Digital Commons Network^™

Use Of Antibiotics And Its Association With Wheezing, Bacterial Resistance And Virulence, Daleniece Higgins

Electronic Theses and Dissertations Archive

The discovery of antibiotics was one of the greatest advancements in medicine, reducing mortality and increasing life expectancy. Unfortunately, the widespread use of antibiotics has adverse side effects that are not yet fully understood. Our purpose in this research was to explore areas lacking in data to bring new information to the forefront in terms of antibiotic use and resistance to create awareness and increase measures of control and management of antibiotic use. To do this, we first investigated the relationship between wheezing and antibiotic use during pregnancy. Then, we examine a broader issue of antibiotic resistance and its effects …

Investigating The Impacts Of The Fungal Pathogen, Batrachochytrium Dendrobatidis, On Growth, Behavior, And Reproductive Investment In Salamanders, Bailey Patillo

Electronic Theses and Dissertations Archive

Amphibians are declining globally, with the fungal pathogen Batrachochytrium dendrobatidis (Bd) implicated as a contributing factor. Bd infects keratinized tissue of amphibians, including the skin of post-metamorphic individuals. Susceptibility to Bd varies among species, with many carrying sublethal infections, which can alter growth, behavior, and reproduction. The goals of these experiments were to determine the impact that Bd has on growth and body condition, feeding behavior, performance, and reproductive investment in salamanders with sublethal infections. The impacts of Bd infection on growth were assessed in post-metamorphic spotted salamanders (Ambystoma maculatum). They were monitored for 12 weeks, and the amount of …

A Failed Water Intervention In The Haitian Central Plateau, Christine M. Platt

Electronic Theses and Dissertations Archive

Secular and non-secular mission efforts to developing countries continue to grow and voluntourism is at an all-time high. The literature is corpulent with examples of failed mission health interventions. However, a noticeable gap exists of studies that address conflict leading to intervention failures as a result of intercultural communication. The purpose of this exploratory is to better understand intercultural communication challenges existing in short-term medical missions (STMMs) by better understanding the lived experience of participants of a clean water intervention in the Haitian Central Plateau. The intervention was planned and executed after the devastating 2010 earthquake and resulting cholera outbreak. …

Cultural Practices And The Transmission Of Ebola In Sierra Leone: Lessons Learned From A Medical Anthropology Perspective, Abubakarr Jalloh

Dissertations and Theses @ UNI

The link between culture and infectious diseases has long been established. This is primarily due to the notion that culture shapes and influences people’s beliefs, actions, and ways of life. Such beliefs and their accompanying actions ultimately contribute to people’s risk of contracting an infectious disease. As such, there is a need for a cultural perspective in understanding infectious diseases because human behavior plays a significant role in the emergent, transmission, and spread of such diseases. This study explores the cultural practices that may have contributed to the transmission of Ebola Virus Disease (EVD) in Sierra Leone during the 2013-2016 …

Intertwined Strands For Ecology In Planetary Health, Pierre Horwitz, Margot W. Parkes

Research outputs 2014 to 2021

Ecology is both blessed and burdened by romanticism, with a legacy that is multi-edged for health. The prefix ‘eco-’ can carry a cultural and political (subversive) baggage, associated with motivating environmental activism. Ecology is also practiced as a technical ‘science’, with quantitative and deterministic leanings and a biophysical emphasis. A challenge for planetary health is to avoid lapsing into, or rejecting, either position. A related opportunity is to adopt ecological thought that offers a rich entrance to understanding living systems: a relationality of connectedness, interdependence, and reciprocity to understand health in a complex and uncertain world. Planetary health offers a …

Diagnostic Clinical Foundations, Steelman Library, Megan Wagner

Syllabus Repository

No abstract provided.

Population Data Centre Profile - The Western Australian Data Linkage Branch, Steve Hodges, Tom Eitelhuber, Alexandra Merchant, Janine Alan

Research outputs 2014 to 2021

Established in 1995, the Western Australian Data Linkage Branch (DLB) is Australia’s longest running data linkage agency. The Western Australian Data Linkage System (WADLS) employs an enduring linkage model spanning over 60 data collections supported by internally developed and supported software and IT infrastructure. DLB has delivered, and continues to deliver, a range of significant data linkage innovations, many of which have been adopted elsewhere. A current restructure within the Western Australian Department of Health (which we will refer to as the Department of Health) will provide an improved funding model geared toward addressing issues with staff retention, capacity and …

Dna Methylation Of The Clusterin Promoter: Associations With Alzheimer’S Disease Risk And Related Phenotypes, Madeline Peretti

Theses: Doctorates and Masters

Background

In 2017 approximately 50 million people worldwide were living with dementia. With Alzheimer’s disease (AD), accounting for 50-70% of dementia cases making this debilitating disease, with no current effective prevention, treatment or cure, a critical healthcare concern. Genome wide association studies (GWAS) have identified a number of risk genes for late onset AD (LOAD); Apolipoprotein E (APOE), a gene involved in the cholesterol/lipid pathway is considered the gene with the greatest risk. The third most associated AD risk gene is Clusterin (CLU), is also involved in the cholesterol/lipid pathway. CLU has been implicated in both …

Privacy-Preserving Attribute-Based Keyword Search In Shared Multi-Owner Setting, Yibin Miao, Ximeng Liu, Robert H. Deng, Robert H. Deng, Jjguo Li, Hongwei Li, Jianfeng Ma

Research Collection Yong Pung How School Of Law

Ciphertext-Policy Attribute-Based Keyword Search (CP-ABKS) facilitates search queries and supports fine-grained access control over encrypted data in the cloud. However, prior CP-ABKS schemes were designed to support unshared multi-owner setting, and cannot be directly applied in the shared multi-owner setting (where each record is accredited by a fixed number of data owners), without incurring high computational and storage costs. In addition, due to privacy concerns on access policies, most existing schemes are vulnerable to off-line keyword-guessing attacks if the keyword space is of polynomial size. Furthermore, it is difficult to identify malicious users who leak the secret keys when more …

Different Molecular Characteristics And Antimicrobial Resistance Profiles Of Clostridium Difficile In The Asia-Pacific Region, Yun Luo, Elaine Cheong, Qiao Bian, Deirdre A. Collins, Julian Ye, Jeong Hwan Shin, Wing Cheong Yam, Tohru Takata, Xiaojun Song, Xianjun Wang, Mini Kamboj, Thomas Gottlieb, Jianmin Jiang, Thomas V. Riley, Yi-Wei Tang, Dazhi Jin

Research outputs 2014 to 2021

Molecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence typing (ST) and antimicrobial susceptibility testing. Totally, 394 isolates were collected from Hangzhou, Hong Kong, China; Busan, South Korea; Fukuoka, Japan; Singapore; Perth, Sydney, Australia; New York, the United States. C. difficile isolates included 337 toxin A-positive/B-positive/binary toxin-negative (A+B+CDT-), 48 A-B+CDT-, and nine A+B+CDT+. Distribution of dominant STs varied geographically with ST17 in Fukuoka (18.6%), Busan …

The Association Between Normal Bmi With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation, Di Liu, Qihuan Li, Jing Dong, Dong Li, Xizhu Xu, Weijia Xing, Xiaoyu Zhang, Weijie Cao, Haifeng Hou, Hao Wang, Manshu Song, Lixin Tao, Xiaoping Kang, Qun Meng, Wei Wang, Xiuhua Guo, Youxin Wang

Research outputs 2014 to 2021

Background: The mechanism by which normal body mass index (BMI) with central adiposity (NWCA) increases the risk of the diseases has not been completely elucidated. The inflammatory role of immunoglobulin G (IgG) N-glycosylation in obesity defined by BMI or central adiposity defined by waist-to-hip ratio (WHR) was reported, respectively. We undertook this three-center cross-sectional study to determine the association between the IgG N-glycans and NWCA. Methods: The participants were categorized into four different phenotypes: normal BMI with normal WHR (NW), normal BMI with central adiposity (NWCA), obesity with normal WHR (ONCA) and obesity with central adiposity (OCA). The …

Summary Of Aboriginal And Torres Strait Islander Health Status 2018, Australian Indigenous Healthinfonet, Millie Harford-Mills, Andrea Macrae, Neil Drew

Research outputs 2014 to 2021

This latest Summary of Aboriginal and Torres Strait Islander health provides an up-to-date, plain language summary of the health of Aboriginal and Torres Strait Islander people. It includes Aboriginal and Torres Strait Islander-specific information on:

• population
• births
• deaths
• common health conditions
• key health risk and protective factors.

The Summary has been prepared by the HealthInfoNet as part of its effort to help 'close the gap' by providing the evidence base to inform practice and policy in Aboriginal and Torres Strait Islander health. The Summary aims to make this information available to all people, including those without a specialised knowledge …

The Detection Of Cmv In Saliva Can Mark A Systemic Infection With Cmv In Renal Transplant Recipients, Shelley Waters, Silvia Lee, Megan Lloyd, Ashley Irish, Patricia Price

Research outputs 2014 to 2021

Human cytomegalovirus (CMV) is often transmitted through saliva. The salivary gland is a site of CMV replication and saliva can be used to diagnose congenital CMV infections. CMV replication is monitored in whole blood or plasma in renal transplant recipients (RTR) and associates with clinical disease. However, these assays may not detect replication in the salivary gland and there is little data linking detection in saliva with systemic infection and clinical sequelae. RTR (n = 82) were recruited > 2 years after transplantation. An in-house quantitative PCR assay was used to detect CMV UL54 in saliva samples. CMV DNA was …

Recurrence Of Clostridium Difficile Infection In The Western Australian Population, M. Alfayyadh, Deirdre A. Collins, S. Tempone, R. Mccann, P. K. Armstrong, Thomas V. Riley, A. Cook

Research outputs 2014 to 2021

Clostridium difficile, the most common cause of hospital-associated diarrhoea in developed countries, presents major public health challenges. The high clinical and economic burden from C. difficile infection (CDI) relates to the high frequency of recurrent infections caused by either the same or different strains of C. difficile. An interval of 8 weeks after index infection is commonly used to classify recurrent CDI episodes. We assessed strains of C. difficile in a sample of patients with recurrent CDI in Western Australia from October 2011 to July 2017. The performance of different intervals between initial and subsequent episodes of CDI was investigated. …

The Global Preclinical Antibacterial Pipeline, Ursula Theuretzbacher, Kevin Outterson, Aleks Engel, Anders Karlén

Faculty Scholarship

Antibacterial resistance is a great concern and requires global action. A critical question is whether enough new antibacterial drugs are being discovered and developed. A review of the clinical antibacterial drug pipeline was recently published, but comprehensive information about the global preclinical pipeline is unavailable. This Review focuses on discovery and preclinical development projects and has found, as of 1 May 2019, 407 antibacterial projects from 314 institutions. The focus is on Gram-negative pathogens, particularly bacteria on the WHO priority bacteria list. The preclinical pipeline is characterized by high levels of diversity and interesting scientific concepts, with 135 projects on …

Comparative Assessment Of Methicillin Resistant Staphylococcus Aureus Diagnostic Assays For Use In Resource-Limited Settings, A. Ayebare, Lisa M. Bebell, Joel Bazira, S. Ttendo, V. Katawera, David Bangsberg, Mark J. Siedner, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: The rise of methicillin-resistant Staphylococcus aureus(MRSA) is a global health concern. Paucity of data on MRSA carriage prevalence and diagnostic methods in resource-limited settings hampers efforts to define the problem and plan an appropriate response. Additionally, high variability in cost and logistical characteristics of MRSA screening methods may impede infection control efforts. We compared the performance of locally-available chromogenic agar BD CHROMagar MRSA II and two PCR-based assays (Hain GenoQuick MRSA and Cepheid Xpert SA Complete) for the detection of asymptomatic MRSA carriage in nasal swabs.

Results: During 2015, we enrolled 500 patients from five hospital …

Antibiotic Prescribing Without Documented Indication In Ambulatory Care Clinics: National Cross Sectional Study, Michael J. Ray, Gregory B. Tallman, David T. Bearden, Miriam R. Elman, Jessina C. Mcgregor

OHSU-PSU School of Public Health Faculty Publications and Presentations

To identify the frequency with which antibiotics are prescribed in the absence of a documented indication in the ambulatory care setting, to quantify the potential effect on assessments of appropriateness of antibiotics, and to understand patient, provider, and visit level characteristics associated with antibiotic prescribing without a documented indication.

Cardiovascular Risk Factors Associated With Venous Thromboembolism, John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Carlos J. Crespo, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Importance It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).

Objective To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.

Design, Setting, and Participants This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February …

Law, Technology And Patient Safety, Kathryn Zeiler, Gregory Hardy

Faculty Scholarship

Medical error is the third leading cause of death in the United States, In an effort to increase patient safety, various regulatory agencies require reporting of adverse events, but reported counts tend to be inaccurate. In 2005, in an effort to reduce adverse event rates, Congress proposed a list of “never events,” adverse events, such as wrong-site surgery, that should never occur in hospitals, and authorized CMS to refuse payment for care required following such events. CMS has since pushed for further regulation, “such as putting more payment at risk, increasing transparency, increasing frequency of quality data reviews, and stepping …

Art Adherence And Viral Suppression Are High Among Most Non-Pregnant Individuals With Early-Stage, Asymptomatic Hiv Infection: An Observational Study From Uganda And South Africa, Jessica E. Haberer, Bosco M. Bwana, Catherine Orrell, Stephen Asiimwe, Gideon Amanyire, Nicholas Musinguzi, Mark J. Siedner, Lynn T. Matthews, Alexander Tsai, Ingrid T. Katz, Kathleen Bell, Annet Kembabazi, Stephen Mugisha, Victoria Kibirige, Anna Cross, Nicola Kelly, Bethany Hedt-Gauthie, David R. Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction

The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS‐free generation depend on high adherence in individuals initiating ART during early‐stage HIV infection; however, adherence may be difficult in the absence of illness and associated support.

Methods

From March 2015 to October 2017, we prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non‐pregnant women with early‐stage HIV infection (CD4 > 350 cells/μL), pregnant women with early‐stage HIV infection and men and non‐pregnant women with late‐stage HIV infection (CD4 < 200 cells/μL). Socio‐behavioural questionnaires were administered and viral loads were performed at 0, 6 and 12 months. Adherence was monitored electronically.

Results

Adherence data were available for 869 participants: 322 (37%) early/non‐pregnant, …

Timing Of Antiretroviral Therapy And Systemic Inflammation In Sub-Saharan Africa: Results From The Meta Longitudinal Cohort Study, Mark J. Siedner, Bosco M. Bwana, Stephen Asiimwe, Gideon Amanyire, Nicholas Musinguzi, Jose R. Castillo-Mancilla, Russell P. Tracy, Ingrid T. Katz, David Bangsberg, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/μL) or late-stage disease (CD4 T-cell count <200/ μL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in latestage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.

Monitored Indoor Environmental Quality Of A Mass Timber Office Building: A Case Study, Jason Stenson, Suzanne L. Ishaque, Aurélie Laguerre, Andrew Loia, Georgia Maccrone, Ignace Mugabo, Dale Northcutt, Mariapaola Riggio, Andre Barbosa, Elliott T. Gall, Kevin Van Den Wymelenberg

Mechanical and Materials Engineering Faculty Publications and Presentations

A broad range of building performance monitoring, sampling, and evaluation was conducted periodically after construction and spanning more than a year, for an occupied office building constructed using mass timber elements such as cross-laminated timber (CLT) floor and roof panels, as well as glue-laminated timber (GLT) beams and columns. This case study contributes research on monitoring indoor environmental quality in buildings, describing one of the few studies of an occupied mass timber building, and analyzing data in three areas that impact occupant experience: indoor air quality, bacterial community composition, and floor vibration. As a whole, the building was found to …

The Effect Of Interval Intensity On Time To Exhaustion During High Intensity Interval Training (Hiit) Running In Recreational Male Runners, Andrew M. Hahn

Cal Poly Humboldt theses and projects

High Intensity Interval Training (HIIT) has become extremely popular in recent years, however, current HIIT prescriptions lack guidelines regarding interval intensities and associated margins. The purpose of this study is to investigate Run Time to Exhaustion (Te) and provide insight regarding HIIT intensities for future aerobic exercise programming. Ten healthy adult male recreational runners (Age=22.9 ± 2.5 yr., Ht=1.72 ± 0.1m, BM=74.1 ± 7.4 kg) measured maximal oxygen consumption (VO2max) (52.4 ± 6.1ml/kg/min) with a graded exercise test (GXT). Running speed was determined using ACSM running equation for exercise metabolism. Protocols 1-3 were HIIT running sessions, and Protocol 4 was …

State Benchmark Plan Coverage Of Opioid Use Disorder Treatments And Services: Trends And Limitations, Stacey A. Tovino

Scholarly Works

Professor Tovino offers a survey of state benchmark plan coverage of opioid use disorder treatments and services, and identifies trends and limitations relevant thereto. Part II of the article provides background information regarding opioid use disorder and the treatments and services available for individuals with this disorder. Part III reviews federal mental health parity law and federal mandatory mental health and substance use disorder law as applied to insurance coverage of treatments and services for opioid use disorder, with a focus on the Affordable Care Act's (ACA's) state benchmark health plan selection requirement and the effect on that requirement of …

Going Rogue: Mobile Research Applications And The Right To Privacy, Stacey A. Tovino

Scholarly Works

This Article investigates whether nonsectoral state laws may serve as a viable source of privacy and security standards for mobile health research participants and other health data subjects until new federal laws are created or enforced. In particular, this Article (1) catalogues and analyzes the nonsectoral data privacy, security, and breach notification statutes of all fifty states and the District of Columbia; (2) applies these statutes to mobile-app-mediated health research conducted by independent scientists, citizen scientists, and patient researchers; and (3) proposes substantive amendments to state law that could help protect the privacy and security of all health data subjects, …

Seasonal Patterns In Risk Factors For Taenia Solium Transmission: A Gps Tracking Study Of Pigs And Open Human Defecation In Northern Peru, Ian W. Pray, Claudio Muro, Ricardo Gamboa, Percy Vilchez, Wayne Wakeland, William Pan, William E. Lambert, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Taenia solium (cysticercosis) is a parasitic cestode that is endemic in rural populations where open defecation is common and free-roaming pigs have access to human feces. The purpose of this study was to examine the roaming patterns of free-range pigs, and identify areas where T. solium transmission could occur via contact with human feces. We did this by using GPS trackers to log the movement of 108 pigs in three villages of northern Peru. Pigs were tracked for approximately six days each and tracking was repeated in the rainy and dry seasons. Maps of pig ranges were analyzed for …

Protocol For A Longitudinal Study To Evaluate The Use Of Tenofovir-Based Prep For Safer Conception And Pregnancy Among Women In South Africa, Lynn T. Matthews, Manjeetha Jaggernath, Yolandie Kriel, Patricia Smith, Kasey O’Neil, David Bangsberg, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction Women who choose to conceive a baby with a partner living with HIV or a partner whose HIV serostatus is unknown in HIV-endemic settings need prevention strategies to mitigate HIV acquisition during conception and pregnancy.

Methods and analysis We are conducting a single-arm longitudinal study offering oral tenofovirdisoproxil fumarate/emtricitabine (TDF/FTC) as pre-exposure prophylaxis (PrEP) for periconception use to 350 HIV-uninfected women in KwaZulu-Natal, South Africa. PrEP is offered as part of woman-centred safer conception programme that promotes couples-based HIV counselling and testing, antiretroviral therapy for partners who are HIV-infected, treatment for sexually transmitted infections and safer conception strategies, such …

Digital Monitoring Technologies Could Enhance Tuberculosis Medication Adherence In Uganda: Mixed Methods Study, Angella Musiimenta, Wilson Tumuhimbise, Aaron T. Mugaba, Conrad Muzoora, Mari Armstrong-Hough, David Bangsberg, J. Lucian Davis, Jessica E. Haberer

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Effective administration of tuberculosis therapy remains challenging. The recommended strategy of direct observed therapy is challenging and its implementation has been limited in many settings. Digital adherence technologies could be promising patient-centered strategies for monitoring adherence. However, few quality studies have assessed patients’ experiences with these technologies. Objective: To explore TB patients’ perceptions of a digital adherence intervention composed of a digital adherence monitor and SMS texts. Methods: We purposively sampled TB patients who owned phones, had been taking TB medication for at least a month, and were receiving their treatment from Mbarara Regional Referral Hospital. We interviewed 35 …

Words Matter: Putting An End To “Unsafe” And “Risky” Sex, Julia L. Marcus, Jonathan Snowden

OHSU-PSU School of Public Health Faculty Publications and Presentations

Change is constant in sexual health, as in health care more broadly. Novel pathogens are identified, epidemics emerge and reemerge, and new preventive and therapeutic agents are introduced and taken up by populations. On the other hand, some care strategies and practices fall by the wayside among clinicians and populations. Just as health and health care evolve, so too should the language that we use to describe them.

In this commentary, we express our concerns about the use of ambiguous and stigmatizing language when describing sexual behavior. A search on PubMed in September 2019 yielded over four thousand articles with …

Development Of Information Diffusion Models Based On Mathematical Models Of Disease Diffusion, Farzaneh Fazli Dr, Seyyed Aliakbar Famil-Rohani Dr, Alireza Isfandyari-Mogaddam Dr, Manoochehr Karami Dr

Library Philosophy and Practice (e-journal)

Abstract

Purpose: Analysis of information diffusion process based on models of spread of epidemics is one of the issues considered by the researchers. Limited studies have addressed investigation and analysis of scientific information diffusion. Current study was conducted aiming at identifying scientific information diffusion process among academic faculty members using mathematical models of spread of diseases during 2016.

Methodology: Mathematical models of spread of epidemics including SIS, SI, and SIR models were used for analysis of scientific information diffusion. The study was conducted using semi-experimental method on 147 faculty members in three stages including evaluation of current status …