Digital Commons Network^™

Dengue Fever Presenting As Quadriparesis Due To Hypokalaemia: A Rare Presentation, Syed Muhammad Zubair, Syed Ahsan Ali, Saira Furqan

Section of Internal Medicine

Dengue is one of the leading causes of arthropod borne viral haemorrhagic fever. Majority of the times, it clinically manifests as fever, arthralgia and rash; however, we present a case of a young man who presented with progressively increasing weakness of all four limbs. Initial investigations showed low potassium, hence he was managed as hypokalaemic periodic paralysis. With initial history of fever and low platelets, dengue was suspected. Dengue antibody was checked which came out to be positive. Potassium was replaced which led to improvement in power of his limbs. He was discharged in a stable condition with a diagnosis …

Diagnosis Of B-Cell Lymphoproliferative Disorder Through Concomitant Management Of Medication-Related Osteonecrosis Of The Jaw: A Case Report, Robert Diecidue, Allen F. Champion, Ruifeng Zhou, James G. Buckley

Department of Oral and Maxillofacial Surgery Faculty Papers

No abstract provided.

Evaluation Of Qualitative Phytochemical Analysis Of Water Extract Of Achyranthes Aspera And Achyranthes Aspera 30, Usha Kushwaha

Indian Journal of Research in Homoeopathy

Introduction: Plant sources are a valuable starting material for drug development. These plants are the potential therapeutic agents, which provide maximum benefits with minimum adverse effects. Objective: The objective of the study is to evaluate the qualitative phytochemical analysis of water extract of whole plant excluding root of Achyranthes aspera and 30 potency of the same drug. Methodology: The qualitative phytochemical analysis of water extract of whole plant excluding root of Achyranthes aspera and Achyranthes aspera 30 has been performed to confirm the presence of alkaloid, saponin, phenolic compound, carbohydrate and proteins. Physicochemical constants such as ash, extractive values and …

Adherence To International Guidelines For The Treatment Of Meningitis Infections In Lebanon, Sahar M. Haydar, Souheil R. Hallit, Rabih R. Hallit, Pascale R. Salameh, Lama J. Faddoul, Bahia Ag. Chahine, Diana N. Malaeb

Saudi Medical Journal

Objectives: To assess meningitis treatment in Lebanon’s compatibility with the Infectious Diseases Society of America (IDSA) guidelines and the effect of non-compliance on mortality. Methods: This is a retrospective study, conducted in 5 Lebanese hospitals, and enrolling all patients diagnosed with meningitis who presented to the involved hospitals from January 2008 to December 2016. Results: A total of 252 participants were enrolled in the study. Of these patients, 205 (82.7%) were diagnosed with viral meningitis and 47 (17.3%) with bacterial meningitis, which was confirmed using laboratory tests. For patients with viral meningitis, 128 (62.4%) remained on the initial prescribed antibiotics …

Diversity Of Resistance Mechanisms In Carbapenem-Resistant Enterobacteriaceae At A Health Care System In Northern California, From 2013 To 2016, Fiona Senchyna, Rajiv L. Gaur, Johanna Sandlund, Cynthia Truong, Guillaume Tremintin, Dietmar Kültz, Carlos A. Gomez, Fiona B. Tamburini, Tessa Andermann, Ami Bhatt, Isabella A. Tickler, Nancy Watz, Indre Budvytiene, Gongyi Shi, Fred C. Tenover, Niaz Banaei

Biology Faculty Publications

The mechanism of resistance in carbapenem-resistant Enterobacteriaceae (CRE) has therapeutic implications. We comprehensively characterized emerging mechanisms of resistance in CRE between 2013 and 2016 at a health system in Northern California. A total of 38.7% (24/62) of CRE isolates were carbapenemase gene-positive, comprising 25.0% (6/24) blaOXA-48 like, 20.8% (5/24) bla_KPC, 20.8% (5/24) bla_NDM, 20.8% (5/24) bla_SME, 8.3% (2/24) bla_IMP, and 4.2% (1/24) bla_VIM. Between carbapenemases and porin loss, the resistance mechanism was identified in 95.2% (59/62) of CRE isolates. Isolates expressing bla_KPC were 100% susceptible to ceftazidime–avibactam, meropenem–vaborbactam, …

Ethiopia’S High Childhood Undernutrition Explained: Analysis Of The Prevalence And Key Correlates Based On Recent Nationally Representative Data, Tafere Gebreegziabher Belay, Nigatu Regassa

All Faculty Scholarship for the College of the Sciences

Objective

To examine the contribution of child, maternal and household factors in stunting, wasting and underweight among children under 5 years in Ethiopia. Design

Quantitative cross-sectional design based on nationally representative data. Setting

Urban and rural areas of Ethiopia. Participants

Younger (0–24 months; n 4199) and older age groups (25–59 months; n 5497), giving a total of 9696 children. Results

Among the younger age group, 29 % were stunted, 14 % were wasted and 19 % were underweight; and among the older age group, the prevalence of stunting, wasting and underweight was 47, 8 and 28 %, respectively. Being female, …

An Iterative Process For Training Design And Implementation Increased Health Workers' Knowledge For Taking Nutrition Behavior Change To Scale, Wendy Gonzalez, Anabelle Bonvecchio Arenas, Armando García-Guerra, Mireya Vilar-Compte, Alejandría Villa De La Vega, Laura Quezada, Cynthia Rosas, Ana Lilia Lozada-Tequeanes, Amira Hernández

Department of Public Health Scholarship and Creative Works

The shortage of skilled, motivated, and well-supported health workers is a major barrier to scaling up nutrition interventions and services. Objective: The objective of this study is to describe the process for developing and implementing a training of health personnel for the delivery of the Integrated Strategy for Attention to Nutrition (EsIAN), an evidence-based strategy for promoting infant and young child feeding through primary health care in Mexico. The specific objective is to provide a case study and highlight challenges, as well as elements to successfully mitigate these, and discuss potential applications of findings beyond the Mexican context. Methods: The …

Beyond The Ethical Boundaries Of Solidarity: Increasing Vaccination Rates Through Mandatory Education To Solidarity, Nili Karako- Eyal Dr.

Texas A&M Law Review

Mandatory vaccination laws require children to be vaccinated against certain communicable diseases to attend school. These laws also provide exemptions to school vaccination requirements.1 All states exempt children from vaccination requirements for medical reasons, and most states also provide an exemption for religious and/or other personal reasons.2 Seven states include an educational component in their religious or philosophical exemption process, requiring that parents receive information regarding the benefits of vaccination and the risks of not being vaccinated.3 Of these seven states, five require that information regarding the social benefits of vaccination will be provided to parents.4

This type of legislation …

Affordable Housing: Of Inefficiency, Market Distortion, And Government Failure, Michael Diamond

University of Richmond Law Review

In this essay, I examine the types of costs that are imposed on society as a whole due to the absence of a sufficient number of decent housing units that are affordable to the low-income population. These costs present themselves in relation to health care, education, employment, productivity, homelessness, and incarceration. Some of the costs are direct expenditures while others are the result of lost opportunities. My hypothesis is that these costs are significant and offer, at the very least, a substantial offset to the cost of creating and subsidizing the operation of the necessary number of affordable housing units …

Ribosomally Synthesized And Post-Translationally Modified Peptides As Potential Scaffolds For Peptide Engineering, Devan Bursey

Theses and Dissertations

Peptides are small proteins that are crucial in many biological pathways such as antimicrobial defense, hormone signaling, and virulence. They often exhibit tight specificity for their targets and therefore have great therapeutic potential. Many peptide-based therapeutics are currently available, and the demand for this type of drug is expected to continue to increase. In order to satisfy the growing demand for peptide-based therapeutics, new engineering approaches to generate novel peptides should be developed. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of peptides that have the potential to be effective scaffolds for in vivo peptide engineering projects. These …

Antibiotics Resistance Among Clinical Isolates Of Staphylococcus Aureus, Pseudomonas Aeruginosa And Escherichia Coli, Mohammed Hayder Hashim, Marwa Hameed Alkhafaji

Al-Nisour Journal for Medical Sciences

The pattern of antibiotic susceptibility of nine isolate of (E. coli, P. aerugensa and S. aureus) to five antibiotics ceftazidime (CAZ), azithromycin (AZM), amoxicillin-clavulanate (AMC), ciprofloxacin (CIPR), and cefoxitin (CTX) was determined using disc diffusion method. The results showed that S. aureus isolates were 100% resistant all to antibiotics AMC, CAZ, CTX (Extended-spectrum β-lactamases). While 66.6% of isolates were AZM resistant and 33.3% of S. aureus isolates resist CIP. All E. coli isolate (100%) were resistant to (CTX and CAZ) and 66.6% of E. coli isolates were resistant to CIPR and AMC. P. aerugensa were 100% resistant to AMC and …

Species Specificity Between The Trematoda Fasciola Hepatica And The Molluscan Host, Ilham Abdulwahid Majeed

Al-Nisour Journal for Medical Sciences

Larval development of Fasciola hepatica in abnormal snail intermediate host Lymnaea palustris was studied. This incompatible host-parasite relationship was investigated under Transmission Electron Microscopy (TEM) to determine the fate of penetrated miracidia. It is believed that no larval development beyond the sporocyst was allowed to proceed by the defense system of L. palustris. This reaction was in the form of defense cell (haemocytes) aggregation around sporocyst. These haemocytes vary in appearance under TEM, some have a vary electron dense cytoplasm, others are much more electron lucid. These appeared to correspond to granulocytes and amoebocytes respectively, as described by other workers. …

Determining Levels Of Rheumatoid Factor (Rf) And C - Reactive Protein (Crp) In A Blood Sample Of Iraqi Patients With Rheumatoid Arthritis (Ra), Muataz Mohammed Al-Taee, Duaa Ibrahim Mohmood, Mayada Mahmood Muhammed

Al-Nisour Journal for Medical Sciences

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation and joint destruction. The aim of this study was to investigate levels of Rheumatoid factor (RF) and C- Reactive protein in Iraqi RA patients. Blood samples were obtained from 50 RA patients (males and females) referred to Rheumatology consultation clinic in Baghdad teaching hospital, Medical city, with a mean age of 40.88±18.75 years. On the other hand, blood samples were obtained from 50 healthy controls with a mean age of 38.90±14.73 years. Results showed that Rheumatoid factor (RF) was detected in all serum samples taken from RA patients …

Effect Of 10-Valent Pneumococcal Conjugate Vaccine On The Incidence Of Radiologically-Confirmed Pneumonia And Clinically-Defined Pneumonia In Kenyan Children: An Interrupted Time-Series Analysis, Micah Silaba, Michael Ooko, Christian Bottomley, Joyce Sande, Rachel Benamore, Kate Park, James Ignas, Kathryn Maitland, Neema Mturi, Anne Makumi

Imaging & Diagnostic Radiology, East Africa

Background: Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of pneumococcal disease in low-income and middle-income countries is dominated by pneumonia, most of which is non-bacteraemic. We examined the effect of 10-valent PCV on the incidence of pneumonia in Kenya.

Methods: We linked prospective hospital surveillance for clinically-defined WHO severe or very severe pneumonia at Kilifi County Hospital, Kenya, from 2002 to 2015, to population surveillance at Kilifi Health and Demographic Surveillance System, comprising 45000 children younger than 5 years. Chest radiographs were read according to a WHO standard. A …

Development Of A Real-Time Pcr Assay For Pneumocystis Jirovecii On The Luminex Aries® Platform, Subathra Marimuthu, Kuldeep Ghosh, Leslie A Wolf

The University of Louisville Journal of Respiratory Infections

Pneumocystis pneumonia (PCP) is an opportunistic infection caused by the fungus Pneumocystis jirovecii. Infection with P. jirovecii can result in serious illness in patients with a weakened immune system, and can lead to death if it is not properly diagnosed and treated. Direct detection of P. jirovecii in lower respiratory tract specimens such as bronchoalveolar lavage (BAL) is preferred for rapid diagnosis, a laboratory service currently not available locally. We report here the development of a diagnostic real-time Polymerase Chain Reaction (PCR) assay using BAL specimens to detect P. jirovecii. By targeting the multi-copy mitochondrial large subunit ribosomal …

Composure Behaviours Of Advanced Beginner Nurses And Their Effects On The Wellness Outcome Among Selected Orthopaedic Patients: Basis For Action Plans, Bea-Gracia M. Cruz

Dissertations

The study determined the effects of the COMPOSURE behaviours of advanced beginner nurses on the wellness outcome among selected orthopaedic patients and used quasi-experimental 2-group pretest posttest design.

Role Of L-Carnitine And Green Tea In Prevention Of Tilmicosin Induced Cardiotoxicity In Healthy Dogs: An Experimental Study, Mohamed Youssef, Dina El-Esseily

Mansoura Veterinary Medical Journal

Objective: The aim of the present study was to highlight on the effect of cardiotoxicity of Tilmicosin on dogs’ health as well as the advantages of protective doses of antioxidants on the incidence of cardiotoxicity. Design: Experimental study Animals: Twenty adult Mongerl dogs Procedures: were divided into 4 groups each group consisted of five dogs, the first group was considered to be the control negative, the second group was treated with a single injection of tilmicosin, the third group was treated with L.carnitine followed by single injection of tilmicosin, the fourth group was treated with green tea followed by single …

Survival Probability In Patients With Sickle Cell Anemia Using The Competitive Risk Statistical Model., Emilia Matos Do Nascimento, Clarisse Lopes De Castro Lobo, Basilio De Bragança Pereira, Samir K. Ballas

Cardeza Foundation for Hematologic Research

The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and followed at HEMORIO for 15 years were retrospectively collected and analyzed. Statistical modeling was performed using survival analysis in the presence of competing risks estimating the covariate effects on a sub-distribution hazard function. Eight models were implemented, one for each cause of death. The …

Covert Pathogenesis: Transient Exposures To Microbes As Triggers Of Disease, Nicole M. Gilbert, Amanda L. Lewis

Open Access Publications

No abstract provided.

The ‘Seven S’ Approach To Subject-Based Banding In Schools, David Chan

Research Collection School of Social Sciences

In an invited commentary, SMU Behavioural Sciences Institute Director Professor David Chan discussed the issues surrounding the replacement of streaming at secondary school with the subject-based banding system. He explained how we can approach issues by reflecting on what he called the "Seven S" elements of education.

The Demographic And Life-History Costs Of Fear: Trait-Mediated Effects Of Threat Of Predation On Aedes Triseriatus, Geoffrey D. Ower, Steven A. Juliano

Faculty Publications – Biological Sciences

1. Predators alter prey populations via direct lethality (density-mediated effects), but in many taxa, the indirect nonlethal threat of predation may be almost as strong an effect, altering phenotypically plastic traits such as prey morphology, behavior, and life history (trait-mediated effects). There are costs to antipredator defenses and the strength of prey responses to cues of predation likely depends on both the perceived level of risk and food availability.
2. The goal of this study was to test the hypothesis that the costs of nonlethal trait-mediated interactions impacting larvae can have carryover effects that alter life-history traits, adult characteristics, and ultimately population …

Probable Donor-Derived Human Adenovirus Type 34 Infection In 2 Kidney Transplant Recipients From The Same Donor., Matthew A. Pettengill, Tara M. Babu, Paritosh Prasad, Sally Chuang, Michael G. Drage, Marilyn Menegus, Daryl M. Lamson, Xiaoyan Lu, Dean Erdman, Nicole Pecora

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.

Effect Of Conditioning Regimen Dose Reduction In Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation., Claudio G. Brunstein, Marcelo C. Pasquini, Soyoung Kim, Mingwei Fei, Kehinde Adekola, Ibrahim A. Ahmed, Mahmoud Aljurf, Vaibhav Agrawal, Jeffrey J. Auletta, Minoo Battiwalla, Nelli Bejanyan, Joseph Bubalo, Jan Cerny, Lynette Chee, Stefan O. Ciurea, Cesar Freytes, Shahinaz M. Gadalla, Robert Peter Gale, Siddhartha Ganguly, Shahrukh K. Hashmi, Peiman Hematti, Gerhard Hildebrandt, Leona A. Holmberg, Oscar B. Lahoud, Heather Landau, Hillard M. Lazarus, Marcos De Lima, Vikram Mathews, Richard Maziarz, Taiga Nishihori, Maxim Norkin, Richard Olsson, Ran Reshef, Seth Rotz, Bipin Savani, Harry C. Schouten, Sachiko Seo, Baldeep M. Wirk, Jean Yared, Shin Mineishi, John Rogosheske, Miguel-Angel Perales

Manuscripts, Articles, Book Chapters and Other Papers

Data are limited on whether to adjust high-dose chemotherapy before autologous hematopoietic cell transplant (autoHCT) in obese patients. This study explores the effects of dose adjustment on the outcomes of obese patients, defined as body mass index (BMI) ≥ 30 kg/m2. Dose adjustment was defined as a reduction in standard dosing ≥20%, based on ideal, reported dosing and actual weights. We included 2 groups of US patients who had received autoHCT between 2008 and 2014. Specifically, we included patients with multiple myeloma (MM, n = 1696) treated with high-dose melphalan and patients with Hodgkin or non-Hodgkin lymphomas (n = 781) …

Affordable Housing: Of Inefficiency, Market Distortion, And Government Failure, Michael R. Diamond

Georgetown Law Faculty Publications and Other Works

In this essay, I examine the types of costs that are imposed on society as a whole due to the absence of a sufficient number of decent housing units that are affordable to the low-income population. These costs present themselves in relation to health care, education, employment, productivity, homelessness, and incarceration. Some of the costs are direct expenditures while others are the result of lost opportunities.

My hypothesis is that these costs are significant and offer, at the very least, a substantial offset to the cost of creating and subsidizing the operation of the necessary number of affordable housing units …

Neutralizing Antibody Against Enterovirus D68 In Children And Adults Before 2014 Outbreak, Kansas City, Missouri, Usa, Christopher J. Harrison, William C. Weldon, Barbara A. Pahud, Mary Anne Jackson, M. Steven Oberste, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

© 2019, Centers for Disease Control and Prevention (CDC). All rights reserved. We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012-2013. Neutralizing antibodies against Fermon and the dominant 2014 Missouri isolate were universally detected. Titers increased with age. Widespread circulation of enterovirus D68 occurred before the 2014 outbreak. Research is needed to determine a surrogate of protection.

Trends In Antimicrobial Susceptibility Patterns In King Fahad Medical City, Riyadh, Saudi Arabia, Sara M. Farah, Mohammed A. Alshehri, Tariq S. Alfawaz, Faisal A. Alasmeri, Abdulaziz A. Alageel, Dayel A. Alshahrani

Saudi Medical Journal

Objectives: To describe and interpret local antibiograms from a single tertiary care center to monitor the trends of antimicrobial resistance (AMR) patterns and establish baseline data for further surveillance. Methods: We performed a retrospective descriptive review of antibiograms data between January 2010 and December 2015 from King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. Results: A total of 51,491 isolates were identified, and most were gram-negative (76.2%). Escherichia coli was the most frequently isolated organism (36.8%), followed by Coagulase-negative Staphylococcus (28.4%) and Staphylococcus aureus (27.5%). The detection of antibiotic-resistant organisms, especially extended-spectrum beta-lactamase-producing Escherichia coli (31%-41%), increased over time. …

Temporal Trends In The Incidence And Demographics Of Cancers, Communicable Diseases, And Non-Communicable Diseases In Saudi Arabia Over The Last Decade, Hatem K. Herzallah, Belavendra R. Antonisamy, Mohammed H. Shafee, Sultan T. Al-Otaibi

Saudi Medical Journal

Objectives: To describe the trends in the incidence rates of 5 most common cancers, communicable diseases, and non-communicable diseases in Saudi Arabia over the last decade. Methods: The incidence rates of cancers (2001-2014), communicable diseases (2003-2016), and non-communicable diseases (1990-2017) were retrieved, classified, and analyzed retrospectively during November 2017, based on data available with the Ministry of Health and were analyzed at the Imam Abdulrahman Bin Faisal University in Dammam, Kingdom of Saudi Arabia. Results: Age-standardized incidence rate (ASR) (per 100,000 population) of breast cancer among women increased dramatically from 11.8 in 2001 to 22.7 in 2014, indicating a 92.4% …

Association Of Blood Concentrations Of Complement Split Product Ic3b And Serum C3 With Systemic Lupus Erythematosus Disease Activity, Alfred H J Kim, Vibeke Strand, Deepali P Sen, Qiang Fu, Nancy L Mathis, Martin J Schmidt, Robin R Bruchas, Nick R Staten, Paul K Olson, Chad M Stiening, John P Atkinson

Open Access Publications

OBJECTIVE: To examine correlations between blood levels of complement split product iC3b and serum component C3 with clinically meaningful changes in disease activity in patients with systemic lupus erythematosus (SLE).

METHODS: A total of 159 consecutive patients with SLE, diagnosed according to the American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria, were enrolled in CASTLE (Complement Activation Signatures in Systemic Lupus Erythematosus), a prospective observational study. Patients with 1-7 study visits were included in this longitudinal analysis. In addition, 48 healthy volunteers were enrolled to establish a normal reference value for the ratio of blood iC3b …

Early Neonatal Vitamin A Supplementation And Infant Mortality: An Individual Participant Data Meta-Analysis Of Randomised Controlled Trials, Rajiv Bahl, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Biannual vitamin A supplementation is a well-established survival tool for preschool children 6 months and older in vitamin A deficient populations but this schedule misses the opportunity to intervene on most young infant deaths. Randomised trials of neonatal vitamin A supplementation (NVAS) in the first few days of life to assess its impact on under 6-month mortality in low/middle-income countries have had varying results.
Methods: Investigators of 11 published randomised placebo-controlled NVAS trials (n=163 567 children) reanalysed their data according to an agreed plan and pooled the primary outcomes of mortality from supplementation through 6 and 12 months of …

Effectiveness Of 10-Valent Pneumococcal Conjugate Vaccine Against Vaccine-Type Invasive Pneumococcal Disease In Pakistan, Atif Riaz, Syed Mohiuddin, Sara Husain, Mohammad Tahir Yousafzai, Muhammad Sajid, Furqan Kabir, Najeeb Rehman, Waseem Mirza, Basit Salam, Naila Naila, Khatidja Pardhan, Anita K. M. Zaidi, Syed Asad Ali

Department of Paediatrics and Child Health

Objective: To assess the effectiveness of 10-valent pneumococcal conjugate vaccine (PCV10) against invasive pneumococcal disease (IPD) due to vaccine serotypes of Streptococcus pneumoniae post introduction of the vaccine into the routine immunization program in Pakistan.
Methods: A matched case-control study was conducted at 16 hospitals in Sindh Province, Pakistan. Children aged (eligible to receive PCV10) who presented with radiographically confirmed pneumonia and/or meningitis were enrolled as cases. PCR for the lytA gene was conducted on blood (for radiographic pneumonia) and cerebrospinal fluid (for meningitis) samples to detect S. pneumoniae. The proportion of IPD due to vaccine serotypes (including vaccine-related serogroups) …