Digital Commons Network^™

Graft Immaturity And Safety Concerns In Transplanted Human Kidney Organoids, Sun Ah Nam, Kohei Uchimura, Benjamin D. Humphreys, Et Al.

Open Access Publications

No abstract provided.

Dissemination And Stakeholder Engagement Practices Among Dissemination & Implementation Scientists: Results From An Online Survey, Christopher E. Knoepke, M. Pilar Ingle, Daniel D. Matlock, Ross C. Brownson, Russell E. Glasgow

Open Access Publications

No abstract provided.

Urinary Tract Infections After Combat-Related Genitourinary Trauma, Stephen Y. Liang, Brendan Jackson, Janis Kuhn, Faraz Shaikh, Dana M. Blyth, Timothy J. Whitman, Joseph L. Petfield, M. Leigh Carson, David R. Tribble, Jay R. Mcdonald, Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group

Open Access Publications

No abstract provided.

Stunting Is Preceded By Intestinal Mucosal Damage And Microbiome Changes And Is Associated With Systemic Inflammation In A Cohort Of Peruvian Infants, Mara Zambruni, Theresa J Ochoa, Anoma Somasunderam, Miguel M Cabada, Maria L Morales, Makedonka Mitreva, Bruce A Rosa, Gonzalo J Acosta, Natalia I Vigo, Maribel Riveros, Sara Arango, David Durand, Maitreyee N Berends, Peter Melby, Netanya S Utay

Open Access Publications

Stunting, defined as height-for-age

Heterogeneity Diffusion Imaging Of Gliomas: Initial Experience And Validation, Qing Wang, Gloria J. Guzmán Pérez-Carrillo, Maria Rosana Ponisio, Pamela Lamontagne, Sonika Dahiya, Daniel S. Marcus, Mikhail Milchenko, Joshua Shimony, Jingxia Liu, Gengsheng Chen, Amber Salter, Parinaz Massoumzadeh, Michelle M. Miller-Thomas, Keith M. Rich, Jonathan Mcconathy, Tammie L. S. Benzinger, Yong Wang

Open Access Publications

OBJECTIVES: Primary brain tumors are composed of tumor cells, neural/glial tissues, edema, and vasculature tissue. Conventional MRI has a limited ability to evaluate heterogeneous tumor pathologies. We developed a novel diffusion MRI-based method-Heterogeneity Diffusion Imaging (HDI)-to simultaneously detect and characterize multiple tumor pathologies and capillary blood perfusion using a single diffusion MRI scan.

METHODS: Seven adult patients with primary brain tumors underwent standard-of-care MRI protocols and HDI protocol before planned surgical resection and/or stereotactic biopsy. Twelve tumor sampling sites were identified using a neuronavigational system and recorded for imaging data quantification. Metrics from both protocols were compared between World Health …

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.

Two-Photon Microperimetry: Sensitivity Of Human Photoreceptors To Infrared Light, Daniel Ruminski, Grazyna Palczewska, Maciej Nowakowski, Agnieszka Zielińska, Vladimir J Kefalov, Katarzyna Komar, Krzysztof Palczewski, Maciej Wojtkowski

Open Access Publications

Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged …

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Lindsay L. Peterson, Et Al

Open Access Publications

No abstract provided.

The Children's Respiratory And Environmental Workgroup (Crew) Birth Cohort Consortium: Design, Methods, And Study Population, James E. Gern, Leonard B. Bacharier, Et Al

Open Access Publications

No abstract provided.

Building A Culture Of Health And Well-Being At Merck, Cathryn E. Gunther, Virginia Peddicord, Joseph Kozlowski, Yi Li, Danielle Menture, Raymond Fabius, Sharon Glave Frazee, Peter J. Nigro

Open Access Publications

No abstract provided.

A Fatal Case Of Disseminated Microsporidiosis Due To Anncaliia Algerae In A Renal And Pancreas Allograft Recipient, Neil W. Anderson, Atis Muehlenbachs, Sana Arif, Jackrapong Bruminhent, Paul J. Deziel, Raymund R. Razonable, Mark P. Wilhelm, Maureen G. Metcalfe, Yvonne Qvarnstrom, Bobbi S. Pritt

Open Access Publications

No abstract provided.

Prevalence And Impact Of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living In The Us And Canada, David R. Mcgivern, Hsing-Hua S. Lin, Junyao Wang, Tiffany Benzine, Henry L.A Janssen, Mandana Khalili, Mauricio Lisker-Melman, Robert J. Fontana, Steven H. Belle, Michael W. Fried

Open Access Publications

No abstract provided.

Seasonal Changes In The Prevalence Of Antibiotic-Susceptible Acinetobacter Calcoaceticus-Baumannii Complex Isolates Result In Increased Multidrug Resistance Rates During Winter Months, Jason P. Burnham, Mario F. Feldman, Juan J. Calix

Open Access Publications

No abstract provided.

The Role Of Fecal Microbiota Transplantation In Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape And Future Directions, Michael H. Woodworth, Mary K. Hayden, Vincent B. Young, Jennie H. Kwon

Open Access Publications

No abstract provided.

Clinical Impact Of Revised Cefepime Breakpoint In Patients With Enterobacteriaceae Bacteremia, Kap Sum Foong, Abigail L. Carlson, Munigala Satish, Carey-Ann D. Burnham, David K. Warren

Open Access Publications

No abstract provided.

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–Cb1-R Signaling, Janos Paloczi, Csaba Matyas, Resat Cinar, Zoltan V. Varga, György Hasko, Thomas H. Schindler, George Kunos, Pal Pacher

Open Access Publications

No abstract provided.

Obesity Alters The Muscle Protein Synthetic Response To Nutrition And Exercise, Joseph W Beals, Nicholas A Burd, Daniel R Moore, Stephan Van Vliet

Open Access Publications

Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling …

Physician Documentation Of Access To Firearms In Suicidal Patients In The Emergency Department, Sonya Naganathan, Kristen L. Mueller

Open Access Publications

No abstract provided.

U.S. Adolescent And Adult Women's Experiences Accessing And Using Toilets In Schools, Workplaces, And Public Spaces: A Multi-Site Focus Group Study To Inform Future Research In Bladder Health, Deepa R Camenga, Sonya S Brady, Cecilia T Hardacker, Beverly R Williams, Jeni Hebert-Beirne, Aimee S James, Kathryn Burgio, Jesse Nodora, Jean F Wyman, Amanda Berry, Lisa K Low, Prevention Of Lower Urinary Tract Symptoms (Plus) Research Consortium

Open Access Publications

The World Health Organization recognizes access to clean and safe toilets as crucial for public health. This study explored U.S. adolescent and adult cisgender women's lived experiences accessing toilets in schools, workplaces, and public spaces. As part of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, we conducted 44 focus groups with female participants (n = 360; ages 11-93). Focus groups were stratified by age (11-14, 15-17, 18-25, 26-44, 45-64, 65+) and conducted across 7 geographically diverse U.S. sites from July 2017-April 2018. Using a transdisciplinary approach, we conducted conventional qualitative coding informed by our PLUS conceptual framework …

Associations Among Neighborhood Socioeconomic Deprivation, Physical Activity Facilities, And Physical Activity In Youth During The Transition From Childhood To Adolescence, Morgan N Clennin, Min Lian, Natalie Colabianchi, Andrew Kaczynski, Marsha Dowda, Russell R Pate

Open Access Publications

BACKGROUND: This study aims to examine the longitudinal association of neighborhood socioeconomic deprivation (SED) with physical activity in youth during the transition from elementary to middle school, and to determine if access to physical activity facilities moderates this relationship.

METHODS: Data were obtained from the Transitions and Activity Changes in Kids (TRACK) study, which was a multilevel, longitudinal study designed to identify the factors that influence changes in physical activity as youth transition from elementary to middle school. The analytic sample for the current study included 660 youth with complete data in grades 5 (baseline) and 7 (follow-up). A repeated …

Pcna Accelerates The Nucleotide Incorporation Rate By Dna Polymerase Δ, Tanumoy Mondol, Joseph L. Stodola, Roberto Galletto, Peter M. Burgers

Open Access Publications

No abstract provided.

Me-Class2 Reveals Context Dependent Regulatory Roles For 5-Hydroxymethylcytosine, Christopher E. Schlosberg, Dennis Y. Wu, Harrison W. Gabel, John R. Edwards

Open Access Publications

No abstract provided.

Csf1r Antagonism Limits Local Restimulation Of Antiviral Cd8+ T Cells During Viral Encephalitis, Kristen E. Funk, Robyn S. Klein

Open Access Publications

No abstract provided.

Aebp1 Down Regulation Induced Cell Death Pathway Depends On Pten Status Of Glioma Cells, Swati Sinha, Arun Renganathan, Prathima B. Nagendra, Vasudeva Bhat, Brian Steve Mathew, Manchanahalli R. Satyanarayana Rao

Open Access Publications

No abstract provided.

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.

International Meta-Analysis Of Ptsd Genome-Wide Association Studies Identifies Sex- And Ancestry-Specific Genetic Risk Loci, Laura J. Bierut, Elliot C. Nelson, John P. Rice, Nancy L. Saccone, Andrew C. Heath, Et Al.

Open Access Publications

No abstract provided.

Updated Results From The Phase 3 Helios Study Of Ibrutinib, Bendamustine, And Rituximab In Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Nancy Lee Bartlett, Et Al.

Open Access Publications

No abstract provided.

Shared Autonomic Pathways Connect Bone Marrow And Peripheral Adipose Tissues Across The Central Neuraxis, Natalie K Y Wee, Madelyn R Lorenz, Yusuf Bekirov, Mark F Jacquin, Erica L Scheller

Open Access Publications

Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The central nervous system (CNS) is a key mediator of adipose tissue function through sympathetic adrenergic neurons. Thus, we hypothesized that central autonomic pathways may be involved in BMAT regulation. To test this, we first quantified the innervation of BMAT by tyrosine hydroxylase (TH) positive nerves …

Perturbing Cohesin Dynamics Drives Mre11 Nuclease-Dependent Replication Fork Slowing, Denisse Carvajal-Maldonado, Andrea K. Byrum, Jessica Jackson, Sarah Wessel, Delphine Lemacon, Laure Guitton-Sert, Annabel Quinet, Stephanie Tirman, Simona Graziano, Jean-Yves Masson, David Cortez, Susana Gonzalo, Nima Mosammaparast, Alessandro Vindigni

Open Access Publications

No abstract provided.

Need To Improve Availability Of "Access" Group Antibiotics And Reduce The Use Of "Watch" Group Antibiotics In India For Optimum Use Of Antibiotics To Contain Antimicrobial Resistance, Sumanth Gandra, Anita Kotwani

Open Access Publications

No abstract provided.