A Comprehensive Diagnostic System For Orthodontists- Beyond Angle’S Classification, Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Traditionally orthodontists have used the classification system developed by Edward H. Angle in 1900 to describe the malocclusion of an orthodontic patient. This classification is very limited with respect to the information it provides and should be replaced by a more detailed and inclusive description of a patient’s malocclusion as well as the underlying biology. In this review article we propose a new technique that ensures all pertinent information gets considered and we suggest a systematic approach to a more differentiated orthodontic diagnosis. Our approach divides the diagnosis into clearly defined categories that bring together the clinical findings into a …

Mandibular Molar Protraction For Edentulous Space Closure: A Systematic Review, Yueh-Tse Lee, Proudchompoo Paungmalit, Eric Jein-Wein Liou

Taiwanese Journal of Orthodontics

Objective: Orthodontic molar protraction into the edentulous space is a treatment option for patients with missing mandibular molars or premolars. Space closure by moving the molars mesially into edentulous ridge is difficult, especially in the mandible. This systematic review aimed to evaluate the dental and periodontal changes after mandibular molar protraction into an edentulous ridge. Material and Methods: Literature search was conducted using PubMed, Medline (Ovid), Cochrane Library, Web of Science, and Scopus until September 2019 limited to English publications. Specific inclusion and exclusion criteria were extracted and analyzed. Study quality was objectively assessed. Results: In total, 490 studies were …

Factors Influencing Fixed Orthodontic Treatmentoutcomes In A University Dental Clinic, Zhan Yan Fang, Sneha Ravindranath, Allan Pau

Taiwanese Journal of Orthodontics

Objective: To assess the orthodontic treatment outcomes in a university dental clinic and to determine factors associated with the treatment outcomes. Methods and materials: Firstly, the records of all patients who have completed fixed orthodontic treatment from 2012 to 2017 were identified and included in the study. Age at start of treatment, gender, decayed, missing filled teeth (DMFT), malocclusion classification, type of appliance used and type of treatment (extraction or non-extraction) were recorded. The pre-treatment and post-treatment study models were assessed by the Peer Assessment Rating (PAR) Index. The treatment outcomes were tabulated in a nomogram to show the proportions …

Effects Of Canagliflozin On Renal And Urinary Angiotensin Converting Enzyme 2 (Ace2) And Neprilysin (Nep) In Db/Db Diabetic Mice, Unmesha Hemant Thanekar

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Diabetes is one of the major causes of chronic kidney disease (CKD) which could lead to end-stage renal disease. Angiotensin-II (Ang-II), a major bioactive peptide of renin angiotensin system (RAS) plays a pivotal role in the pathogenesis and progression of diabetic nephropathy. The reno-degenerative effects of Ang-II can be partially counteracted by Ang (1-7). Therefore, Ang (1-7) forming enzymes, angiotensin converting enzyme 2 (ACE2) and neprilysin (NEP), are hypothesized to have reno-protective effects. In our previous studies, we have demonstrated increased renal shedding of ACE2 and NEP in the urine of type-2 diabetic mice which was attenuated by normalizing hyperglycemia …

What It Means To Be Out: Queer, Trans, And Gender Nonconforming Identities In Library Work, Zoe Fisher, Stephen G. Krueger, Robin Goodfellow Malamud, Ericka Patillo

Dartmouth Library Staff Publications

Queer library workers face the decision of how and when to express their gender identities and sexual orientations at work. In what ways does being “out” in the library workplace impact our work? This coauthored chapter brings together the perspectives of two academic librarians, a current LIS grad student, and an academic library administrator to provide multiple ways of seeing the complexities of expressing gender identity and sexual orientation in the library workplace. We discuss the intersection of library values, politics, change management, patron interactions, and work environments.

Evaluating State Anxiety Levels In Nursing Students, Rachel Stevens, Rachel Nussbaum, Tyler Blake

Williams Honors College, Honors Research Projects

Anxiety, dependent upon the frequency and severity, can be a serious problem that reduces physical, cognitive, and clinical performance. Nursing students have been found to experience especially high levels of state and trait anxiety which, according to Dorothea Orem’s self-care deficit theory, causes a deficit in health promotion and the health of oneself. There is little evidence available about how progression through a baccalaureate nursing program in the United States impacts anxiety. This research investigates anxiety in baccalaureate nursing students and how progression through the program influences self-reported anxiety levels. A descriptive cross-sectional study was performed on a convenience sample …

Improving The Delivered Specific Impulse Of Composite Rocket Propellant Through Alteration Of Chemical Composition: Methodology And Parameters For Characterization Of Propellant And Validation Of Simulation Software Common To The Amateur Rocketry Community, Isaac O'Brien, Austin Ryan

Williams Honors College, Honors Research Projects

In this study, two solid composite rocket propellants were designed utilizing ProPEP, a rocket propellant formulation software common in the amateur and hobby rocketry communities. The two propellants were designed to optimize specific impulse relative to a literature propellant designed by 1020 Research Labs. The literature propellant was also tested in order to validate the design of experiment as well as the mixing and testing procedures. All three propellants, which includes the literature propellant RCS-P, and the two novel propellants AKR-P1 and AKR-P2 were characterized with static tests. The results of the static tests provide data on propellant performance and …

Effects Of Adaptive Sports On Quality Of Life In Individuals With Disability, Victoria Reljin

Williams Honors College, Honors Research Projects

Purpose: The purpose of this study was to identify any correlation between quality of life and adaptive sport participation in individuals with disability. Methods: A questionnaire including the World Health Organization’s Quality of Life - BREF questionnaire and an adaptive sports impact questionnaire were electronically distributed to adults participating in an adaptive sport program. Athletes participating in the adaptive sport program’s wheelchair rugby team completed skill assessments that were examined for changes in physical domain. Results: All participants (n=11) rated their quality of life good or very good. Participants performed best in the environmental and physical domains of the WHOQOL-BREF. …

Battery Powered Handheld Drain Cleaner, Sarah Michaud, Kaylin Cozzens, Emily Jo Spinelli

Williams Honors College, Honors Research Projects

By pairing up with Ridge Tool Company in Elyria, Ohio, we developed a competitive redesign based on their K-45 Sink Machine. Some goals set forth at the beginning were to take the machine from a corded system with a brushed motor to a battery powered one with a brushless motor, and to address some consumer concerns in regards to weight support and ease-of-use. Our final objective was to assemble a functional prototype that could be submitted to Ridge Tool Company for review. This redesign should help this machine remain competitive in the field, and give us the chance to present …

Prevention Of Harmful Algal Blooms By The Mitigation Of Phosphorus Nutrient Loading Via Filtration By Steel Wool And Activated Carbon, Sara Kidd, Ronald Simpson, Samantha Zidd

Williams Honors College, Honors Research Projects

Harmful Algal Blooms (HABs) are a devastating ecological and economic consequence of the abundance of nutrient-rich agricultural runoff entering aquatic ecosystems (Baker et al. 2014). Bioavailable phosphorus from synthetic fertilizers is one of the major nutrients contributing to this global issue. Preliminary studies indicate that dissolved phosphorus can be removed from an aqueous environment when passed through a composite mixture of granular steel wool particles and activated carbon (Erickson, Gulliver, and Weiss (2007). Further research was conducted using higher quality concentration measurements to determine what grades of steel wool (0000, 000, 00) and types of activated carbon (GAC, PAC, EAC) …

Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young

Williams Honors College, Honors Research Projects

The main objective of this project was to create a prosthetic arm for a 15 year old boy named Jaiden Foden. Jaiden was born with only one fully developed limb as a result of a genetic disorder, Hanhart Syndrome II. His right arm becomes a residual limb below the elbow, but has two fingers which act in a “claw-like” movement. Jaiden’s left arm becomes a residual limb above the elbow, and his left leg becomes a residual limb above the knee. The goal of the arm was to increase Jaiden’s overall independence and to help in completing daily tasks, such …

An Exploratory Study Of The Relationship Between Community Involvement And Lgb Identity, Jenna Collins

Williams Honors College, Honors Research Projects

Found families are common within the LGBT community, and many models of LGB identity development include contact with other same-sex attracted individuals, or involvement in the LGBT community as important to identity development. However there has been little research investigating the connection between community involvement and identity development or acceptance. This exploratory study will compare LGB identity, measured with the Lesbian Gay Bisexual Identity Survey, to respondents’ answers to open-ended questions about their LGB community involvement. Open-ended questions will be coded by the researcher using content analysis to find commonalities between responses. Comparisons will look for any relationships between stages …

Comparison Of Crnas With And Without Supervision On Cost And Safety Of Anesthesia, Kelly Mccurdy, Austin Phillips

Williams Honors College, Honors Research Projects

There has been controversy in the field of anesthesia regarding whether certified registered nurse anesthetists (CRNAs) or anesthesiologists provide safer and more cost-effective care. This study was done to compare CRNAs with and without supervision of an anesthesiologist and how it affects the cost and safety of anesthesia delivery. The results of this systematic review could provide information to affect policies regarding who is responsible for providing anesthesia, with safety and cost as the necessary variables. Twenty articles, published between the years 1999 and 2017, retrieved from the databases PubMed and Cinahl were analyzed and synthesized as part of this …

Fabrication And Characterization Of Nanofiber Nylon-6-Mwcnt As An Electrochemical Sensor For Sodium Ions Concentration Detection In Sweat, Kelsey Mills

Williams Honors College, Honors Research Projects

Fabrication and characterization nylon-6-MWCNT nanofiber as an electrochemical sensor to detect sodium ion concentrations specifically in sweat. Using contact angle to determine surface morphology and chronoamperometry testing to identify ideal sensor conditions, tests optimized parameters like weight percent of nylon or other polymers, carbon nanotube (CNT) isomer, and solution concentration to determine reproducibility of functional sensors. Utilizing the electric qualities of carbon nanotubes partnered with the sodium ion selectivity of calixarene treatment and polymers unique properties like flexibility and scalability create open an arena for optimizing sodium ion sensors for further development for functional prototypes. Morphology tests showed that the …

Long-Term Effects Of Breastfeeding Compared With Alternative Food Sources: A Systematic Review, Charlotte Bates

Williams Honors College, Honors Research Projects

The topic of the long-term impact of breast milk and alternative foods on the health status of children continues to be a focus of discussion and research. The aim of this systematic review was to describe and appraise evidence about the effects of breast feeding on health outcomes in children four years and older. Seventeen studies about on infant feeding were identified using Google Scholar and scholarly databases through The University of Akron. Google Scholar, CINAHL, and MEDLINE PLUS methods of searching were utilized, incorporating keywords, i.e., “breastfeeding” AND “cognitive development;” “obesity,”, “intelligence,”, and “immune system.” Based on appraisal of …

Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley

Williams Honors College, Honors Research Projects

Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes. In this proposal, we further examine the chemical and toxicological properties of cuprizone. Immunofluorescence imaging and microarray data on MO3.13 cells treated with cuprizone revealed the possibility of alterations in lysosomal function, as well as mitochondrial disruption via mTOR and Electron Transport Chain (ETC) related pathways. Cell viability assays conducted suggest that addition of Branched-Chain Amino Acids, most commonly used from literature, leucine, can increase …

Assessing The Benefits Of A Collegiate-Run Wellness Program For Akron Inner City Residents, Alaina Gent

Williams Honors College, Honors Research Projects

This paper offers insight into the University of Akron Wellness Wednesday Program, an interprofessional organization of campus students and faculty that present wellness programming to three off-campus housing developments: Edgewood Village, Belcher Apartments, and Saferstein Towers I. The residents of these complexes receive wellness programming from many different disciplines for six months of the year, and then experience a large, four-month gap when the university breaks for summer. With this gap, residents often vocalized that they felt as if information was lost and that they were not able to remember as much when the program returned in the fall. In …

Total Laryngectomy Surgery In The United States And Spain: A Tale Of Two Healthcare Systems, Anna Nyszczy

Williams Honors College, Honors Research Projects

For individuals entering the field of health professions, an understanding of variation among global health systems can foster more informed viewpoints when working with multicultural populations. To investigate this relationship between the Spanish and U.S. systems, I analyzed the macro-structure of the healthcare systems in the United States and Spain to better understand plans of treatment, economic burden to patients and quality of life of patients undergoing total laryngectomy surgery in each country. A critical review of scholarly journals and studies relating to the healthcare systems of each country and total laryngectomy surgeries showed a unique picture of each system. …

The Buffering Role Of Character Virtues On The Relationship Between Burnout And Its Antecedents, Allison Bachmann

Williams Honors College, Honors Research Projects

This project explores the relationship between character virtues and burnout among student employees. It reviews and elaborates on the previous research findings in positive psychology and uses existing research on human virtues in order to further study their relationship with burnout. In exchange for extra course credit, students completed an online survey comprised of a demographic questionnaire and measures of character virtues, burnout, job control, and work overload. Analysis of the results focused on the specific virtues of courage and transcendence and the burnout antecedents of work overload, and lack of control. A multiple regression analysis was used to determine …

Åstrand-Rhyming And Ymca: A Compare And Contrast Literature Review Of Two Submaximal Cycle Ergometer Tests, Sean Roberts

Williams Honors College, Honors Research Projects

In the world of exercise prescription there are two major protocols that are used to test an individual’s aerobic capacity at a submaximal intensity using a stationary bicycle. These protocols require participants to exercise at a constant work rate until a specified hear rate is reached. Data can then be analyzed to determine the participant’s aerobic capacity. The objective of this literature review is to look at these two tests – the Åstrand-Rhyming cycle ergometer test (ARCET) and the YMCA cycle ergometer test – and determine if one is better than the other for different populations and which one an …

Synthesis Of Polyurethane From Sustainable Sources, Jovan Jevric

Williams Honors College, Honors Research Projects

The most common method of polyurethanes involves a reaction between various petroleum-based isocyanates and a polyol along with a catalyst; all of which have a negative impact on environmental and human health. The objective of this research project is to eliminate or mitigate the risks and hazards associated with the production and degradation of polyurethane. Hexamethylene diisocyanate isocyanurates (3HDI) are one of the most common isocyanates used in the polyurethane processing industry. 3HDI contains numerous toxins, and it has a negative impact on the environment and human health¹. It has been found that there are other compounds that …

Optimization Of Primary Cilia Detection In Musculoskeletal Tissue, Ragen Engel

Williams Honors College, Honors Research Projects

The objective of this research project was to optimize a laboratory technique for visualizing primary cilia in musculoskeletal tissue of young swine, specifically the growth plate of long bones. This was accomplished through varying fixation procedures, antigen retrieval methods, antibody concentrations, and incubation times. By varying these parameters, a reproducible procedure was developed to examine the primary cilia in multiple tissues including ligament, fascia, and growth plate. This experiment introduced variances in fixation methods, with methanol or formalin. Paraffin and frozen embedding techniques were also varied for comparison with regards to cilia visualization. Results from the acetylated alpha tubulin (aTUB) …

Chronoamperometry Analysis Of Sweat Sensor Technology, Evan Fritz

Williams Honors College, Honors Research Projects

Due to the demand for in-situ electrolyte sodium sensors, prototype sensors have been produced to create a product for athletes and marathoners to monitor hydration levels. These senors address a desire in the marketplace for athletic monitoring for overall athlete wellness and performance. Sweat sensor samples were created using Multi-walled Carbon Nanotubes functionalized on a Nylon-6 fiber mat using cyclo-oligomeric Calixarene. This production process produces sensors capable of detecting sodium ion concentration present in human sweat in presence of an electric current. Chronoamperometry analysis is used in this manner to determine the functionality of the sensors. Much of the research …

Effects Of Acute Hypoxia On Danio Rerio, Karly Crail

Williams Honors College, Honors Research Projects

The purpose of this research experiment was to determine the effects of acute hypoxia on the embryonic zebrafish (Danio rerio) cardiovascular system and assess the critical oxygen level at which embryonic function is compromised. This goal was achieved by exposing embryos to decreasing oxygen concentrations, (6.0 mg/L-0 mg/L) and observing the heart under an inverted microscope. Data analysis was conducted to determine end systolic volume, end diastolic volume, stroke volume, heart rate, and cardiac output. It was hypothesized that hypoxia would stimulate cardiac activity, because in early developmental stages, tissues are supplied with oxygen through bulk diffusion, and …

Investigating Iron Metabolism In Subarachnoid Hemorrhage Patients, Alexander A. Maynard, Gardenia Pacheco

Williams Honors College, Honors Research Projects

Subarachnoid hemorrhage (SAH) is a stroke characterized by bleeding into the subarachnoid space of the brain, typically resulting in high mortality rate.⁸ Delayed cerebral ischemia (DCI), characterized by vasospasms induced arterial constriction, occurs in roughly one third of the surviving patients.²⁰ The development of DCI and neurodegeneration could be linked to metabolic pathology that occurs after SAH, specifically iron induced changes in redox status. The oxidized environment induced by iron has the potential to functionally affect the ferroxidase ceruloplasmin (Cp), which is linked to neurodegeneration.¹⁵ Global LC-MS based metabolomics data revealed alterations in metabolism in the CSF …

Cloning The Vision Related G Protein Transducin For Live Cell Fluorescence Studies, Deanna M. Bowman

Williams Honors College, Honors Research Projects

G coupled protein receptors (GCPR) are one of the largest families of receptors and mediate a variety of biological responses. Rhodopsin is the largest family and aids in sight, the α-subunit of the GCPR complex in extremely important to the activation and downstream signaling effects of GCPR. The α-subunit contains a small trans-domain portion and in this project the sequence of that portion will be inserted into a vector containing a fluorescent tag. These vectors will then be used to collect fluorescent cross correlation spectroscopy or FCCS data. The unit was cloned using assembly methods that include PCR and purification …

Pick-And-Place Robot For The 2019 Asme Student Design Competition, Riniah A. Foor, Megan Schmit, Aaron Urban, Jeanetta Davidsaver, Daniel Mugongo

Williams Honors College, Honors Research Projects

This project was undertaken as an opportunity to participate in a holistic experience of designing, building, and competing as an engineering design team. In the ASME Student Design Competition, undergraduate students are able to experientially learn the process of design inception, manufacture, and product performance in addition to the development of critical project management skills. This is done through a creative design challenge to build a device capable of accomplishing a “pick-and-place” task in a fast and efficient manner.

Immersive Rehearsal In A Simulated Environment (Irise), Cassandra Clouse

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Recent advancements in virtual environment (VE) technology and the growth of VE use in treating and training individuals are opening up new possibilities for rehearsal in safe and rich environments. Research has shown that VEs can be used to treat those with Post Traumatic Stress Disorder (PTSD), but very little research has been done to suggest good guidelines for creating an effective environment. This research was conducted to help inform the design of systems that let veterans rehearse potentially stressful experiences in a safe environment before having to physically step into that environment. We investigated responses to specific design components …

Differential Microrna Expression In Barrett's Esophagus Correlates With Regulation Of Posterior Homeotic Genes, Reilly June Clark

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Barrett’s Esophagus (BE) is characterized by the appearance of an intestinal-like epithelium in the distal esophagus. The molecular mechanisms behind BE development are unknown. BE is often preceded by Gastroesophageal Reflux Disease (GERD) and predisposes patients to esophageal adenocarcinoma (EAC). Due to the high mortality rate associated with EAC, BE patients are continuously monitored through upper endoscopy with biopsy for progression to low grade dysplasia (LGD), high grade dysplasia, and EAC. This monitoring technique poses numerous risks, so alternative surveillance and diagnostic techniques for BE pathogenesis are continually studied. microRNA biomarkers in BE pathogenesis may provide alternative means of diagnosis …

Towards Data And Model Confidentiality In Outsourced Machine Learning, Sagar Sharma

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With massive data collections and needs for building powerful predictive models, data owners may choose to outsource storage and expensive machine learning computations to public cloud providers (Cloud). Data owners may choose cloud outsourcing due to the lack of in-house storage and computation resources or the expertise of building models. Similarly, users, who subscribe to specialized services such as movie streaming and social networking, voluntarily upload their data to the service providers' site for storage, analytics, and better services. The service provider, in turn, may also choose to benefit from ubiquitous cloud computing. However, outsourcing to a public cloud provider …