Digital Commons Network^™

Accumulation And Spatial Distribution Of Lead And Other Trace Elements In Keratinized Tissues : Investigations Based On Analytical Atomic Spectrometry, Mina W. Tehrani

Legacy Theses & Dissertations (2009 - 2024)

Human biomonitoring for toxic metals such as lead (Pb) provides information about absorbed dose from all exposure routes, and is critical for identifying exposed individuals and assessing health risks. Blood Pb and bone Pb are the primary validated biomarkers for assessing short-term and historical Pb exposures, respectively, while non-traditional matrices, including keratinized tissues, can provide complementary exposure information. Hard keratinized tissues – including hair, nails, hooves, and horns – grow incrementally, potentially preserving chemical exposure histories over a span of days to years. Analytical limitations and poor interlaboratory reproducibility, however, have led to debate around the use of human nails …

Computational Modeling As A Tool For Designing Ligands And Receptors, Waqas S. Awan

Legacy Theses & Dissertations (2009 - 2024)

Computational methods can be used for a wide range of applications, especially regarding DNA and RNA. Interactions such as sugar torsions, receptor-ligand interactions, ligand docking/drug docking, receptor modeling, and drug design are excellent candidates for computational analysis and in silico experiments. The use of molecular dynamics software (GROMACS) coupled with molecular design software (MOE) produce insights that may have been otherwise difficult to assess. All these problems are academic in nature but have practical uses outside of academia. Understanding alternate linkages can lead to antibiotic assays to address potential superbug epidemics. Modeling DNA superstructures can provide insight into how large …

Current And Future Environmental And Human Health Impacts Associated With Biofuel/Biofuel Feedstock Production, Eun Kyung Lee

Legacy Theses & Dissertations (2009 - 2024)

Background: The demand for biobased products, such as food, fuel, and chemicals, has been continuously increasing. Meanwhile, agricultural production, serving as the primary stage of biobased products, is one of the largest contributors to greenhouse gas (GHG) emissions and nutrient releases. Although assessing spatially and temporally explicit environmental releases and impacts are required to inform a sustainable trajectory for agricultural production, such analyses are largely lacking due to data unavailability and feasibility of data analysis. Moreover, our current understanding of health impacts associated with biofuel production are lacking due to the limited assessment of health impacts resulted from biofuels’ entire …

Migration, Resettlement, And Transition In The Aftermath Of The Maya Collapse : A Case Study Of A Terminal Classic Maya Community In Northern Belize, Josalyn M. Ferguson

Legacy Theses & Dissertations (2009 - 2024)

While there is consensus that the processes of decline and abandonment at many sites associated with the Terminal Classic Maya “collapse” (A.D. 750-1050) included the movement of peoples across the Maya lowlands, there has been little focused archaeological research on the resettlement and regeneration of these migrant groups. The movement of peoples across the Maya landscape was partially encouraged by a declining and ever increasingly taxed environment, as well as a revolution in exchange systems, with a notable increase in entrepreneurialism across the Maya subarea. This more integrated economic system focused on a wider range of commodities that served to …

The Cognitive And Contextual Underpinnings Of Food Cravings : A Multi-Method Exploration, Martha Niemiec

Legacy Theses & Dissertations (2009 - 2024)

The notion of addiction pervades Western vernacular. While firmly established in the substance and drug literature, the concept of addiction is now increasingly associated with other ingested substances (coffee, chocolate, highly processed foods) and a range of compulsive behaviors (gambling, sex, online social networking, gaming). Addiction is associated with substantial morbidity and mortality, and a greater understanding of its etiology has significant public health implications. The physiological mechanisms thought to contribute to the development and maintenance of addiction (tolerance, withdrawal, and, possibly, craving) are widely considered hallmark features and primary treatment targets, while psychological and contextual factors are often underappreciated …

The Everyday Sacred : A Symbolic Analysis Of Contemporary Yucatec Maya Women's Daily Realities, Crystal Sheedy

Legacy Theses & Dissertations (2009 - 2024)

As a collaborative effort between myself and the Maya women with whom I worked, who live in Xocén, this dissertation seeks to illuminate the sacred world of Maya women, as well as dismantle the insidious narrative that younger generations of Mayas are losing their culture. Instrumental to this process is the use of decolonial methods (Lawless 1993) and descriptive theoretical premises (Geertz 1973; Turner 1967, 1969) that allowed me to analyze Maya women’s discursive speech, referred to as both chismes and heridos in Spanish, which can be translated as gossip, as well as the speech genre of u t’àan nukuč …

Contrasting Roles Rna Binding Proteins G3bp1 And Hur Influence Zika Virus And A Proposed Mechanism By Which Zika Virus Induces Neurological Complications, Gaston Bonenfant

Legacy Theses & Dissertations (2009 - 2024)

Globalization and climate change have contributed to the rampant spread of mosquitos from tropical and subtropical climates into more moderate climates, and thus also the spread of a number of vector-borne viruses. As of 2016, the World Health Organization (WHO) estimates that of all human infections world-wide, 16% result from vectors such as flies, ticks, and mosquitos. The spread of such viruses has encouraged expedient evolutionary pressures resulting in more pathogenic viruses that continually pose a serious threat to public health. First discovered in 1947, Zika virus (ZIKV) has only recently presented as a detriment to public health. The importance …

Proceedings Of Learn X Design 2019: Insider Knowledge, Naz A.G.Z. Börekçi, Dalsu Özgen Koçyıldırım, Fatma Korkut, Derek Jones

DRS Conference Volumes

The Fifth DRS Learn X Design International Conference for Design Education Researchers took place July 9-12, 2019 with the main theme “Insider Knowledge” at Middle East Technical University, Ankara, Turkey. A total of 111 paper submissions, 11 workshop proposals, and 28 PhD Pit-Stop applications were received. In all, 86 papers were presented and six workshops were conducted in a variety of topics, ranging from emerging practices in design education to innovative approaches in bridging design education and society. The conference hosted 150 delegates from 81 institutions in 31 countries.

Faster Science: Why Scientist.Com's Blockchain Approach Is The Answer To The Pharmaceutical Industry's 21 C.F.R. Part 11 Compliance Challenges, Kelly Kagan

Law Student Scholarship

No abstract provided.

Intimate Indigeneities: Aspirational Affective Solidarity In 21St Century Indigenous Mexican Representation, Jacob S. Neely

Theses and Dissertations--Hispanic Studies

This dissertation analyzes six contemporary texts (2008–18) that represent indigenous Mexicans to transnational audiences. Despite being disparate in authorship, genre, and mode of presentation, all address the failings of the Mexican state discourse of mestizaje that exalts indigenous antiquities while obfuscating the racialized socioeconomic hierarchies that marginalize contemporary indigenous peoples. Casting this conflict synecdochally as the national imposing itself on quotidian life, the texts help the reader/viewer come to understand it in personal, affective terms. The audience is encouraged to identify with how it feels to exist in a space where, paradoxically, the interruption of everyday life has become the …

Las Islas En La Literatura Castellana De La Baja Edad Media, Martha Elena Granados Sáenz

Theses and Dissertations--Hispanic Studies

This dissertation explores references to islands in 13^th and 14^th century Iberian literature in a corpus of encyclopedias, travel books and chivalry novels from 1223 through 1396. I explore how island geography became part of the Medieval imago mundi. Many Medieval readers were interested in these faraway lands where, they believed, monstrous races flourished, sea monsters lurked, and Paradise awaited to be rediscovered. The physical and human geography featured in these narratives, gave birth to an imaginary, utopian, exotic, extravagant, and mysterious concept of “islandness” located in idyllic places to be interpreted as cognitive maps of the …

The Human Rights Movement And The Prevention Of Evil: The Need To Look Inward As Well As Out, Jeffrey A. Brauch

Catholic University Law Review

The modern human rights movement began as a response to great evil perpetrated by individuals and nations against others during and preceding World War II. The movement has been dedicated to protecting the rights of individuals by confronting evil and holding nations accountable should efforts to prevent it fail.

This article contends that while the human rights movement is good at confronting evil “out there,” it has failed in important ways to recognize flaws within itself. In particular, it displays a hubris that shows itself in two ways. First, the movement has embraced a utopian expansion of rights to be …

The Religious Roots Of The Progressive Income Tax In America, Joshua Cutler

Catholic University Law Review

I examine the debate over the first peacetime income tax in the United States in 1894 to investigate the role of religion in enacting the tax and providing moral legitimacy. I find that congressional proponents repeatedly and explicitly argued that a progressive income tax was a biblical tax that best conformed to Judeo-Christian teachings on economics and fundraising. I discuss the history of American religious fundraising practices, including the trend leading up to 1894 that advocated for proportionate giving of income as the best method of giving, as well as the related tithing movement. I document that congressional income tax …

Introduction: The Future Of Religious Liberty In America, Mark L. Rienzi

Catholic University Law Review

No abstract provided.

Mastering Masterpiece, Kristen K. Waggoner

Catholic University Law Review

Religious freedom ensures that every person has the right to explore life’s deepest questions and to live out their religious convictions in public life. Free speech similarly ensures that all have the liberty to express their views and pursue truth without fear of government punishment. Free exercise of religion and free speech are durable rights that do not turn on cultural popularity or political power; these freedoms enable us to coexist peacefully with each other despite deep differences. Yet these freedoms are being sorely tested today by government efforts to suppress the rights of creative professionals—painters, filmmakers, printers, and many …

2019 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.

Evaluating The Impacts Of Antidepressant Use On The Risk Of Dementia, Ran Duan

Theses and Dissertations--Epidemiology and Biostatistics

Dementia is a clinical syndrome caused by neurodegeneration or cerebrovascular injury. Patients with dementia suffer from deterioration in memory, thinking, behavior and the ability to perform everyday activities. Since there are no cures or disease-modifying therapies for dementia, there is much interest in identifying modifiable risk factors that may help prevent or slow the progression of cognitive decline. Medications are a common focus of this type of research.

Importantly, according to a report from the Centers for Disease Control and Prevention (CDC), 19.1% of the population aged 60 and over report taking antidepressants during 2011-2014, and this number tends to …

Diagnostic Accuracy Of Computed Tomography Scout Film And Chest X-Ray For Detection Of Rib Fractures In Patients With Chest Trauma: A Cross-Sectional Study., Muhammad Awais, Basit Salam, Naila Nadeem, Noor B. Baloch

Department of Radiology

Background:
Rib fractures are a major source of morbidity in patients with chest trauma. Computed tomography (CT) scout film is a low-dose image that is obtained prior to a complete chest CT study for all patients undergoing a CT scan. In this study, we evaluated the diagnostic performance of CT scout film vis-à-vis that of chest X-ray for detection of rib fractures using chest CT scan as the reference standard. Methods: A cross-sectional study was performed at the radiology department of Aga Khan University Hospital (Karachi, Pakistan) from October 1, 2013 to September 31, 2014. Patients who underwent CT chest …

Reference Guide: Factorial Focus Group Analysis Methods For Studying Social Norm Change, Bettina Shell-Duncan, Amadou Moreau, Katherine Wander, Sarah Smith

Reproductive Health

The factorial focus group methodology described in this guide provides a powerful means of illuminating the social norms that uphold female genital mutilation/cutting (FGM/C), and the ways in which meanings have at times become contested or rejected. The methods described here can be applied to the study of a wide range of behaviors influenced by social norms, such as early marriage, adoption of contraception, and more.

Long-Term Voluntary Wheel Running Does Not Alter Vascular Amyloid Burden But Reduces Neuroinflammation In The Tg-Swdi Mouse Model Of Cerebral Amyloid Angiopathy, Lisa S. Robinson, Dominique L. Popescu, Maria E. Anderson, Nikita Francis, Joshua Hatfield, Joseph K. Sullivan, Steven I. Beigelman, Feng Xu, Brenda J. Anderson, William E. Van Nostrand, John K. Robinson

Psychology Faculty Publications

Background: Cardiovascular exercise (CVE) has been shown to be protective against cognitive decline in aging and the risk for dementias, including Alzheimer’s Disease (AD). CVE has also been shown to have several beneficial effects on brain pathology and behavioral impairments in mouse models of AD; however, no studies have specifically examined the effects of CVE on cerebral amyloid angiopathy (CAA), which is the accumulation of amyloid-beta (Aβ) in the cerebral vasculature. CAA may be uniquely susceptible to beneficial effects of CVE interventions due to the location and nature of the pathology. Alternatively, CVE may exacerbate CAA pathology, due to added …

Ground Vehicle Driving Aids: Assessing Driver Workload And Performance In Degraded Visual Environments, Kayla Riegner

Dissertations, Master's Theses and Master's Reports

With degraded visual environments being a current priority to the Army, several research programs have been initiated to develop a complete sensor-to-soldier systems to allow operators to see through DVE conditions while conducting ground vehicle tactical operations. To enable indirect-driving maneuverability and threat detection in degraded visual environments (DVEs), CCDC’s ground DVE program developed and tested a range of sensors and driver aid display systems. Six candidate driving aids were identified and tested in three simulator studies and two field tests to examine the effect of driving aids on driver workload and performance in different visibility conditions. The simulator-based testing …

Extreme Molecular Diversity In Biomass Burning Atmospheric Organic Aerosol Observed Through Ultrahigh Resolution Mass Spectrometry, Matthew Brege

Dissertations, Master's Theses and Master's Reports

Ambient atmospheric aerosol is ubiquitous in the atmosphere, originating from a variety of natural and man-made sources. These microscopic particles have profound impacts on the global climate system as well as human health. The organic fraction of atmospheric aerosol is an extremely complex mixture which is not yet fully characterized. These unknown organic aerosol species contribute to the uncertainty in the effect of aerosol on climate and uncertainty in overall ambient aerosol toxicity. Light absorbing organic aerosol can interact with incoming solar radiation and contribute to atmospheric heating; however, the source apportionment and overall fate of these absorbing organic aerosol …

"'[A] Wholly New And Original Poetic Genius': Thomas Wentworth Higginson, Emily Dickinson, And Literary Immortality", Harrison Dietzman

Faculty Publications - Department of English

Beyond Higginson's personal friendship with Dickinson, his literary criticism—much of which Dickinson may have read in The Atlantic Monthly—and his editing of her poems weave a narrative about the United States' poetry to which Dickinson is the logical conclusion. Higginson relentlessly attacked Whitman, (who he perceived to be a degenerate, self-promoting charlatan), and used his literary criticism to extol characteristics, personal and poetic, that carved out a place for Dickinson, or a poet like her, in the American literary tradition. Higginson's criticism persistently seeks to answer one question: in America, what is a poetic genius? Judging by Higginson's decades-long …

Insights Into Gemcitabine Resistance And The Potential For Therapeutic Monitoring, Teklab Gebregiworgis, Fatema Bhinderwala, Vinee Purohit, Nina V. Chaika, Pankaj K. Singh, Robert Powers

Department of Chemistry: Faculty Publications

Introduction—Gemcitabine is an important component of pancreatic cancer clinical management. Unfortunately, acquired gemcitabine resistance is widespread and there are limitations to predicting and monitoring therapeutic outcomes.

Objective—To investigate the potential of metabolomics to differentiate pancreatic cancer cells that develops resistance or respond to gemcitabine treatment.

Results—We applied 1D ¹H and 2D ¹H-¹³C HSQC NMR methods to profile the metabolic signature of pancreatic cancer cells. ¹³C₆-glucose labeling identified thirty key metabolites uniquely altered between wild-type and gemcitabine-resistant cells upon gemcitabine treatment. Gemcitabine resistance was observed to reprogram glucose metabolism and to enhance the pyrimidine …

Controlling Biogenic Volatile Organic Compounds For Air Quality, Brian Sawers

Indiana Law Journal

This Article tells a story that is true but seems completely wrong: Trees can make air pollution worse. Smog and ground-level ozone require two chemical ingredients to form: nitrous oxides (NOx) and volatile organic compounds (VOCs). On a warm, sunny day, these two precursors combine to form smog and ground-level ozone, a pollutant. While NOx are pollutants that are largely human-created, VOCs can originate with plants. In fact, emissions of just one type of VOC from trees exceed all human-caused emissions.

This Article presents new research on the impact of plants, especially trees, on air quality. The science is complicated …

Introduction, June Carbone

Minnesota Journal of Law & Inequality

Introduction of articles published as a part of the North American Regional Meeting of the International Society of Family Law

Eleven Things They Don’T Tell You About Law & Economics: An Informal Introduction To Political Economy And Law, Frank Pasquale

Minnesota Journal of Law & Inequality

Many legal scholars have critiqued the dominant law and economics paradigm. However, important work is all too often neglected because it is not popularized in an accessible form. This Article features experts who synthesize their key insights into memorable and concise vignettes. Our 11 Things project is inspired by the work of the Cambridge economist Ha-Joon Chang, who distilled many facets of his work into a book called 23 Things They Don’t Tell You About Capitalism. That book was a runaway success, translated for markets around the globe, because it challenged conventional economic reasoning with a series of short and …

The Missing Image-Bearers At College: The Inclusion Of People With Intellectual Disabilities On The Christian University Campus, Emmy Edwards

Growth: The Journal of the Association for Christians in Student Development

Since the passage of the Higher Education Opportunities Act of 2008, higher education has expanded and improved access for individuals with intellectual disabilities. However, Christian colleges and universities have fallen behind in terms of creating innovative and spiritually formative programs for people with intellectual disabilities. Through the exploration of a literature review, a theological framework, and the description of three Christian programs that currently exist, this paper argues for the good of the inclusion of people with intellectual disabilities on the Christian college campus as fellow image-bearers. Additionally it contends that the Christian university has a unique position of to …

Preaching To Episodic Ears: Practicing A Dramaturgical Homiletic, Sunggu Yang

Faculty Publications - George Fox School of Theology

This article is a critical attempt to develop a homiletic methodology for preaching to the episodic self of the 21st century. The British philosopher Galen Strawson contends that postmodern people today do not regard themselves as living out their lives in a diachronic or narrative sense, but rather in an episodic-existential sense. This episodic-existential way of perceiving one’s life has recently posed a significant challenge to the current preaching practice that is mostly composed and delivered from the pulpit through a narrative. This article provides a considerate response to that episodic-existential challenge. Specifically, the article proposes a dramaturgical narrative form …

Avondale: A Neighborhood In Transition, Laura King

Vulcan Historical Review

pp. 44-54