Digital Commons Network^™

Glutamate Afferents From The Medial Prefrontal Cortex Mediate Nucleus Accumbens Activation By Female Sexual Behavior, Kelsey M. Moore, Wyatt L. Oelberg, Rose Glass '17, Matthew D. Johnson, Laura Been

Psychology Faculty Scholarship

No abstract provided.

Just Preservation, Adrian Treves, Francisco J. Santiago-Ávila, William S. Lynn

Animal Sentience

We are failing to protect the biosphere. Novel views of conservation, preservation, and sustainability are surfacing in the wake of consensus about our failures to prevent extinction or slow climate change. We argue that the interests and well-being of non-humans, youth, and future generations of both human and non-human beings (futurity) have too long been ignored in consensus-based, anthropocentric conservation. Consensus-based stakeholder-driven processes disadvantage those absent or without a voice and allow current adult humans and narrow, exploitative interests to dominate decisions about the use of nature over its preservation for futurity of all life. We propose that authentically non-anthropocentric …

Political And Non-Political Speech And Guns, Gregory P. Magarian

Scholarship@WashULaw

Constitutional rights depend on justifications. Some combination of theory, his- tory, and practical reasoning needs to establish why and to what extent a given right warrants legal protection. The justifications that courts and theorists articulate for a given right determine the right’s breadth and the specific contours of its protection. Justification has particular importance at the formative stage of a newly recognized constitutional right. At present, courts are building doctrine around the Second Amendment “right of the people to keep and bear Arms,”1 recognized as an individ- ual right just over a decade ago in District of Columbia v. Heller.2 …

Data-Driven Constitutional Avoidance, Gregory P. Magarian, Lee Epstein, James L. Gibson

Scholarship@WashULaw

This article uses a case study to explain how empirical analysis can promote judicial modesty. In Matal v. Tam, the U.S. Supreme Court invoked the First Amendment to strike down the Lanham Act's bar on federal registration of "disparaging" trademarks. The Tam decision has great constitutional significance. It expands First Amendment coverage into a new field of economic regulation, and it deepens the constitutional prohibition on viewpoint-based speech regulations. This article contends that empirical analysis could have given the Court a narrower basis for the Tam result, one that would have avoided the fraught First Amendment issues the Court decided. …

Who Needs A Mind When You Have Thousands Of Fingers?, Yoram Gutfreund

Animal Sentience

Mather’s target article aligns with a common tendency of granting the octopus a mind or consciousness. But what is the meaning of an octopus’s mind? Is it part of nature or is it observer-dependent, imputed to satisfy our own psychological needs? In this commentary, I build on my own experience with octopuses to challenge the notion that we can conclusively attribute a mind to an animal; and I question the scientific usefulness of doing so.

Octopus Minds Must Lead To Octopus Ethics, Barbara J. King, Lori Marino

Animal Sentience

Mather argues convincingly for the existence of minds in octopuses based largely on laboratory experiments. Many of these experiments are highly invasive and involve mutilation and death. Moreover, octopuses are now being hailed as a “new model” for biological research and are being enthusiastically bred in captivity, both for research and for food. We argue that the compelling evidence for mind in octopuses must be accompanied by intense scrutiny of the ethics that shape how we treat them and that the intrinsic value of their individual lives must be recognized.

The Perfecting Of The Octopus, Ila France Porcher

Animal Sentience

Cephalopods split away from the phylogenetic tree about half a billion years ago, and octopus evolution has been accelerated by an extremely low survival rate. This helps explain why this unusual animal presents qualities found in no other. It has a radially organized nervous system with a processing centre for each of its eight tentacles. Yet, although this might suggest that each tentacle has its own centre of consciousness, it remains just one animal, with one mouth to feed, and one life to lose, and it behaves as if it is centrally controlled. Its capacity for a range of intelligent …

What We Don't Know About Cephalopods And How To Define It, Catia Correia Caeiro

Animal Sentience

Despite the reputation of octopuses as intelligent animals, their cognitive abilities seem to be mostly unknown. This should be the starting point of a long process of scientific enquiry about these taxa, which must include discussions on operational definitions first and foremost. Discussing octopus mind might prove fruitless without more basic concepts. Some approaches are suggested here.

Faculty Publications 2018, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 810 publications.

Mta3-Sox2 Module Regulates Cancer Stemness And Contributes To Clinical Outcomes Of Tongue Carcinoma., Zhimeng Yao, Liang Du, Min Xu, Kai Li, Haipeng Guo, Guodong Ye, Dianzheng Zhang, Robert P Coppes, Hao Zhang

PCOM Scholarly Works

Cancer cell plasticity plays critical roles in both tumorigenesis and tumor progression. Metastasis-associated protein 3 (MTA3), a component of the nucleosome remodeling and histone deacetylase (NuRD) complex and multi-effect coregulator, can serve as a tumor suppressor in many cancer types. However, the role of MTA3 in tongue squamous cell cancer (TSCC) remains unclear although it is the most prevalent head and neck cancer and often with poor prognosis. By analyzing both published datasets and clinical specimens, we found that the level of MTA3 was lower in TSCC compared to normal tongue tissues. Data from gene set enrichment analysis (GSEA) also …

Rhabdomyosarcoma And Wilms Tumors Contain A Subpopulation Of Noggin Producing, Myogenic Cells Immunoreactive For Lens Beaded Filament Proteins, Jacquelyn Gerhart, Kathryn Behling, Michele Paessler, Labraya Milton, Gregory Bramblett, Denise Garcia, Meghan Pitts, Reginald Hurtt, Mitchell Crawford, Richard Lackman, Daniela Nguyen, Joseph Infanti, Paul Fitzgerald, Mindy George-Weinstein

PCOM Scholarly Works

Myo/Nog cells are identified by their expression of the skeletal muscle specific transcription factor MyoD and the bone morphogenetic protein inhibitor noggin, and binding of the G8 monoclonal antibody. Their release of noggin is critical for morphogenesis and skeletal myogenesis. In the adult, Myo/Nog cells are present in normal tissues, wounds and skin tumors. Myo/Nog cells in the lens give rise to myofibroblasts that synthesize skeletal muscle proteins. The purpose of this study was to screen human lens tissue, rhabdomyosarcoma cell lines, and tissue sections from rhabdomyosarcoma, Wilms and tumors lacking features of skeletal muscle for co-localization of antibodies to …

Methods For The Visualization Of Placental Vasculature In Fetoscopic Surgery, Praneeth Sadda

Yale Medicine Thesis Digital Library

Twin-to-twin transfusion syndrome is a potentially fatal disease of placental vasculature in twin pregnancies. It is treated with fetoscopic laser photocoagulation surgery, a procedure in which a surgeon uses an endoscope to find and cauterize abnormal vascular anastamoses on the placental surface. However, even after surgery, mortality remains as high as twenty to forty-eight percent, largely due to anastamoses being missed during the operation. Many technical challenges contribute to anastamoses being missed, including poor endoscopic image quality and a limited field of view. Any tools capable of addressing these challenges would be clinically valuable. This thesis presents the design and …

Evaluation Of The Mechanisms Of Anti-Cancer Immune Responses, Noel Turner

Yale Medicine Thesis Digital Library

Metastatic melanoma historically carries a grim prognosis, with a median survival of 9 months and a long-term survival rate of 10%. Melanoma is highly immunogenic, and the development of immunotherapies has dramatically changed the landscape of metastatic melanoma treatment. To study the immune mechanisms engaged by these therapies, the Bosenberg lab developed YUMMER, an immunogenic mouse melanoma line that forms tumors when injected into mice. This and other immunogenic murine cancer models were used to demonstrate that B cell depletion does not impair the anti-PD-1-induced anti-tumor immune response in mice. In addition, supplementing immune checkpoint inhibition with therapies targeting myeloid …

Social Vulnerability Assessment Of Dog Intake Location Data As A Planning Tool For Community Health Program Development: A Case Study In Athens-Clarke County, Ga, 2014-2016, Lisa Milot, Jessie Lee Dyer

Scholarly Works

A retrospective spatial analysis of dog intake data from an open admission animal shelter in Georgia was conducted to explore patterns within dog demographics and outcomes by pickup location or by the home address of the person who transferred ownership rights of the dog to Athens-Clarke County Animal Control during the period 2014–2016. Spatial analysis found the relationship between these intake locations and the final disposition of the dogs to be non-random, suggesting social and environmental influences on distribution. Statistically significant clusters were identified using the Getis-Ord Gi* statistic. This study found statistically significant hot spots (i.e., areas with higher …

Book Review: Not Enough: Human Rights In An Unequal World, Harlan G. Cohen

Scholarly Works

Review of the book Not Enough: Human Rights in an Unequal World. By Samuel Moyn. Cambridge, Massachusetts, Harvard University Press 2018. Pp. ix, 220. Index.

Infracompetitive Privacy, Greg Day, Abbey R. Stemler

Scholarly Works

One of the chief anticompetitive effects of modern business lies in antitrust’s blind spot. Platform-based companies (“platforms”) have innovated a business model whereby they offer consumers “free" and low-priced services in exchange for their personal information. With this data, platforms can design products, target consumers, and sell such information to third parties. The problem is that platforms can inflict greater costs on users and markets in the form of lost privacy than efficiencies generated from their low prices. Consumers, as examples, spend billions of dollars annually to remedy privacy breaches and, alarmingly, participate unwittingly in experiments designed to manipulate their …

Building From Scratch: University Of Georgia School Of Law's Practicum In Animal Welfare Skills, Lisa Milot, Deena Agamy

Scholarly Works

The Practicum in Animal Welfare Skills (PAWS) brings together students from the University of Georgia School of Law, legal and law enforcement professionals from the Athens-Clarke County (ACC) Unified Government, and private parties interested in improving animal welfare in the Athens area, for the sake of the animals and the people who care about them. This Article focuses on the evolution of the Practicum in Animal Welfare Skills (PAWS) at UGA School of Law.

Teaching Communication Skills In Transactional Simulations, Eric J. Gouvin, Katherine M. Koops, James E. Moliterno, Carol Morgan, Carol D. Newman

Scholarly Works

This Article describes the role of communication exercises in transactional law and skills education, and provides several examples of such exercises. After a discussion of fundamental differences between communication in the context of litigation and transactional law, the Article discusses exercises designed to improve written communication skills, including the use of e-mail, in the context of transactional law. It follows with a similar discussion of exercises focusing on oral communication skills, including listening, interviewing, counseling, negotiation, and presentations. The Article concludes with examples of exercises combining oral and written communication skills in the context of simulated transactions.

Clinical Syllabi As Demonstration Of Best Practices Implementation, Jean Goetz Mangan, Fernanda Mackay

Scholarly Works

This Article posits that the University of Georgia School of Law for Clinical Programs course syllabi demonstrate implementation of recommendations found in leading works that advocate for change in traditional legal education. This Article reviews some high points of legal education reform with a focus on clinical legal education and then discusses the role of syllabi in the classroom and the potential within the document that many professors miss. This Article then turns to using syllabi to measure the extent that the clinics are implementing instruction that addresses all three apprenticeships as defined in the Carnegie Report.. To assess the …

A Brief History Of The Catholic Church In Vietnam, Peter N. V. Hai

Asia Pacific Mission Studies

In a succinct form, Peter N. V. Hai traces the historical growth of the Church in Vietnam from its beginning (1533) to its present maturation. He brings out salient features of such development: the lay people’s exemplary witness of faith, at times to the point of shedding their blood, their fidelity to the Church, and their zeal for lay ministry. At present they are taking a fuller role in the evangelizing mission of the Church.

Is There An Asian Way Of Doing Theology?, Michael Amaladoss Sj

Asia Pacific Mission Studies

Michael Amaladoss, S.J., gives us further insights into Asian theology, describing it as contextual, holistic, and more right-brain-oriented. He gives many interesting examples and concludes with an appeal for the acceptance of pluralism in theology.

Prophetic Dialogue With Cultures And Religions In Fiji: A Pastoral Imperative, Timoci Kolodisi

Asia Pacific Mission Studies

Timoci Kolodisi begins with a survey of the geography, ethnic groups, socio-cultural and political landscape, and the religious affiliations of the islands of Fiji. He then describes the society’s traditional social structures with its worldview, values, and beliefs before discussing the coming of Christianity to the islands, and the early efforts at inculturation. In conclusion, he invites the Church—if it wishes to be an effective sign and a path to peace—to focus on its spiritual meaning and enhance its relations with the different communities and religions in Fiji.

A New Way Of Being Church: Fabc Teachings On Basic Ecclesial Communities, Ramesh Lakshmanan

Asia Pacific Mission Studies

Asian bishops and general AsIPA (Asian Integral Pastoral Approach) assemblies have always insisted that the Asian Church has to be participatory. This is realized through Basic Ecclesial Communities (BECs). BECs encourage lay participation in the life and mission of the Church, particularly in the parishes. BECs have brought a new dimension to the ministry of the Church. They have become a good platform to carry out new ministries. This article presents the teachings of the Asian bishops and the AsIPA in their final statements.

Applications Of 3d Printing On Craniofacial Bone Repair, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren

School of Dentistry Faculty Research and Publications

Objectives

Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.

Data & sources

A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.

Study selection

43 …

Stability Conditions For Coupled Oscillators In Linear Arrays, Pablo Enrique Baldivieso Blanco, J.J.P. Veerman

Mathematics and Statistics Faculty Publications and Presentations

In this paper, we give necessary conditions for stability of flocks in R. We focus on linear arrays with decentralized agents, where each agent interacts with only a few its neighbors. We obtain explicit expressions for necessary conditions for asymptotic stability in the case that the systems consists of a periodic arrangement of two or three different types of agents, i.e. configurations as follows: ...2-1-2-1 or ...3-2-1-3-2-1. Previous literature indicated that the (necessary) condition for stability in the case of a single agent (...1-1-1) held that the first moment of certain coefficients governing the interactions between agents has to be …

Applying Unoccupied Aircraft Systems To Study Human Behavior In Marine Science And Conservation Programs, Michelle B. Nowlin, Stephen E. Roady, Everette Newton, David W. Johnston

Faculty Scholarship

The declining costs of Unoccupied Aircraft Systems (UAS, aka drones), their ease of use, and their ability to collect high resolution data from a variety of sensors has resulted in an explosion of applications across the globe. Scientists working in the marine environment are increasingly using UAS to study a variety of topics, from counting wildlife populations in remote locations to estimating the effects of storms and sea level rise on shorelines. UAS also provide transformative potential to study the ways in which humans interact with and affect marine and coastal ecosystems, but doing so presents unique ethical and legal …

Patent Trial And Appeal Board's Consistency-Enhancing Function, Michael D. Frakes, Melissa F. Wasserman

Faculty Scholarship

Agency heads, who have the primary responsibility for setting an agency's policy preferences, have a variety of tools by which they attempt to minimize the discretion of their staff officials in an effort to ensure agency policy preferences are consistently applied. One such mechanism is subjecting agency official's determinations to higher-level agency review. While scholars have long surmised that judges seek to minimize reversal of their decisions by a higher-level court, how agency officials' decisions are influenced by higher-level agency reconsideration has mostly eluded analysis.

In this Essay, we begin to fill this gap by examining the extent to which …

Association Of Mbl2 Gene Polymorphisms With Pulmonary Tuberculosis Susceptibility: Trial Sequence Meta-Analysis As Evidence, Raju K. Mandal, Munawwar Ali Khan, Arif Hussain, Sajad A. Dar, Sultan Aloufi, Arshad Jawed, Mohd Wahid, Aditya K. Panda, Mohtashim Lohani, Naseem Akhter, Saif Khan, Bhartendu Nath Mishra, Shafiul Haque

All Works

© 2019 Mandal et al. Background: Mannose-binding lectin (MBL) or mannose-binding protein (MBP), encoded by MBL2 gene and secreted by the liver, activates complement system through lectin pathway in innate immunity against the host’s infection. Conflictingly, a number of MBL2 variants, rs1800450 (A>B), rs1800451 (A>C), rs5030737 (A>D), rs7096206 (Y>X), rs11003125 (H>L), and rs7095891 (P>Q) allele, have been found to be associated with compromised serum levels and pulmonary tuberculosis (PTB) susceptibility. The present meta-analysis study was performed to evaluate the potential association of these MBL2 gene variants with PTB susceptibility. Materials and methods: A quantitative …

Removal Of Intertidal Grazers By Human Harvesting Leads To Alteration Of Species Interactions, Community Structure And Resilience To Climate Change, Ana Chaverra, Evie Wieters, Andy Foggo, Antony M. Knights

School of Biological and Marine Sciences

Extreme fluctuations in abiotic conditions can induce a biological stress response (e.g. bleaching) detrimental to an organism's health. In some instances, organisms can recover if conditions are alleviated, such as through co-occurrence with other species that confer protection. Biodiverse, multitrophic communities are increasingly recognised as important promoters of species persistence and resilience under environmental change. On intertidal shores, the role of grazers as top-down determinants of algal community structure is well recognised. Similarly, the harvesting of grazers for human consumption is increasingly prevalent with potential to greatly alter the community dynamics. Here, we assess how differences in harvesting pressure of …

Will Giant Polar Amphipods Be First To Fare Badly In An Oxygen-Poor Ocean? Testing Hypotheses Linking Oxygen To Body Size, John I. Spicer, Simon A. Morley

School of Biological and Marine Sciences

No abstract provided.