Digital Commons Network^™

Insuring The Integrity Of Global Registries, Aardhra Meenakshi Venkatachalam

Dissertations and Theses (Open Access)

Data quality is a priority in public health because it is used for public health program planning and implementation, research, as well as policy. The information gleaned from the data allows us to assess health status, and improve health needs. This paper evaluated methods for cleaning, managing and addressing missing data in the Lagos State Ambulance Service registry. The techniques included screening, data organization, diagnostic phase, treatment phase and a missing data phase to holistically handle the data. The percentage of systemic errors was reduced through the use of the 5-step method. Missing data was informative for state of origin, …

Nonlinear Functional Models On Causal Inference, Rong Jiao

Dissertations and Theses (Open Access)

Statistical analysis has experienced significant progress on association study, but it remains elusive to understand the etiology and mechanism of complex phenotypes. As a major analytical platform, association analysis may hamper the theoretic development of biomedical science and its application. Thus, many researchers suggest making the transition from association to causation. The mainstream of research in genetics and epigenetics data analysis focuses on statistical association or exploring statistical dependence between variables. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), the signals identified by association analysis can only explain a small proportion of …

Additional Graduate Degrees Associated With Promotion Among Primary Care Clinical Faculty, Michael A. Hansen

Dissertations and Theses (Open Access)

Introduction: Many young and ambitious physicians purposefully seek out meaningful careers in academic medicine, yet there are no evidence-based findings to assist these individuals in how to succeed in advancing their careers in this unique work environment. For early and mid-career faculty, a growing number of trainings and opportunities are available but with little insight as to which choices may have the biggest impact. One common perception is the need for additional advanced training, such as a Master of Public Health. Aims and Method: This study sought to provide evidence-based information about additional training by quantifying the benefit of added …

Promoting Youth Competence Through Balanced And Restorative Justice: A Community-Based Pyd Approach, Rebecca Dillard, Tarkington Newman, Melissa Kim

Journal of Youth Development

As responses to first-time, nonviolent juvenile offenders move towards community-based restorative justice, approaches such as the Balanced and Restorative Justice (BARJ) Model are prominent. The BARJ Model engages the youth offender, offense victim(s), and community in which the offense occurred with three associated goals: accountability, community safety, and competency development. However, while the goals of accountability and community safety are often prioritized, many community-based restorative justice programs neglect the goal of competency development, which is ultimately a disservice not only to the youth offender, but to the community. To interrupt the cyclical nature of juvenile offending and support the long-term …

Civic Engagement Among Youth Exposed To Community Violence: Directions For Research And Practice, Sonia Jain, Alison Cohen, Kei Kawashima-Ginsberg, Catherine Duarte

Journal of Youth Development

Historically and contemporarily marginalized youth who are disproportionately exposed to community violence are often the same youth who are less likely to be civically engaged. However, the community violence and civic engagement literatures have not yet fully explored how these experiences may be linked in young people’s lives and in relation to what other forces. Using developmental assets and ecological-transactional frameworks, we review the emerging literature on civic engagement among youth exposed to community violence and how external developmental assets and neighborhood collective efficacy may create opportunity for their increased civic engagement. We present numerous conceptually- and empirically-based hypotheses to …

Resampling-Based Analysis Of Multivariate Data And Repeated Measures Designs With The R Package Manova.Rm, Sarah Friedrich, Frank Konietschke, Markus Pauly

The R Journal

Nonparametric statistical inference methods for a modern and robust analysis of longitudinal and multivariate data in factorial experiments are essential for research. While existing approaches that rely on specific distributional assumptions of the data (multivariate normality and/or equal covariance matrices) are implemented in statistical software packages, there is a need for user-friendly software that can be used for the analysis of data that do not fulfill the aforementioned assumptions and provide accurate p value and confidence interval estimates. Therefore, newly developed nonparametric statistical methods based on bootstrap- and permutation-approaches, which neither assume multivariate normality nor specific covariance matrices, have been …

Cvcrand: A Package For Covariate-Constrained Randomization And The Clustered Permutation Test For Cluster Randomized Trials, Hengshi Yu, Fan Li, John A. Gallis, Elizabeth L. Turner

The R Journal

The cluster randomized trial (CRT) is a randomized controlled trial in which randomization is conducted at the cluster level (e.g., school or hospital) and outcomes are measured for each individual within a cluster. Often, the number of clusters available to randomize is small (≤ 20), which increases the chance of baseline covariate imbalance between comparison arms. Such imbalance is particularly problematic when the covariates are predictive of the outcome because it can threaten the internal validity of the CRT. Pair-matching and stratification are two restricted randomization approaches that are frequently used to ensure balance at the design stage. An alternative, …

Biclustermd: An R Package For Biclustering With Missing Values, John Reisner, Hieu Pham, Sigurdur Olafsson, Stephen Vardeman, Jing Li

The R Journal

Biclustering is a statistical learning technique that attempts to find homogeneous partitions of rows and columns of a data matrix. For example, movie ratings might be biclustered to group both raters and movies. biclust is a current R package allowing users to implement a variety of biclustering algorithms. However, its algorithms do not allow the data matrix to have missing values. We provide a new R package, biclustermd, which allows users to perform biclustering on numeric data even in the presence of missing values.

Coxed: An R Package For Computing Duration-Based Quantities From The Cox Proportional Hazards Model, Jonathan Kropko, Jeffrey J. Harden

The R Journal

The Cox proportional hazards model is one of the most frequently used estimators in duration (survival) analysis. Because it is estimated using only the observed durations’ rank ordering, typical quantities of interest used to communicate results of the Cox model come from the hazard function (e.g., hazard ratios or percentage changes in the hazard rate). These quantities are substantively vague and difficult for many audiences of research to understand. We introduce a suite of methods in the R package coxed to address these problems. The package allows researchers to calculate duration-based quantities from Cox model results, such as the expected …

Serological Survey And Pathogen Exposure Of Adult Female White-Tailed Deer In The Western Dakotas, Katherine L. Moratz, Bailey S. Gullikson, Eric S. Michel, Daniel M. Grove, Jonathan A. Jenks, William Jensen

The Prairie Naturalist

Establishing baseline values for pathogen exposure and nutritional indices is necessary to monitor population health. However, little is known about white-tailed deer (Odocoileus virginianus) pathogen exposure and nutritional condition in the Northern Great Plains. Our objective was to assess pathogen exposure and establish nutritional indices for female white-tailed deer in Dunn and Grant counties, North Dakota and Perkins County, South Dakota. During 2014, we collected blood serum from 150 adult female white-tailed deer. Pathogens with the highest antibody prevalence included West Nile Virus (WNV; 85%), epizootic hemorrhagic disease (48%), and malignant catarrhal fever (32%). Serum values for creatine …

Spgarch: An R-Package For Spatial And Spatiotemporal Arch And Garch Models, Philipp Otto

The R Journal

In this paper, a general overview on spatial and spatiotemporal ARCH models is provided. In particular, we distinguish between three different spatial ARCH-type models. In addition to the original definition of Otto et al. (2016), we introduce an logarithmic spatial ARCH model in this paper. For this new model, maximum-likelihood estimators for the parameters are proposed. In addition, we consider a new complex-valued definition of the spatial ARCH process. Moreover, spatial GARCH models are briefly discussed. From a practical point of view, the use of the R-package spGARCH is demonstrated. To be precise, we show how the proposed spatial ARCH …

Fitting Tails By The Empirical Residual Coefficient Of Variation: The Ercv Package, Joan Del Castillo, Isabel Serra, Maria Padilla, David Moriña

The R Journal

This article is a self-contained introduction to the R package ercv and to the methodology on which it is based through the analysis of nine examples. The methodology is simple and trustworthy for the analysis of extreme values and relates the two main existing methodologies. The package contains R functions for visualizing, fitting and validating the distribution of tails. It also provides multiple threshold tests for a generalized Pareto distribution, together with an automatic threshold selection algorithm.

Rollmatch: An R Package For Rolling Entry Matching, Kasey Jones, Rob Chew, Allison Witman, Yiyan Liu

The R Journal

The gold standard of experimental research is the randomized control trial. However, interventions are often implemented without a randomized control group for practical or ethical reasons. Propensity score matching (PSM) is a popular method for minimizing the effects of a randomized experiment from observational data by matching members of a treatment group to similar candidates that did not receive the intervention. Traditional PSM is not designed for studies that enroll participants on a rolling basis and does not provide a solution for interventions in which the baseline and intervention period are undefined in the comparison group. Rolling Entry Matching (REM) …

The Idspatialstats R Package: Quantifying Spatial Dependence Of Infectious Disease Spread, John R. Giles, Henrik Salje, Justin Lessler

The R Journal

Spatial statistics for infectious diseases are important because the spatial and temporal scale over which transmission operates determine the dynamics of disease spread. Many methods for quantifying the distribution and clustering of spatial point patterns have been developed (e.g. K-function and pair correlation function) and are routinely applied to infectious disease case occurrence data. However, these methods do not explicitly account for overlapping chains of transmission and require knowledge of the underlying population distribution, which can be limiting when analyzing epidemic case occurrence data. Therefore, we developed two novel spatial statistics that account for these effects to estimate: 1) …

Final Thoughts As Editor-In-Chief, Christopher N. Jacques

The Prairie Naturalist

Greetings GPNSS members! I write this editorial during a time of reflection as Editor-in-Chief of The Prairie Naturalist (TPN), and during unprecedented times as the global COVID-19 pandemic continues. In full disclosure, I do not have a particular topic for this editorial, other than to offer a few final thoughts as my time serving the Great Plains Natural Science Society and TPN.

Structured Sensemaking Of Videographic Information Within Dataphoric Space, Michael J. Pritchard

Masters Theses & Doctoral Dissertations

Attempts to create a structured sensemaking model have proven difficult. Much of the research today has evolved into a cacophony of conceptual models. Many of these sensemaking models have been proposed but not tested. Using structural equations, a unified model of sensemaking was developed and tested. This structured sensemaking model contains five sensemaking constructs: chaos, anchoring, articulation, retrospection, and identity. This model was tested using data collected from 224 educationally focused YouTube videos. The confirmatory factor model developed for this research has a measured Comparative Fit Index of 0.979, a measured Standardized Root Mean Square Residual of 0.078, and a …

Reading Fluency And Gonoodle© Brain Breaks Among Elementary-Aged Children, Hannah Jeanne Wold

Theses and Dissertations

This study examines the immediate and chronic effects of physical activity (PA) breaks on reading fluency. While many teachers recognize the value of PA for increasing engagement and focus (getting the wiggles out) in academic endeavors, these results reveal increases in academic achievement in reading fluency are also possible.This study examines 384 second and third grade students with low income backgrounds from the Rocky Mountain region. A two-way analysis of variance (ANOVA) was used to examine the effects of chronic and acute brain breaks via GoNoodle© (McQuigg, 2013) on reading fluency and physical activity (steps). Between group differences were further …

Synthetic Cannabinoids: Characterizing Their Use And Cessation, Richard Vernon Turner

Dissertations

Since their introduction to the United States in 2008, synthetic cannabinoids became the most widely used recreational drug behind marijuana, then regressed to an estimated prevalence of less than 1%. Contrary to expectations for a drug declining in use, emergency department presentations and acute poisonings related to the use of synthetic cannabinoids are increasing. Alongside this phenomenon, a growing body of literature is beginning to uncover a relationship between psychosis and synthetic cannabinoid use. A current gap in the literature exists surrounding harm prevention methods and targeted intervention strategies for users of synthetic cannabinoids. To date, no known studies have …

The Importance Of Being A Consequential Public Health Journal, Alfredo Morabia

Publications and Research

No abstract provided.

Engineering Education Through Problem Based Learning: A Case Study Of Teaching Mechanical Engineering Design In Tu Dublin, Kevin Delaney, Ger Nagle

Articles

Undergraduate students, having learnt to quantify the performance of specific elements of engineering objects, often find it difficult to integrate these elements into quite basic design concepts. Employers expect these engineering graduates to be able to do a great deal more than solve the technical problems taught in engineering school once they enter the workforce. To help students meet this expectation by developing real-world engineering skills as part of their engineering education, the Mechanical Engineering Discipline in Technological University Dublin (TU Dublin) introduced Problem Based Learning (PBL) module for Third Year Mechanical Engineering students in 2005. This module was well …

A Generalisable Bottom-Up Methodology For Deriving A Residential Stock Model From Large Empirical Databases, Ciara Ahern, Brian Norton

Articles

Specifying representative reference buildings as a prerequisite for calculating cost-optimal energy performance requirements for buildings and building elements. Appropriate characterisation is prerequisite data for an overall national building energy consumption model to produce valid outcomes. Energy Performance Certificates (EPCs) are issued in the EU, for dwellings whenever they are constructed, sold or leased. Where acquiring data for an EPC would be prohibitively costly, nationally applicable default-values are employed for the building envelope thermal transmittance coefficients. Significant levels of retrofits led to the default-values used now being higher than is typical in reality, leading to characterisations of reference dwellings based on …

Factors Associated With C5 Palsy Following Cervical Spine Surgery: A Systematic Review., Andrew Jack, Wyatt L Ramey, Joseph R Dettori, Zane Tymchak, Rod J Oskouian, Robert A Hart, Jens R Chapman, Dan Riew

Articles, Abstracts, and Reports

Study Design: Systematic review.

Objectives: C5 palsy (C5P) is a not uncommon and disabling postoperative complication with a reported incidence varying between 0% and 30%. Among others, one explanation for its occurrence includes foraminal nerve root tethering. Although different risk factors have been reported, controversy about its causation and prevention persists. Inconsistent study findings contribute to the persistent ambiguity leading to an assumption of a multifactorial nature of the underlying C5P pathophysiology. Here, we report the results of a systematic review on C5P with narrow inclusion criteria in the hope of elucidating risk factors for C5P due to a common …

A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response To Obeticholic Acid In Patients With Nash., Samer Gawrieh, Xiuqing Guo, Jingyi Tan, Marie Lauzon, Kent D Taylor, Rohit Loomba, Oscar W Cummings, Sreekumar Pillai, Pallav Bhatnagar, Kris V Kowdley, Katherine Yates, Laura A Wilson, Yii-Der Ida Chen, Jerome I Rotter, Naga Chalasani

Articles, Abstracts, and Reports

A significantly higher proportion of patients with nonalcoholic steatohepatitis (NASH) who received obeticholic acid (OCA) had histological improvement relative to placebo in the FLINT (farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, NASH treatment) trial. However, genetic predictors of response to OCA are unknown. We conducted a genome-wide association study (GWAS) in FLINT participants to identify variants associated with NASH resolution and fibrosis improvement. Genotyping was performed using the Omni2.5 content GWAS chip. To avoid false positives introduced by population stratification, we focused our GWAS on white participants. Six regions on chromosomes 1, 4, 6, 7, 15, and 17 …

Editorial., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert

Articles, Abstracts, and Reports

No abstract provided.

Phase Iib, Randomized, Double-Blind Trial Of Gc4419 Versus Placebo To Reduce Severe Oral Mucositis Due To Concurrent Radiotherapy And Cisplatin For Head And Neck Cancer., Carryn M Anderson, Christopher M Lee, Deborah P Saunders, Amarinthia Curtis, Neal Dunlap, Chaitali Nangia, Arielle S Lee, Sharon M Gordon, Philip Kovoor, Roberto Arevalo-Araujo, Voichita Bar-Ad, Abhinand Peddada, Kyle Colvett, Douglas Miller, Anshu K Jain, James Wheeler, Dukagjin Blakaj, Marcelo Bonomi, Sanjiv S Agarwala, Madhur Garg, Francis Worden, Jon Holmlund, Jeffrey M Brill, Matt Downs, Stephen T Sonis, Sanford Katz, John M Buatti

Articles, Abstracts, and Reports

PURPOSE: Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the efficacy and safety of GC4419, a superoxide dismutase mimetic, with placebo to reduce the duration, incidence, and severity of severe OM (SOM).

PATIENTS AND METHODS: A total of 223 patients (from 44 institutions) with locally advanced oral cavity or oropharynx cancer planned to be treated with definitive or postoperative intensity-modulated RT (IMRT; 60 to 72 Gy [≥ 50 Gy to two or more oral sites]) plus cisplatin (weekly …

Incorporating In-Source Fragments Improves Metabolite Identification Accuracy In Untargeted Lcms And Lcms/Ms Datasets., Brian C Searle, Jacob C Lippincott, Phillip M Seitzer

Articles, Abstracts, and Reports

In untargeted metabolomics experiments library search engines detect metabolites using several features, including precursor mass, isotopic distribution, retention time, and MS2 fragmentation. Matching acquired MS2 to library spectra is vital as numerous compounds share molecular formulas, resulting in identical precursor measurements and similar retention times. However, many metabolomics experiments are still collected using LC-MS only, and even in LC-MS/MS experiments many precursors lack MS2 spectra due to the stochastic nature of data dependent acquisition. We observe that when metabolites ionize they can produce unanticipated MS1 features resulting from neutral losses, in-source fragmentation, multimerization, and adducts. Here we present a new …

Large Scale Improvement Model In Primary Care, Lisa Scardina, Evan Krause

Articles, Abstracts, and Reports

It can be surprisingly hard for organizations to prioritize, structure, and pace initiatives in a way that creates focus and alignment. Often leaders are unaware of all the initiatives under way and their impact on the organization. Overload can result in costly productivity and quality problems and caregiver burnout. With record low unemployment, companies that do not adjust the workload are also at risk of losing valuable talent.

Antithrombin Population Pharmacokinetics In Pediatric Ventricular Assist Device Patients, Brady S Moffett, Marc Anders, Timothy Humlicek, Marianne Galati, Jun Teruya, Iki Adachi, Sebastian Tume

Library Staff Publications

OBJECTIVES: Describe the pharmacokinetics of antithrombin in pediatric patients undergoing ventricular assist device therapy and provide dosing recommendations for antithrombin in this population.

DESIGN: A retrospective population pharmacokinetic study was designed.

SETTING: Large tertiary care children's hospital Subject inclusion criteria consisted of less than 19 years old.

PATIENTS: Subjects less than 19 years old undergoing therapy with a HeartWare ventricular assist device (HeartWare, Framingham, MA) or Berlin EXCOR ventricular assist device (Berlin GmbH, Berlin, Germany), who received a dose of antithrombin with a postdose antithrombin activity level from January 1, 2011, to June 30, 2017.

INTERVENTIONS: Population pharmacokinetic analysis and …

Gut Feelings: Race And The Embodied Self: An Interview With Shannon Sullivan, Shannon Sullivan, Shannon Branfield, Ruwen Chang, J. D. Saperstein

disClosure: A Journal of Social Theory

Shannon Sullivan is Chair of Philosophy and Professor of Philosophy and Health Psychology at UNC Charlotte. She specializes in feminist philosophy, critical philosophy of race, American philosophy (especially pragmatism), . and continental philosophy. She is the author of four books, most recently, Good White People: The Problem with Middle-Class White Anti-Racism (2014) and The Physiology of Sexist and Racist Oppression (2015). She also is co-editor of four books, including Race and Epistemologies of Ignorance (2007) and Feminist Interpretations of William James (2015).

I May Be Slightly Broken: Experiences Of Children Of Parents With Personality Disorders, Miriam Tepper

Social Work Theses - Archive

Child abuse is defined as any emotional, psychological or physical abuse or neglect inflicted on a child, that causes distress and impaired functioning for that child. A child’s caregiver was reported to be the main source of child abuse, with increasing chances if the parent struggles with a mental health disorder and or co-morbid substance use disorder or physical issues. The mental health issues that have been noted as a significant source of abuse include a parent who struggles with a personality disorder including borderline personality disorder (BPD) and narcissistic personality disorder (NPD). These personality disorders stem from years of …