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2019

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Synthesis And Characterization Of Polyethylene Glycol-Doxorubicin Conjugates Containing Β-Thiopropanamide Linkers For Enhanced Selective Cytotoxicity Against Breast Cancer Cells, Wiwat Supasena Jan 2019

Synthesis And Characterization Of Polyethylene Glycol-Doxorubicin Conjugates Containing Β-Thiopropanamide Linkers For Enhanced Selective Cytotoxicity Against Breast Cancer Cells, Wiwat Supasena

Chulalongkorn University Theses and Dissertations (Chula ETD)

Doxorubicin (DOX) is a chemotherapeutic agent that suffers from its severe adverse effects due to non-selective cytotoxicity. This study aims to design novel beta-thiopropanamide linkers (-S-CH2-C(R)H-CONH-) for DOX conjugation to promote cancer cell selectivity and cytotoxicity. Two series of DOX conjugates with various beta-thiopropanamide linkers were synthesized and evaluated for their cytotoxic selectivity. The first series contains 7 DOX analogues with different beta-thiopropanamide linkers. The DOX analogues were synthesized using ethyl thioglycolate and acrylic acid analogues to establish a series of beta-thiopropanamide linkages with DOX, and the potential linkers were intended to be incorporated in polymer-DOX conjugates. The other series …

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Development Of Cyclodextrin-Based Pickering Nanoemulsion Containing Amphotericin B For Treatment Of Fungal Keratitis, Phyo Darli Maw Jan 2019

Development Of Cyclodextrin-Based Pickering Nanoemulsion Containing Amphotericin B For Treatment Of Fungal Keratitis, Phyo Darli Maw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to develop pickering nanoemulsions (NEs) containing amphotericin B (AmB) for fungal keratitis therapy. The phase-solubility profiles of AmB in various aqueous cyclodextrin (CD) solutions were determined. The AmB solubilization in oils and surfactants was also examined. Two CDs i.e., gCD and 2-hydroxypropyl-g-CD (HPgCD), medium-chain triglycerides (MCT oil) and phosphatidylcholine (lecithin) were chosen because of their high solubility increment of AmB. Solution-state by 1H-NMR studies demonstrated the formation of MCT oil/αCD, AmB/gCD and AmB/HPgCD complexes. Some interactions between AmB and CD have been observed by solid-state characterizations (FT-IR, PXRD and DSC). The interfacial tension at …

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Expression Of Human Dentin Matrix Protein 1 In Escherichia Coli And Nicotiana Benthamiana And Their Effect On Proliferation And Osteogenic Differentiation Of Human Periodontal Ligament Stem Cells, Aktsar Roskiana Ahmad Jan 2019

Expression Of Human Dentin Matrix Protein 1 In Escherichia Coli And Nicotiana Benthamiana And Their Effect On Proliferation And Osteogenic Differentiation Of Human Periodontal Ligament Stem Cells, Aktsar Roskiana Ahmad

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to express recombinant protein human Dentin Matrix Protein 1 (hDMP1) in Escherichia coli and Nicotiana benthamiana and investigated the osteogenic differentiation effects in human Periodontal Ligament Stem Cells (hPDLSCs). The gene encoding hDMP1 was ligated into the pET22b and pBY2R2e expression vectors. Recombinant hDMP1 protein has been productively expressed in E. coli and N. benthamiana. E. coli-produced hDMP1 resulted in 60 kDa and 100, and the optimal condition to produce highly expression was demonstrated at 0.5 mM IPTG and incubation at 37oC for 6 hr. N. benthamiana-produced hDMP1 protein showed in a 100 kDa that indicated the …

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Cytotoxic Effects Of Mansonone G And Ethoxy Mansonone G From Mansonia Gagei Drumm In Non-Small Cell Lung Cancer, Arachawipa Wannachote Jan 2019

Cytotoxic Effects Of Mansonone G And Ethoxy Mansonone G From Mansonia Gagei Drumm In Non-Small Cell Lung Cancer, Arachawipa Wannachote

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mansonones are naphthoquinone-containing compounds extracted from the heartwood of Mansonia gagei. Several studies have reported that mansonones have various pharmacological activities such as antibacterial, antifungal, antioxidant, antiestrogenic, antiadipogenic and anticancer effects. A previous study reported that ether analogues of mansonone G (MG), a major compound isolated from Mansonia gagei Drumm, displayed higher antibacterial and antiadipogenic activities than parent MG. However, the anticancer activities of MG and ethoxy MG (EMG) on lung cancer cells have never been investigated. This study aimed to determine cytotoxic activities of MG and EMG and the underlying mechanism(s) in two non-small cell lung cancer cell lines, …

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Inhibitory Effects Of Compounds Isolated From Ethyl Acetate Extracts Of Glycosmis Parva Branches And Leaves On Lps-Induced Raw 264.7 Macrophage Activation, Chanyanuch Laprasert Jan 2019

Inhibitory Effects Of Compounds Isolated From Ethyl Acetate Extracts Of Glycosmis Parva Branches And Leaves On Lps-Induced Raw 264.7 Macrophage Activation, Chanyanuch Laprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophages play major roles to produce several inflammatory mediators in many chronic inflammatory diseases. Current anti-inflammatory drugs target these mediators to alleviate inflammation symptoms. Searching for new anti-inflammatory agents is always needed due to problems from currently used anti-inflammatory drugs. This study aimed to investigate the anti-inflammatory potential of three main compounds, arborinine, N-methylatalaphylline and S-deoxydihydroglyparvin (DDGP), isolated from Glycosmis parva leaves and branches on lipopolysaccharide (LPS)-activated macrophage RAW 264.7 cells. Only DDGP demonstrated a potent inhibitor of LPS-activated macrophages. It inhibited expression of inducible nitric oxide synthase and decreased nitric oxide production with IC50 3.47 ± 0.1 µM. It …

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Phytochemicals With Α-Glucosidase Inhibitory Activity From Cissus Javana, Dendrobium Christyanum, Gastrochilus Bellinus And Huberantha Jenkinsii, Htoo Tint San Jan 2019

Phytochemicals With Α-Glucosidase Inhibitory Activity From Cissus Javana, Dendrobium Christyanum, Gastrochilus Bellinus And Huberantha Jenkinsii, Htoo Tint San

Chulalongkorn University Theses and Dissertations (Chula ETD)

Phytochemical investigations of Cissus javana DC., Dendrobium christyanum Rchb. f., Gastrochilus bellinus Rchb. f. Kuntze and Huberantha jenkinsii (Hook. f. & Thomson) Chaowasku led to the isolation of twenty-seven compounds, six of which were new naturally occurring compounds. From Cissus javana, three known compounds were isolated, including bergenin, stigmast-4-en-3-one, and β-sitosterol. From Dendrobium christyanum, thirteen known compounds were identified, namely, n-eicosyl trans-ferulate, n-docosyl 4-hydroxy-trans-cinnamate, 4,5-dihydroxy-2-methoxy-9,10-dihydrophenanthrene, moscatilin, aloifol I, gigantol, batatasin III, dendrosinen B, coniferyl aldehyde, methyl haematommate, atraric acid, vanillin and diorcinolic acid. From Gastrochilus bellinus, four new compounds, comprising three phenanthropyrans and a phenanthrene derivative, were isolated and structurally …

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Effects Of Rhinacanthin-C In Multidrug-Resistance Breast Cancer Cells, Suwichak Chaisit Jan 2019

Effects Of Rhinacanthin-C In Multidrug-Resistance Breast Cancer Cells, Suwichak Chaisit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rhinacanthin-C (RN-C) is a major bioactive naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae). This compound has potential therapeutic value as an anticancer agent. Rhinacanthin-C was reported to enhance doxorubicin cytotoxicity in breast cancer cells through direct inhibition of P-gp activity. However, its ability in reversing multidrug resistance (MDR) in cancer cells through the down-regulation of P-gp expression, alteration of detoxification system, and increase in apoptosis proteins remains unreported. Thus, this study was to investigate the potential MDR reversal effect of rhinacanthin-C and its underlying mechanisms in MCF-7/DOX. In this study, rhinacanthin-C (1 µM, 48 h) significantly enhanced cytotoxicity of …

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Bioengineered Regenerative Therapy For Diabetes Mellitus: Establishment Of Canine Mesenchymal Stem Cell-Derived Insulin Producing Cells, Watchareewan Rodprasert Jan 2019

Bioengineered Regenerative Therapy For Diabetes Mellitus: Establishment Of Canine Mesenchymal Stem Cell-Derived Insulin Producing Cells, Watchareewan Rodprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Trend of regenerative therapy for diabetes in human and veterinary practice has conceptually been proven according to Edmonton protocol and animal models. Establishing an alternative insulin-producing cell (IPC) resource is a challenge task for further clinical application. In this study, IPC generation from two practical canine mesenchymal stem cells (cMSCs), canine bone marrow-derived MSCs (cBM-MSCs) and canine adipose-derived MSCs (cAD-MSCs), was of interest. The results illustrated that cBM-MSCs and cAD-MSCs contained distinct pancreatic differentiation potential and required the tailor-made induction protocols. Generation of functional cBM-MSC-derived IPCs needed an integration of genetic and microenvironment manipulation using hanging-drop culture of PDX-1-transfected cBM-MSCs …

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Association Between Nat2 Polymorphisms And Anti-Tuberculosis Drug-Induced Liver Injury In Myanmar Patients In Thailand, Khin Sandi Thaw Jan 2019

Association Between Nat2 Polymorphisms And Anti-Tuberculosis Drug-Induced Liver Injury In Myanmar Patients In Thailand, Khin Sandi Thaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aims of this study were to determine the N-acetyl transferase 2 (NAT2) genetic distribution of Myanmar tuberculosis (TB) patients and evaluate the association of NAT2 polymorphisms and antituberculosis drug-induced liver injury (AT-DILI) in Myanmar patients. A case-control study was conducted in adult Myanmar TB patients at Samut Sakorn Hospital. Fifty-four patients who completed anti-TB treatment without liver injury (controls) and five patients with AT-DILI during their anti-TB treatment (cases) were enrolled. Patients’ baseline characteristics, anti-TB doses, and liver enzyme levels were collected from the hospital’s record. Blood samples were collected and four NAT2 SNPs, rs1041983, rs1799929, rs1799930, and rs1799931, …

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Effect Of Gigantol On Tumorigenicity Of Non-Small Cell Lung Cancer Cells Via Cancer Stem Cell Signal Suppression, Nattanan Losuwannarak Jan 2019

Effect Of Gigantol On Tumorigenicity Of Non-Small Cell Lung Cancer Cells Via Cancer Stem Cell Signal Suppression, Nattanan Losuwannarak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung cancer is a major cause of cancer-related death. Tumor growth is a fundamental process of cancer progression. Vital characteristics that potentiate tumor growth are cancer stem cell (CSC) and enhance cell proliferation. Previous studies reported that targeting on CSC-promoting pathways or proliferative signals was a promising strategy in cancer treatment. Gigantol, a bibenzyl compound from Dendrobium draconis, was reported to have a suppressive activity on CSC phenotypes, in vitro. However, the effects of gigantol on tumorigenicity in vivo, cancer cell proliferation and related CSC-promoting and proliferation regulatory mechanisms have not been explored. In this study, ectopic tumor xenograft in …

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N, N-Bis (5-Ethyl-2-Hydroxybenzyl) Methylamine Induces Apoptosis Of Non-Small Cell Lung Cancer Cells Via C-Myc Protein Degradation, Nicharat Sriratanasak Jan 2019

N, N-Bis (5-Ethyl-2-Hydroxybenzyl) Methylamine Induces Apoptosis Of Non-Small Cell Lung Cancer Cells Via C-Myc Protein Degradation, Nicharat Sriratanasak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung cancer is a common cancer disease that contributes as a major cause of cancer related death. The oncoprotein, c-Myc plays a major role in oncogenic malignancies. It has been shown that the up—regulated c-Myc relates with aggressiveness of cancers and treatment failure. In this study, we purposed N, N-bis (5-ethyl-2-hydroxybenzyl) methylamine (EMD), a benzoxazine dimer to be a novel c-Myc targeting compound and displayed evidence presenting the potential effect of EMD on c-Myc degradation in human lung cancer cells. EMD exhibited cytotoxicity to lung cancer cells through apoptosis induction. EMD dramatically eliminated c-Myc in the cells and initiated caspase-dependent …

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Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The University Of Washington - Pain Related Self-Efficacy Scale 6 (Uw-Prse6), Angkana Khampanthip Jan 2019

Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The University Of Washington - Pain Related Self-Efficacy Scale 6 (Uw-Prse6), Angkana Khampanthip

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To cross-culturally adapt the University of Washington Pain related Self-Efficacy Scale (UW-PRSE6) into Thai and evaluate its psychometric properties. Methods: The original UW- PRSE6 was cross-culturally adapted using the Functional Assessment of Chronic Illness Therapy translation methodology. 241 individuals with chronic low back pain completed the Thai version of UW-PRSE6 (T-UW-PRSE6), Thai Fear Avoidance Beliefs Questionnaire (T-FABQ), and Thai Medical Outcome Study Short-Form 36 (T-SF-36). 241 participants completed the T-UW-PRSE6 and again after 7-days interval. 152 participants rated their overall condition as having little to no change at the second assessment. Cronbach’s alpha and intraclass correlation coefficients were calculated …

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Factors Of Age, Anthropometric Characteristics And Lower Extremity Strength On Multi-Directional Reach Test In Typical Children Aged 7 - 12 Years, Benjaporn Hirunyaphinun Jan 2019

Factors Of Age, Anthropometric Characteristics And Lower Extremity Strength On Multi-Directional Reach Test In Typical Children Aged 7 - 12 Years, Benjaporn Hirunyaphinun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to investigate the associations of age, anthropometric characteristics and lower extremity strength with the Multi-Directional React Test (MDRT). Sixty children with typical development, aged 7 to 12 years old, were categorized into each age group. Pearson correlation coefficient and Spearman rank correlation coefficient were conducted to examine the relationship between interesting variables (age, anthropometric characteristics and lower extremity strength) and the reach distances in forward, backward, leftward and rightward directions. The results of this study showed that multi-directional reach distances increased with age for all directions. Fair to moderate relationship (r = 0.28 – …

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Responsiveness Of The Thai Version Of The Patient Reported Outcomes Measurement Information System-29 (Promis-29) In Patients With Chronic Low Back Pain, Kornkanok Khutok Jan 2019

Responsiveness Of The Thai Version Of The Patient Reported Outcomes Measurement Information System-29 (Promis-29) In Patients With Chronic Low Back Pain, Kornkanok Khutok

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) questionnaire assesses 7 health related quality of life domains. However, research to evaluate the responsiveness and minimal clinically important differences (MCIDs) of the PROMIS-29 scores in patients with chronic low back pain (cLBP) is limited. Purpose: To evaluate responsiveness and estimate the MCIDs for PROMIS-29 scales in patients with cLBP. Method: One hundred and eighty-three participants with cLBP took part in the study. They completed the PROMIS-29 scales at baseline, 4 weeks, and 8 weeks of the study. Responsiveness of the PROMIS-29 scale scores was evaluated by examining the mean change scores, …

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Effects Of Achilles Tendon Stretching In Individuals With Plantar Fasciitis, Phoomchai Engkananuwat Jan 2019

Effects Of Achilles Tendon Stretching In Individuals With Plantar Fasciitis, Phoomchai Engkananuwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background and rationale: Since the plantar fascia and the Achilles tendon are anatomically connected, it is therefore plausible that stretching of both structures simultaneously will result in a better outcome. Methods: Fifty participants aged 40-60 years with a history of plantar heel pain greater than one month were recruited. They were randomly assigned into two groups. Group 1 was instructed to stretch the Achilles tendon while Group 2 simultaneous stretched the Achilles tendon and plantar fascia. The stretching interventions were performed for four weeks and the outcome measures were recorded at baseline, at the end of the 4th week, and …

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Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The University Of Washington - Concerns About Pain Scale 6 (Uw-Cap6), Sukhonwaroch Youprasart Jan 2019

Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The University Of Washington - Concerns About Pain Scale 6 (Uw-Cap6), Sukhonwaroch Youprasart

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Pain catastrophizing has been shown to be an important psychosocial factor that predicts disability and other important pain-related outcomes in individuals with chronic pain. The University of Washington - Concerns about Pain scale (UW-CAP6) is the brief version of a new item bank that assesses pain-related catastrophizing. Objective: To cross-culturally adapt the UW-CAP6 items into Thai and to evaluate its psychometric properties. Methods: The original UW-CAP6 instructions and items were cross-culturally adapted into Thai using the Functional Assessment of Chronic Illness Therapy translation methodology. Chronic low back pain individuals completed the Thai version of UW-CAP6 (T-UW-CAP6), Thai Fear Avoidance …

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Curling Probe Measurement In Plasma, Chatchai Sirithipvanich Jan 2019

Curling Probe Measurement In Plasma, Chatchai Sirithipvanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

The curling probe is one of the active resonance absorption spectroscopic methods, the methods utilized the probe reflection coefficient spectrum to determine the plasma density. The proposed model of the curling probe uses the deviation of the most matched frequency, the frequency in which the minimum reflection coefficient occurs, when the probe is submerged in different mediums. The probe structure is simple and claimed to be robust and efficient. The experiments of a curling probe were performed and the simulations for the probe reflection coefficient for both previously reported probe and the constructed probe configuration have been conducted. The previously …

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Ads₄/Cft₃ Holography From Four-Dimensional Gauged Supergravity, Khem Upathambhakul Jan 2019

Ads₄/Cft₃ Holography From Four-Dimensional Gauged Supergravity, Khem Upathambhakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

We study holographic RG flows from N = 3 and N = 4 gauged supergravities in four dimensions. The scalar manifold of N = 3 gauged supergravity is in the form of the coset space G/H = SU(3, n)/SU(3) × SU(n) × U(1). Possible gauge groups, in this study, are given by SO(3) × SO(3), SO(3, 1), SO(2, 2), SO(2, 1) × SO(2, 2), and SL(3, R). We then study N = 4 gauged supergravity from type II compactification on T⁶/Z₂ × Z₂ with non-semisimple gaugings. The scalar manifold of N = 4 gauged supergravity is in the form of …

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Multipole Resonance Probe Measurement In Plasma, Natthapong Jampaiboon Jan 2019

Multipole Resonance Probe Measurement In Plasma, Natthapong Jampaiboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Active plasma resonance spectroscopy (APRS) is one of the interesting methods which could avoid plasma contamination problem occurs in a conventional Langmuir probe measurement. It is because the probe conductors are covered by a dielectric material. The APRS probe can be of any shape. A multipole resonance probe is a hemisphere APRS probe since a sphere imposes the simplest way to find an analytical solution by solving the Laplace equation in the spherical coordinates with the azimuthal symmetry. In this study, the APRS probes in the hemisphere, microstrip, and parallel rod shapes were constructed. Plasma density was obtained by using …

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Effects Of Magnesium Substitution On Electronic Properties Of Calcium Difluoride, Natthasart Chintananon Jan 2019

Effects Of Magnesium Substitution On Electronic Properties Of Calcium Difluoride, Natthasart Chintananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

We use density functional theory to find the phase transitions of CaF2. The results show that CaF2 adopts the fluorite structure, with the space group Fm-3m, in the range 0f 0-8 GPa and transforms into the cotunnite structure, with the space group Pnma, above 8 GPa. The electronic band structure of the Pnma-CaF2 structure expresses an insulating phase, and the bandgap collapses under pressure above 70 GPa. In this work, we proposed a new decoration of Ca/Mg-substituted fluorides MgxCa1-xF2, using the cluster expansion technique which is commonly used to study alloys. We found that the Mg0.25Ca0.75F2, with a Pm structure, …

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Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa Jan 2019

Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Early childhood caries is a common oral disease found in children which could affect their general health. Streptococcus mutans is an important cariogenic pathogen since it possesses cariogenic properties, which are acid production, acid tolerance and biofilm formation. Recent studies showed that Candida albicans, which is frequently found together with S. mutans in plaques of children with dental caries, enhances cariogenicity. At the same time, increasing prevalence of non-albicans Candida species (NACs) in children and immune-compromised patients has been reported. Therefore, this study aims to investigate the effects of NACs when co-cultured with S. mutans on cariogenic properties and virulence …

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The Incidence Of Antibiotic-Resistant Staphylococcus Spp. Colonization And Infection In Children And Adults With Atopic Dermatitis, Matchima Laowansiri Jan 2019

The Incidence Of Antibiotic-Resistant Staphylococcus Spp. Colonization And Infection In Children And Adults With Atopic Dermatitis, Matchima Laowansiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic and recurrent eczematous rash. AD occurs in both children and adults, but children are more affected. An important aggravating factor is caused by Staphylococcus aureus (S. aureus) infection. Therefore, topical (beta-lactam, macrolides, clindamycin) and systemic (mupirocin and fusidic acid) antibiotics are essential for treatment of AD. However, frequent use of antibiotics results in an increase in the incidence of antibiotic-resistant S. aureus. Methicillin resistance S. aureus (MRSA) becomes a problem in the treatment of skin diseases. It’s found that the change from penicillin binding protein (PBP) to PBP2a with …

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Effects Of Polyaniline Thickness On Photovoltaic Properties Of Pani/Tio2 Photovoltaic Cells, Akkharaphak Auisakul Jan 2019

Effects Of Polyaniline Thickness On Photovoltaic Properties Of Pani/Tio2 Photovoltaic Cells, Akkharaphak Auisakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Polyaniline (PANI) is a cheap conducting polymer that exhibits p-type properties with high conductivity and unique redox properties. In this work, PANI was synthesized directly on TiO2/FTO substrates by electropolymerisation from acidic aqueous solutions of aniline to form PANI/TiO2 p-n junctions with photovoltaic properties. The thickness of the PANI layer was varied by varying electrodeposition time: 15, 30, and 45 min at the same current density of 2 mA cm-2. The thicknesses of the deposited PANI layers were examined with Scanning Electron Microscope (SEM). Short-circuit currents (ISC) and open-circuit voltages (VOC) of fabricated Pt/PANI/TiO2/FTO cells are investigated. It was found …

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The Visegrád Group And The European Migrant Crisis : Cause Factors And The Case Of Hungary, Onvara Vadhanavisala Jan 2019

The Visegrád Group And The European Migrant Crisis : Cause Factors And The Case Of Hungary, Onvara Vadhanavisala

Chulalongkorn University Theses and Dissertations (Chula ETD)

The European migrant crisis has propelled the European Union (EU) to face many challenges, starting from the division of different ideas on how to manage a high number of refugees and migrants. The crisis is marked as a turning point for right-wing populism to gain its strength in modern European politics. The European Member States (EMS) have started to lose their trust in European institutions because of their unclear strategic direction on solving the refugee and migrant crisis. Correspondingly, Euroscepticism is spreading all over Europe. The situation has been worsened as more refugees are continuously entering Europe. Therefore, populists and …

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Prediction Of Lncrna-Protein Interactions Based On Deep Learning Model, Natsuda Navamajiti Jan 2019

Prediction Of Lncrna-Protein Interactions Based On Deep Learning Model, Natsuda Navamajiti

Chulalongkorn University Theses and Dissertations (Chula ETD)

One main function of long non-coding RNAs (lncRNAs) is to act as a scaffold facilitating multiple proteins to form complexes. Most of available prediction models for protein-RNA interactions, however, were proposed as a binary classifier, which limited on predicting the interaction between the non-coding RNAs and each individual RNA-binding protein (RBP). Hence, to predict if a lncRNA is acting as a scaffold, we consider this problem as a multiclass multilabel classification problem. To solve this problem, the high confident CLIP-seq data were selected from the POSTAR2 database with an augmentation of the data for the RBP classes with a small …

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Effects Of Microplastic Accumulation On Floc Characteristics And Fouling Mechanism In Sequencing Batch Membrane Bioreactor, Thitiwut Maliwan Jan 2019

Effects Of Microplastic Accumulation On Floc Characteristics And Fouling Mechanism In Sequencing Batch Membrane Bioreactor, Thitiwut Maliwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research investigated the effects of microplastic accumulation on the floc characteristics and mechanism of membrane fouling in a sequencing batch membrane bioreactor (SB-MBR). At first, the jar test experiment was performed for 120 min. The results indicate that spiking microplastics of 100-1,000 MPs/L resulted in an increase in floc size by 27.9±9.2% to 70.9±5.1%, while the control set (without microplastic) showed a greater increase in the floc size at 113.3±5.6% of the initial floc size. Afterwards, the SB-MBR, which was equipped with a flat-sheet microfiltration membrane, was operated at 24 hours/cycle with 4 reactors at the influent COD of …

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Elastic Half-Plane Under Surface Excitations With Consideration Of Couple Stress And Surface Stress Effects, Toan Minh Le Jan 2019

Elastic Half-Plane Under Surface Excitations With Consideration Of Couple Stress And Surface Stress Effects, Toan Minh Le

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents the modeling and analysis of an elastic half-plane under the surface loading and the frictionless contact of a rigid indentor by taking the influence of both surface and couple stresses into account. The corresponding boundary value problem is formulated by adopting the surface elasticity and couple stress theories. The method of Fourier integral transform is employed together with the boundary conditions on the top surface to derive the complete elastic field of the half-plane subjected to arbitrary surface loadings. The proposed solution scheme is also applied to construct a set of fundamental solutions associated with a normal …

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Front Cover, North American Bird Bander Jan 2019

Front Cover, North American Bird Bander

North American Bird Bander

No abstract provided.

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Front Cover, North American Bird Bander Jan 2019

Front Cover, North American Bird Bander

North American Bird Bander

No abstract provided.

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Back Cover, North American Bird Bander Jan 2019

Back Cover, North American Bird Bander

North American Bird Bander

No abstract provided.

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