Evaluating The Use Of Competing Items In A Multiple Schedule During Reinforcement Schedule Thinning, Scott A. Miller

Theses & Dissertations

Multiple schedules are schedules of reinforcement that are often used to facilitate more manageable rates of a replacement behavior such as a communication response following functional communication training as an intervention for destructive behavior. Commonly, reinforcement schedule thinning involves multiple fading steps that can take more than 100 sessions to achieve therapeutic goals. The purpose of this experiment was to evaluate a method for rapidly achieving fading steps in a multiple schedule by including competing items during the extinction interval. Four children diagnosed with autism successfully reached the terminal extinction interval with a ≥80% reduction in problem behavior. Two of …

Patterns Of Approaches To Digital Transformation: An Institutional Arrangements Perspective, Mojca Indihar Štemberger, Jure Erjavec, Anton Manfreda, Jurij Jaklič

Economic and Business Review

Companies face huge challenges in managing their digital transformation in terms of key actors, their roles and the way they interplay. Based on a survey of 181 large and medium-sized Slovenian companies, we discover six differently successful organizational patterns. The most successful identified pattern is the business–IT partnership approach, where top management and the IT department are responsible for the digital transformation, and the CIO is an orchestrator and a member of top management. However, this is not the only possible successful approach for digital transformation. Recommendations and possible evolutionary paths for companies in each pattern are also outlined in …

Acclimation, Long-Term Repeatability, And Phenotypic Correlations Of Aerobic Metabolic Traits In The Gulf Killifish, Fundulus Grandis, Jessica E. Reemeyer

LSU New Orleans Theses and Dissertations

This research examined the effects of acclimation to lowered salinity, elevated temperature, and hypoxia on aerobic metabolism of the Gulf killifish, Fundulus grandis, a common estuarine resident of the Gulf of Mexico. Standard metabolic rate (SMR), maximum metabolic rate (MMR), absolute aerobic scope (AAS), and critical oxygen tension (P_crit) were each influenced by one or more acclimation treatments. Assessing the consistency of these traits measured in the same individuals over time, all were found to be significantly repeatable with no indication that the repeatability of any traits was affected by acclimation conditions. Significant correlations were found between …

Vertical Acoustic Propagation In The Non-Homogeneous Layered Atmosphere For A Time-Harmonic, Compact Source, Edward J. Yoerger Jr

LSU New Orleans Theses and Dissertations

In this work we study vertical, acoustic propagation in a non-homogeneous media for a spatially-compact, time-harmonic source. An analytical, 2-layer model is developed representing the acoustic pressure disturbance propagating in the atmosphere. The validity of the model spans the distance from the Earth's surface to 30,000 meters. This includes the troposphere (adiabatic), ozone layer (isothermal), and part of the stratosphere (isothermal). The results of the model derivation in the adiabatic region yield pressure solutions as Bessel functions of the First (J) and Second (Y) Kind of order $-\frac{7}{2}$ with an argument of $2 \Omega \tau$ (where $\Omega$ represents a dimensionless …

Structural Connectivity And Immunological Correlates Of Emotion Processing In Children With Chromosome 22q11.2 Deletion Syndrome, Ashley F. P. Sanders

LSU New Orleans Theses and Dissertations

Neurological abnormalities are associated with emotion processing deficits seen in children with neurodevelopmental disorders. Research suggests that inflammatory mechanisms can negatively impact brain structure and function and are thought to play a role in these processing atypicalities. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit emotion processing impairments and associated neural abnormalities. We investigated the roles of inflammatory factors and structural connectivity in relation to emotion processing deficits in 28 children with 22q11.2DS and 33 typically developing children (M = 11.12 years old; SD = 2.17). Results indicate poorer social skills and significantly lower emotion recognition scores in children …

Euclidean Dynamical Triangulations: Running Couplings And Curvature Correlation Functions, Scott David Bassler

Dissertations - ALL

Quantum field theories have been incredibly successful at describing many fundamental aspects of reality with great precision, sometimes relying on the powerful computational tool of lattice methods. Gravity has so far eluded a quantum field theory description, leading many to consider alternate theories like String Theory. However, recent results in lattice quantum gravity have brought some renewed interest in the subject. After reviewing the progress made so far in Euclidean Dynamical Triangulations, a lattice theory of gravity, we examine how the couplings of the theory run with scale. We find that the dimensionless couplings $\hat{G}$ and $\hat{\Lambda}$ are not separately …

Novel Shape Memory And Multi-Shape Memory Polymers For Biomaterial Applications, Shelby Lois Buffington

Dissertations - ALL

Biomaterial platforms have been used to probe how cells respond to chemical, topographical or mechanical changes in their environments. However, these traditionally static biomaterial platforms have not enabled the study of how cells respond to dynamic changes in their environment. Driven by a need to better understand cell behavior and its role it disease, development and tissue regeneration recent efforts have focused on designing dynamic biomaterial platforms to better mimic a cell’s natural environment. In this work, advanced shape memory polymers (SMPs) that respond to non-thermal triggers and multi-shape memory materials capable of multiple topographical transitions were developed for advanced …

Digital Readout And Control Of A Superconducting Qubit, Caleb Jordan Howington

Dissertations - ALL

In the quest to build a fault-tolerant quantum computer, superconducting circuits based on Josephson junctions have emerged as a leading architecture. Coherence times have increased significantly over the last two decades, and processors with ∼ 50 qubits have been experimentally demonstrated. These systems traditionally utilize microwave frequency control signals, and heterodyne based detection schemes for measurement. Both of these techniques rely heavily on room temperature microwave generators, high-bandwidth lines from room temperature to millikelvin temperatures, and bulky non-reciprocal elements such as cryogenic microwave isolators. Reliance on these elements makes it impractical to scale existing devices up a single order of …

Network Sampling Through Crawling, Katchaguy Areekijseree

Dissertations - ALL

In recent years, researchers have increasingly used OSN data to study human behavior. Before such a study can begin, one must first obtain appropriate data. A platform, e.g, Facebook or Twitter, may provide an API for accessing data, but such APIs are often ratelimited, restricting the amount of data that an individual collects in a given amount of time. In order for the data collector to efficiently collect data, she needs to make intelligent use of her limited budget. Therefore, when collecting data, efficiency is extremely important. We consider the problem of network sampling through crawling, in which the data …

Lifestyle Management For Vestibular Disorders, Michelle Pock

Student Capstone Papers

Individuals with vestibular disorders have concerns that impact lifestyle including limiting activities of daily living, limiting participation in social events, difficulty driving, and difficulty working (Cohen, 2014). Occupational therapists are able to help individuals with vestibular disorders by task analyzing symptom provoking activities, assessing the impact of symptoms on occupations, providing adaptations, and providing ways to modify environments (Gronski, Neville, Kannenberg, & Cohen, 2017). While occupational therapists are qualified to provide services to sustain and improve the occupational performance of individuals with vestibular disorders, occupational therapy is not well represented in this area particularly in addressing lifestyle components for vestibular …

Mechanism Of Bax/Bak Activation In Apoptotic Signaling, Kai Huang

Theses & Dissertations

The Bcl-2 family proteins, including the anti-apoptotic members, pro-apoptotic effectors Bax/Bak, and the BH3-only proteins, are key components of the mitochondrial apoptotic pathway. The BH3-only protein Bid is critical for the mitochondrial pathway of apoptosis after TRAIL-induced death receptor activation. However, the mechanism of Bid activation during TRAIL-induced apoptosis is unclear. By putting back wild-type and mutants of Bid in Bid deficient (Bid KO) and Bid/Bax/Bak TKO colon cancer cells, we demonstrated that cleavage by caspase 8 and mitochondrial targeting are critical events for Bid activation. One of the biggest mysteries in apoptosis is how Bax/Bak was activated by BH3-only …

Brca1 & Ctdp1 Brct Domainomics In The Dna Damage Response, Kimiko L. Krieger

Theses & Dissertations

Genomic instability is one of the enabling characteristics of cancer. DNA damage response pathways are important for genomic integrity and cell cycle progression. Defects in DNA damage repair can often lead to cell cycle arrest, cell death, or tumorigenesis. The activation of the DNA damage response includes tightly regulated signaling cascades that involve kinase phosphorylation and modular domains that scaffold phosphorylated motifs to coordinate recruitment of DNA repair proteins. Modular domains are conserved tertiary structures of a protein that can fold, function, and evolve independently from an intact protein. One of the most common modular domains involved in DNA damage …

The Role Of E3 Ubiquitin Ligase Fbxo9 In Normal And Malignant Hematopoiesis, R. Willow Hynes-Smith

Theses & Dissertations

Hematopoiesis is a critical system that provides blood cells necessary for nutrient and oxygen transfer throughout an organism and for protection from harmful agents. It is maintained throughout life by the hematopoietic stem cells (HSCs) that reside within the bone marrow (BM) and are responsible for providing billions of new cells each day. HSCs maintain a careful balance between a quiescent state, that sustains the integrity of the stem cells, and a proliferative state, that provides new cells to replenish those that undergo apoptosis. Hematopoiesis is regulated by a variety of intrinsic pathways and extrinsic signals such as cytokine signaling, …

Cholesterol Biosynthesis In The Nervous System With An Emphasis On Desmosterolosis, Luke Allen

Theses & Dissertations

Cholesterol biosynthesis is integral to proper neurodevelopment due to the reliance on de novo synthesis of cholesterol in the brain. Disruptions in this process have devastating outcomes for human life characterized by several phenotypic manifestations concomitant with developmental delay. The cholesterol biosynthesis disorder desmosterolosis is an extremely rare disorder with a severe clinical phenotype, however, the models used to study this disease are not well characterized. In addition to genetic disruptions in cholesterol biosynthesis, pharmacological perturbation is an understudied side effect of many commonly prescribed drugs. Here we present a characterization of the sterol profile of the mouse model of …

Targeted Inhibition Of Histone Deacetyltransferases For Pancreatic Cancer Therapy, Richard Laschanzky

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal five-year survival rate of less than 10%. One major obstacle in PDAC treatment is acquired drug resistance. Pan-histone deacetylase inhibitors (pan-HDACi) are a relatively new class of anti-cancer drugs, with demonstrated ability to overcome drug resistance and re-sensitize PDAC tumors to Gemcitabine (Gem). These agents target HDACs, a family of 18 enzymes (divided into four classes, I-IV) that catalyze the deacetylation of histones and other cellular proteins and have multiple effects on cell growth, differentiation, survival, and tumorigenesis. Although pan-HDACi have shown significant efficacy in preclinical analysis, and some …

The Vezo Communities And Fisheries Of The Coral Reef Ecosystem In The Bay Of Ranobe, Madagascar, Shane Abeare

LSU New Orleans Theses and Dissertations

Madagascar, a country whose extraordinary levels of endemism and biodiversity are celebrated globally by scientists and laymen alike, yet historically has received surprisingly little research attention, is the setting of the present dissertation. Here, I contribute to the need for applied research by: 1) focusing on the most intensely fished section of the Toliara Barrier Reef, the Bay of Ranobe; 2) characterizing the marine environment, the human population, and the fisheries; and 3) collecting the longest known time-series of data on fisheries of Madagascar, thereby providing a useful baseline for future analyses. In Chapter 1, the bathymetry of the Bay …

Two Clamped Pipe Support Connections For Oil And Gas Brownfield Projects, Helen M. Claycomb

LSU New Orleans Theses and Dissertations

In the oil and gas industry, brownfield projects focus on the modification of or addition to an existing production facility that is fully operational and operating. Welding is typically avoided on these projects. The drilling of holes in existing primary structural elements is also prohibited. Clamped connections are often used when adding additional services in a brownfield project. There are different types of clamped connections utilized when a new structural support must be attached to an existing vertical structural pipe. The short bolt clamped connection is a well-established connection and typically used on offshore projects. The U-bolt clamped connection is …

The Effects Of Automated Grading On Computer Science Courses At The University Of New Orleans, Jerod F A Dunbar

LSU New Orleans Theses and Dissertations

This is a study of the impacts of the incorporation, into certain points of the Computer Science degree program at the University of New Orleans, of Course Management software with an Autograding component. The software in question, developed at Carnegie Mellon University, is called “Autolab.” We begin by dissecting Autolab in order to gain an understanding of its inner workings. We can then take out understanding of its functionality and apply that to an examination of fundamental changes to courses in the time since they incorporated the software. With that, we then compare Drop, Failure, Withdrawal rate data from before …

Multi-Agent Narrative Experience Management As Story Graph Pruning, Edward T. Garcia

LSU New Orleans Theses and Dissertations

In this thesis I describe a method where an experience manager chooses actions for non-player characters (NPCs) in intelligent interactive narratives through story graph representation and pruning. The space of all stories can be represented as a story graph where nodes are states and edges are actions. By shaping the domain as a story graph, experience manager decisions can be made by pruning edges. Starting with a full graph, I apply a set of pruning strategies that will allow the narrative to be finishable, NPCs to act believably, and the player to be responsible for how the story unfolds. By …

Working Memory Deficits Are Associated With Altered Regional Brain Volume And Structural Connectivity In Children With Chromosome 22q11.2 Deletion Syndrome., Diana Hobbs

LSU New Orleans Theses and Dissertations

Background: Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit nonverbal learning disability that may manifest in part because of working memory (WM) deficits. 22q11.2DS is a complex developmental disorder with serious physical, learning, cognitive, and psychiatric symptoms including a risk of developing schizophrenia 30 times that of the general population. WM impairment likely contributes to and exacerbates learning difficulties, school problems, existing neuropsychological disorders such as attention deficit hyperactivity disorder (ADHD); and a poor WM may be a biological risk marker for future mental illness. WM impairment is established in this population, but less is known about its neurological origins. …

Teachers' Perceptions Of How The Teacher Evaluation Process Impacts Classroom Instruction In Three High Poverty School Districts, Zina R. Jones Ms

LSU New Orleans Theses and Dissertations

Abstract

Improving the educational system for students and teachers is of the upmost importance. Educational leaders have realized that the best way to improve student success is by improving teachers’ instructional practices and measuring their effectiveness (Mathers, Oliva, & Laine, 2008). Because of this awareness, educators have realized the importance of connecting student achievement with instructional practices and instructional practices with teacher effectiveness. Evaluation tools are used to measure how effective teachers are in their classrooms. Evaluations are crucial in assisting our teachers in their professional growth. When evaluations are utilized as supportive tools, they help teachers and administrators identify …

Overcoming Negative Employer Attitudes: Exploring The Lived Experiences Of Employeees With Visual Impairments, James Mcneil

Electronic Theses and Dissertations

Negative employer attitudes toward people with visual impairments who are already employed is a topic that rarely has been discussed in the literature. The purpose of this hermeneutic phenomenological study was to explore, understand, and describe how employees with visual impairments process and overcome perceived negative employer attitudes. Seventeen themes emerged as a result of this study. Some of the themes emphasize the lived existentials (lived time, lived space, lived body, and lived other) connected with being the object of an employer’s negative attitude. Other themes emphasize the risk factors that exist in the environment(s) of employees with visual impairments …

Genetic Analysis Of A Novel Ftsk Homolog, Hfka, In Streptomyces Coelicolor Development-Associated Chromosome Segregation, Sumedha Sethi

Electronic Theses and Dissertations

A quintessential phenomenon occurring during prokaryotic development is accurate segregation of the replicated genomes into the daughter cells. Key energy-dependent processes like chromosome condensation and subcellular partitioning of the genomes are driven by conserved proteins like SMC, ParB, FtsK. During its complex developmental cycle, Streptomyces coelicolor segregates its genomes into chains of unicellular spores when its multigenomic syncytial aerial hyphae undergo division.

A novel ftsK-like gene, hfkA (Homolog of FtsK protein A), was examined for function and localization during development-associated chromosome segregation. Individual deletions did not affect segregation, but a ΔhfkA ΔftsK mutant exhibited 8% anucleate …

Digital Tools In The Classroom: Measuring The Effectiveness, Jeff Carpenter

Current Issues in Emerging eLearning

The purpose of the study is to determine if, compared to traditional practice, digital practice increases student measuring accuracy on an authentic task. Therefore the study explores the relative efficacy of digital versus traditional practice for increasing student measurement skills in applied situations. Research tells us that students’ poor performance with measuring skills is directly related to lack of practice. To increase the ability to accurately use a ruler, Junior High, Intermediate and Middle Schools students require more time on task than they typically spend practicing this skill. Since more time is hard to come by in the classroom, educators …

State V. Robles Respondent's Brief Dckt. 47063

Not Reported

No abstract provided.

The Histone Deacetylase Inhibitor Tubacin Mitigates Endothelial Dysfunction By Up-Regulating The Expression Of Endothelial Nitric Oxide Synthase., Jihui Chen, Jian Zhang, Noor F. Shaik, Bing Yi, Xin Wei, Xiao-Feng Yang, Ulhas P. Naik, Ross Summer, Guijun Yan, Xinyun Xu, Jianxin Sun

Center for Translational Medicine Faculty Papers

Endothelial nitric oxide (NO) synthase (eNOS) plays a critical role in the maintenance of blood vessel homeostasis. Recent findings suggest that cytoskeletal dynamics play an essential role in regulating eNOS expression and activation. Here, we sought to test whether modulation of cytoskeletal dynamics through pharmacological regulation of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation affects eNOS expression and endothelial function in vitro and in vivo.Wefound that tubulin acetylation inducer (tubacin), a compound that appears to selectively inhibit HDAC6 activity, dramatically increased eNOS expression in several different endothelial cell lines, as determined by both immunoblotting and NO production assays. Mechanistically, we found …

Determining Levers Of Cost-Effectiveness For Screening Infants At High Risk For Peanut Sensitization Before Early Peanut Introduction, Matthew Greenhawt, Marcus Shaker

Dartmouth Scholarship

Importance Early peanut introduction reduces the risk of developing peanut allergy, especially in high-risk infants. Current US recommendations endorse screening but are not cost-effective relative to other international strategies.

Objective To identify scenarios in which current early peanut introduction guidelines would be cost-effective.

Design, Setting, and Participants This simulation/cohort economic evaluation used microsimulations and cohort analyses in a Markov model to evaluate the cost-effectiveness of early peanut introduction with and without peanut skin prick test (SPT) screening in high-risk infants during an 80-year horizon from a societal perspective. Data were analyzed from April to May 2019.

Exposures High-risk infants with …

Effect Of Yaw Torque On Load Sharing And Dynamics Of Co-Axial Rotors, Dakshi Jindal, Davide A. Peters

Mechanical Engineering and Materials Science Independent Study

The previous load sharing method for a coaxial rotor system with an infinite number of blades is expanded for a system with a finite number of blades. In the previous methods, the load sharing case was developed only for the case where the load was evenly shared between the two rotors. However, an even distribution is not always needed and therefore a load distribution factor, f, was added to the system to accommodate for uneven load distributions. The addition of f allowed for the development of a correlation to adjust the input f to adjust the load sharing in the …

Bradykinesia Is Driven By Cumulative Beta Power During Continuous Movement And Alleviated By Gabaergic Modulation In Parkinson’S Disease., Emma J. Prokic, Gavin L. Woodhall, Adrian C. Williams, Ian M. Stanford, Stephen D. Hall

School of Psychology

No abstract provided.

The Role Of Occupational Therapy For Survivors Of Human Trafficking, Margaux Mariano

Student Capstone Papers

Human trafficking involves sex trafficking, labor trafficking, and trafficking of children. The needs of survivors of human trafficking are widespread due to the traumatic experiences they face. Concerns that may arise include decreased participation in meaningful activities in an individual's life, possibly due to anxiety, depression, suicidal ideation, memory loss, posttraumatic stress disorder, and social isolation. Individuals who have been subjected to human trafficking often experience occupational deprivation and occupational therapy has yet to establish its role in the recovery process for survivors. This capstone project consists of the process towards the development of an occupation-based, trauma-informed, evidence-based, and survivor-centered …