacrylate, acrylic acid, 1-vinyl-3-allylimidazolium bromide, and 1-vinyl-3-hexylimidazolium bromide have been grafted from the surface of a PVDF membrane. The modified and base membranes were tested in a direct contact membrane distillation system. All membranes were challenged with real produced water. In addition, …


Fractional Order State Feedback Control For Improved Lateral Stability Of Semi-Autonomous Commercial Heavy Vehicles, Rasheed Mazen Abdulkader Dec 2019

Fractional Order State Feedback Control For Improved Lateral Stability Of Semi-Autonomous Commercial Heavy Vehicles, Rasheed Mazen Abdulkader

Graduate Theses and Dissertations

With the growing development of autonomous and semi-autonomous large commercial heavy vehicles, the lateral stability control of articulated vehicles have caught the attention of researchers recently. Active vehicle front steering (AFS) can enhance the handling performance and stability of articulated vehicles for an emergency highway maneuver scenario. However, with large vehicles such tractor-trailers, the system becomes more complex to control and there is an increased occurrence of instabilities. This research investigates a new control scheme based on fractional calculus as a technique that ensures lateral stability of articulated large heavy vehicles during evasive highway maneuvering scenarios. The control method is …


Theoretical Investigations Of The Electronic, Magnetic, And Thermoelectric Properties Of Transition-Metal Based Compounds, Haleoot Edaan Raad Dec 2019

Theoretical Investigations Of The Electronic, Magnetic, And Thermoelectric Properties Of Transition-Metal Based Compounds, Haleoot Edaan Raad

Graduate Theses and Dissertations

The electronic, magnetic, and thermoelectric properties of transition-metal based compounds were investigated by using the density functional theory and Boltzmann transport formalism. It was found that the Co-based Heusler compounds and InSe monochalcogenide are among the materials that may be used for future thermoelectric devices. Furthermore, the investigation showed that the quaternary Heusler compounds, such as, CoFeYGe, where Y is Ti or Cr, are half-metallic ferromagnetic materials with full electron spin polarization. The lattice thermal conductivity (κL) was found to decrease for these alloys as the temperature increases. The present investigation indicated that the phonon optical modes have a major …


Observable Persistent Effects Of Habitat Management Efforts In The Ozark Highlands After 10 Years, Maxwell Carnes-Mason Dec 2019

Observable Persistent Effects Of Habitat Management Efforts In The Ozark Highlands After 10 Years, Maxwell Carnes-Mason

Graduate Theses and Dissertations

I investigated the lasting impacts of a management plan designed to improve oak regeneration and benefit wildlife in the Ozark Highlands in Madison, Co., AR. To assess the efficacy of the management plan, I used variables relevant to the success and establishment of oak trees. Controlled burns and selective logging were used to thin the canopy, increase ground level productivity, and increase the abundance of small mammals. I used measurements of overstory and understory densities, light availability, and the density of mice in the genus Peromyscus across time to look at the lasting impacts of management. Different treatment plots were …


Sentiment Analysis, Quantification, And Shift Detection, Kevin Labille Dec 2019

Sentiment Analysis, Quantification, And Shift Detection, Kevin Labille

Graduate Theses and Dissertations

This dissertation focuses on event detection within streams of Tweets based on sentiment quantification. Sentiment quantification extends sentiment analysis, the analysis of the sentiment of individual documents, to analyze the sentiment of an aggregated collection of documents. Although the former has been widely researched, the latter has drawn less attention but offers greater potential to enhance current business intelligence systems. Indeed, knowing the proportion of positive and negative Tweets is much more valuable than knowing which individual Tweets are positive or negative. We also extend our sentiment quantification research to analyze the evolution of sentiment over time to automatically detect …


Asymmetric Synthesis Of The C29-C34 Moiety Of Fragment A Of The Antascomicin B & Thermal Azole Based Claisen Rearrangements, Dharma Theja Nannapaneni Dec 2019

Asymmetric Synthesis Of The C29-C34 Moiety Of Fragment A Of The Antascomicin B & Thermal Azole Based Claisen Rearrangements, Dharma Theja Nannapaneni

Graduate Theses and Dissertations

The dissertation describes asymmetric synthesis towards C29-C34 moiety of fragment A of the Antascomicin B and Thermal azole based Claisen rearrangements. In chapter 1, we describes asymmetric synthesis towards C29-C34 moiety of fragment A of the Antascomicin B. The non-immunosuppressant Rapamycin, Ascomycin, and Tacrolimus (FK506), strongly binds with FKBP12, the ligand FKBP12 complexes responsible for immunosuppressive activity. Antascomicin B structurally related to Rapamycin, Ascomycin, and Tacrolimus (FK506), binds strongly to FKBP12, yet does not shown immunosuppressive activity. The ligand FKBP12 binding complexes shown to have potent neuroprotective and neurogenerative properties in mouse models of Parkinson’s disease. The linear synthesis of …


Probing Of Carbohydrate-Protein Interactions Using Galactonoamidine Inhibitors, Jessica B. Pickens Dec 2019

Probing Of Carbohydrate-Protein Interactions Using Galactonoamidine Inhibitors, Jessica B. Pickens

Graduate Theses and Dissertations

Glycoside hydrolases are ubiquitous and one of the most catalytically proficient enzymes known, and thus understanding their mechanisms are crucial. Most research has focused on the interaction of the glycon of substrates and their inhibitors within the active site of glycoside hydrolases. The inhibitors employed to probe these interactions generally had small aglycons (i.e. a hydrogen atom, amidines, small aliphatic groups, or benzyl groups). Here, the interactions of the aglycon with glycoside hydrolases are examined by probing the active sites with a library of 25 galactonoamidines. The studies described in this dissertation aim to increase the understanding of stabilization of …