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2019

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Synthesis And Bioevaluation Of Methionine Depletion Agents, Houssine Ikhlef Jan 2019

Synthesis And Bioevaluation Of Methionine Depletion Agents, Houssine Ikhlef

Electronic Theses and Dissertations

The native polyamines (putrescine, spermidine, and spermine) are low molecular weight amines that exist as polycations at physiological pH. These polycations interact with DNA, RNA, and influence many cellular processes. Intracellular polyamine levels are maintained via a balance of polyamine biosynthesis, catabolism, and transport. Ornithine, an amino acid obtained from L-arginine, is decarboxylated by ornithine decarboxylase (ODC) to form putrescine. The biosynthesis of the higher polyamines, spermidine and spermine, requires the addition of an amino-propyl group donated by decarboxylated S-adenosylmethionine (dc-SAM), which itself is derived from the amino acid L-methionine (Met). Tumor cells are heavily reliant on methionine because it …

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Lifetime History Of Concussions And Behavioral Measures Of Anhedonia, John O'Donnell Jan 2019

Lifetime History Of Concussions And Behavioral Measures Of Anhedonia, John O'Donnell

Electronic Theses and Dissertations

Concussions are the most common neuropsychological problem in the United States and are associated with sequelae such as cognitive complaints and depression-related symptoms. Recent research suggests that head trauma is associated with anhedonia and that concussions have the potential to damage axons and postsynaptic connections in neural circuits that play a role in reward processing. Anhedonia may be better understood as an overarching construct with multiple subtypes including motivational, decisional, and consummatory. The current study examines the relationship between lifetime concussion history and subtypes of anhedonia using behavioral measures of reward processing: the Effort Expenditure for Rewards Task (EEfRT), Probabilistic …

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Do Global Cities Make Green Cities? How Global Governance Impacts Transportation In Bogotá And Medellín, Eleanor Jackson Jan 2019

Do Global Cities Make Green Cities? How Global Governance Impacts Transportation In Bogotá And Medellín, Eleanor Jackson

Honors Theses

This thesis examines how global and local governance has combined to deliver effective and sustainable public transportation in cities by comparing Bogotá’s bus rapid transit (BRT) system, TransMilenio, with Medellín’s mass transit system, STIMVA, often referred to as Metro de Medellín. After considering the rationales used to justify local and global authority over climate change, this analysis problematizes the supposed benefits of empowering global and local actors by highlighting the conflicts of interest that plague the elites who mediate the global and the local. In analyzing the global and local interactions, this work draws from extensive literature to highlight three …

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Human Action Recognition In Videos Using Transfer Learning, Kaiqiang Huang, Sarah Jane Delany, Susan Mckeever Jan 2019

Human Action Recognition In Videos Using Transfer Learning, Kaiqiang Huang, Sarah Jane Delany, Susan Mckeever

Session 1: Active Vision, Tracking, Motion Analysis

A variety of systems focus on detecting the actions and activities performed by humans, such as video surveillance and health monitoring systems. However, published labelled human action datasets for training supervised machine learning models are limited in number and expensive to produce. The use of transfer learning for the task of action recognition can help to address this issue by transferring or re-using the knowledge of existing trained models, in combination with minimal training data from the new target domain. Our focus in this paper is an investigation of video feature representations and machine learning algorithms for transfer learning for …

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Exogenous Shocks And Political Unrest, Didara Nurmanova Jan 2019

Exogenous Shocks And Political Unrest, Didara Nurmanova

Electronic Theses and Dissertations

This dissertation explores the role of exogenous shocks such as economic shocks and natural disasters in producing political unrest in the form of anti-government protests and ethnic riots. It is integrated by three articles, each covering a different topic. The first article argues that economic shocks play a crucial role in protest mobilization in rentier states conditional on weaker repressive capacity or higher taxation. Empirically, it conducts a cross-national study of high resource-dependent states in the period of 1995-2014. The second article contends that there is a variation in the degree to which a country's regions are exposed to economic …

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An Investigation Of Science Of Reading And Learning Representation In Undergraduate Elementary Education Reading Courses In The State University System Of Florida, Jessica Camara Jan 2019

An Investigation Of Science Of Reading And Learning Representation In Undergraduate Elementary Education Reading Courses In The State University System Of Florida, Jessica Camara

Electronic Theses and Dissertations

This study investigated the extent to which the science of reading instruction components and five science of learning principles were addressed in undergraduate elementary education required reading courses in the State University System (SUS) of Florida institutions. A document analysis of textbooks and syllabi was completed and evidence recorded in The Matrix for State University System (SUS) of Florida Scoring©. The results were reported in summary tables and an analysis of the data was conducted on the extent to which each science of reading component and science of learning principle were labeled explicitly, indirectly stated, or not present in syllabi …

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National Security And Political Polarization, Joseph Funderburke Jan 2019

National Security And Political Polarization, Joseph Funderburke

Electronic Theses and Dissertations

This dissertation explores how partisan polarization among the political elites (the President and key Members of Congress) impacts national security decision-making. The research examines the relationship over time beginning at the start of the Cold War through 2014. In doing so, the research tests several hypotheses to determine the nature of the relationship and what the implications might be for future U.S. national security policy-making. There are three different approaches used in the research centered on the same theory of partisan polarization. The first approach examines changes in the level of polarization and defense budgets each year. The second explores …

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The Effects Of Presence And Cognitive Load On Episodic Memory In Virtual Environments, Paul Barclay Jan 2019

The Effects Of Presence And Cognitive Load On Episodic Memory In Virtual Environments, Paul Barclay

Electronic Theses and Dissertations

Episodic memory refers to an individual's memory for events that they have experienced in the past along with the associated contextual details. In order to more closely reflect the way that episodic memory functions in the real world, researchers and clinicians test episodic memory using virtual environments. However, these virtual environments introduce new interfaces and task demands that are not present in traditional methodologies. This dissertation investigates these environments through the lenses of Presence and Cognitive Load theories in order to unravel the ways that basic technological and task differences may affect memory performance. Participants completed a virtual task under …

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Hurricane Maria: A Qualitative Study Of Recently Displaced Students To The State Of Florida, Esmeralda Cabrera Jan 2019

Hurricane Maria: A Qualitative Study Of Recently Displaced Students To The State Of Florida, Esmeralda Cabrera

Electronic Theses and Dissertations

Over the past ten years Puerto Rico has been experiencing a severe economic crisis that was worsened when Hurricane Maria made landfall on September 20, 2017. Maria hit Puerto Rico as a category 4 storm, devastating the whole island and its 3.4 million residents. Many students were left with minimal educational choices after Hurricane Maria hit Puerto Rico. Research on Latino/a students shows that they are met with unique experiences and challenges as they pursue higher education. The current study uses qualitative data to investigate what are the unique challenges and needs of displaced students from Puerto Rico? and what …

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Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain Jan 2019

Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain

Electronic Theses and Dissertations

This study aimed to explore factors affecting seniors' intention to relocate to a senior living facility. More specifically, the purpose of this study was to examine the influence of push and pull motivational factors and perceived barriers on seniors' intention to relocate to a senior living facility (SLF). In addition, the mediating role of perceived barriers on the relationships between push motivational factors and intention to relocate and pull motivational factors and intention to relocate were explored. The data of the study was collected from 363 seniors. Structural equation modeling (SEM) analysis was conducted to test the study hypotheses. The …

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Victimization And Health Experiences For Tgnc Individuals In Women's Prisons, Kristina Davis Jan 2019

Victimization And Health Experiences For Tgnc Individuals In Women's Prisons, Kristina Davis

Electronic Theses and Dissertations

This text examines the health-related experiences of transgender and gender nonconforming persons assigned female at birth within the criminal justice system. It moves through a transgender-centric approach to explore the ways gender nonconformity relates to experiences of violence and healthcare disparities for those interacting with law enforcement and incarcerated in women's prisons. The study utilized statistical analyses of nationally representative data in the 2015 U.S. Transgender Survey carried out by the National Center for Transgender Equality. Multivariate analyses suggested significant connections between race and education and experiences of harassment and assault within the criminal justice context. There were largely mixed …

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Preservice Teachers And Perceived Stress: A Comparative Study, Kelsey Evans Jan 2019

Preservice Teachers And Perceived Stress: A Comparative Study, Kelsey Evans

Electronic Theses and Dissertations

Teachers are being pushed to the brink of burnout and leaving the profession, placing teachers' health and wellness in jeopardy (Daniels & Strauss, 2009; Maslach & Leiter, 2008; Stephenson, 2012; Vladut & Kallay, 2010; Wilkerson, 2009). Yet, it has become increasingly clear teacher stress may start prior to entering the profession (Brown & Ryan, 2003, Darling-Hammond, 2006). The researcher used a non-experimental design to evaluate the perceived stress among pre-service teachers enrolled in internship, and if the coping style of mindfulness had any correlation on self-reported stress levels. The quantitative study surveyed 332 student interns using the Perceived Stress Survey …

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Factors Contributing To Victim Employment, Victim Income Status, And Intimate Partner Violence In Jamaica, Marsha Fraser Jan 2019

Factors Contributing To Victim Employment, Victim Income Status, And Intimate Partner Violence In Jamaica, Marsha Fraser

Electronic Theses and Dissertations

Using 166 IPV police reports in Jamaica, this mixed-methods study (a) explored the utility of routine activities theory and control balance theory for explaining the relationship between victim employment and IPV; (b) explored risk factors for IPV; and (c) examined the relationships between victim employment and victim income status with IPV murder and IPV severity in the Jamaica. Content analysis of the narratives of the police reports supported both theories suggesting an integration of the two theories may be most fitting. Estrangement and infidelity emerged as bold themes. Infidelity was identified as an additional risk factor in the Jamaican context. …

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Atp Induced Molecular Disassembly Of Cytolethal Distending Toxin's B/C Heterodimer, George Huhn Jan 2019

Atp Induced Molecular Disassembly Of Cytolethal Distending Toxin's B/C Heterodimer, George Huhn

Electronic Theses and Dissertations

Cytolethal distending toxin (CDT) is a virulence factor produced by many Gram-negative bacteria, including Haemophilus ducreyi. This fastidious pathogen is the causative agent of genital cancroid. CDT is a heterotrimeric toxin with an AB2 structure consisting of a cell-binding "B" domain (CdtA + CdtC) and a catalytic "A" domain (CdtB) that has DNase activity. This toxin assembles in the bacterial periplasm that lacks ATP and is secreted into the extracellular environment. After cell binding, CDT is internalized by endocytosis and travels through the endosomes and Golgi before arriving in the endoplasmic reticulum (ER). CdtA is lost from the holotoxin before …

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Frames And Phase Retrieval, Ted Juste Jan 2019

Frames And Phase Retrieval, Ted Juste

Electronic Theses and Dissertations

Phase retrieval tackles the problem of recovering a signal after loss of phase. The phase problem shows up in many different settings such as X-ray crystallography, speech recognition, quantum information theory, and coherent diffraction imaging. In this dissertation we present some results relating to three topics on phase retrieval. Chapters 1 and 2 contain the relevant background materials. In chapter 3, we introduce the notion of exact phase-retrievable frames as a way of measuring a frame's redundancy with respect to its phase retrieval property. We show that, in the d-dimensional real Hilbert space case, exact phase-retrievable frames can be of …

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It Takes Two To Tango: The Toxin-Chaperone Relationship, Alisha Kellner Jan 2019

It Takes Two To Tango: The Toxin-Chaperone Relationship, Alisha Kellner

Electronic Theses and Dissertations

Cholera toxin (CT) enters the cell via receptor-mediated endocytosis and travels in a retrograde fashion to the endoplasmic reticulum (ER). The catalytic A1 subunit (CTA1) is then displaced from the rest of the holotoxin, unfolds, and is exported to the cytosol where it regains an active conformation for the ADP-ribosylation of its G-protein target. We have shown that the cytosolic chaperones Hsp90 and Hsc70 are required for CTA1 translocation to the cytosol. We have also shown that both are able to independently bind and refold CTA1. Using libraries of CTA1-derived peptides, we have identified a single Hsc70 binding site, YYIYVI …

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Holographic Optical Elements For Visible Light Applications In Photo-Thermo-Refractive Glass, Fedor Kompan Jan 2019

Holographic Optical Elements For Visible Light Applications In Photo-Thermo-Refractive Glass, Fedor Kompan

Electronic Theses and Dissertations

This dissertation reports on design and fabrication of various optical elements in Photo-thermo-refractive (PTR) glass. An ability to produce complex holographic optical elements (HOEs) for the visible spectral region appears very beneficial for variety of applications, however, it is limited due to photosensitivity of the glass confined within the UV region. First two parts of this dissertation present two independent approaches to the problem of holographic recording using visible radiation. The first method involves modification of the original PTR glass rendering it photosensitive to radiation in the visible spectral region and, thus, making possible the recording of holograms in PTR …

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Defining Effective Teacher Practices Among Students With Emotional Behavioral Disabilities, Zerek Mayes Jan 2019

Defining Effective Teacher Practices Among Students With Emotional Behavioral Disabilities, Zerek Mayes

Electronic Theses and Dissertations

This phenomenological study examined the lived experiences of special education teachers who worked with students with emotional behavioral disabilities (EBD) across various urban settings and educative environments. Given that the overall percentage of students receiving special education services has increased, the overall percentage of students with EBD served among all school-aged children and youth has remained below 1% (U.S. Department of Education, National Center for Education Statistics, 2018). The current failings of reform efforts to improve the academic achievement of students with EBD brings the roles, responsibilities and practices of teachers and their preparation into view. This study examined the …

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Protective Behavioral Strategies And Alcohol-Related Sex Among College Students, Roselyn Peterson Jan 2019

Protective Behavioral Strategies And Alcohol-Related Sex Among College Students, Roselyn Peterson

Electronic Theses and Dissertations

Adverse sexual outcomes (e.g., sexual regret, sexual risk, and sexual assault) are a common experience among college students. In particular, regretted sex is reported by a third of college students and may result in psychological harm. Previous literature has found that alcohol is involved in approximately one third of regretted sex experienced by college students. A gap exists in the literature identifying who is more susceptible to experiencing a regretted sexual experience. Previous research has shown that students who implement protective behavioral strategies (PBS) while drinking are able to reduce alcohol-related negative consequences, including regretted sexual experiences. Three sub-types of …

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Biochemical Characterization Of Rv2633c From Mycobacterium Tuberculosis And The Effects Of Mutagenesis On Iron Binding, Kyle Strickland Jan 2019

Biochemical Characterization Of Rv2633c From Mycobacterium Tuberculosis And The Effects Of Mutagenesis On Iron Binding, Kyle Strickland

Electronic Theses and Dissertations

Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium that is the causative agent of the disease Tuberculosis (TB). TB kills an estimated 1.8 million people annually and roughly one third of the world's population carries Mtb in a dormant state. Drug resistant Mtb strains are on the rise, thus a new method of combating this disease is paramount. Mtb survival inside of macrophages requires overcoming various stressors such as; iron restriction, reactive oxygen species, and hypoxic conditions. Mtb employs the use of catalases, nitric oxide reductase, superoxide dismutase, and siderophores to aid in survival. These functions have also been found in …

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Sea Star Wasting Disease In Pisaster Ochraceus On The Washington Coast And In Puget Sound, Caitlin Wilkes Jan 2019

Sea Star Wasting Disease In Pisaster Ochraceus On The Washington Coast And In Puget Sound, Caitlin Wilkes

All Master's Theses

Pisaster ochraceus is a common west coast sea star whose predation of Mytilus californianus (the California mussel) increases the biodiversity of its intertidal community. Sea star wasting disease is an illness that causes sea star tissues to become necrotic until the creature wastes away and dies. In 2013, a coast wide outbreak of sea star wasting disease caused a mass mortality event in P. ochraceus. The goals of this study were to try to identify some of the possible causes for the outbreak, as well as analyze the impact that sea star wasting disease prevalence has on biodiversity. In this …

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Estimating The Economic Value Of Rock Climbing In Smith Rock: An Individual Travel Cost Approach, Cassandra Koefod Jan 2019

Estimating The Economic Value Of Rock Climbing In Smith Rock: An Individual Travel Cost Approach, Cassandra Koefod

All Master's Theses

In this study I estimate the economic value of rock climbing in Smith Rock State Park, Oregon. This area has seen an increase in recreational visits over the years, especially in rock climbing, necessitating economic valuation of the site in order to assist park managers in optimal management of this resource. Given regular conflicts over use of rock climbing areas by a variety of stakeholders (recreational users, habitats, cultural uses, etc.) this study will help in understanding how benefits of recreation is affected when policies limit access to such areas. I collect original survey data on travel to Smith Rock …

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Quantifying Magma Recharge At Parinacota Volcano, Northern Chile (52 Ka - Recent): Insight From The Magma Chamber Simulator, Jennifer Mcleod Jan 2019

Quantifying Magma Recharge At Parinacota Volcano, Northern Chile (52 Ka - Recent): Insight From The Magma Chamber Simulator, Jennifer Mcleod

All Master's Theses

The Magma Chamber Simulator (MCS; Bohrson et al., 2014) was used to produce new thermodynamic models that constrain and quantify recharge and fractional crystallization (RFC) processes for the Old Cone (OC; 52-20 ka; 56-66 wt.% SiO2) and Healing Flows (HF; >8 ka-recent; 58-64 wt.% SiO2) eruptive stages of Parinacota volcano, northern Chile. Using the MCS, over 200 RFC models were produced that constrain host magma initial conditions, including pressure, fO2 and H2O, and host and recharge magma masses, temperatures and compositions. A Rhyolite Domes (RD; 47-40 ka; 74 wt.% SiO2) …

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The United States' Convention Against Torture Ruds: Allowing The Use Of Solitary Confinement In Lieu Of Mental Health Treatment In U.S. Immigration Detention Centers, Erika Voreh Jan 2019

The United States' Convention Against Torture Ruds: Allowing The Use Of Solitary Confinement In Lieu Of Mental Health Treatment In U.S. Immigration Detention Centers, Erika Voreh

Emory International Law Review

Currently in civil immigration detention centers around the United States, the practice of placing detained immigrants who are mentally ill is allowed by U.S. Immigration and Customs Enforcement. In some detention centers, placement into solitary confinement is now the main form of psychological ¿treatment.¿ Solitary confinement can have negative psychological effects especially for individuals with mental illness. Other international bodies, including the European Court of Human Rights, have acknowledged the harmful effects of solitary confinement. This Comment focuses on decisions by the European Court of Human Rights as to what constitutes torture. This Comment argues that placing detained immigrants who …

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Survey Report Kosovo, Romario Shehu Jan 2019

Survey Report Kosovo, Romario Shehu

Occasional Papers on Religion in Eastern Europe

During April and May 2019, approximately 120 surveys were distributed to high-level individuals involved in political, economic and cultural spheres in Kosovo.

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Internal Funding Newsletter, Academic Year 2018-2019, Uno Office Of Research And Creative Activity, University Of Nebraska At Omaha Jan 2019

Internal Funding Newsletter, Academic Year 2018-2019, Uno Office Of Research And Creative Activity, University Of Nebraska At Omaha

Internal Funding Newsletters

The University of Nebraska at Omaha is committed to fostering the academic and scholarly pursuits of faculty, staff, and students. In the 2018- 2019 Academic Year, UNO has continued to invest in a multitude of funding programs to promote research and creative activity. This year’s programs provided over $580,000 for a broad range of projects that reflect the varied scholarly interests of the UNO community: genetic changes in Great Plains bees as a result of fire frequency, the economic impact of free higher education, a virtual reality media arts gallery, investigating different factors which affect how squirrels run and jump, …

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Delayed Diagnosis Of Annular Pancreas In 11 Year Old Girl With Digeorge Syndrome, Mary Margaret Barr, James Gilbert, Zaria Murrell Jan 2019

Delayed Diagnosis Of Annular Pancreas In 11 Year Old Girl With Digeorge Syndrome, Mary Margaret Barr, James Gilbert, Zaria Murrell

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Acquired Hemophilia A Due To Alemtuzumab Therapy For Multiple Sclerosis, Jesse Faulk, Dennis Sehgal, Jorge Diaz, Panchavati Pavan Jan 2019

Acquired Hemophilia A Due To Alemtuzumab Therapy For Multiple Sclerosis, Jesse Faulk, Dennis Sehgal, Jorge Diaz, Panchavati Pavan

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Suffocating Sub-Mental Hematoma- A Rare Allergic Reaction To A Drug, Sanjay Muttineni, Elizabeth Thottacherry, Timothy Littmann, Nessy Abraham Jan 2019

Suffocating Sub-Mental Hematoma- A Rare Allergic Reaction To A Drug, Sanjay Muttineni, Elizabeth Thottacherry, Timothy Littmann, Nessy Abraham

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Technology For Integrated Groyne-Vetiver Erosion Reduction (Tiger): Case Study In A West African River, Chase M. West Jan 2019

Technology For Integrated Groyne-Vetiver Erosion Reduction (Tiger): Case Study In A West African River, Chase M. West

Dissertations, Master's Theses and Master's Reports

River erosion is a problem all over the world. The effects of river erosion are especially hard for farmers in developing countries, where the river is an important part of their farming practices and daily lives. A case study was done in the small village of Fode Binea in Senegal, West Africa to reduce this stream erosion. A new hybrid approach, Technology for Integrated Groyne-Vetiver Erosion Reduction (TIGER) method, was developed. The method includes combining groynes at the toe of the riverbank to reduce toe erosion in the channel and planting a buffer strip with vetiver grass to reduce erosion …

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