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2019

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From Treading Water To Swimming Uphill: A Comprehensive And Innovative Assessment Program For Teaching Swimming In Belgian Primary Schools., Filip Roelandt Aug 2019

From Treading Water To Swimming Uphill: A Comprehensive And Innovative Assessment Program For Teaching Swimming In Belgian Primary Schools., Filip Roelandt

International Journal of Aquatic Research and Education

According to the World Health Organization (WHO), every child should learn to swim as a recognised life skill. Which swimming skill or stroke to learn first is not the most important question. What is important is to teach children to learn tasks or techniques which allow them to they feel safe. Emphasizing foundational principles of motor development and focusing on safety in and around the water are paramount. Beginning in 2016 school swimming lessons in Flanders (Belgium) were given a new focus in all educational institutions. Foundational competence tasks replaced the focus on acquiring competitive swimming strokes as the primary …

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Eng 1001g-250: College Composition I Dual Credit, Laura Wagner Aug 2019

Eng 1001g-250: College Composition I Dual Credit, Laura Wagner

Fall 2019

No abstract provided.

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Eng 3405-001: Children's Literature, Charlotte England Aug 2019

Eng 3405-001: Children's Literature, Charlotte England

Fall 2019

No abstract provided.

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Eng 5061a-600: Topics In Literature And Literary Theory, Robin Murray Aug 2019

Eng 5061a-600: Topics In Literature And Literary Theory, Robin Murray

Fall 2019

No abstract provided.

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Eng 5061a-001: Topics In Literature And Literary Theory, Robin Murray Aug 2019

Eng 5061a-001: Topics In Literature And Literary Theory, Robin Murray

Fall 2019

No abstract provided.

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The Indiana Statesman, Move In Guide 2019, Indiana State University Aug 2019

The Indiana Statesman, Move In Guide 2019, Indiana State University

Student Newspaper

Move In Guide 2019

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Delaware Riverkeeper Network V. Sec Pa Dept Env Protection Aug 2019

Delaware Riverkeeper Network V. Sec Pa Dept Env Protection

2019 Decisions

Agency

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Response Of Human Small Intestinal Epithelium To Fractionated Irradiation: Dynamical Modeling Approach, Francis A. Cucinotta, Olga A. Smirnova Aug 2019

Response Of Human Small Intestinal Epithelium To Fractionated Irradiation: Dynamical Modeling Approach, Francis A. Cucinotta, Olga A. Smirnova

Health Physics and Diagnostic Sciences Faculty Research

A biologically motivated mathematical model of the dynamics of the small intestinal epithelium in humans treated with fractionated radiotherapy has been developed and is further investigated here. This model, originating from our previous work, is implemented as a system of nonlinear ordinary differential equations, in which the variables and parameters have a clear biological meaning. The model also includes, as input, the key parameters of fractionated irradiation. The modeling results on the dynamical response of the human normal small intestinal epithelium to fractionated radiation therapy regimens were in agreement with the corresponding empirical data, which, in turn, demonstrates the capability …

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Meta-Analysis Of Cognitive Performance By Novel Object Recognition After Proton And Heavy Ion Exposures, Eliedonna Cacao, Francis A. Cucinotta Aug 2019

Meta-Analysis Of Cognitive Performance By Novel Object Recognition After Proton And Heavy Ion Exposures, Eliedonna Cacao, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton and carbon beams in Hadron therapy. However, distinct radiation types and doses, cognitive tests and rodent models have been used by different laboratories, while few studies have considered detailed dose-response characterizations, including estimates of relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis of the dose response for proton and heavy ion rodent studies of …

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Advances In Gene Ontology Utilization Improve Statistical Power Of Annotation Enrichment, Eugene Waverly Hinderer Iii, Robert M. Flight, Rashmi Dubey, James N. Macleod, Hunter N. B. Moseley Aug 2019

Advances In Gene Ontology Utilization Improve Statistical Power Of Annotation Enrichment, Eugene Waverly Hinderer Iii, Robert M. Flight, Rashmi Dubey, James N. Macleod, Hunter N. B. Moseley

Maxwell H. Gluck Equine Research Center Faculty Publications

Gene-annotation enrichment is a common method for utilizing ontology-based annotations in gene and gene-product centric knowledgebases. Effective utilization of these annotations requires inferring semantic linkages by tracing paths through edges in the ontological graph, referred to as relations. However, some relations are semantically problematic with respect to scope, necessitating their omission or modification lest erroneous term mappings occur. To address these issues, we created the Gene Ontology Categorization Suite, or GOcats—a novel tool that organizes the Gene Ontology into subgraphs representing user-defined concepts, while ensuring that all appropriate relations are congruent with respect to scoping semantics. Here, we demonstrate the …

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Equine Or Porcine Synovial Fluid As A Novel Ex Vivo Model For The Study Of Bacterial Free-Floating Biofilms That Form In Human Joint Infections, Jessica M. Gilbertie, Lauren V. Schnabel, Noreen J. Hickok, Megan E. Jacob, Brian P. Conlon, Irving Shapiro, Javad Parvizi, Thomas P. Schaer Aug 2019

Equine Or Porcine Synovial Fluid As A Novel Ex Vivo Model For The Study Of Bacterial Free-Floating Biofilms That Form In Human Joint Infections, Jessica M. Gilbertie, Lauren V. Schnabel, Noreen J. Hickok, Megan E. Jacob, Brian P. Conlon, Irving Shapiro, Javad Parvizi, Thomas P. Schaer

Department of Orthopaedic Surgery Faculty Papers

Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice. Biofilms, in the form of free-floating clumps or aggregates, are involved with the pathogenesis of infectious arthritis and periprosthetic joint infection (PJI). Infection of a joint containing an orthopedic implant can additionally complicate these infections due to the presence of adherent biofilms. Because of these biofilm phenotypes, bacteria within these infected joints show increased antimicrobial tolerance even at high antibiotic concentrations. To date, animal models of PJI or infectious arthritis have been limited to small animals such …

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Early Species Developed Much Faster Than Previously Thought, Ohio University Research Shows (August 15, 2019), University Communications And Marketing Aug 2019

Early Species Developed Much Faster Than Previously Thought, Ohio University Research Shows (August 15, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

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Ohio Research Team Explores The Science Of Longevity And Wellness (August 15, 2019), University Communications And Marketing Aug 2019

Ohio Research Team Explores The Science Of Longevity And Wellness (August 15, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

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Local Social Inequality, Economic Inequality, And Disparities In Child Height In India, Diane Coffey, Ashwini Deshpande, Jeffrey Hammer, Dean Spears Aug 2019

Local Social Inequality, Economic Inequality, And Disparities In Child Height In India, Diane Coffey, Ashwini Deshpande, Jeffrey Hammer, Dean Spears

Journal Articles

This study investigates disparities in child height—an important marker of population-level health—among population groups in rural India. India is an informative context in which to study processes of health disparities because of wide heterogeneity in the degree of local segregation or integration among caste groups. Building on a literature that identifies discrimination by quantifying whether differences in socioeconomic status (SES) can account for differences in health, we decompose height differences between rural children from higher castes and rural children from three disadvantaged groups. We find that socioeconomic differences can explain the height gap for children from Scheduled Tribes (STs), who …

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From Single Cells To Human Disease: High-Resolution Phenotyping Of Male Infertility Models Using Single-Cell Rna Sequencing, Min Jung Aug 2019

From Single Cells To Human Disease: High-Resolution Phenotyping Of Male Infertility Models Using Single-Cell Rna Sequencing, Min Jung

Arts & Sciences Graduate Student Theses and Dissertations

Male infertility is a complex disease that can result in significant emotional distress and treatment costs. Globally, male infertility affects 7% of males, and while its incidence is rising, its etiology remains elusive. In order to improve patient care, it is critical to identify the nature of spermatogenic failure in as many men as possible. The extensive cellular heterogeneity of testis has limited the application of bulk expression measurements to capture crucial information to dissect molecular mechanisms of defects in the infertile patients. Thus, the application of single-cell RNA-sequencing on male germ cells provides an amazing new set of scientific …

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Mesothelium-Derived Factors Shape Tissue Resident Macrophage, Chin-Wen Lai Aug 2019

Mesothelium-Derived Factors Shape Tissue Resident Macrophage, Chin-Wen Lai

Arts & Sciences Graduate Student Theses and Dissertations

The studies outlined in this thesis provide several new insights into Msln-related pathways necessary for peritoneal immune responses and mucosal repair. We found that Msln and its binding partner mucin 16 from mesothelium influenced peritoneal and pleural macrophage differentiation. We found that Msln was required for proper tissue repair after colonic biopsy injury and was required for maximal polyp growth in APCMin/+ mice. Overall, this work describes mesothelial and epithelial-derived factors that are important for tissue resident macrophage differentiation and wound repair after colonic mucosal injury. Understanding the complex interactions between stromal cells and immune cells will lead to better …

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Expression And Function Of Snornas In Acute Myeloid Leukemia, Wayne Alsworth Warner Aug 2019

Expression And Function Of Snornas In Acute Myeloid Leukemia, Wayne Alsworth Warner

Arts & Sciences Graduate Student Theses and Dissertations

Small nucleolar RNAs (snoRNAs) are non-coding RNAs that contribute to ribosome biogenesis and RNA splicing by modifying ribosomal RNA and spliceosome RNAs, respectively. These modifications are critical for a variety of cellular processes, including ribosomal biogenesis and splicing of RNAs. Recent studies have suggested an expanded role for snoRNAs beyond ribosomal biogenesis and splicing, including, regulation of chromatin structure, metabolism, and neoplastic transformation. The contribution of snoRNAs to the regulation of normal and malignant hematopoiesis is largely unknown. The lack of a method to accurately and comprehensively assess snoRNA expression has limited research in this area. In particular, array-based methods …

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Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott Aug 2019

Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott

Arts & Sciences Graduate Student Theses and Dissertations

This work is focused on iron trafficking through ABC transporters in Staphylococcus aureus and combatting the growing antimicrobial resistance crisis by exploiting virulence factors as therapeutic targets. Specifically, the goal was to understand the role of a siderophore-binding lipoprotein FhuD2 in S. aureus iron trafficking. While S. aureus endogenously produces three metallophores for metal sequestration from the host, FhuD2 is thought to scavenge metals from hydroxamate-based xenosiderophores encountered in the host environment. FhuD2 is a critical virulence factor and vaccine candidate (Novartis) for MRSA. Since xenosiderophore scavenging systems are often dispensable, it was hypothesized that FhuD2 must be playing another …

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Can Swimming Depth Data From Multiple Pacific Herring Individuals Be Used To Estimate Characteristics Of Their School? Verification By Micro Bio-Loggers, Makoto Tomiyasu, Yuki Iino, Hokuto Shirakawa, Kazushi Miyashita Aug 2019

Can Swimming Depth Data From Multiple Pacific Herring Individuals Be Used To Estimate Characteristics Of Their School? Verification By Micro Bio-Loggers, Makoto Tomiyasu, Yuki Iino, Hokuto Shirakawa, Kazushi Miyashita

Journal of Marine Science and Technology–Taiwan

Bio-logging and bio-telemetry are effective methods for monitoring the activity of aquatic animals. Tagging technology has recently advanced, and it is now possible to use tracking devices on small fish and multiple individuals. For species that live in schools such as small pelagic fish, analyzing the activity of multiple individuals may help to further our understanding of school activity in nature. In this study, we tracked the swimming depth of multiple individuals of schooling Pacific herring and examined whether the school’s characteristics and activity can be estimated from the individuals’ swimming depth in the laboratory and a set net experiment. …

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Scholarly Communication Brown Bag Lunch Session: Disney & Copyright, Kryslynn E. Collazo Aug 2019

Scholarly Communication Brown Bag Lunch Session: Disney & Copyright, Kryslynn E. Collazo

Scholarly Communication Brown Bag Series

No abstract provided.

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Novel Self-Assembly Of Fullerene-Based Dyads, Ashley D. Anderson Aug 2019

Novel Self-Assembly Of Fullerene-Based Dyads, Ashley D. Anderson

Theses and Dissertations

Eventual depletion and environmental toxicity of natural non-renewable energy resources are two issues pushing research toward alternative energy resources. Nature’s process of renewable, unlimited, clean energy production is photosynthesis and porphyrins are a critical component due to their ability to undergo photoinduced electron transfer. This property also makes porphyrins excellent candidates for applications such as solar cells, water splitting, and optical sensing. Researchers have previously tethered porphyrins to fullerene (C60), an excellent electron acceptor, to mimic the reaction centers in photosynthesis. Photoinduced electron transfer in these donor-acceptor dyads has been investigated with particular focus on factors such as the donor, …

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Development And Application Of New Methods For Magnetic Resonance Elastography Of The Brain, Charlotte Anne Guertler Aug 2019

Development And Application Of New Methods For Magnetic Resonance Elastography Of The Brain, Charlotte Anne Guertler

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate mechanical properties of the intact, living brain are essential for modeling traumatic brain injury (TBI). However, the properties of brain tissue in vivo have traditionally been measured in ex vivo samples. Magnetic resonance elastography (MRE) can be used to measure motion and estimate material properties of soft tissues in vivo, but MRE typically assumes tissue isotropy and homogeneity. The objective of this thesis is to improve MRE of soft tissue, like the brain, by developing and evaluating methods for in vivo estimation of heterogeneous, anisotropic properties. This was achieved through pursuit of the following aims: (1) quantifying the differences …

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Metabolic Engineering Of Cyanobacteria For Production Of Chemicals, Po-Cheng Lin Aug 2019

Metabolic Engineering Of Cyanobacteria For Production Of Chemicals, Po-Cheng Lin

McKelvey School of Engineering Graduate Student Theses & Dissertations

Concerns over the impact of climate change caused by CO2 emission have driven the research and development of renewable energies. Microbial production of chemicals is being viewed as a feasible approach to reduce the use of fossil fuels and minimize the impact of climate change. With recent advances in synthetic biology, microorganisms can be engineered to synthesize petroleum-based chemicals and plant-derived compounds. Cyanobacteria are photosynthetic prokaryotes that use only sunlight, CO2, and trace minerals for growth. Compared to other microbial hosts, cyanobacteria are attractive platforms for sustainable bioproduction, because they can directly convert CO2 into products. However, the major challenge …

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Joint Reconstruction For Single-Shot Edge Illumination Phase-Contrast Tomography (Eixpct), Yujia Chen Aug 2019

Joint Reconstruction For Single-Shot Edge Illumination Phase-Contrast Tomography (Eixpct), Yujia Chen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Edge illumination X-ray phase-contrast tomography (EIXPCT) is an emerging X-ray phasecontrast tomography technique for estimating the complex-valued X-ray refractive index distribution of an object with laboratory-based X-ray sources. Conventional image reconstruction approaches for EIXPCT require multiple images to be acquired at each tomographic view angle. This contributes to prolonged data-acquisition times and elevated radiation doses, which can hinder in vivo applications. In this dissertation, a new “single-shot” method without restrictive assumptions related to the object, imaging geometry or hardware is proposed for joint reconstruction (JR) of the real and imaginary-valued components of the refractive index distribution from a tomographic data …

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Metabolic Engineering Of Cyanobacteria For Production Of Chemicals, Po-Cheng Lin Aug 2019

Metabolic Engineering Of Cyanobacteria For Production Of Chemicals, Po-Cheng Lin

McKelvey School of Engineering Graduate Student Theses & Dissertations

Concerns over the impact of climate change caused by CO2 emission have driven the research and development of renewable energies. Microbial production of chemicals is being viewed as a feasible approach to reduce the use of fossil fuels and minimize the impact of climate change. With recent advances in synthetic biology, microorganisms can be engineered to synthesize petroleum-based chemicals and plant-derived compounds. Cyanobacteria are photosynthetic prokaryotes that use only sunlight, CO2, and trace minerals for growth. Compared to other microbial hosts, cyanobacteria are attractive platforms for sustainable bioproduction, because they can directly convert CO2 into products. However, the major challenge …

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On The Fabrication And Development Of Tissue On A Chip Devices With Included Perfused Vasculatures, Usama Ismail Aug 2019

On The Fabrication And Development Of Tissue On A Chip Devices With Included Perfused Vasculatures, Usama Ismail

McKelvey School of Engineering Graduate Student Theses & Dissertations

The advent of Tissue-on-a-Chip (TiOC) devices has provided a novel way for researchers to approach biological study and drug development. As a platform that enables human in vivo conditions to be accurately replicated ex vivo, TiOC can accelerate both fundamental biological research to answer basic questions regarding tissue behavior and function (e.g., cell-cell interactions in the tumor microenvironment (TME)) and translational research that includes testing of standard and novel therapeutics. The reported work focuses on development of processes and technologies common to two classes of TiOC. The first device is a single-layer, multi-compartment microfluidic device for investigation of pancreatic …

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Individual Differences In Human Brain Functional Network Organization, Benjamin A. Seitzman Aug 2019

Individual Differences In Human Brain Functional Network Organization, Benjamin A. Seitzman

Arts & Sciences Graduate Student Theses and Dissertations

The human brain is organized at many spatial scales, including the level of areas and systems. Resting-state functional magnetic resonance imaging is a non-invasive technique that allows for the study of areal- and systems-level brain organization in vivo. Over two decades of research has sought to identify and characterize the functional communities that comprise the brain’s network architecture. Consequently, a convergent description of group-average functional network organization in healthy adults has emerged. Recent advances have allowed for the study of such organization in single individuals. Investigation of functional network organization in highly sampled individuals has revealed brain regions that deviate …

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Affective Materiality: Latin American Science Fiction At The Turn Of The Twenty-First Century, Kyeongeun Park Aug 2019

Affective Materiality: Latin American Science Fiction At The Turn Of The Twenty-First Century, Kyeongeun Park

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores diverse shapes of the future as represented in literary production at the turn of the century—from the late 1980s to the present day—through examining the science fiction (sf) of Argentina, Chile, and Mexico. I focus primarily on materiality as an actor and on the agency of things in dialogue with human society through an investigation of the material and cultural productions of sf texts by further scrutinizing the impact of new networking technology. While analyzing the absence and presence of material culture and technological ecology in the selected texts, I work to identify the unique shades and …

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Determining The Genetic Contributions Of The Williams Syndrome Critical Region To Behavior Using Mouse Models And Human Genetics, Nathan David Kopp Aug 2019

Determining The Genetic Contributions Of The Williams Syndrome Critical Region To Behavior Using Mouse Models And Human Genetics, Nathan David Kopp

Arts & Sciences Graduate Student Theses and Dissertations

Williams syndrome is a neurodevelopmental model caused by the deletion of 26-28 genes on chr7q11.23. The loss of these genes affects multiple organ systems resulting in severe cardiovascular disease, craniofacial dysmorphology, intellectual impairment, a specific Williams syndrome cognitive profile made up of deficits in visual-spatial processing with preserved language skills, and a characteristic hypersocial personality. The reciprocal duplication occurs at a lower frequency and manifests with diametric phenotypes to the deletion. This suggests that this locus harbors dosage sensitive genes that play a role in neurodevelopment. Large efforts have been taken to identify which genes are responsible for causing the …

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Aging Of The Reproductive System And Of Germline Stem Cells In Caenorhabditis, Zuzana Kocsisova Aug 2019

Aging Of The Reproductive System And Of Germline Stem Cells In Caenorhabditis, Zuzana Kocsisova

Arts & Sciences Graduate Student Theses and Dissertations

C. elegans hermaphrodites display dramatic age-related decline of reproduction early in life while somatic functions are still robust. To understand why the germline fails so early, we analyzed the assembly line of oocyte production that generates fertilized eggs in mated hermaphrodites with sufficient sperm. Aging germlines displayed both sporadic and population-wide changes. A small fraction of aging animals displayed endomitotic oocytes in the germline and other defects. By contrast, all animals displayed age-related decreases in germline size and function. As early as day 3 of adulthood, animals displayed fewer stem cells and a slower cell cycle, which combine to substantially …

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