Digital Commons Network^™

Ohio University Awarded National Grant To Study Community-Benefit Investments Made By For-Profit Healthcare Organizations (December 17, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Stanford Program Inspiring Ohio Students To Be The Change (December 17, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Patton College Faculty Member Danny Twilley Gives Edtalk On The Role That Outdoor Recreation Can Play In Community Development (December 17, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Rideshare Issues And Implications For Curb Management, Brandon Leonard Utterback

Landscape Architecture Masters & Design Theses - Archive

As autonomous vehicles continue to prove themselves on our roads today, a look at the considerations of implementation will be necessary. The potential for rethinking our infrastructure requirements, as a result of this new technology, could be a significant benefit to everyday life in terms of safety, congestion, and travel behavior. We must also consider the potential impact on the environment, which is often overlooked. If automobile infrastructure such as roads and parking lots are reduced in urban areas, how will this rediscovered urban space be used? How will planners, designers, and policymakers adapt our infrastructure needs when less pressure …

Force-Stabilizing Synergies Can Be Retained By Coordinating Sensory-Blocked And Sensory-Intact Digits, Wei Zhang, Sasha Reschechtko, Barry Hahn, Cynthia Benson, Elias Youssef

Publications and Research

The present study examined the effects of selective digital deafferentation on the multi-finger synergies as a function of total force requirement and the number of digits involved in isometric pressing. 12 healthy adults participated in maximal and sub-maximal isometric pressing tasks with or without digital anesthesia to selective digits from the right hand. Our results indicate that selective anesthesia paradigm induces changes in both anesthetized (local) and non-anesthetized (non-local) digits’ performance, including: (1) decreased maximal force abilities in both local and non-local digits; (2) reduced force share during multi-finger tasks from non-local but not local digits; (3) decreased force error-making; …

Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan

Internal Medicine Faculty Patents

Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Ra or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful …

Individual Based Modeling And Analysis Of Pathogen Levels In Poultry Chilling Process, Zachary Mccarthy, Ben Smith, Aamir Fazil, Jianhong Wu, Shawn D. Ryan, Daniel Munther

Mathematics and Statistics Faculty Publications

Pathogen control during poultry processing critically depends on more enhanced insight into contamination dynamics. In this study we build an individual based model (IBM) of the chilling process. Quantifying the relationships between typical Canadian processing specifications, water chemistry dynamics and pathogen levels both in the chiller water and on individual carcasses, the IBM is shown to provide a useful tool for risk management as it can inform risk assessment models. We apply the IBM to Campylobacter spp. contamination on broiler carcasses, illustrating how free chlorine (FC) sanitization, organic load in the water, and pre-chill carcass pathogen levels affect pathogen levels …

Alanyl-Trna Synthetase Quality Control Prevents Global Dysregulation Of The Escherichia Coli Proteome, Paul Kelly, Nicholas Backes, Kyle Mohler, Christopher Buser, Arundhati Kavoor, Jesse Rinehart, Gregory Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mechanisms have evolved to prevent errors in replication, transcription, and translation of genetic material, with translational errors occurring most frequently. Errors in protein synthesis can occur at two steps, during tRNA aminoacylation and ribosome decoding. Recent advances in protein mass spectrometry have indicated that previous reports of translational errors have potentially underestimated the frequency of these events, but also that the majority of translational errors occur during ribosomal decoding, suggesting that aminoacylation errors are evolutionarily less tolerated. Despite that interpretation, there is evidence that some aminoacylation errors may be regulated, and thus provide a benefit to the cell, while others …

Recovering Trauma Patient With An Eye Toward Naval Career Vows To "Use Every Breath I Have To Help Others", Alicia Rohan

Browse All News

No abstract provided.

Lindenwood Digest, December 17, 2019, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Quliriuralta (Lets Keep Telling Stories): Pace Model With Traditional Yup'ik Storytelling In A Second Grade Dual Language Classroom, Irene M. Wassilie

Linguistics

This research was conducted in a setting where the students are losing their Indigenous language. It is centered around the retention and revitalization of the Yugtun language. The goal of the research was to gain insights into how second graders in a dual language enrichment school constructed meaning and focus on form in their classroom. The instructional model employed as part of this investigation is the PACE Model, which is a story-based approach to teaching grammar through focus on form with an emphasis on meaning making. The model is consistent with Indigenous oral storytelling, cultural values, traditions and expectations. The …

Modeling Volcanic Ash And Sulfur Dioxide With The Weather Research Forecasting With Chemistry (Wrf-Chem) Model, Sean D. Egan

Chemistry and Biochemistry

The Weather Research Forecasting with Chemistry (WRF-Chem) model is capable of modeling volcanic emissions of ash, sulfur dioxide and water vapor. Here, it is applied to eruptions from three volcanoes: the 2008 eruption of Kasatochi Volcano in Alaska, the 2010 eruption of Eyjafjallajökull in Iceland and the 2019 eruption of Raikoke in the Kurile Islands. WRF-Chem's ability to model volcanic emissions dispersion is validated through comparison of model output to remote sensing, in situ and field measurements. A sensitivity of the model to modeled plume height is discussed. This work also modifies the base WRF-Chem code in three ways and …

Development Of A Nonformal Education Program Evaluation Plan: An Evaluation Design For Two Youth Programs In Denali National Park And Preserve, Dana Lindauer

Education

This project proposes an evaluation design for two youth programs that operate out of the Murie Science and Learning Center in Denali National Park and Preserve. The two programs, Denali Backcountry Expeditions and Denali Summer Science Academy, are offered to Alaskan high school and college aged students and are co-managed by the National Park Service and Alaska Geographic. A formative, utilization-focused evaluation for instructors and managers of the programs was created. The evaluation seeks to facilitate targeted program development through articulating program goals and assessing participant outcomes related to these goals. In an effort to establish collaborative goals, eleven stakeholders …

Comparative Study Of 10 X-Str Markers In Populations Of Northeast Argentina, G. Paula Di Santo Meztler, Laura A. Glesmann, Esther Esteban, Santiago Del Palacio, Marta G. Méndez, Cecilia Inés Catanesi

Human Biology Open Access Pre-Prints

In northeast Argentina, different Amerindian communities share territory and history with settlers, mainly Europeans. Due to miscegenation, the current Argentinian population has a particular structure that can be de- scribed through the X chromosome variation. Our objectives are: to describe the variation of 10 X-STRs in urban populations of the Argentinian regions known as Gran Chaco and Mesopotamia; to report the forensic parameters of these STRs, and to estimate the European and indigenous genetic components in these regions. Population and forensic parameters were estimated for 419 individuals from the analysed populations, including two indigenous groups, Wichí and Mocoví, previously reported. …

Replication Study: Biomechanical Remodeling Of The Microenvironment By Stromal Caveolin-1 Favors Tumor Invasion And Metastasis, Mee Rie Sheen, Jennifer L. Fields, Brian Northan, Judith Lacoste, Lay-Hong Ang, Steven Fiering

Dartmouth Scholarship

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling in vitro compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). In vivo, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors …

Sleep Aspects And Sleep Disorders In Children And Adolescents, Sameh Morkous Md, Faan

Department of Pediatrics

No abstract provided.

Attitudes Towards Teaching Computational Thinking And Computer Science: Insights From Educator Interviews And Focus Groups, Jorge Valenzuela

Journal of Computer Science Integration

In the last three years, integration of both computational thinking (CT) and computer science (CS) into K-12 instruction has become a focus of many schools throughout the Commonwealth of Virginia and the United States. With this new widespread demand, educational leaders and educators are focusing efforts on understanding the core concepts and practices of CT and CS, looking for logical connections for integrating across curriculum, and seeking strategies for implementing a wide variety of educational technology tools (apps and devices). This phenomenological research study was designed to gather depth information from 14 K-16 educators through both semi-structured interviews and two …

My News, Georgia Southern University

My News (2014-2020)

• Armstrong State University Historical Marker unveiling takes place Dec. 17
• Georgia Southern psychology graduate looking to make diference in children's lives
• Georgia Southern first-generation student graduates magna cum laude
• Georgia Southern graduate rediscovers passion for art in Betty Foy Sanders Department of Art
• Georgia Southern graduate dedicated to giving back, will join Peace Corps in May
• Georgia Southern student overcomes hurdles to complete her degree after 21 years
• From apartheid to academia, Georgia Southern graduate student beats odds to earn degree
• Georgia Southern graduate students gain real-world experience through mock trial

N-Amino Peptide Beta-Sheet Mimics For The Treatment Of Alzheimer's Disease, Juan R. Del Valle

USF Patents

Disclosed herein are compounds comprising short N-aminated peptides and compositions comprising the same. The disclosed compounds and compositions maybe used in methods of inhibiting amyloid-beta aggregation and treating Alzheimer's disease.

To Freeze Or Not To Freeze: That Is The Question: A Look At Freezeback Landfills And Final Cover Designs, Sarah Durand

Engineering

Freezeback landfills are an exciting concept but challenging in execution. There is not a single variable that leads to the success of a freezeback landfills but multiple variables in balance with each other that allow for freezeback to occur. Freezeback landfills should be engineered to the site-specific environment at the initial design stage for a better chance of success rather than following the generalized regulatory requirements. This project looked at three freezeback landfills as case studies and evaluated the final cover design of the first two in identifying parameters that lead to success in reaching and maintaining freezeback status. The …

Explorations Of Intergenerational Healing, Resilience, And Post-Traumatic Growth By Helpers And Healers On The Blackfeet Nation, Tyler J. Hoyt

Psychology

This project explored intergenerational healing, resilience, and post-traumatic growth within the context of the Blackfeet Nation in Montana, the roles of helpers and healers in this setting, and community experiences of familial trauma and the idiosyncratic healing and resilience processes according to their worldview. The central goal of this study was to provide a contemporary public narrative surrounding healing and resilience as these topics related to historical and intergenerational trauma in this specific community. This exploratory study was composed of the narratives of 14 co-participants working as helpers and healers on the Blackfeet Nation. Indigenous narrative and a cosmic relationality …

Using Nano- And Micro- Structural Materials For Concrete Environmental Applications, Hala Nabeel Elia

Theses and Dissertations

Utilized globally in the construction industry, concrete is an integral component of homes, roads, airports, skyscrapers, and tunnels. Traditional concrete components are cement, fine aggregate (sand), coarse aggregate (gravel or crushed stone), and water. When cement and water compound together they will make a paste which binds all the aggregates together to make the concrete. Unfortunately, every one ton of cement manufactured emits 0.9 ton of CO2into the air. The goal of this two-part work was to obtain an environmentally friendly concrete. The first part used supplementary cementitious materials (SCM), fly ash and silica fume, to create concrete with high …

“Treat Me Covalently” – New Tools To Improve Covalent Drug Design For Advancement Of Cancer Treatments, Yuliya Mazo

Student Theses and Dissertations

The goal of this project was to investigate the complex mechanism of covalent bonding among different molecules and their targets in a modeling software ICM-Pro. Specifically, it included the identification of fundamental aspects of a covalent bonding mechanism of the Michael addition reaction. Michael addition reaction of electrophilic α, β-unsaturated carbonyl compounds with a nucleophilic cysteine residue in thymidylate synthase, papain, and EGFR tyrosine kinase were examined. Thymidylate synthase and EGFR were chosen because they are important targets in the treatment of various types of cancer. In order to find the most optimal parameters, identification and assessment of the effect …

Mutation Signature Analysis Identifies Increased Mutation Caused By Tobacco Smoke Associated Dna Adducts In Larynx Squamous Cell Carcinoma Compared With Oral Cavity And Oropharynx., Andrew P. South, Nicoline Y Den Breems, Tony Richa, Uche Nwagu, Tingting Zhan, Shiv Poojan, Ubaldo E. Martinez-Outshoorn, Jennifer M. Johnson, Adam J. Luginbuhl, Joseph Curry

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene mutations which divert cell fate from differentiation to proliferation, HNSCC are considered a heterogeneous group of tumors categorized by site of origin within the aero-digestive mucosa, and the presence or absence of HPV infection. Tobacco use is a major driver of carcinogenesis in HNSCC and is a poor prognosticator that has previously been associated with poor immune cell infiltration and higher mutation numbers. Here, we study patterns of mutations in HNSCC that are …

Statistical Analysis Of Social Network Change, Teresa Danielle Schmidt

Dissertations and Theses

This project explores two statistical methods that infer social network structures and statistically test those structures for change over time: regression-based differential network analysis (R-DNA) and information theory-based differential analysis (I-DNA). R-DNA is adapted from bioinformatics and I-DNA employs reconstructability analysis.

This project applies both R-DNA and I-DNA to analyze Medicaid claims data from one-year periods before (May 2011- Apr 2012) and after (Jan 2013-Dec 2013) the formation of the Health Share of Oregon Coordinated Care Organization (CCO). The formation of CCOs was legislated by the state of Oregon in 2012 with the triple aim of improving health outcomes, reducing …

Destress For Success: Improving Student Mental Health With A New Healthy Monday Program, Mary Kate Schutt

Population Health Research Brief Series

College students’ mental health is declining at alarming rates. Rates of depression and suicidal ideation among students have doubled since 2007. This causes campus counseling centers and staff to become overburdened and under resourced. This issue brief describes the launch of the DeStress for Success program, a new Healthy Monday program that provides a positive resource for students to help increase mental health and improve academic performance.

Potential Arm Preference Within Starfish Species Including Asterias Vulgaris And Luidia Clathrata: A Study And Summary, Rebecca Jones, Young Robert

Honors Theses

Foraging arm preference was tested in two species of starfish: Asterias vulgaris and Luidia clathrata. No evidence was found for a species-wide preference or for a preference by individual sea stars, but trials were impacted by illness and resulting low sample size.

The Effectiveness Of Diversity & Inclusion Programs Within The Workplace, Madelynne F. Rodriguez

Honors Theses

The importance of diversity and inclusion programs within the workplace has long been a controversial topic, hindered in part by the lack of quantitative evidence to prove its effectiveness and an overall lack of understanding. Corporate America has been dedicated to only meeting compliance standards and has continually turned a blind eye at the potential positive impact a properly implemented diversity and inclusion program can bring to the table. Unawareness of the true meaning of diversity, and what an inclusive work environment looks like, is also a main contributing factor. Properly implemented diversity and inclusion programs can elevate a business’ …

State V. Belcher Respondent's Brief Dckt. 46872

Not Reported

No abstract provided.

Human-Infrastructure Interfaces (Hii) Enabled Using Augmented Reality (Ar), Dilendra Maharjan

Civil Engineering ETDs

The modern industrial society is built upon the productivity of advanced computing and agile machines assisting the human workforce to perform their tasks more effectively, accurately and efficiently. The industrial revolution termed as "Industry 4.0" is based on the intelligence of machines working with humans in a collaborative work-space. Contrarily, infrastructure management has relied on the human for making day to day decisions. New emerging technologies can assist during infrastructure inspections, to quantify structural condition with more objective data. However, today's’ owners agree in trusting the inspector's decision in the field over data collected with sensors. If data collected in …