Digital Commons Network^™

Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered To Blockade Prostate Cancer Senescence, Prashanth K.B. Nagesh, Pallabita Chowdhury, Elham Hatami, Sonam Kumari, Vivek K. Kashyap, Manish Tripathi, Santosh Wagh, Bernd Meibohm, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

School of Medicine Publications

Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes cancer relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, is known to induce cellular senescence which often limits the overall survival of patients. Strategic therapies that counter the cellular and drug-induced senescence are an unmet clinical need. Towards this an effort was made to develop a novel therapeutic strategy that targets and removes senescent cells from the tumors, we developed a nanoformulation of tannic acid−docetaxel self-assemblies (DSAs). The construction of DSAs was confirmed through particle size …

Development Of A Tunable Platform For The Study Of Geomacromolecular Matrices Using Controlled Radical Polymerization, Arjun Pandey

LSU Doctoral Dissertations

Soil is an important environmental component, and the study of soil processes have many practical implications such as improvement in agriculture, mitigation of climate change etc. The widespread use of Agricultural Chemicals (ACs) in modern agriculture has resulted in adverse effects in environment and human health mostly through contamination into food and water sources. Study of fate, bioavailability, and transport of ACs involves molecular level understanding of their interactions with soil. This can be challenging due to complex and heterogeneous nature of soil. One common approach used is the correlation of macroscopic properties of soil, (e.g. sorption) with empirical parameters …

Training And Certification, None None

JADARA

None

Visualization And Quantitation Of Radioiodine Distribution In Silver Zeolite Cartridges, Daniel Dimarco

LSU Master's Theses

Iodine 131 is a major fission product released during a nuclear incident. This isotope provides a serious health hazard for humans and the environment, therefore nuclear power plants must monitor releases using air sampling. The air sampling is accomplished using air filter cartridges using silver zeolite as a filter media. During an emergency situation, silver zeolite is useful for its affinity to I-131 without adsorbing other radioactive gases. After leaving the plume, these cartridges are counted in a low background area. This measurement does not take into account the distribution of radioiodine in the cartridge. This study explores two methods …

Hemp As A Livestock Feedstuff: A Review Of Current Literature, Sarah Mead, Alyx Shultz

Posters-at-the-Capitol

Hemp was removed from the list of controlled substances in the 2018 Farm Bill, making regulated hemp production legal in the United States. Kentucky agriculturalists and entrepreneurs are at the cutting edge of the United States hemp production and processing industries. Hemp production generally falls into one of three categories: grain, fiber, or floral (CBD extraction). Each production category also produces byproducts; one such byproduct is meal. In order to make hemp oil and fiber processing viable, markets for the remaining meal must be found. The high fiber, fat, and protein of hemp meal make it a potential feedstuff for …

Cannibidiol (Cbd) Supplementation In Horses: A Pilot Study, Kiara Jones, Evan Thomas, Shea Porr

Posters-at-the-Capitol

Cannibidiol (CBD) is sold for various uses in humans and animals. Thus far, CBD has not demonstrated effects similar to delta-9 tetrahydrocannabinol (THC), the psychoactive component of marijuana. While some animal species have demonstrated responses to CBD supplementation, published literature on equines is absent. The lack of FDA approval and studies to support claimed benefits make regulating product quality and recommending dosages difficult. The objectives of this project were to: 1) determine dosages that allowed for CBD detection in equine blood; and 2) evaluate time required for the appearance of maximum concentration and half-life of CBD in equine blood. Two …

Warning Mobile Device Camera Users Of Potential Dangers, N/A

Defensive Publications Series

This publication describes methods of warning a user of a mobile device camera application of potentially dangerous locations and situations. In aspects, a danger warning manager on the mobile device acquires context signals (e.g., captured images, global navigation satellite system location information, social media history for a location) and analyzes these context signals to determine a level of risk. Upon determining that the user is potentially in danger, the danger warning manager causes the mobile device to present warning notifications to the user.

Greed, A Forgotten Vice?, Kwok Tung Cheung

Journal of Religion and Business Ethics

There is a surprising lack of discussion on greed in business ethics. Whether in popular textbooks or in the literature, there is hardly any philosophical explication of greed. In this paper, I investigate the popular idea that greedy people desire more and more, the Christian idea of avarice as in the seven deadly sins, and Aristotle’s idea of pleonexia which has incorporated a condition of justice. These three different ideas are respectively psychological, metaphysical and socio-political. I propose the three of them should be integrated to give a concept of greed that is relevant and useful in the contemporary world …

The Indiana Statesman, October 22, 2019, Indiana State University

Student Newspaper

From the Earth to the moon: A celebration of the 50th anniversary of the moon landing; S’more about NRHH; Open education resources are now available

Invertebrate Retinal Progenitors As Regenerative Models In A Microfluidic System, Caroline D. Pena, Stephanie Zhang, Robert Majeska, Tadmiri Venkatesh, Maribel Vazquez

Publications and Research

Regenerative retinal therapies have introduced progenitor cells to replace dysfunctional or injured neurons and regain visual function. While contemporary cell replacement therapies have delivered retinal progenitor cells (RPCs) within customized biomaterials to promote viability and enable transplantation, outcomes have been severely limited by the misdirected and/or insuffcient migration of transplanted cells. RPCs must achieve appropriate spatial and functional positioning in host retina, collectively, to restore vision, whereas movement of clustered cells differs substantially from the single cell migration studied in classical chemotaxis models. Defining how RPCs interact with each other, neighboring cell types and surrounding extracellular matrixes are critical to …

Enhancing Our Students' Critical Thinking Skills: What The Research Shows And How To Apply It To Our Classrooms, Josh Eyler

About ThinkForward

This content was originally a presentation on Prezi.com that can no longer be downloaded.

The Turkey Blessing, Linda W. Curtis

Erma Bombeck Writers' Workshop Blog

Few people knew our pastor was a Harley rider at first. He only rode early in the morning on Saturdays when school buses were parked and the school children and teacher reveled in a late-morning sleep.

“Donning The Skins”: The Problem Of Shapeshifting In The Saga Of The Volsungs, David Mudrak

Seton Hall University Dissertations and Theses (ETDs)

“Fafnir became so ill-natured that he set out for the wilds and allowed no one to enjoy the treasure but himself. He has since become the most evil serpent and lies now upon his hoard” (Byock 59). Regin, recounting the tale of his brother’s transformation to Sigurd, describes an act of shapeshifting, a magical transformation of one’s body. While many scholars of Icelandic sagas focus their attention on the family sagas because of the clear message they provide for the Icelandic society, the magical elements of the mythical sagas also offer insight into the cultural workings of that people. In …

The Current Volume 30 : Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

2019 October 22 - Student Government Association Minutes, Student Government Association, East Tennessee State University

Student Government Association Agendas and Minutes

No abstract provided.

Summer 2019: Conservation Champion Hangs Up Ranger Uniform After 35 Years, St. Norbert College

St. Norbert College Magazine 2019-2023

Throughout his long career at the Bay Beach Wildlife Sanctuary, Mike Reed ’75 worked to provide the community with the right educational tools for conservation.

Metabolic Modeling Elucidates The Transactions In The Rumen Microbiome And The Shifts Upon Virome Interactions, Mohammad Mazharul Islam, Samodha C. Fernando, Rajib Saha

Department of Chemical and Biomolecular Engineering: Faculty Publications

The complex microbial ecosystem within the bovine rumen plays a crucial role in host nutrition, health, and environmental impact. However, little is known about the interactions between the functional entities within the system, which dictates the community structure and functional dynamics and host physiology. With the advancements in high-throughput sequencing and mathematical modeling, in silico genome-scale metabolic analysis promises to expand our understanding of the metabolic interplay in the community. In an attempt to understand the interactions between microbial species and the phages inside rumen, a genome-scale metabolic modeling approach was utilized by using key members in the rumen microbiome …

Testing Protocols For Surveying Captive Limulus Polyphemus Microbiomes, Fabian Leija, Sean A. Neiswenter Dr.

LSAMP Poster Presentations

Limulus polyphemus, the Atlantic horseshoe crab, is a marine arthropod that primarily resides in the shallow intertidal zone of brackish water, water where high salinity seawater meets fresh water. The ecological niche that horseshoe crabs reside in makes them an ideal animal to be placed in an aquarium touch-tank, only needing a shallow pool of water to live comfortably as well as having a tough chitin carapace that won’t be easily damaged by visitors touching them. However, the implications of these human-animal interactions are severely unexplored with limited research being conducted regarding touch-tanks. In contrast, the consequences and hygienic practices …

Targeting Tauopathy With Engineered Tau-Degrading Intrabodies, Gilbert Gallardo, Connie H Wong, Sara M Ricardez, Carolyn N Mann, Kent H Lin, Cheryl E G Leyns, Hong Jiang, David M Holtzman

Open Access Publications

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tauopathy in animal models. We previously found that passive immunotherapy with anti-tau antibody to human tau or expression of an anti-tau secreted single-chain variable fragment (scFv) in the central nervous system of a mouse model of tauopathy decreased but did not remove all tau-associated pathology. Although these and other studies demonstrate that conventional immunotherapeutic approaches targeting tau can influence tau pathogenesis, the …

Omani School Students’ Attitudes Toward Agriculture: Investigating The Role Of Gender And Geographical Regions, Abdullah Ambusaidi, Mohammed Al-Saidi

Journal of Educational and Psychological Studies

A 24-item questionnaire was designed to collect specific data in order to determine Omani students’ attitudes toward agriculture and, specifically, whether or not these attitudes differ according to gender and the geographical regions where students reside. A survey research method based on the use of a questionnaire was employed. The questionnaire items were divided into four domains: participants’ general knowledge about agriculture, their personal interest about agriculture, the role of government in supporting agriculture, and the role of agriculture in food security. The questionnaire was administered to 394 randomly selected Grade 10 students. Participants consisted of 189 male students and …

An Augmented Reality Based Human-Robot Interaction Interface Using Kalman Filter Sensor Fusion, Chunxu Li, Ashraf Fahmy, Johann Sienz

School of Engineering, Computing and Mathematics

In this paper, the application of Augmented Reality (AR) for the control and adjustment of robots has been developed, with the aim of making interaction and adjustment of robots easier and more accurate from a remote location. A LeapMotion sensor based controller has been investigated to track the movement of the operator hands. The data from the controller allows gestures and the position of the hand palm’s central point to be detected and tracked. A Kinect V2 camera is able to measure the corresponding motion velocities in x, y, z directions after our investigated post-processing algorithm is fulfilled. Unreal Engine …

Multi-Day Longitudinal Assessment Of Physical Activity And Sleep Behavior Among Healthy Young And Older Adults Using Wearable Sensors, Rahul Soangra

Physical Therapy Faculty Articles and Research

Objectives

The number of elderly people is growing rapidly and aging is found to affect activities of daily living. Older adults are found to perform less physical activity when compared to younger ones. In the perspective of movement behavior, it is not well understood how are elderly different from younger ones. It is not known whether they produce only low frequency movement accelerations or the overall number of movements produced are reduced in elderly. It is also not known how elderly and younger ones perform movement transitions throughout the duration of a day and during night-time sleep.

Material and methods …

Perturbed Mitochondria-Er Contacts In Live Neurons That Model The Amyloid Pathology Of Alzheimer's Disease., Pamela V. Martino Adami, Zuzana Nichtova, David B. Weaver, Adam Bartok Dr., Thomas Wisniewski, Drew R. Jones, Sonia Do Carmo, Eduardo M. Castaño, A. Claudio Cuello, György Hajnóczky, Laura Morelli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The use of fixed fibroblasts from familial and sporadic Alzheimer's disease patients has previously indicated an upregulation of mitochondria-ER contacts (MERCs) as a hallmark of Alzheimer's disease. Despite its potential significance, the relevance of these results is limited because they were not extended to live neurons. Here we performed a dynamic in vivo analysis of MERCs in hippocampal neurons from McGill-R-Thy1-APP transgenic rats, a model of Alzheimer's disease-like amyloid pathology. Live FRET imaging of neurons from transgenic rats revealed perturbed 'lipid-MERCs' (gap width <10 nm), while 'Ca2+-MERCs' (10-20 nm gap width) were unchanged. In situ TEM showed no significant differences in the lipid-MERCs:total MERCs or lipid-MERCs:mitochondria ratios; however, the average length of lipid-MERCs was significantly decreased in neurons from transgenic rats as compared to controls. In accordance with FRET results, untargeted lipidomics showed significant decreases in levels of 12 lipids and bioenergetic analysis revealed respiratory dysfunction of mitochondria from transgenic rats. Thus, our results reveal changes in MERC structures coupled with impaired mitochondrial functions in Alzheimer's disease-related neurons.This article has an associated First Person interview with the first author of the paper.

Coastal And Marine Tourism In The Future, Mohammad Nur Nobi, Md. Alauddin Majumder

Journal of Ocean and Coastal Economics

Having the world's largest unbroken sea-beach and vast coastline, Bangladesh has an immense potentiality to develop sustainable coastal and marine tourism. In Bangladesh, coastal and marine tourism is already in operation, though on a limited scale. But the growth of tourism in this country is lagging behind compared to the world as a whole. The contribution of this sector in the economy of Bangladesh is still below the mark. Therefore, the economy can be benefited by harnessing opportunities pertinent to the country’s coastal and marine tourism. To attract the local and foreign tourists, the country can improve the existing tourist …

Interpreting Non-Amish Perceptions Of The Old Order Amish Using Cultural Relativism And Human Rights Frameworks, Kristin Park

Journal of Amish and Plain Anabaptist Studies

Relatively little is known about how ordinary non-Amish citizens interact with and perceive their Old Order Amish neighbors. This study used interpretive and semi-inductive approaches with in-depth interviews to describe and analyze interactions and perceptions of non-Amish research participants. Sixteen subjects were identified from purposive, snowball and theoretical sampling in a region near a sizeable, very tradition-minded Old Order settlement. All participants engaged in secondary relationships, while several individuals had intimate and enduring relationships with a small number of Amish individuals and families. While most participants perceived their Amish acquaintances and friends as honest, hard-working, caring and community-minded, some expressed …

Use Of Old Order Anabaptist-Produced Publications To Develop An Injury Surveillance System For Old Order Populations, Paul Jones, William Field, Donald Kraybill, Stephen Scott

Journal of Amish and Plain Anabaptist Studies

To achieve a clearer picture of injuries within Old Order Anabaptist communities, Purdue University’s Agricultural Safety and Health Program collaborated with the Young Center for Anabaptist and Pietist Studies at Elizabethtown College to conduct a pilot study on this topic. The team developed an injury surveillance system based not on traditional injury data sources and instruments but on data provided in Old Order-produced publications, specifically The Budget, Die Botschaft, and The Diary. While traditional surveillance methods have generally yielded injury data on less than 30 Old Order cases per year, the Old Order Injury Database, developed through the Purdue/Young Center …

Description Of The Adult Male Of Euscorpius Feti Tropea, 2013 (Scorpiones: Euscorpiidae), With Notes On Cave Ecology Of This Species, Gioele Tropea, Roman Ozimec

Euscorpius

The adult male of Euscorpius feti Tropea, 2013 (Euscorpiidae) is described for the first time. A large series (45 specimens including the type material) has been studied, most of the material previously unpublished. E. feti has been found in as many as 17 caves in Croatia and Bosnia-Herzegovina, including the Adriatic islands, which makes it the most common Euscorpius species so far found in caves. Ecological notes on this species are presented.

Purdue Students In Tanzania: Establishing Connections Through 10 Years Of Service-Learning, Laura Duke, Madison Busch

Purdue Journal of Service-Learning and International Engagement

For ten years, Dr. Jill Newton has coordinated the Maymester in Tanzania program and has created a highly successful and compelling program. Her aim for this program was to create a mini Peace Corps experience for Purdue University students, seeing as she has herself served as a Corps member in Papua New Guinea. One of the most impactful and rewarding components of this program is the service learning opportunities she encourages. Purdue University students attending this program have received a total of over $23,000 in service learning grants to date towards bettering the communities they interact with daily while on …

Unused Medication Collection: An Emerging Service-Learning Experience For Pharmacy Students, Anne E. Packard, Maryam Noureldin, A. Carmine Colavecchia, Patricia L. Darbishire, Jennifer Colavecchia

Purdue Journal of Service-Learning and International Engagement

While the U.S. makes up around 5% of the world’s population, we consume approximately 75% of the world’s prescription drugs—well over 4 billion prescriptions per year. Approximately one third of those are never used, creating an array of public health challenges. These challenges include land and water pollution; unintentional inappropriate use and unintentional human, pet, and wildlife poisonings; and intentional drug abuse and diversion. Misuse of prescription drugs now exceeds that of all illegal drugs combined. Reducing the number of medications prescribed is of primary importance, as well as collecting unnecessary medications from households and disposing of them through environmentally …

More Than A Deliverable: Building Infrastructural Partnerships In Professional Writing, Trinity Overmyer, Lori Bowes

Purdue Journal of Service-Learning and International Engagement

Purdue’s Professional Writing program has worked with the Lafayette Transitional Housing Center for people living with homelessness in recent years through a multimedia writing course. Through this partnership, students have the opportunity to create deliverables to help the center improve their digital media presence and public outreach. In a particular project working with the interviews of individuals living with homelessness who utilize LTHC as a resource, a podcast deliverable was created for the future use and implementation of the Lafayette Transitional Housing Center, in addition to a methodology used to aid LTHC in continued use and creation of the podcast …