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2019

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Study Of Co2 And Bi-Reforming Of Methane On Modified Nickel-Based Catalysts, Nichakorn Buasuk Jan 2019

Study Of Co2 And Bi-Reforming Of Methane On Modified Nickel-Based Catalysts, Nichakorn Buasuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, several currently operated industrial factories significantly increase the rate of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) far higher than those that should be normally. Therefore, various mitigation ways to reduce carbon dioxide and methane are increasingly important. The prevailing methods are dry reforming of methane and bi-reforming of methane. Therefore, this research involves the study of the catalytic activity and coke resistance on the Ni-based catalysts with and without a promoter. The activity tests on the dry reforming of methane reaction and bi-reforming of methane reaction were performed in a fixed-bed reactor under atmospheric pressure at …

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Development And Characterization Of Natural Rubber-Cellulose Sponge, Nuttapon Suppanucroa Jan 2019

Development And Characterization Of Natural Rubber-Cellulose Sponge, Nuttapon Suppanucroa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Natural rubber (NR) sponges are a renewable biopolymer material derived from milky sap (latex) from rubber trees. In this study, composite sponges of natural rubber and cellulose (NR-C) with various compositions were synthesized. The Dunlop process was employed to prepare the NR-C sponges in various contents of cellulose fibers as reinforcing agent. The cellulose fibers were extracted from the pulp of eucalyptus trees and sodium alginate (SA) was used as dispersing agent. The aim of this work was to develop a green composite sponge with highly porous, flexible, and hydrophilic properties. The effects of cellulose loading on mechanical performance of …

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Molecular Dynamics Simulation Of Phenolic Compound Adsorption On Amine-Functionalized Carbon Nanotubes, Nutapong Tanatananon Jan 2019

Molecular Dynamics Simulation Of Phenolic Compound Adsorption On Amine-Functionalized Carbon Nanotubes, Nutapong Tanatananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The interactions between green tea phenolic compounds, including (−)-epigallocatechin gallate (EGCG) and (−)-epigallocatechin (EGC), and various amine groups functionalized on carbon nanotube (CNT) were studied by all-atom molecular dynamics (MD) simulations. The amine functional groups: ethylenediamine (EDA), triethylenetetramine (TETA), and melamine (MA) were considered in this study. Simulated results showed that amine molecular structure grafted on CNT surface affected diffusion and adsorption of EGCG and EGC. The EDA-functionalized CNT (EDA/CNT) provided a strong adsorption affinity to EGCG and EGC with their bicyclic segments located within the EDA layer. It is because the functionalized-EDA structure was well-defined and given empty site …

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Chemical Constituents Of Knema Angustifolia Stem And Biological Activities, Dung Le Thi Kim Jan 2019

Chemical Constituents Of Knema Angustifolia Stem And Biological Activities, Dung Le Thi Kim

Chulalongkorn University Theses and Dissertations (Chula ETD)

The medicinal plant Knema angustifolia has been used in Thai folk medicine for the treatment of various diseases, especially related to body tonic or blood tonic agent. Chemical data on this plant are scarce. A novel para-benzoquinone, angustiquinone (3), along with ten known compounds, rapanone (1), embelin (2), quercetin (4), kaempferol (5), bergenin (6), 11-O-acetyl bergenin (7), catechin (8), isovanillic acid (9), protocatechuic acid (10) and gallic acid (11) were isolated from the n-hexane and EtOAc extracts of the stems of K. angustifolia. Their structures were unambiguously elucidated using extensive 1D and 2D NMR analyses, high-resolution mass spectrometry along with …

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Development Of Portable Electrochemical Sensors For Determination Of Heavy Metals, Nitrogen Oxides And Thiocyanate Ion, Kingkan Pungjunun Jan 2019

Development Of Portable Electrochemical Sensors For Determination Of Heavy Metals, Nitrogen Oxides And Thiocyanate Ion, Kingkan Pungjunun

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation focused on the development of portable electrochemical sensors using the paper-based analytical device (ePAD) for the determination of the important compounds/biomarkers in various applications. Considering the target applications, this dissertation can be divided into three main parts including food safety application, environmental analysis and clinical application, respectively. In the first part, two sub-sections relating to the detection of heavy metals contaminated in food will be discussed. For the first sub-section, an ePAD coupled with a boron-doped diamond electrode was developed for the determination of total arsenic. The device was performed using the origami paper device for the preparation …

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Synthesis Of Chalcone Derivatives As Ampk Activators, Duy Vu Nguyen Jan 2019

Synthesis Of Chalcone Derivatives As Ampk Activators, Duy Vu Nguyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Diabetes and diabetic nephropathy are two noticeable disorders in modern life. Chalcones are considered as a feasible candidate for these medication disorders due to the capability to activate AMPK relating to these two diseases. A series of chalcones with A-ring possessing 2'-hydroxy-, 3',4',5'-trimethoxyacetophenones or other types and B-ring decorated with mono-, di-, trisubstitution were accomplished by Claisen–Schmidt, etherification and hydrogenation reactions in almost moderate to high yield. 3-Methoxy group was found to be the best substituent for the activity in case of monosubstitution on B-ring. 3,4-Dimethoxy and 3,4-methylenedioxy groups on B-ring (63 and 65) enhanced the activity of disubstituted chalcones …

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Development Of Sensing Platforms Using Bulk Optode Technique For Detection Of Silver And Mercury Ions, Manoon Phichi Jan 2019

Development Of Sensing Platforms Using Bulk Optode Technique For Detection Of Silver And Mercury Ions, Manoon Phichi

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research described new analytical devices for Ag+ and Hg2+ detection using bulk optode technique. The optode containing 25,27-di(benzothiazolyl)-26,28-hydroxycalix[4]arene (CU1) as an ion-selective ionophore, chromoionophore XIV as a lipophilic pH indicator, and KTpClPB as an ion-exchanger was prepared and used as a sensing agent in the proposed devices. The optode sensors responded to Ag+ and Hg2+ by changing the color from blue to yellow. The colorimetric-based detection was carried out by using the proposed paper-based analytical device. A simple fabrication method was performed by simply dropping the cocktail onto the filter paper, and the detection method was easily performed by …

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Chemical Constituents From The Stems Of Garcinia Cylindrocarpa And The Stem Bark Of Garcinia Picrorhiza And Garcinia Tetrandra, Edwin Risky Sukandar Jan 2019

Chemical Constituents From The Stems Of Garcinia Cylindrocarpa And The Stem Bark Of Garcinia Picrorhiza And Garcinia Tetrandra, Edwin Risky Sukandar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aiming to discover novel bioactive secondary metabolites from genus Garcinia, we performed phytochemical and biological investigations of three Garcinia species collected from Indonesia. A series of chromatographic techniques and spectroscopic data analysis were used to isolate and characterize the Garcinia phytochemicals. The cytotoxicity of the isolated compounds was evaluated against five human cancer cell lines (HeLa S3, Hep G2, HT-29, MCF-7, and KB) using MTT assay. Four new xanthones, cylindroxanthones D–G, and two new biphenyls, cylindrobiphenyls A and B, together with 28 known compounds were successfully isolated from G. cylindrocarpa stems. From the stem bark of G. tetrandra, nine new …

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Development Of Biosensor Using Pyrrolidinyl Pna For Screening Of Hepatitis C Virus Dna, Narathorn Nisab Jan 2019

Development Of Biosensor Using Pyrrolidinyl Pna For Screening Of Hepatitis C Virus Dna, Narathorn Nisab

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this work, a new paper-based analytical device (PAD) that relied on fluorescence measurement was developed for label-free detection of hepatitis C virus (HCV) DNA. Pyrrolidinyl peptide nucleic acid (acpcPNA) was covalently modified onto the patterned cellulose paper to act as a specific probe for capturing the HCV DNA target according to Watson−Crick base-paring rules. The single-stranded (ssDNA)-specific dye which can be electrostatically attached to the surface-bound DNA was employed as the signaling element for the fluorescence-based detection via a smartphone gadget and an iOS application. To acquire the optimal sensitivity, several experimental parameters, namely acpcPNA probe concentration, hybridization time, …

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Chemical Constituents And Antibacterial Activity Of Rhizomes From Globba Schomburgkii Hook.F., Naruemon Suekaew Jan 2019

Chemical Constituents And Antibacterial Activity Of Rhizomes From Globba Schomburgkii Hook.F., Naruemon Suekaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Globba schomburgkii Hook.f. rhizomes were extracted with dichloromethane and fractionated using column chromatography to obtain 10 fractions (FA-FJ). The most active fractions, FE and FG, were further fractionated to give seven and thirteen sub-fractions, respectively. The fractions and sub-fractions were tested for antibacterial activity using 96-well plate microdilution method. The antibacterial activity of several sub-fractions (such as FE.B, FE.C, FE.D, FG.D, FG.G, and FG.H) were higher than that of the crude extract. Chemical compositions of all fractions and sub-fractions were analyzed by gas chromatography hyphenated with mass spectrometry (GC-MS), revealing 167 compounds identified according to match between the experimental MS …

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Detection Of Nitrite By Thread-Based And Paper-Based Devices By Modified Griess Reagent, Pitcha Singhaphan Jan 2019

Detection Of Nitrite By Thread-Based And Paper-Based Devices By Modified Griess Reagent, Pitcha Singhaphan

Chulalongkorn University Theses and Dissertations (Chula ETD)

New thread-based and paper-based devices for the determination of nitrite ions based on modified Griess reagent were developed. The surface of the materials was chemically modified with p-aminobenzoyl moiety and chromotropic acid was used as a coupling reagent. The functionalization of the materials was confirmed by Raman spectroscopy. By using the thread-based device, the detection of nitrite was achieved by measuring the color band length. The optimum concentration of chromotropic acid was 5 mM in 0.10 M sulfuric acid mixed with 0.2 M citric acid. The working range was from 50 to 1,000 µM with a sample volume of 15 …

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Detection Of Cyanide Ions Using Chemosensing Ensembles Under Indicator Displacement Assays, Ratanakorn Teerasarunyanon Jan 2019

Detection Of Cyanide Ions Using Chemosensing Ensembles Under Indicator Displacement Assays, Ratanakorn Teerasarunyanon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Anion recognition is an attractive area of research in recent decades as anions play an important role in a wide range of chemical, biological, and environmental processes. This dissertation reports three projects dedicated to anion recognition with applications in fluoride and cyanide sensing. The first project of the dissertation describes the chemistry of two novel anthracene derivatives bearing one and two dimesitylboryl substituents (compounds 1 and 2, respectively) for the complexation of anions. All investigations provide insights into the electronic structure and effect of fluoride and cyanide binding. The results demonstrate that these boranes have a high affinity for fluoride …

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Development Of Paper-Based Colorimetric Sensor For Determination Of Human Papillomavirus Dna, Sarida Naorungroj Jan 2019

Development Of Paper-Based Colorimetric Sensor For Determination Of Human Papillomavirus Dna, Sarida Naorungroj

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this work, a paper-based analytical device (PAD) based on colorimetric assay using pyrrolidinyl peptide nucleic acid (acpcPNA) probe was developed as a sensor for the detection of Human papillomavirus (HPV) DNA. Dextrin-stabilized gold nanoparticles (d-AuNPs) was employed as a colorimetric reagent. The aggregation of d-AuNPs can be induced by positively charged acpcPNA generating a distinctive color change. After the hybridization of acpcPNA and DNA target, the residual acpcPNA probe can cause different degrees of the d-AuNPs aggregation, resulting in the detectable color change. The different color change before and after the introduction of the DNA target as a function …

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Development Of Fluorinated Rhodacyanine Analogues For Anti-Leishmaniasis, Thitiya Lasing Jan 2019

Development Of Fluorinated Rhodacyanine Analogues For Anti-Leishmaniasis, Thitiya Lasing

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, fluorinated rhodacyanine has been disclosed as a highly effective agent against Leishmania donovani; it was shown that replacement of hydrogen with a fluorine atom on a benzothiazole unit significantly enhanced the anti-leishmanial activity. However, the role of the fluorine substituent in this analogue has not yet been clarified and mechanism of actions remains unclear. In this research, fifteen novel and three known fluorine-containing rhodacyanine analogues (10c, and 11a-11q) were synthesized and tested the anti-leishmanial activity against promastigote and axenic amastigote stages of L. martiniquensis and L. orientalis, the indigenous Leishmania species of Thailand. The SAR knowledge of this series …

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Synthesis Of Coumarins As Carbonic Anhydrase Ii And Α-Glucosidase Inhibitors, Truc Phan Thi Hong Jan 2019

Synthesis Of Coumarins As Carbonic Anhydrase Ii And Α-Glucosidase Inhibitors, Truc Phan Thi Hong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Coumarins have been occupied an important position in medicinal chemistry. In this research, umbelliferone derivatives were evaluated for inhibitory activity of two enzymes, namely carbonic anhydrase II (CA II) and α-glucosidase. First, ether, brominated ether and ester derivatives of umbelliferone were synthesized, characterized and tested for CA II inhibitory activity. However, the inhibition data could not be used to make the exact conclusion about structure-activity relationship owing to their unrepeatable results. For the second part, thirty-four derivatives of umbelliferone (ether, brominated ether, ester, sulfonamide and sulfonate derivatives) were synthesized and explored for anti-α-glucosidase activity. It was disclosed that anti-α-glucosidase activity …

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Development Of Paper-Based 3d Cell Culture Devices And Real-Time Biosensing Applications, Naricha Pupinyo Jan 2019

Development Of Paper-Based 3d Cell Culture Devices And Real-Time Biosensing Applications, Naricha Pupinyo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to its micro fibrous pores, paper has gained traction in the use as a scaffold for 3D cell culture. To study melanoma mechanism, screening the amount of melanin production and invasion study are major keys for drug development. In this work, we developed paper-based devices for culturing melanoma cells. Through the development process, we obtained the optimal parameters, which were applied for 3 different projects; 1) Anti-melanogenic effect screening, 2) Impedance-based E-screen assay, and 3) A membrane insert for real-time invasion assay. As a result of melanin production from melanocytes, the cells can be easily observed after a few …

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Effects And Mechanisms Of Caesalpinia Mimosoides Leaf Extract On Oxidative Stress Resistance And Anti-Aging Activity In Caenorhabditis Elegans And Neurite Outgrowth Activity In Neuro2a Cells, Panthakarn Rangsinth Jan 2019

Effects And Mechanisms Of Caesalpinia Mimosoides Leaf Extract On Oxidative Stress Resistance And Anti-Aging Activity In Caenorhabditis Elegans And Neurite Outgrowth Activity In Neuro2a Cells, Panthakarn Rangsinth

Chulalongkorn University Theses and Dissertations (Chula ETD)

World’s population of older people is rising, dietary supplements promoting healthy lifespan are needed. Moreover, Alzheimer’s disease (AD), an age-related degenerative disease, becomes a public health problem in aging society. Recent reports using cell culture models of AD suggest that amyloid precursor protein (APP), a protein causally related to AD, plays an important role as an inhibitor of neurite outgrowth. Medicinal herbs with neurite outgrowth stimulatory effect may help to prevent and cure AD. Moreover, studies suggest that dietary supplements from plant sources act in preventive nutrition, since they provide antioxidant action against oxidative stress, promote healthspan and prolong lifespan. …

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Population Pharmacokinetics Of Nicotine In Thai Smokers, Kathy Moe San Jan 2019

Population Pharmacokinetics Of Nicotine In Thai Smokers, Kathy Moe San

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite the popularity of nicotine gum in Thailand, population pharmacokinetics of nicotine gum in Thai population has not been investigated yet. This study aimed to develop a population pharmacokinetic model to quantify the effects of genetic and nongenetic factors to nicotine pharmacokinetics after administration of nicotine gum to adult Thai smokers. A population pharmacokinetic analysis was performed using secondary data collected from a previous clinical trial assessing cytochrome P450 2A6 (CYP2A6) genotypes in Thai smokers. Eighteen healthy adult smokers were included in the study. Blood samples were collected at pre-dose, and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4.5, and …

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Qualitative Analysis Of Optic Nerve Head Peripapillary Microvasculature In Healthy Eyes Using Optical Coherence Tomography Angiography, Sittikorn Laojaroenwanit Jan 2019

Qualitative Analysis Of Optic Nerve Head Peripapillary Microvasculature In Healthy Eyes Using Optical Coherence Tomography Angiography, Sittikorn Laojaroenwanit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Primary objective: To evaluate optic nerve head microvasculature/radial peripapillary capillaries (RPCs) in healthy adult eyes using swept-source optical coherence tomography angiography Secondary objectives: To evaluate macular microvascular network in healthy adult eyes using swept-source optical coherence tomography angiography Design: Cross-sectional study Participants: 224 eyes of 112 healthy adult volunteers at eye clinic of King Chulalongkorn Memorial Hospital. Method: En face 3x3-mm OCTA at macular area, 6x6-mm OCTA at optic nerve head and high-definition horizontal lines 16-mm scans crossing the fovea and optic disc were acquired using the SS-OCTA Plex Elite 9000. To evaluate RPCs density, the images were binarized and …

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An Affordable Immunohistochemical Approach To Estimate The Prevalence Of Braf V600e Mutation In Papillary Thyroid Cancer Patients Of King Chulalongkorn Memorial Hospital, Thailand., Sonam Choden Jan 2019

An Affordable Immunohistochemical Approach To Estimate The Prevalence Of Braf V600e Mutation In Papillary Thyroid Cancer Patients Of King Chulalongkorn Memorial Hospital, Thailand., Sonam Choden

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Papillary thyroid carcinoma (PTC) accounts for the majority of diagnoses of thyroid carcinoma. BRAFV600E mutation is the most common genetic alteration in PTC, which has diagnostic and prognostic significance. The rate of BRAFV600E mutation in PTC from Thailand has not been reported. Our purpose was to estimate the prevalence of BRAF mutation in a large institutional series using an affordable approach, which combined mutation-specific immunohistochemistry (IHC) with VE1 antibody and tissue microarray (TMA). Methods: A total of 476 PTC cases plotted on TMA were employed for determining the mutation status in this study. The cancer tissue of initial 100 …

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Predictive Factors For Invasive Fungal Rhinosinusitis In Diabetic Patients, Thwe Phyo Kan Nyunt Jan 2019

Predictive Factors For Invasive Fungal Rhinosinusitis In Diabetic Patients, Thwe Phyo Kan Nyunt

Chulalongkorn University Theses and Dissertations (Chula ETD)

ภูมิหลัง ผู้ป่วยเบาหวานมีโอกาสที่จะเกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกรานได้ง่ายกว่าผู้ป่วยปกติ ซึ่งอัตราการเสียชีวิตจากโรคนี้ในผู้ป่วยเบาหวานมีความหลากหลายค่อนข้างสูงในแต่ละการศึษา วัตถุประสงค์ เพื่อศึกษาปัจจัยที่จะทำนายอัตราการรอดชีวิตของผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน วิธีการศึกษา การศึกษาแบบย้อนหลังนี้ได้จัดทำในโรงพยาบาลระดับตติยภูมิ 4 แห่ง ในประเทศไทย, มาเลเซีย และเมียนมาร์ โดยเก็บรวบรวมข้อมูลในผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน ตั้งแต่ปี ค.ศ. 2008 ถึง ค.ศ.2019 ผลที่ต้องการศึกษาคืออัตราการรอดชีวิต ปัจจัยทำนายที่นำมาวิเคราะห์ ได้แก่ อายุ, ระดับฮีโมโกลบินเอวันซีในเลือด, ภาวะเลือดเป็นกรดคีโต, ระดับเม็ดเลือดขาว, ภาวะน้ำตาลในเลือดสูง, ระยะเวลาที่เป็นโรคเบาหวาน, การใช้ยารักษาเบาหวานในปัจจุบัน, ระดับครีเอทีนีนในเลือด, และการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปที่ตา, คาเวอร์นัสไซนัส และโพรงสมอง ผลการศึกษา มีการเก็บรวบรวมข้อมูลในผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน 65 ราย (อายุเฉลี่ย 57.9±13.4 ปี, เพศชาย 60%) ผลพบว่า อัตราการเสียชีวิตอยู่ที่ 21.5 % โดยพบว่าการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าคาเวอร์นัส ไซนัส (hazard ratio 5.1, 95% CI [1.4–18.2], p=0.01) และโพรงสมอง (hazard ratio 3.4, 95% CI [1.1–11.3], p=0.05) เป็นปัจจัยทำนายอัตราการเสียชีวิต ส่วนการรักษาเบาหวานเป็นปัจจัยที่ลดความเสี่ยงของการเสียชีวิต (hazard ratio 0.2, 95% CI [0.1–0.9], p=0.03) ด้านอัตราการรอดชีวิตในระยะเวลา 6 เดือนในผู้ป่วยที่มีการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปและไม่เข้าไปที่คาเวอร์นัสไซนัสอยู่ที่ 51.4% และ 83.6% ตามลำดับ, (p <0.01), เข้าไปและไม่เข้าไปที่โพรงสมองอยู่ที่ 53.3% และ 88.9% ตามลำดับ, (p <0.01) และมีการใช้ยารักษาเบาหวานและไม่มีการใช้ยารักษาเบาหวานอยู่ที่ 82.3% และ 57.5% ตามลำดับ, (p =0.05) สรุป การกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปที่คาเวอร์นัสไซนัสและโพรงสมองเพิ่มความเสี่ยงต่อการเสียชีวิตในผู้ป่วยเบาหวาน การรอดชีวิตมีความสัมพันธ์กับการใช้ยารักษาเบาหวานในปัจจุบัน

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Access To Malaria Diagnostic Testing, Anti-Malarial Treatment And Long-Lasting Insecticidal Nets Among Immigrant Workers In Yala Province, Southern Thailand, Tinzar Naing Jan 2019

Access To Malaria Diagnostic Testing, Anti-Malarial Treatment And Long-Lasting Insecticidal Nets Among Immigrant Workers In Yala Province, Southern Thailand, Tinzar Naing

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: In Southeast Asia, trans-border migration from neighboring countries into Thailand is a well-known phenomenon. Population movement and migration is a factor having significant implications for vector-borne disease transmissions. Objectives: This study aims to assess migrants’ access to malaria diagnosis and treatment in Yala province who have had fever in the previous three months and to evaluate the coverage and utilization of ITNs (insecticidal nets). Methodology: A survey was conducted among 414 immigrant workers, in which information was sought on socio-demography, history of fever, health seeking behaviours, net ownership and utilization. Survey analysis was employed. Results: As key findings, 36.5% …

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Evaluation Of The Outcomes And Regression Rate After Early Treatment For Retinopathy Of Prematurity Treatment In King Chulalongkorn Memorial Hospital, Yothin Titawattanakul Jan 2019

Evaluation Of The Outcomes And Regression Rate After Early Treatment For Retinopathy Of Prematurity Treatment In King Chulalongkorn Memorial Hospital, Yothin Titawattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Primary objectives: To study the unfavorable outcomes and assess the regression rate after early treatment protocol for the ROP in KCMH. - Secondary objectives: To study the complications and evaluate the progression and recurrence of ROP requiring retreatment after early treatment protocol for the ROP in KCMH. To identify the independent risk factor for the Retinopathy of Prematurity development in KCMH. - Design: The Retrospective descriptive study and retrospective cohort study. - Participants: The study included all premature infants who were screened ROP in King Chulalongkorn Memorial Hospital from January 2009 to January 2014. - Method: The data retrieved from …

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Heuristics Used In Credibility Judgment Of Health Information On Facebook, Yaninee Petcharanan Jan 2019

Heuristics Used In Credibility Judgment Of Health Information On Facebook, Yaninee Petcharanan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Facebook users worldwide had been facing challenges of information credibility. This study aimed to address this issue among Thai Facebook users by focusing on health information in particular, through a lens of heuristic approach. Data were collected from 50 informants by in-depth interviews and 480 responses from online surveys. All participants were at least 18 years old with a minimum of one year experience in using Facebook. The results revealed three different processes and five heuristics, namely, reputation heuristic, authority heuristic, expectancy violation heuristic, persuasive intense heuristic, and bandwagon heuristics that participants adopted when making a credibility judgment of health …

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In Vitro Safety And Permeation Assessments Of Lidocaine Loaded In Dissolving Microneedle Patch For Ocular Administration, Sirikool Thamnium Jan 2019

In Vitro Safety And Permeation Assessments Of Lidocaine Loaded In Dissolving Microneedle Patch For Ocular Administration, Sirikool Thamnium

Chulalongkorn University Theses and Dissertations (Chula ETD)

The challenge in ocular drug delivery have brought much attention in pharmaceutical research. Efforts have been made to improve the low bioavailability causing by physiological limitations of ophthalmic drug administration. Topical lidocaine solution is a popular choice for ocular treatment, but less than 5% of topically applied dose reached to the target site. Lidocaine loaded in dissolving microneedle patch was considered a good alternative approach to treating eyes. The study aimed to investigate the cytotoxicity of the lidocaine loaded in dissolving microneedle administration against human corneal epithelial cells (HCECs) as well as ex vivo drug target localization with tissue penetration. …

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Effect Of Extraction Solvents On Biological Activities Of Murraya Paniculata Leaves In Cosmetic Application, Siriruethai Ruanmai Jan 2019

Effect Of Extraction Solvents On Biological Activities Of Murraya Paniculata Leaves In Cosmetic Application, Siriruethai Ruanmai

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study was to evaluate and compare the antioxidant activity and tyrosinase inhibition activity of Murraya paniculata (Linn.) Jack leaves extract (MPE) obtained from different extraction solvents for the use of cosmetic purposes. The result showed that 75 % ethanolic extract presented the highest antioxidant activity (IC50 = 1.43 mg/mL), the total phenolic content of 66.12 mg GAE/g and the total flavonoids content of 7.83 mg QE/g. All of the obtained extracts had low tyrosinase inhibitory activity. The final MPE lotion contained 1 %w/w of 75 % ethanolic extract dissolved in 50 %w/w of propylene glycol, 20 …

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Projection And Determinants Of Cognitive Ability Among Older Persons In Thailand : Role Of Education, Paolo Miguel Vicerra Jan 2019

Projection And Determinants Of Cognitive Ability Among Older Persons In Thailand : Role Of Education, Paolo Miguel Vicerra

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis examines the role of education on cognitive ability among the older population of Thailand. The nationally-representative data primarily utilised in this thesis is 2016 Population Change and Well-being in the Context of Aging Society. Other datasets had been used in selected themes within this thesis. Multiple analytic approaches had been applied to this study to show various effects of education gradients on cognitive functioning. In the first study, education and other covariates including income, health status, living arrangement, and social participation among others had been analysed by gender to test if the significant factors would be similar. It …

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Wage Compensation Differentials For Job Risk Between Formal And Informal Workers, Pinyada Suwannarat Jan 2019

Wage Compensation Differentials For Job Risk Between Formal And Informal Workers, Pinyada Suwannarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research estimates compensating wage differentials for job risks for formal and informal workers in Thailand, the latter of whom are not covered by prevailing labor laws. Using data from the National Statistical Office’s Thai Labor Force Survey for years 2012 to 2018 merged with job fatality risk collected by the Social Security Office, the results show that the fatality risk rate has a positive, significant effect on wages. The value of statistical life for the median formal workers is 79.33 million baht compared to 41.5 million baht for the median informal worker. Also, we analyze the relationship between self-reported …

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Effects Of Upper Extremity Positions And Movements And Breathing Patterns On Chest Wall Kinematics And Sensation Of Dyspnea In Patients With Chronic Obstructive Pulmonary Disease, Chathipat Kruapanich Jan 2019

Effects Of Upper Extremity Positions And Movements And Breathing Patterns On Chest Wall Kinematics And Sensation Of Dyspnea In Patients With Chronic Obstructive Pulmonary Disease, Chathipat Kruapanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study were to 1) study the influences of the upper extremity (UE) positions and 2) the combination of UE movements coordinated with breathing patterns on chest wall movements and sensation of dyspnea in patients with chronic obstructive pulmonary disease (COPD). Furthermore, the results were also compared to those of the healthy subjects. We invited forty-two subjects, 21 patients with mild to moderate COPD whose aged, gender, and physical activity were matched to healthy subjects, to participate in this study. In the first part of this study, all participants’ chest wall movements and dyspnea were evaluated while …

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Development Of Ecoregion Criteria Through Assessment Of Changing Floating Vegetation: A Case Study Of Intha Communities In Inlelake, Myanmar, Saint N/A Jan 2019

Development Of Ecoregion Criteria Through Assessment Of Changing Floating Vegetation: A Case Study Of Intha Communities In Inlelake, Myanmar, Saint N/A

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Inle Lake ecoregion, one of the fresh water ecoregions in the Global 200 list of ecoregions, is facing impacts of sedimentation from upland catchments. Sediment loads and soil sediment characteristics from degraded forest of Kalaw catchment shallowed and reduced plant nutrients in the Inle Lake ecosystems where used to be well recognized for the balancing between Intha livelihoods and natural production of littoral and pelagic zones. This study aimed to assess causes of ecological function change in terms of high sediment loads influencing Intha livelihoods; floating vegetation and to propose criteria for ecoregion development concerning sustainable floating vegetation yields …

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