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2019

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Articles 241 - 247 of 247

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Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu Jan 2019

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …

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Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin Jan 2019

Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin

Peninsula Medical School

Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied …

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Spheroid-3d And Monolayer-2d Intestinal Electrochemical Biosensor For Toxicity/Viability Testing: Applications In Drug Screening, Food Safety, And Environmental Pollutant Analysis, Evangelia Flampouri, Shahzad Imar, Kieran O'Connell, Baljit Singh Jan 2019

Spheroid-3d And Monolayer-2d Intestinal Electrochemical Biosensor For Toxicity/Viability Testing: Applications In Drug Screening, Food Safety, And Environmental Pollutant Analysis, Evangelia Flampouri, Shahzad Imar, Kieran O'Connell, Baljit Singh

Articles

The rise of three-dimensional cell culture systems that provide in vivo-like environments for pharmaco-toxicological models has prompted the need for simple and robust viability assays suitable for complex cell architectural structures. This study addresses that challenge with the development of an in vitro enzyme based electrochemical sensor for viability/cytotoxicity assessment of two-dimensional (2D) monolayer and three-dimensional (3D) spheroid culture formats. The biosensor measures the cell viability/toxicity via electrochemical monitoring of the enzymatic activity of nonspecific esterases of viable cells, through the hydrolysis of 1-naphthyl acetate to 1-naphthol. The proposed sensor demonstrated strong correlation (r = 0.979) with viable …

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Prevalence Of Chronic Disease, Associated Factors, And Health Related Quality Of Life Among Wesleyan Clergy, Angi May Mook Jan 2019

Prevalence Of Chronic Disease, Associated Factors, And Health Related Quality Of Life Among Wesleyan Clergy, Angi May Mook

All-Inclusive List of Electronic Theses and Dissertations

Clergy believe they have been called to be healthy and role models of good health. However, epidemiological evidence supports that clergy are currently exhibiting higher rates of chronic diseases and associated factors such as obesity, diabetes, and hypertension compared to the general population. Prior studies of clergys health are limited because the few available studies are denomination specific, limiting generalizability to the other denominations who have differing theology and beliefs. The Wesleyan denomination has not been formally studied. The gap in literature, therefore, creates a need for baseline information specific to the Wesleyan clergy. This cross-sectional study assessed the prevalence …

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The Electromagnetic Brain A Review Of Em Theories On The Nature Of Consciousness By Shelli Joye, Pryzdia, Michael, Radin, Dean Jan 2019

The Electromagnetic Brain A Review Of Em Theories On The Nature Of Consciousness By Shelli Joye, Pryzdia, Michael, Radin, Dean

Journal of Conscious Evolution

No abstract provided.

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Nature-Based Designs To Mitigate Urban Heat: The Efficacy Of Green Infrastructure Treatments In Portland, Oregon, Yasuyo Makido, Dana E. Hellman, Vivek Shandas Jan 2019

Nature-Based Designs To Mitigate Urban Heat: The Efficacy Of Green Infrastructure Treatments In Portland, Oregon, Yasuyo Makido, Dana E. Hellman, Vivek Shandas

Urban Studies and Planning Faculty Publications and Presentations

Urban heat is a growing environmental concern in cities around the world. The urban heat island effect, combined with warming effects of climate change, is likely to cause an increase in the frequency and intensity of extreme heat events. Alterations to the physical, built environment are a viable option for mitigating urban heat, yet few studies provide systematic guidance to practitioners for adapting diverse land uses. In this study, we examine the use of green infrastructure treatments to evaluate changes in ambient temperatures across diverse land uses in the city of Portland, Oregon. We apply ENVI-met® microclimate modeling at the …

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Heat Exposure And Adaptation Strategies Of Outdoor Informal Sector Workers In Urban Bulawayo - Zimbabwe, Bigboy Ngwenya Jan 2019

Heat Exposure And Adaptation Strategies Of Outdoor Informal Sector Workers In Urban Bulawayo - Zimbabwe, Bigboy Ngwenya

Theses: Doctorates and Masters

Ambient temperatures have risen over the past few decades and are expected to increase even further due to climate change impacts. Extreme temperatures, accompanied by high humidity levels, will exacerbate occupational heat stress, heat related illnesses and mortality amongst vulnerable groups, particularly among outdoor workers in developing countries in the tropics. In Bulawayo, Zimbabwe, a large portion of the population work outdoors in the informal sector as street vendors (hawkers) due to a lack of employment opportunities. These hawkers spend long hours in the sun or under makeshift sheds with poorly developed adaptation strategies, and no access to cooling systems …

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