Digital Commons Network^™

Design And Biological Evaluation Of Colchicine-Cd44-Targeted Peptide Conjugate In An In Vitro Model Of Crystal Induced Inflammation, Khalid A. Zoghebi, Emira Bousoik, Keykavous Parang, Khaled A. Elsaid

Pharmacy Faculty Articles and Research

Gout is an inflammatory arthritis due to the joint deposition of monosodium urate (MSU) crystals. Phagocytosis of MSU crystals by tissue macrophages results in the generation of reactive oxygen species (ROS) and production of inflammatory cytokines and chemokines. Colchicine use in gout is limited by severe toxicity. CD44 is a transmembrane glycoprotein that is highly expressed in tissue macrophages and may be involved in gout pathogenesis. The P6 peptide is a 20-amino acid residue peptide that binds to CD44. We hypothesized that the conjugation of colchicine to the P6 peptide would reduce its off-target cytotoxicity while preserving its anti-inflammatory effect. …

Why Does The Nhs Struggle To Adopt Ehealth Innovations? A Review Of Macro, Meso And Micro Factors, Sheena Asthana, Ray Jones, Rod Sheaff

Peninsula Medical School

Abstract Background Having a tax-funded and supposedly ‘National’ Health Service (NHS), one might assume that the UK is well-positioned to roll out eHealth innovations at scale. Yet, despite a strong policy push, the English NHS has been limited in the extent to which it has exploited the potential of eHealth. Main body This paper considers a range of macro, meso and micro factors influencing eHealth innovation in the English NHS. Conclusions While barriers to eHealth innovation exist at all scales, the fragmentation of the NHS is the most significant factor limiting adoption and diffusion. Rather than addressing problems of fragmentation, …

Cognitive Impairments And Self-Reported Sleep In Early-Stage Parkinson’S Disease With Versus Without Probable Rem Sleep Behavior Disorder, Jonathan Trout, Taylor Christiansen, M. Brooks Bulkley, Jared J. Tanner, Christopher N. Sozda, Dawn Bowers, Daniel Kay

Faculty Publications

Parkinson’s disease (PD) is associated with cognitive and sleep impairments. The presence of rapid eye movement (REM) sleep behavior disorder (RBD) symptoms may represent a worse disease prognosis for PD individuals. We investigated cognitive functioning and self-reported sleep in early-stage PD individuals with (n = 19) or without (n = 31) probable RBD. Probable RBD was defined as >5 on the REM Sleep Behavior Disorder Screening Questionnaire. Inhibition, visuospatial cognitive abilities, working memory, sustained visual attention, verbal fluency, and episodic memory were assessed. Sleep impairments were assessed using the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and …

Model Selection And Experimental Design Of Biological Networks With Algebraic Geometry, Anyu Zhang

Mathematics Theses and Dissertations

Model selection based on experimental data is an essential challenge in biological data science. In decades, the volume of biological data from varied sources, including laboratory experiments, field observations, and patient health records has seen an unprecedented increase. Mainly when collecting data is expensive or time-consuming, as it is often in the case with clinical trials and biomolecular experiments, the problem of selecting information-rich data becomes crucial for creating relevant models.

Motivated by certain geometric relationships between data, we partitioned input data sets, especially data sets that correspond to a unique basis, into equivalence classes with the same basis to …

It Piques A Novice’S Curiosity And Engages The Experienced: A Review Of Designing Qualitative Research (The Sage Qualitative Research Kit), Julius Kyakuwa

The Qualitative Report

This book is one of ten in The SAGE Qualitative Research Kit and addresses the fundamental design issues in qualitative research. It outlines a framework for the other books in the kit on a practical and methodological level. Flick discusses obstacles in realizing success, technical matters like ethics, achieving quality, generalization, and considerations regarding the researcher’s perspective in qualitative research designs. Several examples that support and motivate the text are derived from the author’s qualitative research projects and publications. The book is appropriate for novice qualitative researchers and sufficiently informative to engage but also refresh the perspectives of the experienced …

Smart Factories, Dumb Policy? Managing Cybersecurity And Data Privacy Risks In The Industrial Internet Of Things, Scott J. Shackelford

Minnesota Journal of Law, Science & Technology

No abstract provided.

A Need To Continue Healing: Report Of Findings From An Autoethnographic Study, David T. Culkin

The Qualitative Report

This article reviews the design and findings of an autoethnographic study on identity development over time. The researcher wanted to know how an adult can make meaning from and develop through experiences of mental illness, spiritual awareness, and death. The purpose of this autoethnographic bildungsroman was to explore how a male in the general population describes how life events have influenced his identity development over a period of 23 years, spanning three decades. The author, as the researcher-participant, asked two primary questions: (a) How does the individual describe his adult development in terms of life events or “individual and cultural …

Women's Reproductive Rights Under Marriage Contract, Sri Endah Kinasih, Toetik Koesbardiati, Siti Mas’Udah

Journal of International Women's Studies

In Indonesia, marriage contracts are still common. In addition to culture, women's reproductive rights are also strongly associated with poverty. The poverty factor is very influential in relation to quality of life and women's reproductive health. This article investigates the reproductive health rights of women under a marriage contract. Employing the descriptive qualitative method, the research was conducted in Pasuruan, East Java and Bogor, West Java, Indonesia. The selection of the research contexts was done purposively. This study shows that a marriage contract does not always imply the occurrence of sexual intercourse. Sexual intercourse in a marriage contract may happen …

Women’S Resilience In Preserving Family Life Following An Earthquake In North Lombok Regency, West Nusa Tenggara, Indonesia, Tuti Budirahayu, Anis Farida, Sughmita Maslacha Amala S.

Journal of International Women's Studies

The earthquake in Lombok, West Nusa Tenggara, in August 2018 not only damaged the environment and the area around the epicenter but also shook public order. The shaking of economic and social infrastructure is being paid for by unpreparedness in facing disasters, and this is compounded by the mental deterioration of the community due to the loss of family members. This study aims to describe women's abilities during the aftermath of the disaster, and their efforts to overcome economic and social problems within their families. We also observed women's collective efforts as a way to eliminate trauma (trauma healing). This …

Trafficking Of Women And Children In East Java, Indonesia, Sutinah Sutinah, Karen Mwende Kinuthia

Journal of International Women's Studies

This study investigated the patterns and modes of the occurrence of cases of women and child trafficking in East Java Province, Indonesia. This includes the factors that cause women to become familiar with the trade of women and children. This qualitative descriptive study was conducted in four areas of the East Java Province, known as regions, prone to have victims of trafficking. To collect the data, the researcher conducted in-depth interviews with 115 respondents: 40 commercial sex workers (PSK), 4 transnational/contract marriage victims, 45 beggars, 25 housemaids, 1 victim of child trade trafficking, and 10 concerned experts (researchers and activists …

Violence Against Women And Girls In Harare, Zimbabwe, Maybe Zengenene, Emy Susanti

Journal of International Women's Studies

This article explores the phenomenon of violence against women and girls in Harare, Zimbabwe. Section 25 of the Constitution of Zimbabwe stipulates that the State and all agencies of the government at every level must protect and foster the institutions to adopt measures for the prevention of violence. Regardless of such recognition, there have been rampant incidences of politically motivated and domestic violence against women and girls in the country. Domestic violence against women and girls is a violation of the Constitution of Zimbabwe and all of the treaties, conventions, charters and optional protocols on the rights of women. Owing …

The Role Of Culture In Cross-Cultural Marriage Among Minangkabau Women, Susi Fitria Dewi, Maria Montessori, Randi Ade Saputra, Sintia Farsalena, Fatmariza Fatmariza, Rika Febriani, Febri Yulika

Journal of International Women's Studies

Marriage is the strongest relationship in terms of controlling human behaviour. There are various reasons why men and women want to be tied through marriage, such as religious, economic, social and cultural factors, and even politics. Cultural factors have special characteristics because they are the product of creativity, human feelings and intentions brought from birth that are passed down from generation to generation. This paper aims to describe the cultural values that affect the lives of the Minangkabau ethnic women who marry other ethnic men. This study is based on interviews with 37 women in 7 districts in West Sumatra …

The Social Behaviour Of Pregnant Mothers And The Mothers Of Children Under Five In Relation To Their Children’S Dental Health And Growth, Thalca Hamid, Satiti Kuntari, Naila Marzuqi, Mutia Fauziah

Journal of International Women's Studies

The focus of the research is whether there is a relationship between the behaviour of pregnant mothers and the mothers of children under five and their children’s dental health and growth. This is in addition to any predisposing, enabling and reinforcing factors. This study is intended to reveal the following two key points: 1) to identify the level of knowledge of pregnant women and the mother of toddlers about oral health in children under five and 2) to identify effective models of empowerment for pregnant women and the mothers of toddlers to prevent dental and oral cavity diseases in the …

Feminization Of Poverty Program (Pfk) And The Empowerment Of Women Heads-Of-Household In East Java, Indonesia, Sulikah Asmorowati, Violeta Schubert, Dian Yulie Reindrawati

Journal of International Women's Studies

Severe conditions of poverty have been found in households headed by women in East Java Province, Indonesia. In response to this, the Provincial Government of East Java initiated an innovative program called Jalin Matra (Jalan Lain Menuju Mandiri dan Sejahtera or Another Way Towards Sustenance and Welfare) in which one of the programs is Program Feminisasi Kemiskinan (PFK). This paper is based on a research that is concerned with the implementation of PFK in the regions of Trenggalek and Lamongan, East Java, Indonesia, especially in the village level. It is especially focused on the impacts of the program implementation on …

Achievement Of Gender Mainstreaming In Islamic Schooling Based On The National Education Standard In Indonesia, Riswani Riswani, Rita Susanti, Nurhasanah Bakhtiar, Masud Zein, Eniwati Khaidir, Musa Taher

Journal of International Women's Studies

One of the policies which has been issued by the Indonesian government regarding madrasah (Islamic schooling) is the Government Regulation (PP) No 11 of 2010 on Guidelines for Gender Mainstreaming (Pengarusutamaan Gender-PUG) in Madrasah of the Ministry of Religion of the Republic of Indonesia. The issuance of this policy is an attempt to eliminate the “gender gap” that occurs in madrasah. For almost two decades, it has been issued, but the gender gap still occurs in madrasah. This is shown from the results of several previous studies. However, all of the previous studies on the achievement of PUG in madrasah …

Women’S Knowledge And The Role Of Local Female Leaders In Ending The Practice Of The Early Marriage Of Girls In Rural Communities Of Indonesia, Emy Susanti

Journal of International Women's Studies

The practice of the early marriage of girls (under 16 years old) in the rural communities of Indonesia has remained to this day. This article aims to examine how the role of female leaders and local women’s organisations in rural communities and how they seek to eliminate the practice of child marriage. This article is based on a study conducted in 2 (two) poor villages on Madura Island, East Java Province, namely Sampang District and Bangkalan District. The subjects of this study were women who married at a young age, their husbands, parents, members of the women’s organisations and the …

Gender, Religion And Patriarchy: The Educational Discrimination Of Coastal Madurese Women, East Java, Sudarso Sudarso, Phillipus Edy Keban, Siti Mas’Udah

Journal of International Women's Studies

One of the educational development problems is the gap in the quality of education between regions and community groups, as well as gender. This article has examined gender, religion, patriarchy and the educational discrimination faced by coastal women who are a part of the Madura culture in East Java. This study employed a qualitative approach by interviewing 70 informants who consisted of school dropouts, the parents of daughters who had dropped out, teachers, and community leaders. This study found there to be several key findings. In the Madura culture, the concept of gender for women is always associated with the …

Urbanization And Population Growth: Projected Impacts Of Growth On Ecological Resources In Ontario1, Laura J. Bozzelli

International ResearchScape Journal

No abstract provided.

Frankenstein In Baghdad: A Novel Way Of Understanding The Iraq War And Its Aftermath, Hope Teggart

International ResearchScape Journal

No abstract provided.

Newsletter: Network News, Jacksonville Women's Network

Saffy Collection - All Textual Materials

A newsletter for Jacksonville Women’s Network with information on the JWN board, members and events. Date: April 1993

Full Issue: Volume 14, Number 2 - Fall 2019

Jefferson Surgical Solutions

In This Issue

Jefferson Health Offers Smallest-Incision Open-Heart Surgery - Page 1

The Surgeon Speaks

The Surgeon Speaks - Page 1

Overview

The Academic Cycle - Page 2

New Faculty

New Faculty - Page 2

Meet the Interns

Meet the Interns - Page 2

Changing Lives Through Research

Dang Laboratory Explores Novel Approaches to Diagnosing, Treating Liver Cancer - Page 3

Please Welcome

Jefferson Welcomes Four Surgery Residents from Hahnemann - Page 3

Those Who Give

A Wall of Honor, Hope and Healing: Department of Surgery Recognizes Generous Benefactors - Page 4

News in Brief

News in Brief - Page …

A Wall Of Honor, Hope And Healing: Department Of Surgery Recognizes Generous Benefactors

Jefferson Surgical Solutions

Stroll through the sixth-floor halls of Jefferson’s Curtis and College buildings and you will see portraits of the legends who have made an indelible imprint on American medicine and surgery. These portraits include Thomas Mütter (the father of American Plastic Surgery), John Chalmers DaCosta (a master educator) and John H. Gibbon, Jr., inventor of the heart-lung machine.

Now the names of another group of legends adorns the walls: some of the most generous benefactors of the Department of Surgery. Installed in October, the donor wall pays tribute to those whose support has fueled the Department’s compassionate clinical care, rigorous research …

Dang Laboratory Explores Novel Approaches To Diagnosing, Treating Liver Cancer

Jefferson Surgical Solutions

Since its launch on October 1, 2018, the Dang Laboratory has been dedicated to the study of novel approaches to diagnosing and treating hepatocellular carcinoma (HCC), the most common type of liver cancer. The lab, which is part of the Division of Surgical Research, recently secured two grants and is led by Hien Dang, PhD, with support from Postdoctoral Fellow Kai Zhang, PhD, and Lab Technician Anna Barry, MS.

Before joining the faculty at Jefferson, Dr. Dang worked as a Postdoctoral Fellow supported by a Cancer Research Training Award (CRTA) at the National Cancer Institute, National Institutes of Health in …

New Faculty

Jefferson Surgical Solutions

Caitlyn M. Costanzo, MD, has joined the Division of Colorectal Surgery. Dr. Costanzo is a 2011 graduate of Sidney Kimmel Medical College. She remained at Thomas Jefferson University Hospital where she completed the General Surgery Residency Program in 2018 and Colorectal Surgery Fellowship Program in 2019. She also completed a research fellowship program at St. Christopher’s Hospital for Children in 2016. She sees patients at Thomas Jefferson University Hospital and Jefferson Methodist Hospital.

Jaime M. Glorioso, MD, has joined the Division of Transplant Surgery. Dr. Glorioso completed the General Surgery Residency Program at the Mayo Clinic in Minnesota. …

The Academic Cycle, Charles Yeo, Md, Facs

Jefferson Surgical Solutions

Another academic year commenced this summer. Another academic cycle. Jefferson and our Department remain vibrant, successful and agile. We welcomed six terrific interns in June, then added another intern (and three other residents) upon the closure of Hahnemann Hospital. This summer we added eight faculty members to our Department, several new advanced practice providers and many new staff members. Our administrative team has evolved – we have celebrated the promotion of Florence Williams to Department Administrator, and Andrea DelMastro to the position of Director of Clinical Operations.

Enterprise wide – per the Bob Dylan tune “The Times They Are A-Changin’” …

Jefferson Health Offers Smallest-Incision Open-Heart Surgery

Jefferson Surgical Solutions

As Director of Robotic & Minimally Invasive Cardiac Surgery at Jefferson, T.Sloane Guy, MD, MBA, has a big passion for small incisions. Dr. Guy performs all aspects of adult cardiac surgery, with a focus on mitral valve disease and hypertrophic cardiomyopathy (that is, when part of the heart becomes thickened without an obvious cause). He is particularly well known for his experience in using robotic cardiac surgery to treat these and other conditions. One of the most innovative procedures is totally endoscopic robotic mitral repair. The procedure – the smallest-incision open-heart surgery performed in the world today – relies on …

Have A Good One: A Writer’S Search For Place, Rafael Gallegos

Theatre & Dance ETDs

In this personal essay I will summarize my creative journey as a writer throughout my time in the Dramatic Writing program at the University of New Mexico. I will explore how the notion of home has shaped me and my work, focusing on my childhood in Lubbock, Texas, my theatrical coming of age in New York City, and my return to Albuquerque in search of my personal voice. I will present two works that illustrate my maturation as a dramatist and my focus on community and place as thematic throughlines. Have a Good One is a play set in a …

Impact Of Positive Behavioral Interventions And Supports In California High Schools Year Three And Beyond: A Semi-Replicated Mixed-Methods Study, Jolene Mcgarrah

Dissertations

Purpose: The purpose of this mixed-methods study was to determine what differences

existed between pre- and post-PBIS implementation on suspension rates in California high schools. A further purpose of the study was to determine how experienced high school administrators described the impact of PBIS on their school sites. Methodology: This mixed methods study identified 15 California public schools for data collection and five principals for interviews about their perceptions of the impact of PBIS on their campus. The schools and principals were chosen due to proximity to the researcher. The researcher collected quantitative data from the schools and qualitative data …

Educator Knowledge And Usage Of Evidence-Based Interventions For Students With Emotional And Behavioral Disorders In Special Education Programs Across California, Thelmisha Vincent

Dissertations

Purpose: The purpose of this study was to identify the extent to which evidence-based interventions being utilized with students with emotional and behavioral disorders (EBD) by general education teachers, special education teachers, and behavior interventionists working in K-12 special education programs on comprehensive public and non- public school campuses in California.

Methodology: This mixed method study identified commonly used instructional strategies for students with (EBD) in public and non-public school settings. Respondents were purposefully chosen from general education teachers, special education teachers, and behavior interventionists across California. The data from online survey and interviews were analyzed through factorial ANOVA, descriptive …

Corporate And Canonical Governance: Understanding Church Property, Jane Power

The University of Notre Dame Australia Law Review

No abstract provided.