Digital Commons Network^™

Perceptions Of Blended Learning In The High School Classroom, Kelli Murphy

Electronic Theses and Dissertations

As innovative technologies and accessibility increase in the K12 environment, teachers are offered opportunities to rethink the paradigm of the instructional and learning process. They are at the forefront of instructional change. One type of change is the use of technology as an instructional strategy. Blended learning is a type of instructional strategy which incorporates both online and face-to-face instruction.

The instructional choices a K12 teacher makes under their own volition to present new content in a technology-rich school is the focus of this study. A quantitative research study was performed in a high school with high technology accessibility. Teachers’ …

Females In Stem: Self-Efficacy Within Women Who Pursue Stem Majors, Lori Grata

Electronic Theses and Dissertations

While many efforts have been made within the United States, women are still underrepresented within STEM. Research within this document shows that women and men score similarly on STEM-related standardized tests. The question remains, why are there still large quantities of men outnumbering women in college majors and career fields of STEM? Looking at female STEM self-efficacy and gender role in culture could provide insight to the problem at hand. A survey was given to investigate self-efficacy and students’ STEM backgrounds of undergraduate female students who are currently in a 4-year STEM-related major within one university.

A Pilot Study Examining Differences In Tactile Sensory Processing As A Function Of Borderline Personality Disorder Symptomatology And Non-Suicidal Self-Injury, Julia Elizabeth Hooker

Theses - ALL

Borderline Personality Disorder (BPD) is characterized by a pattern of instability in self-image, interpersonal relationships, emotional regulation, and impulsivity that significantly impacts functioning in everyday life. Non-suicidal self-injury (NSSI) is a hallmark symptom of BPD that serves to regulate affective instability and relieve inner aversive tension. Experimental pain modalities are commonly employed to assess sensory perception in the context of BPD. Although the experience of self-inflicted pain during NSSI is thought to contribute to emotional regulation, individuals with BPD tend to exhibit reduced experimental pain sensitivity when compared to healthy controls. Thus, experimental pain reactivity may not adequately reflect mechanisms …

Investigation Of The Effects Of A Yoga Intervention On Experiential Avoidance, Symptoms Of Psychological Distress, And Substance Use, Samantha Sinegar

Theses - ALL

The current study sought to examine the utility of yoga for reducing experiential avoidance (EA), as well as symptoms of psychological distress (SPD) and substance use. EA refers to the attempt to avoid or control adverse bodily sensations, thoughts, feelings, and memories despite negative consequences. Yoga is a holistic system of mind-body practices which includes physical postures, stretching, and breathing exercises aimed at maintaining and improving both mental and physical health. Undergraduates (n = 43) from a yoga class and basic exercise classes were recruited to participate and served as the intervention and active control group, respectively. Self-reported measures of …

Digital Transformation – The Hype And Conceptual Changes, Luka Tomat, Peter Trkman

Economic and Business Review

Digital transformation (DT) is attracting increased attention; many papers and special issues focus on various aspects of DT. Still, DT often serves solely as a repackaging of previously existing ideas. Our paper argues that the term is over-hyped and has been used to rebrand various fields to attract management attention. However, this alone cannot explain the reasons for such an immense rise in the popularity of the concept. To understand the underlying motives for current DT adoration, our paper aims to identify conceptual changes that have happened in the last decade. These changes have to be considered if companies want …

Caregiver Perspectives On Telehealth: A Service Delivery For Occupational Therapy, Rebecca Johnston

Student Capstone Papers

Telehealth; also known as telerehabilitation, telecare, telemedicine, teletherapy, and telepractice; is an emerging healthcare service that is utilized in various healthcare facilities with a span of ages, conditions, and locations (World Federation of Occupational Therapy [WFOT], 2014). Telehealth utilizes information and communication technologies to deliver services to a patient when the healthcare provider is not in the same location (WFOT, 2014). Telehealth can provide an online platform for evaluations, consultations, monitoring, supervision, and intervention with patients and other professionals (WFOT, 2014).

Telehealth is an emerging method of delivering occupational therapy (OT) services to various populations, including: children and youth; productive …

Regionalist Social Movements In Contemporary Chile: Production Of Space, Place, Territory, And Scale Through Collective Action, Miguel A. Contreras

Dissertations - ALL

In the last decade, the organization of several territorially based social movements in Chile has expressed a significant level of social discomfort about the political and economic system of the country. The central objective of this dissertation is to analyze how motivations, achievements, and failures of these movements have a dialectical relationship with the spatial features, specifically with the concepts place, territory and scale. Critical geography, political geography, and social movements’ studies provide the theoretical framework for the analysis, highlighting the significance of social movements as producers of collective knowledge. This research used a qualitative approach with a mix-methods design …

Raising An Indoor Generation: Outdoor Environmental Education Impact On Adolescent Development, Daisy Elizabeth Bewley

Student Theses 2015-Present

In an increasingly digital world, children are growing up with less involvement and interaction with the environment. Hands-on and experiential learning is less popular in schools and a more test-oriented and numerical evaluation is increasingly popular. This thesis explores the decrease in outdoor environmental education and the impact that has on adolescent development and developmental milestones in children. This impact extends past just mental development and impacts the physical health development of children. Obesity, attention deficit disorders, and other behavioral issues are just a few of the signs of the problems that have arisen due to a decrease in environmental …

Designing The City, Sustainably: Sustainability And Climate Change Resiliency In New York City, Cosima Balletti-Thomas

Student Theses 2015-Present

Abstract

This paper explores how New York City and especially Manhattan has integrated sustainability into its agenda as a coastal metropolitan nucleus. Secondly, it assesses the New York City’s resiliency strategies that utilize environmental policy and design to confront its vulnerability to changes in the environment on account of global climate change, which has primarily manifested in the Northeastern region in the form of sea level rise, storm surge, and frequent flooding. Chapter 1 uses quantitative climate data from a multitude of sources such as the New York State Department of Environmental Conservation'sreport on the “Impacts of Climate Change …

Preparing For Climate Change In New York City - Geographic Information Systems As A Valuable Tool For Natural Hazard Management, Amy Carrillo

Student Theses 2015-Present

This paper addresses the impact of climate change in New York City. Chapter 1 focuses on details found in the United Nations Intergovernmental Panel on Climate Change Report on the impact of climate change worldwide. At the city level, this paper analyzes New York City’s Risk Landscape: A Guide to Hazard Mitigation and New York City Panel on Climate Change 2019 Report, which provides data on how climate change will impact NYC, specifically. Chapter 2 explores the history of Geographic Information Systems (GIS) and its use in mitigation and conservation practices over time. Chapter 3 studies how GIS has been …

Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng

Theses & Dissertations

Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …

Charge-Based Optimization Of Neurotensin For Neurotensin-Receptor-1 Targeting Utilizing A One-Bead One-Compound Peptide Library Approach, Trey Neeley

Theses & Dissertations

Neurotensin-receptor-1 (NTSR1) is regularly overexpressed in various cancers and contributes to the proliferation, survival, migration, invasion, and angiogenesis of tumors. NTSR1-targeting vectors have demonstrated promise in both diagnostic and therapeutic aspects. Unfortunately, the relatively poor in vivo metabolic stability and high renal uptake and retention of NTSR1-targeted compounds have hampered the translation to the clinic. In this research, we utilized a one-bead one-compound (OBOC) peptide library approach to make targeted modifications at the naturally charged residues of an NTS (4-13) sequence to discover an NTS derivative with comparable affinity to NTSR1, acceptable in vivo stability, and tolerable renal retention. Subsequent …

Synthesis And Characterization Of Long Acting Darunavir Prodrugs, Mary Banoub

Theses & Dissertations

Patient adherence is critical for ART success to ensure adequate viral suppression, therefore, long-acting antiretrovirals are soon replacing current daily regimens. In recent years, two drugs were successfully transformed into long-acting injectables; CAB LA and RPV LA. These long-acting nanoformulations made it possible to abandon the daily pill burden, instead approximately a bimonthly injection of both drugs is enough to suppress and maintain viral load suppression. Our laboratory has been instrumental in transforming FDA-approved and experimental-HIV medications into long-acting slow effective release drugs, also known as LASER ART. LASER ART consists of slow drug metabolism and high permeability and retention …

The Role Of Histone Chaperone Fact Complex In Base Excision Repair Pathway And Its Therapeutic Potential In Colon Cancer And Medulloblastoma, Heyu Song

Theses & Dissertations

Base excision repair (BER) pathway is required for the removal of damaged bases caused by alkylation, oxidation and ring-saturation. Human apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role in BER pathway. Although repair of damaged bases by recombinant APE1 has been well investigated in vitro, how APE1 gains access to damaged bases in the context of chromatin is largely unknown. A prominent member of the histone chaperone family, FACT (Facilitates Chromatin Transcription) is thought to reorganize nucleosomes through the destabilization of multiple intra-nucleosome contacts. FACT complex is composed of two polypeptides identified as SPT16 (Suppressor of Ty 16) and SSRP1 …

Enhancing The Identification Of Rheumatoid Arthritis-Associated Lung Disease, Bryant England

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predisposes afflicted individuals to reduced quality of life, physical disability, and premature mortality. While joint involvement is the primary manifestation of RA, extra-articular features including lung disease are responsible for a significant portion of the excess mortality. In this dissertation I demonstrate the contribution of chronic lung diseases to premature mortality in RA, contrasting with the more widely recognized comorbidity in RA of cardiovascular disease. Then, I establish that a novel serum biomarker, anti-malondialdehyde-acetaldehyde adduct (MAA) antibody, is associated with the presence of interstitial lung disease (ILD) in RA subjects. Further …

Engineering Hyaluronic Acid For Biomedical Applications, Deep S. Bhattacharya

Theses & Dissertations

This work presents research using the naturally available non- sulfated carbohydrate glycosaminoglycan hyaluronic acid (HA) for the synthesis of different chemical derivatives of HA for evaluation of binding kinetics with CD44 and P- selectin proteins for applications in fluorescence image-guided surgery. Chemical derivatives of HA such as deacetylated HA (deHA), sulfated HA (sHA), and deacetylated and sulfated HA (s-deHA) were synthesized by modulating sulfating and deacetylating reagents to alter binding specificities to CD44. Modified HA derivatives and CD44 biophysical interactions were assessed by fluorescence polarization. In silico techniques were also used to determine binding using molecular docking and MM-PBSA approaches. …

Orthodontically Induced External Root Resorption In Extraction Versus Non-Extraction Treatment Modalities – A Retrospective Cone-Beam Computed Tomography (Cbct) Study, Jaykishan Patel

Theses & Dissertations

Purpose of this study was to evaluate orthodontically induced external apical root resorption using cone beam computed tomography in patients receiving orthodontic treatment with or without extractions. Records of 188 consecutively treated patients who received orthodontic treatment with or without extractions were evaluated. Pre-and post-treatment root lengths of maxillary incisors, volumes of maxillary central incisors, and apex displacement of either right or left maxillary central incisors were measured using Invivo 5.4 or ITK-SNAP 3.8.0 software. After adjusting for initial length, treatment duration, tooth, sex, race, bracket type, and malocclusion, maxillary incisor reduction of root length in extraction group was 0.37 …

Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann

Theses & Dissertations

RATIONALE: Our laboratories birthed the field of human immunodeficiency virus (HIV) theranostics. The new field allows simultaneous detection (diagnostics) and treatment (therapeutic) for the identification, treatment and inevitable elimination of virus in cell and tissue compartments. By employing theranostics, antiretroviral drugs (ARVs) can be tracked in lymph nodes, gut, spleen and liver. Cellular viral reservoirs including CD4+ T cell populations and mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) along with subcellular endosomal structures can now be targeted for drug delivery bringing therapeutics to areas where virus replicates. The overarching idea rests in improving precision targeted ARV delivery. …

Characterizing The Combination Of Rpa Inhibitors With Parp Inhibitors In High-Grade Serous Ovarian Cancer, Yat Tang

Theses & Dissertations

High-grade serous ovarian cancer (HGSC) is the most common and deadly gynecologic malignancy. HGSC patients with BRCA1/2 mutations have homologous recombination deficiency (HRD), requiring parallel pathways to maintain genome integrity (e.g., PARP1, PARP2). Approximately 50% of ovarian carcinomas are estimated to exhibit HRD. For the remaining 50% and the large percentage of HRD patients with acquired or innate resistance to single-agent PARP inhibitors, there is a need to develop alternative therapeutic strategies.

Replication Protein A (RPA) is a heterotrimeric protein crucial for genome maintenance. Phosphorylation of RPA in DNA damage response (DDR) is a negative regulator of DNA end resection. …

Role Of Astrocyte-Derived Extracellular Vesicles In Neuroinflammation Mediated By Drug Abuse, Ke Liao

Theses & Dissertations

Neuronal damage and neuroinflammation is a hallmark feature of HIV-associated neurological disorders (HANDs). Opioids abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Extracellular vesicles (EVs) are essential conduits in HIV and drug abuse-mediated synaptodendritic injury and neuroinflammation. Findings from our group have demonstrated that astrocyte-derived EV (ADEV)-miRNA-29b mediates HIV Tat and morphine-induced neuronal injury, thus underscoring the importance of such interactions in NeuroHIV.

Besides, HIV Tat and morphine-mediated synaptodendritic injury via ADEVs, we are also interested in whether ADEVs contributes to neuroinflammation. Microglia are critical players in …

Identification Of More Potent And Efficacious Analogs Of The Novel Host-Derived Immunostimulant Ep67, Abdul Alshammari

Theses & Dissertations

EP67 is a human C5a-derived decapeptide agonist of C5a Receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to stimulate protective innate and adaptive immune responses while potentially minimizing neutrophil-mediated toxicity. Two N-alkyl amino acids Pro⁷ and N-methyl-Leu⁸ (nme-Leu⁸) within EP67 induce structural changes that increase potency and selective activation of mononuclear phagocytes over neutrophils. Cis/trans isomerization at these positions, however, likely limits the activity of EP67 and low coupling efficiency between Pro⁷ and nme-Leu⁸ increases scale-up costs for clinical use. Thus, the goals of this study were to …

Evaluation Of A Technology-Based Survivor Care Plan For Breast Cancer Survivors: Pre-Post Pilot Study., Talya Laufer, Bryan Lerner, Anett Petrich, Anna Quinn, Leah Ernst, Alicin Roop, Janet Knoblauch, Nick C. Leasure, Rebecca J. Jaslow, Sarah Hegarty, Amy Leader, Andrea Barsevick

Department of Medical Oncology Faculty Papers

BACKGROUND: As of 2016, almost 16 million individuals were cancer survivors, including over 3.5 million survivors of breast cancer. Because cancer survivors are living longer and have unique health care needs, the Institute of Medicine proposed a survivor care plan as a way to alleviate the many medical, emotional, and care coordination problems of survivors.

OBJECTIVE: This pilot study for breast cancer survivors was undertaken to: (1) examine self-reported changes in knowledge, confidence, and activation from before receipt to after receipt of a survivor care plan; and (2) describe survivor preferences for, and satisfaction with, a technology-based survivor care plan. …

Bringing The Theory Of Street-Level Bureaucrats Into The 21st Century: A Study Of Social Workers In Louisiana, Quian J. Lewis

LSU New Orleans Theses and Dissertations

This study examines the applicability of Michael Lipsky’s (1980) concept of “street-level bureaucracy” to the profession of social work in 2019. Street-level bureaucrats are public service workers “who interact with citizens in the regular course of their jobs; have significant independence in decision making, and potentially have extensive impact on the lives of their citizens” (Lipsky, 1980:3). They are faced with uncertainties in their work related to inadequate resources, unclear policies, and caseloads/workloads that defy what may be possible to achieve by any one worker. Workers develop routines and “coping mechanisms,” to manage their environments. The routines that they develop …

Acclimation, Long-Term Repeatability, And Phenotypic Correlations Of Aerobic Metabolic Traits In The Gulf Killifish, Fundulus Grandis, Jessica E. Reemeyer

LSU New Orleans Theses and Dissertations

This research examined the effects of acclimation to lowered salinity, elevated temperature, and hypoxia on aerobic metabolism of the Gulf killifish, Fundulus grandis, a common estuarine resident of the Gulf of Mexico. Standard metabolic rate (SMR), maximum metabolic rate (MMR), absolute aerobic scope (AAS), and critical oxygen tension (P_crit) were each influenced by one or more acclimation treatments. Assessing the consistency of these traits measured in the same individuals over time, all were found to be significantly repeatable with no indication that the repeatability of any traits was affected by acclimation conditions. Significant correlations were found between …

: Examining How Factors Associated With Patients, Physicians, Hospitals, And Surrounding Communities Affect Primary And Repeat Cesarean Delivery Through A Social-Ecological Lens, Christina Ventura-Dipersia

Dissertations and Theses

Background: Childbirth is one of the most common reasons for hospitalization in the U.S., and Cesarean delivery (i.e., surgical childbirth) is costlier and has a higher likelihood of birth-related complications, maternal rehospitalization, and postpartum medical care utilization than vaginal delivery. The rate of Cesarean delivery in the United States (U.S.) has increased in recent years by over 60%, from 20.7% of all births in 1996 to 32.9% of all births in 2011. As Although this increasing trend of Cesarean delivery incidence has also been seen in other countries, the rate of Cesarean delivery has been rising more steadily within …

Leader At The Bedside: A Mixed Methods Study Establishing Clinical Staff Nurse Leadership Competencies, Sherron Denise Franks-Meeks

Nursing Theses and Dissertations

Significance and Background

Leadership competencies were established for formal nursing roles (i.e. nurse executives), but not for informal nurse leader roles (i.e. clinical staff nurse leader). A set of comprehensive clinical staff nurse leader (CSNL) competencies would facilitate evaluation of the CSNL role in providing safe, quality, and efficient patient care.

Purpose

The purpose of this pilot was to establish a preliminary set of CSNL competencies with associated set of knowledge, skills, and attitudes (KSAs) for each competency identified through the CSNL’s voice. Theory & Design Underpinned by the Authentic Leadership Theory, this pilot was a multiphase sequential explanatory mixed …

Lifestyle Management For Vestibular Disorders, Michelle Pock

Student Capstone Papers

Individuals with vestibular disorders have concerns that impact lifestyle including limiting activities of daily living, limiting participation in social events, difficulty driving, and difficulty working (Cohen, 2014). Occupational therapists are able to help individuals with vestibular disorders by task analyzing symptom provoking activities, assessing the impact of symptoms on occupations, providing adaptations, and providing ways to modify environments (Gronski, Neville, Kannenberg, & Cohen, 2017). While occupational therapists are qualified to provide services to sustain and improve the occupational performance of individuals with vestibular disorders, occupational therapy is not well represented in this area particularly in addressing lifestyle components for vestibular …

Distinguished Professor Known For Enthusiasm; Scholarship, Micky Bedell

UNH Today Archive

No abstract provided.

Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud

Theses & Dissertations

The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. PPARγ is a target for insulin-sensitizing drugs, and it plays a significant function in prostate cancer. PPARγ antagonists have anti-proliferative effects in a broad range of hematopoietic and epithelial cell lines. The ligand binding domain (LBD) of PPARγ is large and has orthosteric and allosteric binding sites. Several PPARγ-ligand co-crystal structures show two bound molecules, one to the orthosteric pocket and a second to the allosteric …

The Effectiveness Of Resin-Modified Glass Ionomer Varnish In Preventing White Spot Lesions During Fixed Appliance Orthodontic Therapy: An In Vitro Study, Bradley Herman

Theses & Dissertations

The purpose of this investigation was to evaluate the efficacy of a glass ionomer varnish in preventing demineralization of enamel adjacent to and some distance away from an orthodontic bracket. Forty extracted human molars were divided into four different treatment groups (varnish in distilled water, varnish in acetic acid, enamel in acetic acid, and enamel in distilled water). Two 3 x 3 mm graphite windows were drawn on the tooth, one adjacent to the bracket and one 3 mm away from the first window, indicating the scanning area. Varnish was applied to the teeth in the varnish groups and all …