Digital Commons Network^™

Creating And Strengthening The Therapeutic System For Treatment Setting Serving Deaf Children, Asiah Mason, Matthew Mason, Earl T. Braxton

JADARA

Treating deaf children with severe emotional and behavior problems, especially in residential and alternative school treatment settings, is a demanding undertaking. Finding and retaining skilled mental health paraprofessionals are continual challenges faced by mental health service providers. These challenges are even greater when the children served are deaf, and when staff members are expected to be multilingual, be knowledgeable about deaf culture, and be able to treat children with a multitude of severe mental health disturbances. Staff members face the dilemma of both raising and treating children in the same setting with limited resources. Limited funding and limited service models …

Vol.47 N.19 November 28th 2019, Vocie Media Ventures

Black Voice News

No abstract provided.

Drug Interactions With Antimalarial Medications In Older Travelers: A Clinical Guide, Jelena Lewis, Tania Gregorian, Ivan Portillo, Jeff Goad

Pharmacy Faculty Articles and Research

Increasingly older adults are traveling to international destinations with malaria as a present risk. Surveillance systems indicate that older adults are more likely to suffer severe complications from malaria. The role of health care providers in selecting an appropriate medication for chemoprophylaxis or treatment of malaria in adults becomes more difficult as older adults undergo physiologic changes that alter the pharmacokinetic and pharmacodynamic nature of medications potentially causing increased drug interactions, adverse events, and altered drug action. A comprehensive literature search from 1970 to present, with a focus on the last 10 years, was conducted on drug interactions, pharmacokinetic and …

Improving Team-Based Decision Making Using Data Analytics And Informatics: Protocol For A Collaborative Decision Support Design, Don Roosan, Anandi Law, Mazharul Karim, Moom Roosan

Pharmacy Faculty Articles and Research

Background: According to the September 2015 Institute of Medicine report, Improving Diagnosis in Health Care, each of us is likely to experience one diagnostic error in our lifetime, often with devastating consequences. Traditionally, diagnostic decision making has been the sole responsibility of an individual clinician. However, diagnosis involves an interaction among interprofessional team members with different training, skills, cultures, knowledge, and backgrounds. Moreover, diagnostic error is prevalent in the interruption-prone environment, such as the emergency department, where the loss of information may hinder a correct diagnosis.

Objective: The overall purpose of this protocol is to improve team-based diagnostic …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern: Completes Molecular Survey Study for Pathogens and Markers of Pesticide Resistance in Human Head Lice from Madagascar
• Georgia Southern: Completes Pilot Survey of Mosquitos from Southeastern Georgia for Wolbachia and Rickettia felis

Juvenile Life Without Parole: How The Supreme Court Of Ohio Should Interpret Montgomery V. Louisiana, Grace O. Hurley

Cleveland State Law Review

Regardless of the numerous differences between juveniles and adults, some states, including the State of Ohio, continue to impose upon juvenile homicide offenders one of the harshest forms of punishment: life without parole. In 2016, the United States Supreme Court decided Montgomery v. Louisiana, and in doing so, the Court reiterated its previous contention that a sentence of juvenile life without parole should only be imposed upon juvenile homicide offenders whose crimes reflect "irreparable corruption." The Supreme Court of Ohio has yet to apply the Court’s Montgomery decision, but this Note suggests that if it does, the court should …

Using Community Pharmacy Immunization Screening Forms To Identify Potential Immunization Opportunities, Albert T. Bach, Jeffery A. Goad

Pharmacy Faculty Articles and Research

Immunization screening forms are completed for each patient that is to be vaccinated in the pharmacy. Screening forms contain demographic and health questions, which are used to determine if a patient is contraindicated to receive a vaccine. The objective is to determine if patient responses to questions on these forms can be used to identify potential vaccine indications. De-identified data was retrospectively collected from 11 community pharmacies in California and Michigan that included basic demographics, answers to immunization screening questions, and vaccine(s) administered during that visit. The Advisory Committee on Immunization Practices (ACIP) recommendations were used to forecast vaccine needs …

An Open Challenge To Advance Probabilistic Forecasting For Dengue Epidemics, Michael A. Johansson, Karyn M. Apfeldorf, Scott Dobson, Jason Devita, Anna L. Buczak, Benjamin Baugher, Linda J. Moniz, Thomas Bagley, Steven M. Babin, Erhan Guven, Teresa K. Yamana, Jeffrey Shaman, Terry Moschou, Nick Lothian, Aaron Lane

Journal Articles

A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide sufficient forecast skill to be useful. We developed an open collaborative forecasting challenge to assess probabilistic forecasts for seasonal epidemics of dengue, a major global public health problem. Sixteen teams used a variety of methods and data to generate forecasts for 3 epidemiological targets (peak incidence, the week of the …

Determining The Instructional Effectiveness Of Online Vaccine Education Modules: A Focus-Group Analysis, Sarah Williams, Shannon Clark, Sharon Humiston, Barbara Pahud, Donald Middleton, Kadriye O. Lewis

Manuscripts, Articles, Book Chapters and Other Papers

Vaccine education for pediatric and family medicine residents is inadequate. Implementation of evidence-based instructional design methods for medical education is understudied. We conducted four focus groups with residents who had completed a novel immunization curriculum to explore their satisfaction with design, content and impact on confidence. Data were analyzed using thematic content analysis. Overall satisfaction with the curriculum was high. Residents valued the interactive design and content, reported improvement in confidence in discussing vaccines with parents, and shared recommendations for future iterations of the modules. Technical challenges were reported with the learning management system. Medical education modules developed using best …

Entry By Multiple Picornaviruses Is Dependent On A Pathway That Includes Tnk2, Wasl, And Nck1, Hongbing Jiang, Christian Leung, Stephen Tahan, David Wang

Open Access Publications

Comprehensive knowledge of the host factors required for picornavirus infection would facilitate antiviral development. Here we demonstrate roles for three human genes,

Cardiac Dysfunction In Patients With Community-Acquired Pneumonia, Ehab Elmelegy, El-Saied Shaheen, Wael Hossam El Din

Journal of Medicine in Scientific Research

Background Community-acquired pneumonia (CAP) is still an important cause of morbidity and mortality worldwide especially in the elderly. Evidence shows a high correlation between acute respiratory infections and increased risk of cardiovascular events (CVEs). The occurrence of CVE in hospitalized patients with CAP may significantly affect the clinical status, and a severe CVE could be the primary cause of clinical failure. Aim To study the incidence of cardiac complications in patients with CAP. Patients and methods This clinical study was carried out on 120 patients (63 males and 57 females) hospitalized with a primary diagnosis of CAP. Patients with the …

Improving Medication Information Presentation Through Interactive Visualization In Mobile Apps: Human Factors Design, Don Roosan, Yan Li, Anandi Law, Huy Truong, Mazharul Karim, Jay Chok, Moom Roosan

Pharmacy Faculty Articles and Research

Background: Despite the detailed patient package inserts (PPIs) with prescription drugs that communicate crucial information about safety, there is a critical gap between patient understanding and the knowledge presented. As a result, patients may suffer from adverse events. We propose using human factors design methodologies such as hierarchical task analysis (HTA) and interactive visualization to bridge this gap. We hypothesize that an innovative mobile app employing human factors design with an interactive visualization can deliver PPI information aligned with patients’ information processing heuristics. Such an app may help patients gain an improved overall knowledge of medications.

Objective: The …

Picturing Health; Picturing Life: Visual Illness Narratives Of Women With Type 2 Diabetes, Sarah Gurley-Green

Educational Studies Dissertations

The prevalence of diabetes in the U.S. reached 23 million people between 2012 and 2017 and consumed one-quarter of the overall healthcare dollars. Remembering the suffering and pain of individuals behind these numbers becomes difficult and incalculable. Black American women are the most affected by type 2 diabetes (T2D), compared to their white counterparts, as well as twice as likely to be diagnosed with T2D and 2.5 times more likely to die from T2D. Therefore, understanding the problem requires the fundamental consideration of how these women cope daily with this complex illness while often struggling with complex lives. This narrative …

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis And Promotes Parasite Entry., Kamalakannan Vijayan, Igor Cestari, Fred D Mast, Elizabeth K K Glennon, Suzanne M Mcdermott, Heather S Kain, Alyssa M Brokaw, John D Aitchison, Kenneth Stuart, Alexis Kaushansky

Articles, Abstracts, and Reports

The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-associated membrane protein 1 (LAMP1) is increased. Lysosome exocytosis in infected cells occurs independently of sporozoite traversal. Instead, a sporozoite-secreted factor is sufficient for the process. Knockdown of SNARE proteins involved in lysosome-plasma membrane fusion reduces lysosome exocytosis and Plasmodium infection. In contrast, promoting fusion between the lysosome and plasma membrane dramatically increases infection. Our work demonstrates parallels between Plasmodium sporozoite entry of hepatocytes and infection …

Factors Affecting Acceptance Of At-Birth Point Of Care Hiv Testing Among Providers And Parents In Kenya: A Qualitative Study., Catherine Wexler, May Maloba, Melinda Brown, Natabhona Mabachi, Kathy Goggin, Brad Gautney, Beryne Odeny, Sarah Finocchario-Kessler

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: At-birth and point-of-care (POC) HIV testing are emerging strategies to streamline infant HIV diagnosis and expedite ART initiation for HIV-positive infants. The purpose of this qualitative study was to evaluate factors influencing the provision and acceptance of at-birth POC testing among both HIV care providers and parents of HIV-exposed infants in Kenya.

METHODS: We conducted semi-structured interviews with 26 HIV care providers and 35 parents of HIV-exposed infants (including 23 mothers, 6 fathers, and 3 mother-father pairs) at four study hospitals prior to POC implementation. An overview of best available evidence related to POC was presented to participants prior …

Single-Molecule Imaging Of Hiv-1 Envelope Glycoprotein Dynamics And Gag Lattice Association Exposes Determinants Responsible For Virus Incorporation, Nairi Pezeshkian, Nicholas S. Groves, Schuyler B. Van Engelenburg

Biological Sciences: Faculty Scholarship

The HIV-1 envelope glycoprotein (Env) is sparsely incorporated onto assembling virus particles on the host cell plasma membrane in order for the virus to balance infectivity and evade the immune response. Env becomes trapped in a nascent particle on encounter with the polymeric viral protein Gag, which forms a dense protein lattice on the inner leaflet of the plasma membrane. While Env incorporation efficiency is readily measured biochemically from released particles, very little is known about the spatiotemporal dynamics of Env trapping events. Herein, we demonstrate, via high-resolution single-molecule tracking, that retention of Env trimers within single virus assembly sites …

Chemical Tools And Treatments For Neurological Disorders And Infectious Diseases, Andrea Lemus

USF Tampa Graduate Theses and Dissertations

Neurological disorders have multiple etiologies such as genetics and age. Stress related disorders are becoming more common and diagnosed more often. Mental health disorders are no longer being treated as purely psychological. Mechanisms into the underlying factors of these disorders continue to bring this area to new frontiers. Chapter 2 of this dissertation focuses on the efforts made to prove the association of the protein FKBP51 to the stress response. We synthesized and used a molecular tool to discover and prove these interactions.

The study of neurodegenerative diseases is of continued importance as the world reaches record numbers of an …

Antarctic Deep Sea Coral And Tropical Fungal Endophyte: Novel Chemistry For Drug Discovery, Anne-Claire D. Limon

USF Tampa Graduate Theses and Dissertations

Considered the pulse controlling the biological interactions and contributing to the ecological survival of organisms, natural products have intrigued, challenged, and stimulated the scientific and non-scientific minds for millennia. Drug resistance and the lack of suitable potent drugs against neglected tropical diseases further motivate the biological activity assessment of these secondary metabolites, when possible.

This thesis describes the chemical investigation of two marine organisms and the elucidation of eight novel structures.

The study of a deep sea Antarctic coral unveils six novel terpenoid structures from three different molecular classes: sesquiterpenoid alcyopterosins, a triterpene steroid, and three prostaglandins. While mass availability …

Male Burmese Pythons Follow Female Scent Trails And Show Sex-Specific Behaviors, Shannon A. Richard, Eric A. Tillman, John S. Humphrey, Michael L. Avery, M. Rockwell Parker

United States Department of Agriculture Wildlife Services: Staff Publications

Animals communicate with potential mates using species-specific signals, and pheromones are powerful sexual signals that modify conspecific behavior to facilitate mate location. Among the vertebrates, snakes are especially adept in mate searching via chemical trailing, which is particularly relevant given that many snake species are invasive outside their native ranges. Chemical signals used in mate choice are, thus, potentially valuable tools for management of invasive snake species. The Burmese python (Python bivittatus) is an invasive snake in the Florida Everglades where it is negatively impacting native fauna. In this study, we sought to: (i) determine if males can follow conspecific …

Identification Of Human T Cell Biomarkers: A Gene Signature For Cd8 T Cell Exhaustion And Ultrasensitive Elisa Methods For Il-21, Joshua Poorbaugh

Open Access Dissertations

CD8 T cell exhaustion is the progressive, step-wise loss of T cell function due to persistent antigen stimulation. Given the importance of this phenomenon in sustaining chronic infections and preventing clearance of tumors, as well as potentially influencing autoimmune disorders, novel biomarkers must be established to monitor CD8 T cell exhaustion and the factors that influence its development (e.g. presence of CD4 helper cytokines, like IL-21). In this study, a six-day in vitro model of CD8 T cell exhaustion was characterized to evaluate the reduced functional capacity of these cells. Cells derived in this model possessed sustained inhibitory receptor expression …

The Fake News Phenomenon: Impact Of Heuristic Cues On Perceived Credibility And Sharing On Social Media, Khudejah Iqbal Ali

Open Access Dissertations

The growing global health threat of vaccine hesitancy is believed to be fueled by anti-vaccine movements around the world. Overall, the strong presence of anti-vaccination groups on the Internet, particularly social media, are important for bringing attention and attracting people to the cause. Such platforms are an ideal medium for the dissemination of anti-vaccination ideas, which often entail the spread of false or “fake” news and information questioning vaccine efficacy and safety. As this epidemic of online fake news is causing major disruptions in vaccine programs around the world, the current study employed the Heuristic Systematic model (HSM) to elucidate …

The Opioid Crisis Examined, Anatolly Zekhtser

BIO4960: Practicum in Biology I

The Opioid Crisis is a national crisis affecting public, social, and economic healthcare. Nearly 50,000 deaths were caused by opioid overdoses in 2017. Current treatments of opioid addictions include the use of methadone and buprenorphine. These medications have been known to reduce opioid dependency, lower tolerances, increase the opioid overdose threshold, and lower overdose mortality. An analysis was conducted on prominent research studies investigating the effectiveness, safety, side effects, and influence of Methadone and Buprenorphine. The meta-analysis confirmed that both drugs are effective opioid agonists that contribute to decreased opioid dependence and increased opioid abstinence. Due to a series of …

Variation In Host Home Range Size Decreases Rabies Vaccination Effectiveness By Increasing The Spatial Spread Of Rabies Virus, Katherine M. Mcclure, Amy T. Gilbert, Richard B. Chipman, Erin E. Rees, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

1. Animal movement influences the spatial spread of directly transmitted wildlife disease through host-host contact structure. Wildlife disease hosts vary in home range- associated foraging and social behaviours, which may increase the spread and intensity of disease outbreaks. The consequences of variation in host home range movement and space use on wildlife disease dynamics are poorly understood, but could help to predict disease spread and determine more effective disease management strategies.
2. We developed a spatially explicit individual-based model to examine the effect of spatiotemporal variation in host home range size on the spatial spread rate, persistence and incidence of rabies virus …

El Vph Y El Cáncer Cervical En El Perú: Diferencias De Accesibilidad Entre Las Mujeres De Las Zonas Rurales Y Urbanas / Hpv And Cervical Cancer In Peru: The Differences In Accessibility For Rural And Urban Women, Jemma Stratton

James Madison Undergraduate Research Journal (JMURJ)

Este informe examina el estado actual del tratamiento y prevención del VPH en el Perú, y pone énfasis con problemas específicas que han contribuido al riesgo alto de cáncer cervical entre las mujeres rurales. Perú ha tomado grandes pasos en las décadas últimas para establecer programas que se dirigen al VPH y la salud de las mujeres. Sin embargo, las mujeres peruanas tienen una población más probable para contraer cáncer cervical en el mundo. Este informe compara los esfuerzos de prevención del VPH entre las poblaciones rurales y urbanas en el Perú y identificar las barreras que causando esta crisis …

When The Injured Nurse Returns To Work: An Institutional Ethnography, Laurie Clune

Dissertations

Nursing is a high risk profession for injury. A Canadian survey reports many nurses are in poor physical and emotional health; they sustain more musculoskeletal and violence related injuries than other occupational groups. In Ontario, an injury management approach called Early Return to Work (RTW) requires injured workers, including nurses, to go back to work before full recovery. The Workplace Safety and Insurance Board cite this approach as beneficial to both the employer and employee. This study uses an institutional ethnographic approach to examine critically the RTW process from the standpoint of injured registered nurses. Through interviews and mapping activities …

Gravity As A Continuum: Effects Of Altered Gravity On Drosophila Melanogaster Immunity, Amber M. Paul, Joe Olivieri, Sharmila Bhattacharya

Publications

The impact of spaceflight on immune function is undoubtedly a critical focus in the area of space biology and human health research. Heat shock proteins (Hsp) are an evolutionarily conserved family of proteins that are expressed in response to cellular and physiological stressors, experienced during radiation exposure, confinement, circadian rhythm disruption, and altered gravity (hypergravity experienced at launch/landing and microgravity experienced in-flight). In particular, Hsp70 aids in the folding of proteins, facilitates the movement of proteins across the membranes during signal transductions and can stimulate innate immunity. Since Hsp70 is induced during cellular stress, and can act as a stimulator …

Modeled Microgravity Induces Neutrophil Extracellular Trap (Net)Osis Formation And Reduced Phagocytosis Of Polymorphonuclear Neutrophils, Amber M. Paul

Publications

Spaceflight can dysregulate immunity, by way of increasing granulocytes numbers with impaired function. Polymorphonuclear neutrophils (PMN) are granulocytes that are first responders to infection or injury, and consist of the largest pool of immune cells in humans. PMNs function during innate immunity, through phagocytosis and promotion of inflammation, via the release of reactive oxygen species (ROS) mediators and granule-containing enzymes, such as myeloperoxidase (MPO) and NADPH oxidase-2 (NOX-2). In addition, neutrophil extracellular trap (NET) formation is another mechanism of PMN surveillance that works independently of engulfment phagocytosis, and is a last resort function that can induce NETosis or PMN-specific cell …

Characterization Of Sensory And Shelter Enrichment In The Rodent Research Habitat, Amber M. Paul, Yasaman Shirazi-Fard, America Reyes, Moniece Lowe, Margareth Cheng-Campbell, Sungshin Choi, Eduardo Almeida, April Ronca, Ruth K. Globus

Publications

The ISS provides a platform for conducting Rodent Research (RR) in microgravity and 9 missions have been successfully conducted. The results from these experiments have begun to provide new insights into the effects of spaceflight on mammalian physiological systems. After RR-1-4, the Flight IACUC required inclusion of additional cage enrichment into the Rodent Habitats (RH) to “enhance animal well-being by providing animals with sensory and motor stimulation, through structures and resources that facilitate the expression of species typical behaviors”. A Hut, in the form of a rigid, mesh igloo-like shelter was implemented beginning with RR-5. The potential influence of the …

Determinants Of Campylobacter Infection And Association With Growth And Enteric Inflammation In Children Under 2 Years Of Age In Low-Resource Settings, Md Ahshanul Haque, James A. Platts-Mills, Estomih Mduma, Ladaporn Bodhidatta, Pascal Bessong, Sadia Shakoor, Gagandeep Kang, Margaret N. Kosek, Aldo A M Lima, Zulfiqar Ahmed Bhutta

Department of Pathology and Laboratory Medicine

Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1-24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, …

The Effects Of Forced Migration On The Houma Of Louisiana, Jessica R. Parfait

LSU Master's Theses

This thesis seeks to understand the effects of multiple forced migrations on the Indigenous Houma of southern Louisiana. The causes of these migrations have taken many forms such as the dispossession of land and relocating for access to resources. Through ethnographic interviews and historic research, I seek to critically engage the past to understand how it has molded the present and the lives of tribal citizens. I evaluate the power dynamics enacted upon the Houma who have recorded contact with Europeans dating to 1686 but have never been recognized as a sovereign entity by the United States.