Digital Commons Network^™

Metadata-Based Image Collecting And Databasing For Sharing And Analysis, Xi Wu

Theses and Dissertations--Computer Science

Data collecting and preparing is generally considered a crucial process in data science projects. Especially for image data, adding semantic attributes when preparing image data provides much more insights for data scientists. In this project, we aim to implement a general-purpose central image data repository that allows image researchers to collect data with semantic properties as well as data query. One of our researchers has come up with the specific challenge of collecting images with weight data of infants in least developed countries with limited internet access. The rationale is to predict infant weights based on image data by applying …

Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal

Theses and Dissertations--Computer Science

Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …

Depth Enhancement And Surface Reconstruction With Rgb/D Sequence, Xinxin Zuo

Theses and Dissertations--Computer Science

Surface reconstruction and 3D modeling is a challenging task, which has been explored for decades by the computer vision, computer graphics, and machine learning communities. It is fundamental to many applications such as robot navigation, animation and scene understanding, industrial control and medical diagnosis. In this dissertation, I take advantage of the consumer depth sensors for surface reconstruction. Considering its limited performance on capturing detailed surface geometry, a depth enhancement approach is proposed in the first place to recovery small and rich geometric details with captured depth and color sequence. In addition to enhancing its spatial resolution, I present a …

To The Humanities: What Does Communication Studies Give?, Mari Lee Mifsud

Rhetoric and Communication Studies Faculty Publications

This special issue of Review of Communication presents new offerings of the study of communication, forging present and future humanities. This Introduction engages the six essays in this special issue—which extend and intersect across categories of the humanistic study of communication: communication philosophy and ethics, rhetorical theory, history, pedagogy, criticism, and digital humanities—to explore their contributions in defense of the humanities. Taken together, these essays explore the study of communication as 1) a resource for inquiring and exchanging with concepts, practices, and embodiments of difference, the other, and the posthuman; 2) a means of examining the ontological, epistemological, technological, existential, …

Experiencing Displacement And Statelessness: Forced Migrants In Anse-À-Pitres, Haiti, Daniel Joseph

Theses and Dissertations--Anthropology

In 2013, the Dominican state ruled to uphold a 2010 constitutional amendment that stripped thousands of Dominicans of Haitian origin of their citizenship and forced them to leave the country during summer 2015. About 2,200 of these people became displaced in Anse-à-Pitres, where most took up residence in temporary camps. I use the term forced migrants or displaced persons interchangeably to refer to these people. Many endure challenges in meeting their daily survival needs in Haiti, a country with extreme poverty, considerable political instability, and still in the process of rebuilding itself from the devastating earthquake of 2010. Drawing on …

Resilience And Adaptation In A World System Periphery: Long-Term Perspectives From The Lake Atitlan Basin, Highland Guatemala 600 Bc – 1600 Ad, Gavin R. Davies

Theses and Dissertations--Anthropology

The Lake Atitlan Basin of highland Guatemala boasted fertile soils and was rich in natural resources, making it an attractive area for permanent settlement. However, the region lacked a number of important items, such as salt, cotton, and obsidian, all of which had to be obtained through trade. Good agricultural land was also scarce in certain parts of the lake and the steep hillslopes were easily eroded, making it necessary for communities to maintain access to emergency supplies of corn. Lake Atitlan’s communities were therefore highly dependent on exchanges with neighboring groups who occupied contrasting ecological zones, especially those in …

Compelled Subsidies And Original Meaning, Jud Campbell

Law Faculty Publications

The rule against compelled subsidization of speech is at the forefront of modem First Amendment disputes. Challenges to mandatory union dues, laws preventing discrimination on the basis of sexual orientation, and the federal "contraceptive mandate" have all featured variants of the anti-subsidization principle, reasoning that the government cannot compel people to support the objectionable activities of others. But the literature currently fails to evaluate modem compelled-subsidy doctrine in terms of the original meaning of the First Amendment. This Essay takes up that task.

Approaching any question of original meaning requires a willingness to encounter a constitutional world that looks very …

Childcare, Vulnerability, And Resilience, Meredith Johnson Harbach

Law Faculty Publications

The question of how to provide care for America’s youngest children, and the quality of that care, is among the most vexed for family law. Despite seismic demographic shifts in work and family, childcare law and policy in the United States still operates on the assumption that childcare is the private responsibility of parents and families rather than a state concern. But this private childcare model, based on unrealistic assumptions in liberal theory and buttressed by an ascendant neoliberalism, is inadequate to today’s childcare challenges. This project confronts the inadequacies of the private childcare model. Using Martha Albertson Fineman’s Vulnerability …

Maternal Restricted- And Over-Feeding During Gestation Result In Distinct Lipid And Amino Acid Metabolite Profiles In The Longissimus Muscle Of The Offspring, Dominique E. Martin, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Katelyn K. Mcfadden, Steven A. Zinn, Kristen E. Govoni, Sarah A. Reed

Fisheries, Animal and Veterinary Sciences Faculty Publications

Maternal over- and restricted-feeding during gestation have similar negative consequences for the offspring, including decreased muscularity, increased adiposity, and altered metabolism. Our objective was to determine the effects of poor maternal nutrition during gestation (over- and restricted-feeding) on the offspring muscle metabolite profile. Pregnant ewes (n = 47) were fed 60% (RES), 100% (CON), or 140% (OVER) of NRC requirements starting at day 30.2 ± 0.2 of gestation. Offspring sample collection occurred at days 90 and 135 of gestation, and within 24 h of birth. C2C12 myoblasts were cultured in serum collected from offspring at birth (n = …

Texas Sport Leadership Consultants, Llc: A Case Of Cases, Emily S. Sparvero, Randall J. Griffiths, Jacob K. Tingle

School of Business Faculty Research

This immersive, multi-case experience consists of four distinct cases and one meta-case that require students to engage with several organizational behavior topics. First, the meta-case takes the form of Texas Sport Leadership Consultants (TSLC), a fictitious company which consults with local sport management professionals in a variety of contexts. Students participate as temporary members of the company to analyze the issues and challenges associated with working as a member of TSLC. TSLC work groups are hired by four different clients, each of whom has a unique organizational behavior challenge. These clients include: (1) a combat-oriented sport company; (2) a company …

Biology News 2019, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

--Greetings from the Department of Biology
--Upcoming event: Prairie Rendezvous in Celebration of Dr. Daryl Smith
--Staff and faculty news
--May 2019 Study Abroad trips
--Staff and Faculty Transitions
--The Difference He Made-Quotes on Dr. Wiens
--Outreach and Alumni
--Purple and Gold Award Recipient

A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le

All ETDs from UAB

Membrane proteins belonging to the ATP-Binding Cassette (ABC) superfamily are responsible for transporting substrates into or out of cells. ABC transporters, such as P-glycoprotein (Pgp/ABCB1) defend cells by the active efflux of many chemically diverse cytotoxic compounds. The ABC protein, CFTR/ABCC7, is a passive chloride ion channel that provides fluid homeostasis. Pgp and CFTR of are high clinical interest since mutations in CFTR can result in Cystic Fibrosis (CF) and upregulation of Pgp in tumor cells can result in multidrug resistance (MDR). There has been a major effort to develop clinical drugs to treat CF by either repairing defects in …

Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry

All ETDs from UAB

The “gold standard” of bone grafting materials is autograft. Unfortunately, autogenous bone must first be harvested from the patient, leading to complications such as donor site morbidity. Because of this, many surgeons rely on non-autogenous bone grafting materials. While these grafts are more available than autogenous bone, they require extensive processing which significantly reduces their osteoinductivity. Therefore, there is substantial interest in finding ways to add osteoinductive molecules to these grafts. Previously, our lab has focused on utilizing molecules derived from bone morphogenetic protein 2 (BMP2) with an attached hydroxyapatite-binding domain (polyglutamate) to anchor them onto bone grafting materials. Previous …

Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka

All ETDs from UAB

Modern medicine employs many drugs in its disease treatment methods. This is because they provide the best permanent solutions to complicated ailments. However the usefulness of these drugs is mitigated by several factors, namely that of specific release. Common drug delivery mechanisms lack the specificity needed to ensure that release is limited to the diseased area, which can lead to unnecessary side effects. By utilizing medical imaging, both drug delivery devices and physiology can be observed by physicians, which can greatly increase the specificity of drug delivery. Specifically, utilizing a very inert medical imaging modality, such as ultrasound, guarantees minimum …

O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman

All ETDs from UAB

Post translational modification of proteins plays a crucial role in regulating their function, and the role of one such modification, termed O-GlcNAcylation, is understudied. O-GlcNAcylation involves the dynamic cycle of adding and removing an O-linked N-acetylglucosamine (O-GlcNAc) by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which are highly expressed in the hippocampus. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. We have shown that acute and selective increase in O-GlcNAcylation of AMPAR GluA2 subunits underlies expression of a novel form of LTD at CA3-CA1 synapses (O-GlcNAc LTD), as well …

Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford

All ETDs from UAB

Even the most effective and widely used drugs in modern disease treatment can be compromised by low bioavailability and off-target damage which leads to detrimental side effects. Polymeric drug carriers have been developing in recent times with the aim of rendering the therapeutic cargo inert and protecting it from the body’s natural defense mechanisms until arrival at the target site, upon which a specific stimulus will cause the drug to release from the carrier locally. To this end, antioxidant capability in drug carriers can help mediate the cascade of reactive oxygen species that meet injected materials and, in doing so, …

Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black

All ETDs from UAB

The kidneys are complex, multi-faceted organs that are responsible for regulatory processes, such as fluid homeostasis, hormone production, blood pressure regulation, and systemic toxin removal. Sudden disruption of these processes by acute kidney injury (AKI) causes rapid decline in renal function as well as significant morbidity and mortality. AKI is a significant clinical concern, affecting up to 13.3 million people globally each year and has the propensity to progress to chronic kidney disease (CKD), though the mechanism remains undefined. One reason for this is due to the lack of understanding of models used to study both AKI and CKD, hindering …

St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty

All ETDs from UAB

ST6Gal-I adds α2-6 sialic acids to select N-glycosylated cell surface receptors, thereby modulating receptor function and intracellular signaling. ST6Gal-I is upregulated in various carcinomas and confers cancer stem cell (CSC) properties evidenced by tumorspheroid growth, chemoresistance and tumor initiating potential. In pancreatic ductal adenocarcinoma (PDAC), ST6Gal-I conferred gemcitabine resistance by abrogating DNA damage and altering expression levels of gemcitabine metabolism genes. Further, ST6Gal-I promoted resistance to chronic gemcitabine treatment. Additionally, metastatic clones of a PDAC cell line had increased ST6Gal-I expression and ST6Gal-I knockdown enhanced gemcitabine sensitivity. To investigate the physiological consequences of ST6Gal-I in PDAC, murine models were used. …

The Emergence Of A Lay Esprit De Corps: Inspirations, Tensions, Horizons, Christopher Pramuk

Jesuit Higher Education: A Journal

Likening the Ignatian tradition as embodied at Jesuit universities to a family photo album with many pages yet to be added, the author locates the “heart” of the Ignatian sensibility in the movements of freedom and spirit (inspiration) in the life of the community. There are no fixed entry points or criteria of inclusion and exclusion for Ignatian lay educators save a desire to share in the questions proper to all the university disciplines that pull us toward a horizon beyond ourselves. Nevertheless a number of creative tensions endemic to Jesuit apostolic life from the beginning and also new challenges …

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson

All ETDs from UAB

Objective: Unintentional childhood injury is a significant global health burden particularly in low and middle income countries (LMIC). Effective supervision can reduce risk of injury to supervisees. Frequently, older siblings assist in supervising younger siblings, but may not be as effective as adult caregivers at preventing supervisee injury. The current investigation had three primary objectives: 1) Assess Ugandan adult caregivers’ self-reported expectations for children to provide sibling supervision; 2) Assess sixth-grade students’ self-reported experiences providing supervision; 3) Determine whether students’ supervision knowledge and skill improve through participation in the Super Siblings program, a novel classroom-based, culturally-adapted intervention. Methods: Adult caregivers …

Dissecting A Role For Polyamines In Rift Valley Fever Virus Infection, Vincent Mastrodomenico

Master's Theses

Bunyaviruses are emerging viral pathogens that cause encephalitis, hemorrhagic fevers, and meningitis. Rift Valley fever virus is a particularly devastating bunyavirus, infecting both humans and livestock with significant morbidity and mortality. By coordinating several host and viral processes Rift Valley fever virus is able to produce infectious virions. Polyamines are small, positively-charged host-derived molecules that play diverse roles in human cells and in infection. We previously demonstrated that polyamines are crucial for RNA viruses; however, the mechanisms by which polyamines function remain unknown. Here, we investigated polyamines' role in the replication of the Rift Valley fever virus (vaccine strain MP-12). …

Habitat Associations And Community Interactions Of Non-Native Species In The Southern Basin Of Lake Michigan, Erin O'Shaughnessey

Master's Theses

Non-native crayfishes, mollusks, and macrophytes can have large impacts on biodiversity and damage ecosystem services in freshwaters. In 2015 we discovered an established population of the globally widespread invader red swamp crayfish (Procambarus clarkii) in the North Shore Channel of the Chicago Area Waterway System. This population overlaps with a population of rusty crayfish (Faxonius rusticus), a previous invader that is widely distributed and usually the dominant crayfish species across the Great Lakes region. I studied the interactions between these two species while directly competing over shelter and food. In the field, each species was studied to determine the rate …

Zero Tolerance And Self Image: A Systematic Literature Review, Caitlyn Todd

Master's Theses

The use of zero tolerance disciplinary policies in schools have numerous, lasting impacts on children, particularly African American students. This study relies on the use of a systematic literature review to analyze prior data on what these effects are. The study found that the effects include, but are not limited to, destruction of self confidence, increased recidivism, and lastly further psychological issues, all of which contribute to the likelihood of having a poor self image. These findings play are role in the discussion of other, more equitable, styles of discipline, such as restorative justice, as a way to help remedy …

A Possible Role Of Clostridium Difficile Association With The Gi Tract In Relapsing Clostridium Difficile Infection, Asiyya Ashraf

Master's Theses

Clostridium difficile infection (CDI), caused by the anaerobic spore-former C. difficile, is a major cause of health-care associated morbidity. CDI occurs in individuals that have a disrupted GI tract microbiota, typically in patients who are on antibiotic therapy. After recovery from an episode of CDI, approximately, 15-30% of patients experience relapse of disease. The mechanism of relapse is not well understood. It is plausible for relapse to occur if C. difficile cells and spores associate with the GI tract mucosa during infection and persist after infection. However, little is known about the association of cells and spores with the GI …

Molecular And Biochemical Phenotypes Underlying Reactive Astrocytosis In Primary Optic Nerve Head Astrocytes, Anita Kirti Ghosh

Master's Theses

Glaucoma is a progressive optic neuropathy that manifests in a pathological triad of optic nerve head remodeling, damage to optic nerve axons, and retinal ganglion cell death. Optic nerve head astrocytes (ONHAs) are the primary cell type in the optic nerve head. ONHAs undergo reactive astrocytosis, an activated phenotype characterized by altered gene and protein expression and increased cell migration and proliferation, early in the disease pathology. Reactive astrocytosis is thought to underlie optic nerve head remodeling. The first goal of this thesis was to determine if exposure of primary adult rat ONHAs to hyperbaric pressure (25-30 mm Hg above …

Developing A Brain‐Based, Non‐Invasive Treatment For Pain, Logan Thorne Dowdle

MUSC Theses and Dissertations

Chronic pain cost society more than $500 billion each year and contributes to the ongoing opioid overdose crisis. Substantial risks and low efficacy are associated with opiate usage for chronic pain. This dissertation seeks to fill the urgent need for a new pain treatment using a neural-circuit based approach in healthy controls and chronic pain patients. First, we performed a single-blind study examining the causal effects of transcranial magnetic stimulation (TMS), compared to a well-matched control condition. Using interleaved TMS/fMRI we explored brain activation in response to dorsolateral prefrontal cortex (DLPFC) stimulation in 20 healthy controls. This study tested the …

2018 Annual Town Report Lempster, New Hampshire., Lempster Town Representatives

Lempster, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Catch Composition And Selectivity Of Fishing Gears In A Multi-Species Indonesian Coral Reef Fishery, Austin T. Humphries, Kelvin D. Gorospe, Paul G. Carvalho, Irfan Yulianto, Tasrif Kartawijaya, Stuart J. Campbell

Fisheries, Animal and Veterinary Sciences Faculty Publications

There are millions of small-scale fishers worldwide that rely on coral reefs for their livelihood. Yields from many of these coral reef fisheries, however, have been declining. In Indonesia and other coral reefs worldwide, management approaches are dominated by marine protected areas but other options including gear-restrictions may be feasible and more adaptive to local ecological and social conditions. Yet, there is little data on the impacts and selectivity of fishing gears for coral reef fisheries. In this paper, we present results from a case study on the island of Lombok, where we examine the selectivity and overlap in catch …

Ba Environmental Studies, 2019-20, Arkansas State University - Jonesboro

Bachelor of Arts and others

No abstract provided.

Fear Effect In Prey And Hunting Cooperation Among Predators In A Leslie-Gower Model, Saheb Pal, Nikhil Pal, Sudip Samanta, Joydev Chattopadhyay

Journal Articles

The predation strategy for predators and the avoidance strategy of prey are important topics in ecology and evolutionary biology. Both prey and predators adjust their behaviours in order to gain the maximal benefits and to increase their biomass for each. In the present paper, we consider a modified Leslie-Gower predator-prey model where predators cooperate during hunting and due to fear of predation risk, prey populations show anti-predator behaviour. We investigate step by step the impact of hunting cooperation and fear effect on the dynamics of the system. We observe that in the absence of fear effect, hunting cooperation can induce …