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2019

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Professional Knowledges For Early Childhood Education And Care, Vjg Campbell Barr Jan 2019

Professional Knowledges For Early Childhood Education And Care, Vjg Campbell Barr

School of Law, Humanities and Social Sciences

This article proposes reconceptualizing professional knowledge in early childhood education and care (ECEC) as knowledges, incorporating phronesis (practical wisdom), techne (skill), and episteme (pure knowledge). Conceptualizing professional knowledge in the plural broadens perspectives on the professional knowledge base and opens up a discussion of how different forms of knowledge are acquired. Drawing on Bernstein, the author identifies ECEC as requiring horizontal and vertical constructs of knowledge that have different structures and legitimization processes. While phronesis is presented as being a part of ECEC professional knowledges, the discussion explores the difficulties in defining phronesis, because of the variable ways it is …

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11.39 Association Of British Neurologists Sustainability Special Interest Group (Abn Sustainability Sig): Formation, Objectives And Invitation, A Cheesman, D Blackburn, C Carroll, A Cohen, J Coebergh, D Sokhi, Sh Wong, J Woolmore Jan 2019

11.39 Association Of British Neurologists Sustainability Special Interest Group (Abn Sustainability Sig): Formation, Objectives And Invitation, A Cheesman, D Blackburn, C Carroll, A Cohen, J Coebergh, D Sokhi, Sh Wong, J Woolmore

Peninsula Medical School

We introduce the ABN Sustainability SIG. We present our aims & objectives, and practical ways of implementing sustainability strategies in Neurology.At the 2016 ABN annual meeting, a keynote speech by Dr. David Pencheon, then director of the National Health Service Sustainability Development Unit, highlighted the relevance and importance of Sustainability in Neurology. This planted the seed for our SIG’s formation. Initial interest was gathered from an ABN newsletter notice, via word-of-mouth and informal discussions at ABN annual meetings (2017, 2018). A series of teleconferences & email discussions enabled the formation of SIG byelaws and application to the ABN council.Our aims …

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Health Professional Perceptions Of Communicating With Adolescents And Young Adults About Bone Cancer Clinical Trial Participation, Susie Pearce Jan 2019

Health Professional Perceptions Of Communicating With Adolescents And Young Adults About Bone Cancer Clinical Trial Participation, Susie Pearce

School of Nursing and Midwifery

No abstract provided.

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‘I Cried Too’ – Allowing Icu Nurses To Grieve When Patients Die, R Endacott Jan 2019

‘I Cried Too’ – Allowing Icu Nurses To Grieve When Patients Die, R Endacott

School of Nursing and Midwifery

No abstract provided.

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Evaluating The Acceptability Of Assistive Robots For Early Detection Of Mild Cognitive Impairment, Matteo Luperto, Marta Romeo, Francesca Lunardini, Nicola Basilico, Carlo Abbate, Ray Jones, Angelo Cangelosi, Simona Ferrante, N. Alberto Borghese Jan 2019

Evaluating The Acceptability Of Assistive Robots For Early Detection Of Mild Cognitive Impairment, Matteo Luperto, Marta Romeo, Francesca Lunardini, Nicola Basilico, Carlo Abbate, Ray Jones, Angelo Cangelosi, Simona Ferrante, N. Alberto Borghese

School of Nursing and Midwifery

No abstract provided.

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Mobile Health Interventions To Promote Physical Activity And Reduce Sedentary Behaviour In The Workplace: A Systematic Review, Sa Buckingham, Aj Williams, K Morrissey, L Price, J Harrison Jan 2019

Mobile Health Interventions To Promote Physical Activity And Reduce Sedentary Behaviour In The Workplace: A Systematic Review, Sa Buckingham, Aj Williams, K Morrissey, L Price, J Harrison

School of Nursing and Midwifery

Objective This systematic review aimed to assess the effectiveness, feasibility and acceptability of mobile health (mHealth) technology (including wearable activity monitors and smartphone applications) for promoting physical activity (PA) and reducing sedentary behaviour (SB) in workplace settings. Methods Systematic searches were conducted in seven electronic databases (MEDLINE, SPORTDiscus, Scopus, EMBASE, PsycINFO, Web of Science and the Cochrane library). Studies were included if mHealth was a major intervention component, PA/SB was a primary outcome, and participants were recruited and/or the intervention was delivered in the workplace. Study quality was assessed using the Effective Public Health Practice Project (EPHPP) tool. Interventions were …

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Patterns Of Polypharmacy Before Diagnosis Of Dementia: A Data-Driven, Retrospective, Population-Based Study With Primary Care Electronic Health Records, E Longo, L Huo, B Burnett, J Demmler, A Morris, S Brophy, Ra Lyons, S-M Zhou Jan 2019

Patterns Of Polypharmacy Before Diagnosis Of Dementia: A Data-Driven, Retrospective, Population-Based Study With Primary Care Electronic Health Records, E Longo, L Huo, B Burnett, J Demmler, A Morris, S Brophy, Ra Lyons, S-M Zhou

School of Nursing and Midwifery

No abstract provided.

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Bile Acid Metabolism Is Altered In Those With Insulin Resistance After Gestational Diabetes Mellitus, Negar Maghsoodi, Nicholas Shaw, Gemma F. Cross, Jamshid Alaghband-Zadeh, Anthony S. Wierzbicki, Jonathan Pinkney, Ann Millward, Royce P. Vincent Jan 2019

Bile Acid Metabolism Is Altered In Those With Insulin Resistance After Gestational Diabetes Mellitus, Negar Maghsoodi, Nicholas Shaw, Gemma F. Cross, Jamshid Alaghband-Zadeh, Anthony S. Wierzbicki, Jonathan Pinkney, Ann Millward, Royce P. Vincent

Peninsula Medical School

No abstract provided.

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Dex-Csdh Randomised, Placebo-Controlled Trial Of Dexamethasone For Chronic Subdural Haematoma: Report Of The Internal Pilot Phase, Ellie Edlmann, Eric P. Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z. Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G. Kolias, Peter J.A. Hutchinson Jan 2019

Dex-Csdh Randomised, Placebo-Controlled Trial Of Dexamethasone For Chronic Subdural Haematoma: Report Of The Internal Pilot Phase, Ellie Edlmann, Eric P. Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z. Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G. Kolias, Peter J.A. Hutchinson

Peninsula Medical School

No abstract provided.

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Insulin Resistance During Normal Child Growth And Development Is Associated With A Distinct Blood Metabolic Phenotype (Earlybird 72), Joanne Hosking, Jonathan Pinkney, Alison Jeffery, Ornella Cominetti, Silva L Da, Sebastiano Collino, Martin Kussmann, Jorg Hager, Francois Pierre Martin Jan 2019

Insulin Resistance During Normal Child Growth And Development Is Associated With A Distinct Blood Metabolic Phenotype (Earlybird 72), Joanne Hosking, Jonathan Pinkney, Alison Jeffery, Ornella Cominetti, Silva L Da, Sebastiano Collino, Martin Kussmann, Jorg Hager, Francois Pierre Martin

Peninsula Medical School

No abstract provided.

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Assessing The Psychosocial Factors Associated With Adherence To Exercise Referral Schemes: A Systematic Review, Michael Eynon, Jessica Foad, John Downey, Yasmin Bowmer, Hayley Mills Jan 2019

Assessing The Psychosocial Factors Associated With Adherence To Exercise Referral Schemes: A Systematic Review, Michael Eynon, Jessica Foad, John Downey, Yasmin Bowmer, Hayley Mills

School of Nursing and Midwifery

This paper aimed to systematically review the evidence base to uncover the key psychosocial factors that underpin adherence to an exercise referral scheme (ERS). Databases PsycINFO, MEDLINE, SPORTDiscus, Web of Science, PubMed, PsycARTICLES, Open Grey, and PsycEXTRA were systematically searched. A parallel results-based convergent synthesis was performed by identifying key themes from quantitative and qualitative studies separately. After applying inclusion and exclusion criteria, the review included 24 eligible studies. Key findings showed intrinsic motivation, psychological need satisfaction, social support, and self-efficacy to be the prominent psychosocial factors associated with ERS adherence. In addition, lower expectations for change when entering the …

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Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson Jan 2019

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …

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Implementation And Impact Of Co-Locating The Voluntary Sector With A Multidisciplinary, Cross-Sector Community Hub At The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk, F Gradinger, J Elston, S Asthana, C Lilley-Woolnough, C Myers, M Fox, D Butler, R Byng Jan 2019

Implementation And Impact Of Co-Locating The Voluntary Sector With A Multidisciplinary, Cross-Sector Community Hub At The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk, F Gradinger, J Elston, S Asthana, C Lilley-Woolnough, C Myers, M Fox, D Butler, R Byng

Peninsula Medical School

No abstract provided.

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Impact Of “Enhanced” Intermediate Care Located In A Health & Wellbeing Hub At The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk, J Elston, F Gradinger, S Asthana, M Fox, L Dawson, D Butler, R Byng Jan 2019

Impact Of “Enhanced” Intermediate Care Located In A Health & Wellbeing Hub At The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk, J Elston, F Gradinger, S Asthana, M Fox, L Dawson, D Butler, R Byng

Peninsula Medical School

No abstract provided.

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Mrs Smith - Chapter 2: Vertical And Horizontal Integration And Care Model Implementation In The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk - A Workshop On Leadership And Co-Production, F Gradinger, J Elston, M Fox, C Myers, D Butler Jan 2019

Mrs Smith - Chapter 2: Vertical And Horizontal Integration And Care Model Implementation In The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk - A Workshop On Leadership And Co-Production, F Gradinger, J Elston, M Fox, C Myers, D Butler

Peninsula Medical School

No abstract provided.

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Optimising Feedback For Early Career Professionals: A Scoping Review And New Framework, Karen Mattick, Nicola Brennan, Simon Briscoe, Chrysanthi Papoutsi, Mark Pearson Jan 2019

Optimising Feedback For Early Career Professionals: A Scoping Review And New Framework, Karen Mattick, Nicola Brennan, Simon Briscoe, Chrysanthi Papoutsi, Mark Pearson

Peninsula Medical School

No abstract provided.

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Progression Of Hearing Loss In Neurofibromatosis Type 2 According To Genetic Severity, C. Oliver Hanemann, Beatrice Emmanouil, Rory Houston, Anne May, James D. Ramsden, Dorothy Halliday, Allyson Parry, Samuel Mackeith Jan 2019

Progression Of Hearing Loss In Neurofibromatosis Type 2 According To Genetic Severity, C. Oliver Hanemann, Beatrice Emmanouil, Rory Houston, Anne May, James D. Ramsden, Dorothy Halliday, Allyson Parry, Samuel Mackeith

Peninsula Medical School

No abstract provided.

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Patient And Public Involvement In Medical Performance Processes: A Systematic Review, Mirza Lalani, Rebecca Baines, Marie Bryce, Martin Marshall, Sol Mead, Stephen Barasi, Julian Archer, De Bere S Regan Jan 2019

Patient And Public Involvement In Medical Performance Processes: A Systematic Review, Mirza Lalani, Rebecca Baines, Marie Bryce, Martin Marshall, Sol Mead, Stephen Barasi, Julian Archer, De Bere S Regan

Peninsula Medical School

No abstract provided.

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Sofosbuvir/Velpatasvir For 12 Weeks In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease Undergoing Dialysis, Sergio M. Borgia, Janet Dearden, Eric M. Yoshida, Stephen D. Shafran, Ashley Brown, Ziv Ben-Ari, Matthew E. Cramp, Curtis Cooper, Matthew Foxton, Conrado Fernandez Rodriguez, Rafael Esteban, Robert Hyland, Sophia Lu, Brian J. Kirby, Amy Meng, Svetlana Markova, Hadas Dvory-Sobol, Anu O. Osinusi, Rafael Bruck, Javier Ampuero, Stephen D. Ryder, Kosh Agarwal, Raymond Fox, David Shaw, Shariq Haider, Bernard Willems, Yoav Lurie, Jose Luis Calleja, Edward J. Gane Jan 2019

Sofosbuvir/Velpatasvir For 12 Weeks In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease Undergoing Dialysis, Sergio M. Borgia, Janet Dearden, Eric M. Yoshida, Stephen D. Shafran, Ashley Brown, Ziv Ben-Ari, Matthew E. Cramp, Curtis Cooper, Matthew Foxton, Conrado Fernandez Rodriguez, Rafael Esteban, Robert Hyland, Sophia Lu, Brian J. Kirby, Amy Meng, Svetlana Markova, Hadas Dvory-Sobol, Anu O. Osinusi, Rafael Bruck, Javier Ampuero, Stephen D. Ryder, Kosh Agarwal, Raymond Fox, David Shaw, Shariq Haider, Bernard Willems, Yoav Lurie, Jose Luis Calleja, Edward J. Gane

Peninsula Medical School

BACKGROUND & AIMS: Although off-label use of sofosbuvir-containing regimens occurs regularly in patients with hepatitis C virus (HCV) infection undergoing dialysis for severe renal impairment or end-stage renal disease (ESRD), these regimens are not licensed for this indication, and there is an absence of dosing recommendations in this population. This study evaluated the safety and efficacy of sofosbuvir/velpatasvir in patients with HCV infection with ESRD undergoing dialysis. METHODS: In this phase II, single-arm study, 59 patients with genotype 1-6 HCV infection with ESRD undergoing hemodialysis or peritoneal dialysis received open-label sofosbuvir/velpatasvir (400 mg/100 mg) once daily for 12 weeks. Patients …

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Trends In Phenotype In The English Paediatric Neurofibromatosis Type 2 Cohort Stratified By Genetic Severity, Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D. Gareth Evans, Allyson Parry, Patrick Axon, Juliette Gair, Carolyn Smyth, Shazia K. Afridi, Rupert Obholzer, Vanessa Everett, Nicola Jarvis, Kirsty Henshaw, C. Oliver Hanemann, Wendy Howard, Anne May, Carolyn Redman, Rohini Rattihalli, Helen Tomkins Jan 2019

Trends In Phenotype In The English Paediatric Neurofibromatosis Type 2 Cohort Stratified By Genetic Severity, Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D. Gareth Evans, Allyson Parry, Patrick Axon, Juliette Gair, Carolyn Smyth, Shazia K. Afridi, Rupert Obholzer, Vanessa Everett, Nicola Jarvis, Kirsty Henshaw, C. Oliver Hanemann, Wendy Howard, Anne May, Carolyn Redman, Rohini Rattihalli, Helen Tomkins

Peninsula Medical School

No abstract provided.

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Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang Jan 2019

Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang

Peninsula Medical School

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both …

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Neurological Effects Of Glucocerebrosidase Gene Mutations, S. Mullin, D. Hughes, A. Mehta, A. H.V. Schapira Jan 2019

Neurological Effects Of Glucocerebrosidase Gene Mutations, S. Mullin, D. Hughes, A. Mehta, A. H.V. Schapira

Peninsula Medical School

No abstract provided.

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Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng Jan 2019

Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng

Peninsula Medical School

More individuals are requesting medical assistance for gender uncertainty or dysphoria and provision of adult NHS gender identity services (GIS) is changing. Despite minimal medical input to polarised debates, several issues are potentially concerning: reports of poor care; rapid rises in referrals of children and young people to GIS; public conflation of biological sex with socially influenced gender roles; and extensive uncertainty in the evidence base to guide practice. Medical practice should happen within robust human rights frameworks where individual patients always have their concerns heard. Generalists, with expertise in whole-person care, handling uncertainty and complexity, have a key role …

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From Mental Disorder To Shared Understanding: A Non-Categorical Approach To Support Individuals With Distress In Primary Care, Richard Byng, Nora Groos, Christopher Dowrick Jan 2019

From Mental Disorder To Shared Understanding: A Non-Categorical Approach To Support Individuals With Distress In Primary Care, Richard Byng, Nora Groos, Christopher Dowrick

Peninsula Medical School

This article argues that, rather than aiming for a psychiatric diagnosis, generalist professionals such as those working in primary care, as well as in other hospital and community settings, should use a non-diagnostic framework when encountering distress. The conceptual and empirical limitations of the psychiatric diagnostic system and evidence that psychological phenomena are dimensional suggest the need for an alternative approach; one that might also address problems of overdiagnosis and overmedication.1 There are three key problems with the current Diagnostic Statistical Manual (DSM) and International Classification of Diseases (ICD) systems of psychiatric classification. The process can be stigmatising; diagnoses are …

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Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira Jan 2019

Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira

Peninsula Medical School

No abstract provided.

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Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng Jan 2019

Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng

Peninsula Medical School

No abstract provided.

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Exploring How Patients Respond To Gp Recommendations For Mental Health Treatment: An Analysis Of Communication In Primary Care Consultations, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe Jan 2019

Exploring How Patients Respond To Gp Recommendations For Mental Health Treatment: An Analysis Of Communication In Primary Care Consultations, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe

Peninsula Medical School

BackgroundPatient take-up and adherence to antidepressants and talking therapy is low. However, little is known about how GPs recommend these treatments and whether patients accept them.AimTo examine how GPs recommend antidepressants and talking therapy, and how patients respond.Design & settingA total of 52 recorded primary care consultations for depression, anxiety, and stress were analysed.MethodUsing a standardised coding scheme, five ways doctors recommend treatment were coded, conveying varying authority and endorsement. The treatment recommendation types were as follows: more directive pronouncements (I’ll start you on X); proposals (How about we start X?); less directive suggestions (Would you like to try X?); …

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Predictors And Trajectory Of Performance Status In Patients With Advanced Cancer: A Secondary Data Analysis Of The International European Palliative Care Cancer Symptom Study, Jw Boland, Victoria Allgar, Eg Boland, Stein Kaasa, Marianne J. Hjermstad, Miriam J. Johnson Jan 2019

Predictors And Trajectory Of Performance Status In Patients With Advanced Cancer: A Secondary Data Analysis Of The International European Palliative Care Cancer Symptom Study, Jw Boland, Victoria Allgar, Eg Boland, Stein Kaasa, Marianne J. Hjermstad, Miriam J. Johnson

Peninsula Medical School

Background: Performance status, a predictor of cancer survival, and ability to maintain independent living deteriorate in advanced disease. Understanding predictors of performance status trajectory could help identify those at risk of functional deterioration, target support for independent living and reduce service costs. The relationship between symptoms, analgesics and performance status is poorly delineated. Aim: The aim of this study is to determine whether demographics, analgesics, disease characteristics, quality-of-life domains and C-reactive protein predict the trajectory of Karnofsky Performance Status (KPS) in patients with advanced cancer. Design: The study design is the secondary data analysis of the international prospective, longitudinal European …

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Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey Jan 2019

Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey

Peninsula Medical School

Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others’ data indicates that this practice risks excluding ‘Goldilocks’ effects in which a biological variable falls within a range between ‘too much’ and ‘too little’ with a region between where its function is ‘just right’; a concept captured by the Swedish term ‘Lagom’. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical phenomena of the Goldilocks/Lagom form including …

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Computational Instantaneous Wave‐Free Ratio (Ifr) For Patient‐Specific Coronary Artery Stenoses Using 1d Network Models, Jason M. Carson, Carl Roobottom, Robin Alcock, Perumal Nithiarasu Jan 2019

Computational Instantaneous Wave‐Free Ratio (Ifr) For Patient‐Specific Coronary Artery Stenoses Using 1d Network Models, Jason M. Carson, Carl Roobottom, Robin Alcock, Perumal Nithiarasu

Peninsula Medical School

No abstract provided.

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