Digital Commons Network^™

Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study Of Plasmodium Falciparum Hsp70s, Arnold Amusengeri, Lindy Astl, Kevin Lobb, Gennady M. Verkhivker, Özlem Tastan Bishop

Mathematics, Physics, and Computer Science Faculty Articles and Research

Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric …

Memory-Like Inflammatory Responses Of Microglia To Rising Doses Of Lps: Key Role Of Pi3kγ, Trim Lajqi, Guang Ping Lang, Fabienne Haas, David L. Williams, Hannes Hudalla, Michael Bauer, Marco Groth, Reinhard Wetzker, Reinhard Bauer

ETSU Faculty Works

Trained immunity and immune tolerance have been identified as long-term response patterns of the innate immune system. The causes of these opposing reactions remain elusive. Here, we report about differential inflammatory responses of microglial cells derived from neonatal mouse brain to increasing doses of the endotoxin LPS. Prolonged priming with ultra-low LPS doses provokes trained immunity, i.e., increased production of pro-inflammatory mediators in comparison to the unprimed control. In contrast, priming with high doses of LPS induces immune tolerance, implying decreased production of inflammatory mediators and pronounced release of anti-inflammatory cytokines. Investigation of the signaling processes and cell functions involved …

Designing And Developing A Mobile App: An Interprofessional Collaboration, Shuhong Luo

Biennial Convention (CONV)

To describe the collaboration process between two team members in their work on designing and developing this mobile app. We discuss the barriers to the collaboration as well as the partners' plans to overcome them.

Effects Of Educational Program On Wound Care Nurse Knowledge And Application In Outpatient Practice Settings, Lu Ann V. Reed, Donna Green, Deborah Jane Schwytzer

Biennial Convention (CONV)

Chronic lower-extremity wounds are becoming increasingly prevalent. Effective treatment requires that nurses maintain their knowledge of wounds and wound care and that they apply thorough documentation practices. This quality improvement project leverages testing and education to determine whether a formal education program impacts nurse knowledge and documentation efficacy.

A Cultural Immersion Experience To Enhance Nursing Students' Appreciation And Understanding Of Different Cultures, Abigail Mitchell, Connie Jozwiak-Shields

Biennial Convention (CONV)

Nursing students, undergraduate and graduate, often feel left out and are unable to attend study abroad opportunities. By offering a short duration travel experience (Amsterdam, Paris, London ) will this promote professional growth and increase cultural awareness in various populations.

Advancing Nursing Education Globally Through A Fulbright Teaching Award, Ana Maria Kelly

Biennial Convention (CONV)

The aim of my presentation is to encourage more nurse educators to apply for the Fulbright award by sharing my experience as a Fulbright scholar in Malawi. Current literature focuses on the research Fulbright, but I will address the teaching award mechanism.

A Psychometric Evaluation Of The Family Decision-Making Self-Efficacy Scale Among Surrogate Decision-Makers Of The Critically Ill, Grant A. Pignatiello, Elliane Irani, Sadia Tahir, Emily Tsivitse, Ronald L. Hickman Jr.

Faculty Scholarship

Objectives The purpose of this study was to report the psychometric properties, in terms of validity and reliability, of the Unconscious Version of the Family Decision-Making Self-Efficacy Scale (FDMSE). Methods A convenience sample of 215 surrogate decision-makers for critically ill patients undergoing mechanical ventilation was recruited from four intensive care units at a tertiary hospital. Cross-sectional data were collected from participants between days 3 and 7 of a decisionally impaired patient's exposure to acute mechanical ventilation. Participants completed a self-report demographic form and subjective measures of family decision-making self-efficacy, preparation for decision-making, and decisional fatigue. Exploratory factor analyses, correlation coefficients, …

Certified Registered Nurse Anesthetist To Post-Anesthesia Care Unit Registered Nurse Handoff Using A Standardized Screen, Lindsey Hayde

Biennial Convention (CONV)

This was a quality improvement project that optimized an underutilized computerized handoff screen which then created an improved standardized handoff screen for Certified Registered Nurse Anesthetists and Post-Anesthesia Care Unit Registered Nurses. Goals of the project included degreased handoff time and increased staff satisfaction.

Reducing Cardiac Telemetry Nuisance Alarms Through Evidence-Based Interventions, Eleftheria T. Karapas, Kathleen L. Bobay

Biennial Convention (CONV)

Cardiac telemetry nuisance alarms are most often due to leads off and poor signal events. Nuisance alarms increase staff workflow interruptions, decrease staff trust in technology, and can compromise patient safety. Implementation of evidence-based interventions for daily care of cardiac telemetry patients should decrease the number of nuisance alarms.

Enriching The Global Nursing Immersion Experience Through Peer Mentorship, Dawn Fitzgerald, Lynn Ann Leveille

Biennial Convention (CONV)

Nursing students gain invaluable experience by participating in global immersion programs. Most programs lack peer-to-peer mentorship, even though greater student involvement can mitigate common issues. This study evaluates the need for peer mentorship through a pilot mentor program, and surveys to former and current global nursing students at Columbia University.

Clinical Judgment: Nursing Actions And Measurable Indicators, Sheryl Sommer, Christine Mills, Kevin Loughlin

Biennial Convention (CONV)

Recommendations for educators from a study identifying nursing actions associated with the performance of clinical judgment, and measurable indicators providing evidence that clinical judgment occurred.

Shared Learning Meeting Launch – November 8, 2019

Know Diabetes by Heart and Diabetes INSIDE Shared Learning

No abstract provided.

Tensions And Exclusions: The Knotty Policy Encounter Between Sexual And Reproductive Health And Rights And Hiv, Susana T. Fried, Aziza Ahmed, Luisa Cabal

Faculty Scholarship

The International Conference on Population and Development or ICPD (Cairo, 1994) provided a global policy framework centred on reproductive rights instead of population control. Global standards on sexual and reproductive health and rights (SRHR) and on HIV rapidly expanded throughout the 1990s.1 Considerable activist mobilisation in both arenas advanced health issues as politically salient decision-making venues where human rights and health advocacy were urgently needed, rather than scientific and technical showcases.

The ICPD, quickly followed by the Fourth World Conference on Women (1995), stressed that reproductive rights are anchored in governments’ human rights obligations and development commitments, including to …

Retention Relationships: Connecting Higher Education Employees To Students Through Student Organizations, Michelle Sanford

Dissertations

This mixed methods study investigated higher education employee involvement with student organizations to determine if a connection existed between an employee’s engagement with a student organization and the employee’s retention at the university. Research shows that student involvement in campus life and with student organizations increases student retention (Astin, 1984); however, few research studies have focused on the impact this type of involvement has on employee retention. In this study, the researcher explored the following research questions: How does employee engagement with student organizations impact employee retention? Why do employees choose to support student organizations? The researcher examined these questions …

Blood Flow Restriction Exercise: A Systematic Review Of The Literature, James M. Mckivigan

College of Health & Human Services (TUN) Publications and Research

Blood flow restriction training is quickly gaining popularity in the United States. However, it is not without controversy. While there are many reported health benefits, there are equally as many risks. Most concerning is the lack of industry standardizations regarding cuff size and pressure. There is no required training to implement blood flow restriction training, which can be problematic when people with little knowledge practice this type of exercise. When blood flow is restricted, there is an impact on the cardiovascular system, nervous system, and muscular system. Damage can be done when blood flow is restricted with too much pressure …

Adolescent Identity Exploration And Civic Identity Development In A U.S. Government Classroom, Sarah Mead Denney

USF Tampa Graduate Theses and Dissertations

As technological advances provide minute-by-minute updates of current events and personalized media feeds push the boundaries of political polarization, the task of social studies educators to provide students with the tools to become effective citizens becomes increasingly important. Undergirded by theories of psychosocial identity development, civic identity development, and the promotion of identity exploration in the academic curriculum, this qualitative multiple case study attempts to examine the processes of adolescent identity exploration and civic identity development in relation to the assignments and activities in a twelfth-grade Advanced Placement (AP) U.S. Government classroom. Classroom observations, teacher and student interviews, and artifact …

The Experiences Of African American Male Computer Science Majors In Two Year Colleges, Simone Brookins Jenkins

USF Tampa Graduate Theses and Dissertations

As the field of computer science grows and the computing science workforce demands more qualified workers, the United States workforce will require underrepresented minorities to help meet these demands. African American males are a demographic that can help meet this need but there are few of them pursuing computer science careers and successfully graduating with computer science degrees. The purpose of this qualitative study was to examine the experiences of African American male two-year college students who are in pursuit of a degree in computer science. My findings indicated that the study participants’ experiences such as positive interactions with faculty …

An Assessment Of The Role Of Florida Pharmacists In The Administration Of Inactivated Influenza Vaccine To Pregnant Women, Oluyemisi O. Falope

USF Tampa Graduate Theses and Dissertations

The influenza vaccine is a safe and effective vaccine in preventing influenza infection in the general population. The Centers for Disease Control (CDC) recommend that pregnant women receive influenza inactivated vaccine (IIV) due to the high morbidity and mortality associated with influenza infection in pregnant women. Despite the recommendation, the U.S. national influenza vaccine uptake rates among pregnant women continue to remain low. Studies have shown barriers to influenza vaccine uptake in pregnant women to include issues with access, unavailability of vaccine, and lack of time during prenatal visits. These barriers can be overcome using pharmacists because, among healthcare providers, …

State V. Feltman Respondent's Brief Dckt. 46756

Not Reported

No abstract provided.

Macrophage-Associated Wound Healing Contributes To African Green Monkey Siv Pathogenesis Control, Fredrik Barrenas, Kevin Raehtz, Cuiling Xu, Lynn Law, Richard R. Green, Guido Silvestri, Steven E. Bosinger, Andrew Nishida, Qingsheng Li, Wuxun Lu, Jianshui Zhang, Matthew J. Thomas, Jean Chang, Elise Smith, Jeffrey M. Weiss, Reem A. Dawoud, George H. Richter, Anita Trichel, Dongzhu Ma, Xinxia Peng, Jan Komorowski, Cristian Apetrei, Ivona Pandrea, Michael Gale Jr.

Nebraska Center for Virology: Faculty Publications

Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS susceptible species, rhesus macaque (RM). To asses gene expression profiles from acutely SIV infected AGMs and RMs, we developed a systems biology approach termed Conserved Gene Signature Analysis (CGSA), which compared RNA sequencing data from rectal AGM and RM tissues to various other species. We found that AGMs rapidly activate, and then maintain, evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue. The wound healing protein fibronectin …

Physicochemical Properties Of Blend Poly (Vinyl Alcohol) And Sodium Alginate Membranes For Potential Application In Wound Dressings, Martha Pieper

Mechanical Engineering Theses

Poly (vinyl alcohol) (PVA) and sodium alginate (SA) are water-soluble polymers with excellent biocompatibility suitable for biomedical applications in wound dressings. In this study, pure PVA, pure SA, and blends of PVA/SA membranes were solvent cast into films followed by crosslinking in CaCl₂, boric acid, and a mixture of CaCl₂/boric acid solutions for 5, 10, and 30 minutes. Initial feasibility studies showed a strong correlation of film thickness to the observed mechanical properties. Further studies in solvent casting of blend PVA/SA films, using various polymer concentrations, yielded better film appearance with minimal physical changes after crosslinking. …

State V. Rains Respondent's Brief Dckt. 46948

Not Reported

No abstract provided.

State V. Johnson Appellant's Brief Dckt. 47113

Not Reported

No abstract provided.

The Role Of Ict In Antiretroviral Therapy-Related Knowledge Seeking Among Older Chinese Living With Hiv, Yao Zhang, Xiaoming Li Ph.D., Shan Qiao Ph.D., Yuejiao Zhou, Zhiyong Shen

Faculty Publications

Antiretroviral therapy (ART) enables HIV patients to reduce disease progression. ART adherence is closely related to patients’ knowledge about the medical treatment. This study investigated the role of information and communication technologies (ICTs) in supporting ART-related knowledge seeking among older Chinese with HIV, using cross-sectional data collected from 2012 to 2013 in Guangxi, China. Of the 2987 HIV patients, 688 were 45 years or older and going through ART. We used an 11-item scale (α=0.69), which was developed based on existing literature, to assess ART-related knowledge to obtain a composite score (0-11). Less than 5% of the participants sought HIV-related …

Sociotechnical Approach Toward Organizational Leaders Accepting Technology: A Conceptual Relationship, Adam J. Morse, Ryan Chan

Biennial Convention (CONV)

Positive leadership styles are associated with better patient outcomes, increased nurse retention, and higher levels of job satisfaction. As technological innovation continues to influence healthcare practice, it is valuable to promote leadership styles that support clinical units while fostering successful integration of new technology through this proposed relationship.

Testing Of The 10-Item Satisfaction With Nursing Skill Examination: Objective Structured Clinical Assessment (Sine-Osca) Scale, Lucie M. Ramjan, Miranda Daly, Leanne Hunt, Peter Lewis, Yenna Salamonson

Biennial Convention (CONV)

The aim of this study was to develop and test the psychometric properties of the Satisfaction with Nursing Skill Examination: Objective Structured Clinical Assessment (SINE-OSCA) scale that could be used across health professional educational settings.

Development And Psychometric Evaluation Of The Cervical Cancer Belief Scale, Ditsapelo M. Mcfarland

Biennial Convention (CONV)

The primary objective of the study is to report on the development of the instrument to measure beliefs about cervical cancer and screening among women in Botswana.

"Jump Start" A Baccalaureate Degree By Increasing Self-Efficacy In Associate Degree Nursing Students, Janis J. Schiefelbein, Gena Coomes

Biennial Convention (CONV)

The purpose of the project was to develop a "jump start" model to encourage and increase self-efficacy in current associate degree nursing students who have a goal to obtain a baccalaureate in nursing degree. An educational model was developed in collaboration with three community colleges and a RN-BSN program.

Explore The Body Constitution Of Traditional Chinese Medicine In Nurses, Wen-Chun Chen, Jui-Fen Cheng

Biennial Convention (CONV)

The purpose of this study is to explore 1. body constitution (BC) of Traditional Chinese Medicine (TCM) in Nurses, 2. the influence factors of BC.

Will A Self-Compassion Intervention Improve Rural Caregivers Of Persons With Early-Stage Dementia Quality Of Life?, Dorothy J. Dunn, Michael J. Mccarthy, Yolanda E. Garcia

Biennial Convention (CONV)

This descriptive quantitative intervention study is to determine if there is a relationship between self-compassion, increase in caregiver knowledge of dementia care, and improvement of quality of life. Rural caregivers of a person with early-stage dementia will be recruited for this five-week intervention.