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2019

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Pp13 The Nhs Pathways (Nhsp) Medical Call Triage System And New ‘Nature Of Call’ Telephone Screening Tool, Employed Prior To Nhsp, Can Accurately Identify High Acuity Patients: Analysis Of Sensitivity And Specificity Using Routine Ambulance Service Data, J Green, S Ewings, R Wortham, B Walsh Jan 2019

Pp13 The Nhs Pathways (Nhsp) Medical Call Triage System And New ‘Nature Of Call’ Telephone Screening Tool, Employed Prior To Nhsp, Can Accurately Identify High Acuity Patients: Analysis Of Sensitivity And Specificity Using Routine Ambulance Service Data, J Green, S Ewings, R Wortham, B Walsh

School of Health Professions

BackgroundThe NHS Pathways (NHSP) medical call triage system is employed by UK ambulance services. One function is to identify a broad category of ‘high-acuity calls’, distinguishing them from those that do not require an emergency response. A new pre-triage screening tool, Nature of Call (NoC), designed to augment NHSP could be employed as a rapid initial sieve of broad acuity.ObjectivesTo identify the accuracy of NHSP (and NoC) in recognising patients who require an emergency ambulance response (and therefore those who may not).MethodsDiagnostic accuracy. The sample is a retrospective cohort of consecutive calls, over a 4 month period, to a UK …


Evaluation Of A Countywide Alternative To Qof, Aimed At Improving Person-Centred Coordinated Care, J Close, B Fosh, R Byng, R Blackwell, L Witts, L Hall, H Lloyd Jan 2019

Evaluation Of A Countywide Alternative To Qof, Aimed At Improving Person-Centred Coordinated Care, J Close, B Fosh, R Byng, R Blackwell, L Witts, L Hall, H Lloyd

Peninsula Medical School

No abstract provided.


Hemizygous Uba5 Missense Mutation Unmasks Recessive Disorder In A Patient With Infantile-Onset Encephalopathy, Acquired Microcephaly, Small Cerebellum, Movement Disorder And Severe Neurodevelopmental Delay, Karen J. Low, J. Baptista, M. Babiker, R. Caswell, C. King, S. Ellard, I. Scurr Jan 2019

Hemizygous Uba5 Missense Mutation Unmasks Recessive Disorder In A Patient With Infantile-Onset Encephalopathy, Acquired Microcephaly, Small Cerebellum, Movement Disorder And Severe Neurodevelopmental Delay, Karen J. Low, J. Baptista, M. Babiker, R. Caswell, C. King, S. Ellard, I. Scurr

Peninsula Medical School

Introduction Ubiquitin-fold modifier 1 (UFM1) is involved in the post-translational modification of proteins and has been implicated in various human diseases (Padala et al., 2017). UFM1 is ubiquitously expressed and has been demonstrated to play a crucial role in cellular stress response and has also been implicated in cancer pathways (Daniel and Liebau, 2014). However the role of the UFM1 cascade in the nervous system is not well understood. In order for proteins to be modified by ufmylation, UFM1 must first be activated by UBA5, a non-canonical E1 activating enzyme, then transferred to an E2 enzyme (UFC1 in the case …


Book Review: Jonathan P. Thompson, River Of Lost Souls: The Science, Politics, And Green Behind The Gold King Mine Disaster (2018), Clifford J. Villa Jan 2019

Book Review: Jonathan P. Thompson, River Of Lost Souls: The Science, Politics, And Green Behind The Gold King Mine Disaster (2018), Clifford J. Villa

Faculty Scholarship

On August 5, 2015, contractors for the U.S. Environmental Protection Agency (EPA) investigating the Gold King Mine in southwestern Colorado accidently released some three million gallons of contaminated water into the Animas River, triggering weeks of front-page headlines, months of congressional hearings, and now years of litigation. River of Lost Souls: The Science, Politics, and Greed Behind the Gold King Mine Disaster, a new book by Jonathan P. Thompson, suggests by its title a human folly behind this “disaster” much broader and deeper than one tragic accident wrought by EPA contractors. On this thesis, Thompson certainly delivers. However, what …


Can A State's Water Rights Be Damned? Environmental Flows And Federal Dams In The Supreme Court, Reed D. Benson Jan 2019

Can A State's Water Rights Be Damned? Environmental Flows And Federal Dams In The Supreme Court, Reed D. Benson

Faculty Scholarship

Interstate rivers are subject to the doctrine of equitable apportionment, whereby the Supreme Court seeks to ensure that all states that share such rivers get a fair portion of their benefits. The Court has rarely issued an equitable apportionment decree, however, and there is little law on whether the doctrine protects river flows for environmental purposes. The ongoing Florida v. Georgia litigation in the Supreme Court raises this issue, as Florida seeks to limit consumptive uses by upstream Georgia to preserve flows in the Apalachicola River, which provide both economic and environmental benefits. This Article summarizes both the equitable apportionment …


It’S Still Me: Safeguarding Vulnerable Transgender Elders, Sarah Steadman Jan 2019

It’S Still Me: Safeguarding Vulnerable Transgender Elders, Sarah Steadman

Faculty Scholarship

Transgender individuals have many reasons to be concerned about their welfare in the current political and legislative climate. Transgender elders are especially vulnerable. They are more likely to be disabled than the general elder population. Moreover, transgender elders profoundly fear a future when they must rely on others to maintain and protect their gender identity and dignity. This fear is alarmingly realistic because if a transgender elder becomes incapacitated or requires institutional care, they are likely to face discrimination and other harms by their caretakers. In addition, transgender elders who are incapacitated are particularly at-risk if a non-affirming guardian is …


Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson Jan 2019

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …


Motion In The Ocean – Paradigm Shift In Movement Ecology Requires “Sedentary” Organisms To Be Redefined, Emma V. Sheehan Jan 2019

Motion In The Ocean – Paradigm Shift In Movement Ecology Requires “Sedentary” Organisms To Be Redefined, Emma V. Sheehan

School of Biological and Marine Sciences

No abstract provided.


The Importance Of Inter‐Individual Variation In Predicting Species' Responses To Global Change Drivers, Ella Guscelli, John I. Spicer, Piero Calosi Jan 2019

The Importance Of Inter‐Individual Variation In Predicting Species' Responses To Global Change Drivers, Ella Guscelli, John I. Spicer, Piero Calosi

School of Biological and Marine Sciences

No abstract provided.


Efficacy Of Non-Pharmacological Interventions To Treat Malnutrition In Older Persons: A Systematic Review And Meta-Analysis. The Senator Project Ontop Series And Manuel Knowledge Hub Project., Andrea Correa-Pérez, Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Groot Lcpgm De, Van Der Schueren Mae De, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O'Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J.Cruz Jentoft Jan 2019

Efficacy Of Non-Pharmacological Interventions To Treat Malnutrition In Older Persons: A Systematic Review And Meta-Analysis. The Senator Project Ontop Series And Manuel Knowledge Hub Project., Andrea Correa-Pérez, Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Groot Lcpgm De, Van Der Schueren Mae De, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O'Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J.Cruz Jentoft

School of Health Professions

INTRODUCTION: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body …


Early Hour, Golden Hour: An Exploration Of Slovenian Older People’S Meaningful Occupations, Tanja Križaj, Anne Roberts, Alison Warren, Anita Slade Jan 2019

Early Hour, Golden Hour: An Exploration Of Slovenian Older People’S Meaningful Occupations, Tanja Križaj, Anne Roberts, Alison Warren, Anita Slade

School of Health Professions

No abstract provided.


Dietary Intake Of Inorganic Nitrate In Vegetarians And Omnivores And Its Impact On Blood Pressure, Resting Metabolic Rate And The Oral Microbiome, Ann Ashworth, Craig Clarke, Garry Farnham, Luke Liddle, Mia Burleigh, Ana Rodiles, Carla Sillitti, Michele Kiernan, Melanie Moore, Mary Hickson, Chris Easton, Raul Bescos Jan 2019

Dietary Intake Of Inorganic Nitrate In Vegetarians And Omnivores And Its Impact On Blood Pressure, Resting Metabolic Rate And The Oral Microbiome, Ann Ashworth, Craig Clarke, Garry Farnham, Luke Liddle, Mia Burleigh, Ana Rodiles, Carla Sillitti, Michele Kiernan, Melanie Moore, Mary Hickson, Chris Easton, Raul Bescos

School of Health Professions

No abstract provided.


Pre-Intermediate Accounting, Natasha Ware Jan 2019

Pre-Intermediate Accounting, Natasha Ware

Syllabus Repository

No abstract provided.


Accounting Internship, Christopher M. Fairchild Jan 2019

Accounting Internship, Christopher M. Fairchild

Syllabus Repository

No abstract provided.


Accounting Internship, Christopher M. Fairchild Jan 2019

Accounting Internship, Christopher M. Fairchild

Syllabus Repository

No abstract provided.


An Improved Prediction Of The Effective Range Of Stress Intensity Factor In Fatigue Crack Growth, B Yang, Mn James, Y Huang, Jm Vasco-Olmo, Fa Díaz Jan 2019

An Improved Prediction Of The Effective Range Of Stress Intensity Factor In Fatigue Crack Growth, B Yang, Mn James, Y Huang, Jm Vasco-Olmo, Fa Díaz

School of Engineering, Computing and Mathematics

No abstract provided.


Coexistence And The Niche In A Nurse-Cactus Interaction: Is Cyclic Dynamics Justified?, Arnoldo Flores-Torres, Carlos Montaña, Miguel Franco Jan 2019

Coexistence And The Niche In A Nurse-Cactus Interaction: Is Cyclic Dynamics Justified?, Arnoldo Flores-Torres, Carlos Montaña, Miguel Franco

School of Biological and Marine Sciences

1. The interaction between the nurse plant Larrea tridentata and the cacti Cylindropuntia leptocaulis is thought to follow cyclical-replacement dynamics. However, the required changing nature of their interaction, from facilitation to competition, has not been investigated through their full life cycle. 2. In order to test the hypothesised cyclical dynamics, we compared the demography of four sub-populations (LA = Larrea associated to Cylindropuntia; CA = Cylindropuntia associated to Larrea, LS = solitary Larrea; CS = solitary Cylindropuntia) in the Mapimí Biosphere Reserve, Mexico, over the period 2008-2015. This allowed us to compare their demography at varying levels of the generally …


An Investigation Of Reliability Of The Sunderland Tracheosophageal Voice Perceptual Scale., Margaret M. Coffey, Neil Tolley, David Howard, Mary Hickson Jan 2019

An Investigation Of Reliability Of The Sunderland Tracheosophageal Voice Perceptual Scale., Margaret M. Coffey, Neil Tolley, David Howard, Mary Hickson

School of Health Professions

BACKGROUND: The Sunderland Tracheosophageal Voice Perceptual scale (SToPS) is the only perceptual rating scale designed specifically for tracheosophageal voice [Hurren et al.: Clin Otolaryngol. 2009 Dec; 34(6): 533-8]. OBJECTIVE: To investigate the inter rater reliability of the SToPS when analyzing alaryngeal voice. METHODS: Prospective evaluation of inter rater reliability of the SToPS based on audio recordings of 230 voice samples from 41 laryngectomy patients rated by 3 experts. Interval data were analyzed using intraclass correlation coefficients (ICC) while categorical data were analyzed using Kappa. RESULTS: ICC of above 0.6 was observed between raters for each prosthesis on a majority of …


Primary Care Models For Community-Dwelling Adults With Long-Term Conditions: A Scoping Review Protocol, Samantha Whiting, David Robertson, Katrina Bannigan Jan 2019

Primary Care Models For Community-Dwelling Adults With Long-Term Conditions: A Scoping Review Protocol, Samantha Whiting, David Robertson, Katrina Bannigan

School of Health Professions

No abstract provided.


Mitochondrial Integrity In Neurodegeneration, Katrina Cowan, Oleg Anichtchik, Shouqing Luo Jan 2019

Mitochondrial Integrity In Neurodegeneration, Katrina Cowan, Oleg Anichtchik, Shouqing Luo

Peninsula Medical School

No abstract provided.


From Mental Disorder To Shared Understanding: A Non-Categorical Approach To Support Individuals With Distress In Primary Care, Richard Byng, Nora Groos, Christopher Dowrick Jan 2019

From Mental Disorder To Shared Understanding: A Non-Categorical Approach To Support Individuals With Distress In Primary Care, Richard Byng, Nora Groos, Christopher Dowrick

Peninsula Medical School

This article argues that, rather than aiming for a psychiatric diagnosis, generalist professionals such as those working in primary care, as well as in other hospital and community settings, should use a non-diagnostic framework when encountering distress. The conceptual and empirical limitations of the psychiatric diagnostic system and evidence that psychological phenomena are dimensional suggest the need for an alternative approach; one that might also address problems of overdiagnosis and overmedication.1 There are three key problems with the current Diagnostic Statistical Manual (DSM) and International Classification of Diseases (ICD) systems of psychiatric classification. The process can be stigmatising; diagnoses are …


Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng Jan 2019

Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng

Peninsula Medical School

No abstract provided.


Deterrence And Prevention-Based Model To Mitigate Information Security Insider Threats In Organisations, N Safa, C Maple, Sm Furnell, M Azad, C Perera, M Dabbagh Jan 2019

Deterrence And Prevention-Based Model To Mitigate Information Security Insider Threats In Organisations, N Safa, C Maple, Sm Furnell, M Azad, C Perera, M Dabbagh

School of Engineering, Computing and Mathematics

Previous studies show that information security breaches and privacy violations are important issues for organisations and people. It is acknowledged that decreasing the risk in this domain requires consideration of the technological aspects of information security alongside human aspects. Employees intentionally or unintentionally account for a significant portion of the threats to information assets in organisations. This research presents a novel conceptual framework to mitigate the risk of insiders using deterrence and prevention approaches. Deterrence factors discourage employees from engaging in information security misbehaviour in organisations, and situational crime prevention factors encourage them to prevent information security misconduct. Our findings …


Towards Simulated Morality Systems: Role-Playing Games As Artificial Societies, J Casas-Roma, M Nelson, J Arnedo-Moreno, S Gaudl, R Saunders Jan 2019

Towards Simulated Morality Systems: Role-Playing Games As Artificial Societies, J Casas-Roma, M Nelson, J Arnedo-Moreno, S Gaudl, R Saunders

School of Engineering, Computing and Mathematics

No abstract provided.


‘I Cried Too’ – Allowing Icu Nurses To Grieve When Patients Die, R Endacott Jan 2019

‘I Cried Too’ – Allowing Icu Nurses To Grieve When Patients Die, R Endacott

School of Nursing and Midwifery

No abstract provided.


Machine Learning Methods In Predicting Chemotherapy-Induced Neutropenia In Oncology Patients Using Clinical Data, Alexander Holborow, Bryony Coupe, Mark Davies, Shangming Zhou Jan 2019

Machine Learning Methods In Predicting Chemotherapy-Induced Neutropenia In Oncology Patients Using Clinical Data, Alexander Holborow, Bryony Coupe, Mark Davies, Shangming Zhou

School of Nursing and Midwifery

No abstract provided.


The Effect Of Communication And Vehicle Properties On The Search Performance Of A Swarm Of Unmanned Aerial Vehicles, Jenna E. Newcomb, Andrew Ning Jan 2019

The Effect Of Communication And Vehicle Properties On The Search Performance Of A Swarm Of Unmanned Aerial Vehicles, Jenna E. Newcomb, Andrew Ning

Faculty Publications

An unmanned aerial vehicle (UAV) swarm allows for a more time-efficient method of searching a specified area than a single UAV or piloted plane. There are a variety of factors that affect how well an area is surveyed. We specifically analyzed the effect both vehicle properties and communication had on the swarm search performance. We used non-dimensionalization to examine the effect vehicle properties had on search performance so the results can be applied to any domain size with any number and type of vehicle. We found that even if vehicles could only sense 10% of the grid area at any …


Best Practices For Wake Model And Optimization Algorithm Selection In Wind Farm Layout Optimization, Nicholas F. Baker, Andrew P.J. Stanley, Jared J. Thomas, Andrew Ning, Katherine Dykes Jan 2019

Best Practices For Wake Model And Optimization Algorithm Selection In Wind Farm Layout Optimization, Nicholas F. Baker, Andrew P.J. Stanley, Jared J. Thomas, Andrew Ning, Katherine Dykes

Faculty Publications

This paper presents the results of two case studies regarding the wind farm layout optimization problem. We asked members of the computational optimization and wind communities to take part in the studies that we designed. Nine individuals participated. Case study 1 considered variations in optimization strategies for a given simple Gaussian wake model. Participants were provided with a wake model that outputs annual energy production (AEP) for an input set of wind turbine locations. Participants used an optimization method of their choosing to find an optimal wind farm layout. Case study 2 looked at trade-offs in performance resulting from variation …


Comparison Of Wind Farm Layout Optimization Results Using A Simple Wake Model And Gradient-Based Optimization To Large-Eddy Simulations, Jared J. Thomas, Jennifer Annoni, Paul Fleming, Andrew Ning Jan 2019

Comparison Of Wind Farm Layout Optimization Results Using A Simple Wake Model And Gradient-Based Optimization To Large-Eddy Simulations, Jared J. Thomas, Jennifer Annoni, Paul Fleming, Andrew Ning

Faculty Publications

The models used during wind farm layout optimization use simplifying assumptions that can alter the design space. Some characteristics of the simple models may negatively influence the resulting layouts. In this paper, we perform wind farm layout optimization using a simple wake model and compare the resulting improvements to large-eddy simulation (LES) results to confirm that the layout was actually improved. We begin by describing the models used, including changes specific for use with gradient-based optimization. We then compare our models’ output to previously published model and LES results. Using the models described, we performed gradient-based wind farm layout optimization …


Beyond English Only: Addressing Language Interpretation In Professional Psychology Training, Timothy B. Smith, Clay A. Frandsen, Derek Griner, Domenech Rodriguez, Guillermo Bernal Jan 2019

Beyond English Only: Addressing Language Interpretation In Professional Psychology Training, Timothy B. Smith, Clay A. Frandsen, Derek Griner, Domenech Rodriguez, Guillermo Bernal

Faculty Publications

Professional guidelines direct that psychologists working with clients with limited English proficiency should involve an interpreter if a mental health professional fluent in the client’s language is unavailable. However, complexities of interpreted therapy require training. We describe nine relevant areas of trainee skill acquisition and also surveyed 102 multicultural course instructors in APA-accredited psychology programs regarding current professional training. Only 55 (54%) instructors reported providing any training on working with language interpreters, with 16 (16%) providing more than 2 hours of training. Instructors ranked nine proposed skill areas and gave recommendations for over coming barriers and working with interpreters to …