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2019

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Synthesis And Development Of Nanocomposites Of Magnetic Nanoparticles-Silica-Mannan As Vaccine Adjuvants, Kamonlatth Rodponthukwaji Jan 2019

Synthesis And Development Of Nanocomposites Of Magnetic Nanoparticles-Silica-Mannan As Vaccine Adjuvants, Kamonlatth Rodponthukwaji

Chulalongkorn University Theses and Dissertations (Chula ETD)

Over the past years, vaccination has been considered as an effective treatment against a wide range of pathogens and diseases. Despite a promising outcome, the lack of strong immune response of some types of vaccines is still challenging. Therefore, targeting and activating dendritic cells (DCs) using nanomaterial-based vaccine adjuvant is of our interest. Herein, superparamagnetic iron oxide nanoparticles (SPIONs) have been exploited as directing agents to the targeted dendritic cells (DCs). In addition, mannan extracted from Saccharomyces cerevisiae was used as targeting molecules for targeting DCs. Nanocomposites of silica-magnetic nanoparticles-mannan (S-SPION-MN) were successfully fabricated. The synthesized particles were morphologically and …

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Chemical Synthesis Of Galacto-Oligosaccharides And Evaluation Of Their Prebiotic Properties, Pranpariya Ponpakdee Jan 2019

Chemical Synthesis Of Galacto-Oligosaccharides And Evaluation Of Their Prebiotic Properties, Pranpariya Ponpakdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Galacto-oligosaccharides (GOS) are composed of galactose and glucose between 2–8 units or disaccharide comprising 2 units of galactose linked by glycosidic bonds. GOS exhibits prebiotic activity and widely used in infant formula. Commercial GOS was achieved as mixture by enzymatic synthesis of lactose with β-galactosidase. Due to the nature of the enzymatic derived-GOS, the structure-activity relationship of GOS and prebiotic activity is mainly ambiguous. In this work, we presented the development towards a production of GOS by chemical synthesis starting from lactose. First, lactose was isolated from liquid whey with 3.90% w/v recovery. Lactose was then hydrolyzed to produce galactose …

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Monitoring Collagenolysis Utilizing Triple Helical Peptide Probes, Michal Tokmina-Roszyk Jan 2019

Monitoring Collagenolysis Utilizing Triple Helical Peptide Probes, Michal Tokmina-Roszyk

Electronic Theses and Dissertations 2010 - 2019

Collagen is the major structural scaffold in the body and serves as barrier between tissues, and thus its turnover is tightly regulated. Collagen triple-helical structure renders it resistant to general proteolysis. Several proteases are capable of cleaving the triplehelical regions of collagen, including several mammalian matrix metalloproteinases (MMPs) and bacterial collagenases. MMP-mediated collagenolysis is associated with numerous diseases and some bacterial collagenases have found clinical application use due to their efficiency in the hydrolysis of the collagen triple-helix. A selective Förster resonance energy transfer triple-helical peptide (fTHP) probe for monitoring the activity of Clostridial collagenase has been developed. The fTHP …

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