Digital Commons Network^™

Modulation Of Inflammatory Cytokine, Chemokine, And Toll-Like Receptor Genes And Transcriptome Analysis Of Equine Endothelial Cells Following Infection With Equid Herpesvirus-1, And Equine Arteritis Virus., Saranajith Wangisa Dunuwille

Theses and Dissertations--Veterinary Science

EHV-1 is a double-stranded DNA virus whereas EAV is a positive sense, single-stranded RNA virus. Therefore, genetically, they are very different from one another. However, both these viruses are endotheliotropic and thus, infect and replicates in equine endothelial cells resulting in vasculitis. Vasculitis is central to the pathogenesis of these two viruses. Thus, the main objective of this thesis was to investigate the inflammatory and innate immune responses of EECs that contribute towards the development of vasculitis following infection with EHV-1 and EAV in-vitro. Since proinflammatory cytokines and chemokines produced by endothelial cells play a significant role in the …

Mechanisms Of Type-I Ifn Inhibition: Equine Herpesvirus-1 Escape From The Antiviral Effect Of Type-1 Interferon Response In Host Cell, Fatai S. Oladunni

Theses and Dissertations--Veterinary Science

Equine herpesvirus-1 (EHV-1) is one of the most important and prevalent viral pathogens of horses causing a major threat to the equine industry throughout most of the world. EHV-1 primarily causes respiratory disease but viral spread to distant organs enables the development of more severe sequelae; abortion and neurologic disease. In order to produce disease, EHV-1 has to overcome the innate barrier of the type-I interferon (IFN) system in host cells. However, the underlying mechanisms employed by EHV-1 to circumvent the type-I IFN response in host cells are not well understood. In this project study, using molecular techniques, we explored …

California Livestock Owners: An Assessment Of Familiarity With New Antimicrobial Rules And Access To Educational Outreach, Philip Theodor Paulson

Master's Theses

The purpose of this research is to support the California Department of Food & Agriculture (CDFA) with education and outreach about recent changes regarding antimicrobial use in livestock, and to enhance their emergency communications network. This was done by characterizing a population of small-scale livestock owners underserved with regards to educational outreach about animal health issues, such as antimicrobial use rules. The project also seeks to enhance public understanding of the importance of responsible antimicrobial use in animal and human health.

To accomplish this, the study used a survey administered in person at local farm supply stores and online to …

Perilous Passivity: The Insufficient Response To Antimicrobial Resistance, Matthew Gordon

Student Works

No abstract provided.

An Analysis Of The Morality Of The Orphan Drug Act And Its Effects On The Community Using Finnis' Ethical Values As Defined In Natural Law & Natural Rights, Kiersten Fowler

Student Works

No abstract provided.

The Model State Emergency Health Powers Act: Balancing Public Safety And Civil Liberties, Joseph Mishel

Student Works

No abstract provided.

New Epidemic Needs New Epidemiologic Thinking, Shirley Joann Smart, Aurela N. Nikaj, Carlene Robinson, Kadiatou Diallo, Sylvia Ofori, Neil Mistry, Jian Zhang

Eagles Talking About the Public’s Health

No abstract provided.

Economic Perspectives On Free Speech, Daniel Hemel

Public Law and Legal Theory Working Papers

The metaphor of a ‘marketplace of ideas’ has long pervaded discussions of free speech in and beyond the United States.¹ For early scholars of law and economics (L&E), the similarities and differences between the metaphorical marketplace for ideas and literal markets for goods and services were subjects of much attention. Aaron Director—the University of Chicago law professor who helped to found the L&E movement but rarely reduced his own ideas to writing— devoted one of his few published papers to the contrast between the laissez-faire approach to speech and command-and-control regulation of other markets in mid-twentieth century America.^{2 …}

The Effect Of Meloxicam On The Ability Of Neonatal Dairy Calves To Absorb Igg Provided By Colostrum Replacer, Meaghan O.C. Clark

Master's Theses and Capstones

The objective of this study was to determine the effect of meloxicam, administered either in pill form immediately prior to colostrum replacer (CR), or powder form, mixed in solution with CR, on the immunoglobulin G (IgG) uptake, growth, and health of pre-weaned calves. A pilot study considering the potential benefits of meloxicam in pre-weaned heifers indicated administration of the drug following difficult parturition improved body weight (BW) and overall health, but was not associated with passive transfer of immunity (Murray et al., 2015). However, calves from this study were sampled from 10 commercial farms, and therefore, treatment administration was inconsistent, …

The Effects Of Heat-Killed Echinostomatid Parasites On Mice Treated With Dextran Sodium Sulfate (Dss), Natalie Gooder

All Graduate Theses, Dissertations, and Other Capstone Projects

Objective: Autoimmune diseases are chronic, incurable, and affect approximately 50 million Americans. This is a strong need for better ways to treat autoimmune diseases. Parasites and parasite proteins have been observed to protect mice from symptoms of induced colitis in mice treated with dextran sodium sulfate (DSS), a model for inflammatory bowel disease (IBD). I hypothesize that non-living echinostomatid parasites, given during DSS treatment, can decrease intestinal inflammation and weight loss, providing a possible novel treatment for IBD.

Methods: A range of DSS concentrations (0.5%-3%) were delivered to female C57BL/6 mice in their drinking water in order to determine the …

Hydraulic Fracturing And Cause-Specific Mortality: A Multicity Comparative Epidemiological Study, Uzoma C. Nduka

Walden Dissertations and Doctoral Studies

Cause-specific mortality (CSM), among other global health estimates, has garnered prominence in the contemporary public health field. CSM has been associated with several factors, however, research comparing CSM for prefracking versus postfracking periods is sparse. Hydraulic fracturing or fracking is a technique of extracting oil and gas from deep underground. The purpose of this study was to evaluate the difference among mean CSM scores from 1975 through 2015 in the available cities and counties of residence in Colorado and to determine the impact of gender, marital status, county of residence, and city of residence on CSM scores (prefracking period 1975-1977 …

Filamentous Bacteriophage Associated With Shaping Community Structure And Fitness Of Invasive Vibrio Parahaemolyticus St36, Jillian Means

Master's Theses and Capstones

Vibrio parahaemolyticus a ubiquitous coastal inhabitant, is the leading cause of bacterial seafood-borne illnesses in the United States. An increasing number of reported cases and rapid expansion into new areas has led to the classification of V. parahaemolyticus as an emergent pathogen. Most strains of V. parahaemolyticus are not virulent; however, the spread of virulent lineages from their native ranges to new locations has contributed drastically to the increase in vibriosis attributed to V. parahaemolyticus in recent years. In the United States (US), sequence type (ST) 36, a virulent strain endemic to the Pacific Northwest (PNW), spread from its native …

Beta-Lactam Plus Macrolide Vs Fluoroquinolone For Empiric Therapy Of Hospitalized Patients With Cap: Results From The University Of Louisville Pneumonia Study, Vidyulata Salunkhe, Stephen P. Furmanek, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Background

Current guidelines recommend a β-lactam plus a macrolide or fluoroquinolone monotherapy as initial empiric antibiotic therapy for treatment of patients hospitalized with community-acquired pneumonia (CAP). Multiple studies have shown different results comparing the two regimens for the treatment of CAP. Our objective, in a city-wide prospective study, was to compare outcomes among hospitalized patients with CAP who received empiric treatment either with a β-lactam plus a macrolide or fluoroquinolone monotherapy.

Methods

This was a propensity score matched case-control study of the University of Louisville Pneumonia Study. It was a prospective population-based cohort study of all hospitalized adults with CAP. …

Clostridioides Difficile Infection In Chronic Kidney Disease/End-Stage Renal Disease, Mayur Ramesh, Jerry Yee

Nephrology Articles

Clostridioides difficile infection (CDI) is a major health-care burden and increasingly seen in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Increased antibiotic use, alteration in host defenses, and gastric acid suppression are some of the etiologies for increased risk of CDI in these populations. Patients with CKD/ESRD have a higher risk of initial episode, recurrence, and development of severe CDI than those without CKD or ESRD. Diagnosis and management of CDI in patients with CKD/ESRD are similar to that in the general population. The mortality, length of stay, and health-care costs are higher in patients with …

Impact Of Community Factors On The Donor Quality Score In Liver Transplantation, Giovanna Saracino

Walden Dissertations and Doctoral Studies

An increasing prevalence of metabolic syndrome and obesity has been linked to the rise in transplant indication for cryptogenic cirrhosis and nonalcoholic fatty liver disease (NAFLD), creating a growing challenge to public health. NAFLD liver transplant (LT) candidates are listed with low priority, and their waiting mortality is high. The impact of community/geographic factors on donor risk models is unknown. The purpose of this study was to develop a parsimonious donor risk-adjusted model tailored to NAFLD recipients by assessing the impact of donor, recipient, transplant, and external factors on graft survival. The theoretical framework was the social ecological model. Secondary …

Risk-Taking Behaviors Of First-Generation Sub-Saharan African-Born U.S. Resident Men, Henry K.J. Sinyangwe

Walden Dissertations and Doctoral Studies

African-born residents of the United States have a higher incidence of HIV than African Americans. Factors such as lifestyle, habits, behavior practices, and activities may predispose African-born residents to behave sexually in ways that place them at risk of becoming infected with HIV. This study used a qualitative narrative approach to understand the lived experiences first generation Sub-Saharan African-born men who are U.S. residents to analyze the behaviors that expose them to HIV. To analyze data, the study used the health-belief model as the conceptual framework and NVivo for data analysis to assist in identifying, categorizing, and analyzing common themes …

Social Networks And Sense Of Community Effects On Psychological Distress Among Community X Residents, Marci A. Salone

Walden Dissertations and Doctoral Studies

A certain community within the southern region of Texas has consistently been linked to escalating poverty, high crime rates, low educational achievement, and poor physical and mental health. For the purpose of this research, this community will be referred to as Community X. Although some researchers have found that sense of community and supportive social networks are associated with healthy mental and physical functioning, others have suggested that in a debilitated community social networks can facilitate psychological distress and a strong sense of community is difficult to develop. Guided by Bronfenbrenner's ecological model, the purpose of this quantitative correlational study …

Experiences And Attitudes Of Older Homeless Women Toward Healthcare Access, Mary Ann Mueller

Walden Dissertations and Doctoral Studies

Homelessness among older women is a growing problem in many metropolitan areas of the United States. Researchers have indicated that health issues and problems accessing basic care are connected. Older homeless women face increased health issues, multiple challenges related to accessing basic care, and low incomes which put them at higher risk of becoming homeless, staying homeless, and delaying medical treatment. The homeless who lack fulfillment of social support and timely medical care are considered repetitive users of the emergency department and hospital stays. The purpose of this phenomenological study was to explore the experiences and beliefs of older homeless …

African American Masculinity And Its Influence On Hypertension-Related Behaviors, Tangee Denise Thomas

Walden Dissertations and Doctoral Studies

High blood pressure (hypertension) is known to be one of the leading factors that directly contributes to heart disease and stroke, which are the first and third leading causes of disabilities and death in the general U.S. population. The prevalence of high blood pressure among African American men in the United States ranks as one of the highest in the world. Research indicates the roots of this phenomenon are found in physiological, psychosocial, cultural, and socioeconomic factors differentially affecting the African American population. The purpose of this study was to examine the interaction between African American males' masculine perspective and …

Knowledge, Attitudes, And Beliefs About Food Additives And Obesity, Lorna Theresa Ingram

Walden Dissertations and Doctoral Studies

Knowledge, Attitudes, and Beliefs about Food Additives and Obesity

by

Lorna Theresa Ingram

MS, Long Island University, 2007

BA, Florida International University, 1999

Dissertation Submitted in Partial Fulfillment

of the Requirements for the Degree of

Doctor of Philosophy

Walden University

November 2019

Obesity is a chronic health problem that affects the health and well being of its population. The purpose of this cross-sectional, descriptive study was to examine whether there is a relationship between individuals’ knowledge, attitudes, and beliefs regarding food additives and obesity. The research questions concerned knowledge, attitudes, and beliefs participants had regarding food additives and obesity. The …

Medicine@Yale February/March 2019 Volume 15, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale November/December 2019 Volume 15, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Florida Law, Mobile Research Applications, And The Right To Privacy, Stacey A. Tovino

Nova Law Review

No abstract provided.

Oyster-Associated Microbial Community Dynamics, Rebecca Jean Stevick

Open Access Dissertations

Oysters are keystone species in the coastal environment, providing ecological, economic, and cultural services. A significant ecosystem service is their ability to improve water quality by filtration and denitrification. These ecological functions are made possible by oyster-associated microbes, but may also be threatened by microbial pathogens. This positions the oyster as a model system for the study of marine host-associated microbial diversity and function. However, studies of microbial diversity and function in shellfish are lacking, particularly in response to environmental perturbations. As coastal ecosystems change due to anthropogenic impacts and climate variability, it is important to understand how the oyster …

Disease Ecology Of Two Emerging Amphibian Pathogens In Costa Rica, Felicity Jennifer Wynne

School of Biological and Marine Sciences Theses

The emergence of infectious diseases is increasing globally, whilst biodiversity is being lost at an unprecedented rate. The amphibian chytrid fungus (Batrachochytrium dendrobatidis) has driven the extinction of more species than any other known pathogen. This loss was particularly severe among Neotropical amphibians, with several infamous extinctions from Costa Rica. Although chytrid has been attributed to all enigmatic population declines in Costa Rica, its presence has only been investigated from a few populations. Alongside chytrid, another pathogen, ranavirus (Ranavirus spp.), is considered a significant threat to amphibian populations. Very little is known about ranaviruses outside of temperate regions, but its …

Exploring The Role And Impact Of Microscale Phenomena On Electrode, Microdevice, And Cellular Function, Sanaz Habibi

Dissertations, Master's Theses and Master's Reports

Microfluidic technologies enable the development of portable devices to perform multiple high-resolution unit operations with small sample and reagent volumes, low fabrication cost, facile operation, and quick response times. Microfluidic platforms are expected to effectively interpret both wanted and unwanted phenomena; however, a comprehensive evaluation of the unwanted phenomena has not been appropriately investigated in the literature. This work explored an attenuative evaluation of unwanted phenomena, also called here as secondary phenomena, in a unique approach.

Upon electric field utilization within microfluidic devices, electrode miniaturization improves device sensitivity. However, electrodes in contact with medium solution can yield byproducts that can …

Attitudes About Acceptable Risk In The Context Of The Biodiversity Crisis, Thomas Offer-Westort

Dissertations, Master's Theses and Master's Reports

Crafting and enforcing conservation policy requires making normative judgements about what levels of risk are acceptable. These judgements include crucial decisions that impact which species qualify as “endangered.” If a government’s policies are going to represent the values of the public they govern, then public attitudes should be understood. Unfortunately, essentially nothing is known about public attitudes as they pertain to acceptable risk and the biodiversity crisis.

My research aims to address this gap using data from an internet-based survey (n=1050). I focused on the Endangered Species Act of 1973 which defines an endangered species as “any species which is …

Effects Of Different Zinc Levels On Grain Yield And Some Phenological Characteristics Of Red Lentil (Lens Culinaris Medic.) Under Arid Conditions, Ayşe Gülgün Öktem

Turkish Journal of Agriculture and Forestry

This research aimed to determine the effects of different zinc (Zn) levels on the grain yield and some phenological characteristics of the Fırat-87 red lentil variety (Lens culinaris Medic.). The study was conducted during the winter months of 2013-2014 and 2014- 2015 in Zn-deficit areas of Şanlıurfa, Turkey. The experimental design was a randomized complete block design with 4 replicates. The Fırat-87 lentil variety and Zn sulfate (ZnSO4.7H2O) were used as the plant material and Zn source, respectively. The Zn levels used were the control (0 kg ha-1 Zn), 5 kg ha-1 Zn, 10 kg ha-1 Zn, 15 kg ha-1 …

Barriers To Vaccination Service Delivery Within General Practice: Opportunity To Make A Sustainable Difference In Aboriginal Child Health?, Rebecca Carman, Lesley Andrew, Amanda Devine, Jacques Oosthuizen

Research outputs 2014 to 2021

Objective: To identify behavioural barriers of service provision within general practice that may be impacting the vaccination coverage rates of Aboriginal children in Perth, Western Australia (WA). Methods: A purposive developed survey was distributed to 316 general practices across Perth and three key informant interviews were conducted using a mixed-methods approach. Results: Of the surveyed participants (n=101), 67.4% were unaware of the low vaccination coverage in Aboriginal children; 64.8% had not received cultural sensitivity training in their workplace and 46.8% reported having inadequate time to follow up overdue child vaccinations. Opportunistic vaccination was not routinely performed by 30.8% of participants. …

Eligibility And Patient Barriers To Peritoneal Dialysis In Patients With Advanced Chronic Kidney Disease, Saleem Mohamed Abdulkarim

Master of Medicine in Internal Medicine

Introduction: The burden of chronic kidney disease is on the rise in Kenya and is a significant cause of morbidity and mortality. While definitive treatment is renal transplantation, many patients require renal replacement therapy in the form of hemodialysis or peritoneal dialysis. The predominant modality utilized in Kenya is currently hemodialysis despite peritoneal dialysis having similar survival outcomes with the potential benefit of cost-effectiveness. There is need therefore to explore why peritoneal dialysis remains underutilized and whether patient factors may be contributory to barriers that limit the uptake of peritoneal dialysis. Purpose: The main objective of this study is to …