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Asymmetric Synthesis Of The C29-C34 Moiety Of Fragment A Of The Antascomicin B & Thermal Azole Based Claisen Rearrangements, Dharma Theja Nannapaneni

Graduate Theses and Dissertations

The dissertation describes asymmetric synthesis towards C29-C34 moiety of fragment A of the Antascomicin B and Thermal azole based Claisen rearrangements. In chapter 1, we describes asymmetric synthesis towards C29-C34 moiety of fragment A of the Antascomicin B. The non-immunosuppressant Rapamycin, Ascomycin, and Tacrolimus (FK506), strongly binds with FKBP12, the ligand FKBP12 complexes responsible for immunosuppressive activity. Antascomicin B structurally related to Rapamycin, Ascomycin, and Tacrolimus (FK506), binds strongly to FKBP12, yet does not shown immunosuppressive activity. The ligand FKBP12 binding complexes shown to have potent neuroprotective and neurogenerative properties in mouse models of Parkinson’s disease. The linear synthesis of …

Coccidiosis Vaccination And Nutrient Utilization In Broiler Chickens, Alyson Elaine Gautier

Graduate Theses and Dissertations

Four experiments were conducted to evaluate the interrelationships among coccidiosis vaccination and nutrient utilization in floor-reared broiler chickens. Experiment 1 longitudinally compared the effects of coccidiosis vaccination and a chemical coccidiostat on broiler performance, nutrient digestibility, and intestinal morphology. Coccidiosis vaccination had no significant impact on morphology, overall body weight gain and feed intake of vaccinated birds, although vaccination impaired overall FCR. Vaccination elicited a transient reduction in digestibility of energy and nutrients, particularly for lipids, but vaccinated birds were able to recover from these reductions by 20 d. Experiment 2 assessed the impact of vaccination in digestibility of different …

Women In Stem: Strategies And Recommendations For Academic Women And Institutional Leaders, Sarah Jensen

Graduate Theses and Dissertations

Women still comprise a small number of full professors in STEM disciplines in research universities, which have historically been male dominated. The National Science Foundation (NSF) has recognized the challenge of getting more women to enter the professoriate, earn tenure, and advance to full professor. These women can then encourage more women to enter into STEM as educators and researchers. The purpose of this study was to recognize, explore, and depict strategies used by women full professors to overcome obstacles they faced while advancing in academic STEM fields. The study participants also offered recommendations for women faculty desiring to become …

2019 December, Morehead State University. Office Of Communications And Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2019.

Kyle's "Capture Me" (Book Review), Amy C. Rice

The Christian Librarian

No abstract provided.

Production And Purification Of Basic Fibroblast Growth Factor Fused To Two Collagen Binding Domains Expressed In E. Coli Bl21 Using Flask And Fed-Batch, Hazim Aljewari

Graduate Theses and Dissertations

Delivering effective and non-toxic doses of bioactive materials that can aid in activating tissue regeneration to wounded tissue has proven to be an enormous challenge. This study was designed to produce a potential therapeutic recombinant protein by fusing two collagen binding domains to basic fibroblast growth factors (bFGF) through a collagenase cleavage site linker, so it can release the bFGF in a wound site by the action of this enzyme. The novel fusion protein was expressed in Escherichia coli BL-21 (E. coli) using traditional flask shaker and fed-batch cultivation. Cell lysate was purified by FPLC using Immobilized metal affinity chromatography …

Investigating Growth Performance And Intestinal Barrier Integrity In Heat-Stressed Modern Broilers And Their Ancestor Jungle Fowl, Travis Tabler

Graduate Theses and Dissertations

Heat stress (HS) has a negative effect on poultry production sustainability due to its adverse consequence on bird welfare, health, growth, and mortality. Although modern broilers have greater gut mass and higher energy use efficiency than unselected birds, they are more vulnerable to HS that induces “leaky gut syndrome,” or increased intestinal permeability. The aim of the current study was to determine the effect of HS on growth performance and gut barrier integrity in three modern broiler lines and their ancestor the Jungle Fowl. Four chicken populations including Giant Jungle Fowl (JF), Athens Canadian Random Bred (ACRB), 1995 Arkansas Random …

Development Of A Comsol Microdialysis Model, Towards Creation Of Microdialysis On A Chip With Improved Geometries And Recovery, Patrick Pysz

Graduate Theses and Dissertations

Microdialysis (µD) sampling is a diffusion-limited sampling method that has been widely used in different biomedical fields for greater than 35 years. Device calibration for in vivo studies is difficult for current non-steady state analytes of interest correlated with both inflammatory response and microbial signaling molecules (QS); which exist in low ng/mL to pg/mL with molecular weights over a wide range of 170 Da to 70 kDa. The primary performance metric, relative recovery (RR), relating the collected sample to the extracellular space concentration varies from 10% to 60% per analyte even under controlled bench-top conditions. Innovations in microdialysis device design …

Solutions For Fermi Questions, December 2019: Question 1: Electric Cars; Question 2: Chicken Poop, Larry Weinstein

Physics Faculty Publications

How much more electrical energy will the United States need to generate if everyone drives electric cars? B I Answer: i b If we all switch from gasoline-fueled to electricity-fueled cars, then we will need to generate more electrical energy. Thus, if we replace all of our gasoline-fueled cars with electricity-fueled cars, we will need to generate about 30% more electrical energy. [Extracted from the article]

Purged, Veenal Ronald D'Silva

Theses

This paper describes the entire thought process, the work and journey behind the completion of my Thesis Film titled “PURGED”. This film was animated in 3D and created over the course of four semesters. Purged is a thrilling short animated film about a couple’s escape from death. The film mainly revolves around a couple; namely the white king and queen, and how death; the black pieces of a chessboard enact out the game as if it’s happening in real life until the big reveal at the end of it merely being a game of chess.

The film is centered around …

Modeling Interacting Time-Series Signals, Kantha Girish Gangadhara

Theses

Many real-life systems consist of multiple information signals which might be potentially interacting with each other over time. These interactions can be estimated/modeled using techniques like Pearson Correlation (PC), Time lagged Cross Correlation (TLCC) and windowed TLCC, Dynamic Time Warping (DTW), and coupled Hidden Markov Model (cHMM). These techniques, excluding cHMM, cannot capture non-linear interactions and does not work well with multi-variate data. Although cHMM can capture the interactions effectively, it is bound by Markov property and other assumptions like latent variables, prior distributions, etc. These influence the performance of the model significantly. Recurrent Neural Network (RNN) is a variant …

An Ar Enhancement Of Printed Educational Resources: Keeping Printed Educational Materials Competitive In A Digital Age, Dax Simitch Warke

Theses

Digital resources have begun to take over our educational system and overshadow traditional printed resources. While these digital resources are becoming increasingly popular research has shown that printed resources have notable benefits that should not be dismissed. Enhancing these printed resources with augmented reality (AR) technology will allow them to be competitive with digital resources while preserving their academic benefits. The readily available smart devices carried in the pockets of most students have already prepared many classrooms for the use of AR. The interactive and visual potential of AR makes it an appealing educational tool that can dramatically improve the …

What A Night, Jose Hidalgo Thormann

Theses

Producing an audiovisual work is the ability to transform an idea, a story, a script into a tangible product, to bring it closer to the screen. After the production of any project, it is ready to be filmed. In this project, you can find the memories to carry out the production of a fiction short film entitled What A Night. This paper discusses the making of the short film by Jose Hidalgo Thormann to fulfill his thesis requirement to receive his MFA in Film and Animation from the Rochester Institute of Technology

Did I Tell You About My Date Last Night?, Palwasha Azimi

Theses

did i tell you about my date last night? is an animated short that illustrates a transformation in two characters who are experiencing their date together in different ways.

This film gives a small taste of a larger story that all women go through, whether or not they know it’s happening.

It is a tale of toxic masculinity, gaslighting, consent and entitlement. These things have been ever-present in history but never contested and brought to light on a scale like this. Recently, these issues have risen to the forefront of social change. Now, because of the internet, the support of …

Examining Kamma/Karma Doctrine In The Buddhist Jātakas, Chandrabhan P. Yadav

Articles

Several scholars have seriously challenged the cherished egalitarian ethos of Buddhism after Ambedkar’s political as well as academic engagement with Buddhism. However, most have not explored Buddhist sources to examine the nitty gritty of the kamma/karma question.

Imaginary Conquests: Folktales, Film, And The Japanese Empire In Asia, Richard M Davis

Research Collection School of Social Sciences

This article highlights three family-targeted films made under the wartime Japanese empire: Yamamoto Kajir ō ’s musical comedy Songokū (1940) and Seo Mitsuyo’s animated Momotarō films, Sea Eagles (1943) and Divine Warriors of the Sea (1945). Significantly, these films are based on two fantastical premodern stories—the Chinese novel Journey to the West and the Japanese Momotarō legend, respectively—whose quest narratives map onto Japan’s contemporaneous military expansion into mainland China and the islands of the South Pacific. Despite the films’ seeming alignment with ultranationalist ideology, I argue that the geopolitical trajectories of their narratives are rendered ambiguous by their various reception …

Tuning Networks For Prosocial Behavior: From Senseless Swarms To Smart Mobs [Commentary], Sun Sun Lim, Roland Bouffanais

Research Collection College of Integrative Studies

Social media have been seen to accelerate the spread of negative content such as disinformation and hate speech, often unleashing a reckless herd mentality within networks, further aggravated by malicious entities using bots for amplification. So far, the response to this emerging global crisis has centered around social media platform companies making reactive moves that appear to have greater symbolic value than practical utility. Proposes a solution to favor prosocial behavior via social networks.

Acne Severity And Sleep Quality In Adults., Kory P Schrom, Sayeeda Ahsanuddin, Michelle Baechtold, Raghav Tripathi, Amy Ramser, Elma Baron

Ambulatory and Primary Care Articles

Poor sleep quality is extremely prevalent, with about one third of adults in the USA obtaining less than the recommended amount of sleep. In addition, poor sleep quality has been linked to an increased risk of many conditions, including diabetes, hypertension, psychiatric conditions, and overall all-cause mortality. Research has shown that sleep disturbance does impact skin disease, although many details of this relationship are still unclear. The goal of this study is to determine if there is a relationship between acne severity and sleep quality in adults. Forty subjects with acne were recruited from dermatology clinics in Cleveland, OH, to …

Synthesis, Characterization, And Drug Delivery Applications Of Carbohydrate Based Low Molecular Weight Gelators, Kristen Elizabeth Bashaw

Chemistry & Biochemistry Theses & Dissertations

The main aim of the research focuses on the study of self-assembly and gelation by several classes of simple sugar derivatives and the potential applications of them as drug delivery vehicles. Since carbohydrates are naturally abundant renewable resources and are therefore readily available and many of them are inexpensive compared to other raw materials. They are also biocompatible which makes them suitable for a wide variety of applications. Combining the use of carbohydrates with low molecular weight gelators (LMWGs) we can introduce a new class of soft materials that are able to self-assemble into spheres, fibers, sheets, and micelles in …

Living Links Connecting The United Nations Sustainable Development Goals: Small-Scale Farmers And Agricultural Biodiversity, Susan H. Bragdon

San Diego International Law Journal

The 17 Sustainable Development Goals (SDGs) and Agenda 2030 adopted by the global community in September 2015 are applicable to all countries with the commitment “that no one is left behind.” As an agenda for “people, planet, prosperity, peace and partnership”, Agenda 2030 provides a vision for people and planet-centered, human rights-based, and gender-sensitive sustainable development. It promises “more peaceful and inclusive societies” which are free from fear and violence.

Small scale farmers and agricultural biodiversity are critical to the achievement of aspects of most of the SDGs. In addition to being essential for the resilience and stability of agricultural …

High Tensile Permanent Electric Fence, Planning And Design, Matthew Palmer, Eric Thacker, Shannon Cromwell, Kevin Heaton, Kohl Carter

All Current Publications

This fact sheet provides detailed information about planning and designing a permanent electric fence.

Dexamethasone As Abortive Treatment For Refractory Seizures Or Status Epilepticus In The Inpatient Setting, Alexander B. Ramos, Roberto A. Cruz, Nicole R. Villemarette-Pittman, Piotr W. Olejniczak, Edward C. Mader Jr.

School of Medicine Publications

Refractory seizures or status epilepticus (RS/SE) continues to be a challenge in the inpatient setting. Failure to abort a seizure with antiepileptic drugs (AEDs) may lead to intubation and treatment with general anesthesia exposing patients to complications, extending hospitalization, and increasing the cost of care. Studies have shown a key role of inflammatory mediators in seizure generation and termination. We describe 4 patients with RS/SE that was aborted when dexamethasone was added to conventional AEDs: a 61-year-old female with temporal lobe epilepsy who presented with delirium, nonconvulsive status epilepticus, and oculomyoclonic status; a 56-year-old female with history of traumatic left …

Recycled Electronic Plastic And Marine Litter, Emma J. Shaw, Andrew Turner

School of Geography, Earth and Environmental Sciences

No abstract provided.

Estimation Of Complement Components (C3 And C4) And Hs-Crp Level In Kidney Failure Patients, Zaid N. Elia, Nisreen W. Mustafa

Polytechnic Journal

Several kidney diseases associated with complement activation. Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. This study was aimed to detect the level of complement system in kidney failure patients. This study was included (30) patients with renal failure and (15) healthy donors as control group. Serum samples separated from the whole blood of patients and healthy individuals. C3, C4, and high sensitive C- reactive protein (hsCRP) levels were estimated for all samples. The results were analyzed according to patients who were dialysis, non-dialysis, with diabetes, …

Isolation, Identification, And Antibiotics Susceptibility Determination Of Proteus Species Obtained From Various Clinical Specimens In Erbil City, Treska Dhia Kamil, Sanaria Fawzi Jarjes

Polytechnic Journal

Fifty-two Proteus isolates, (47) Proteus mirabilis, (4) Proteus vulgaris, and (1) Proteus hauseri are being isolated from (200) clinical specimens taken from patients admitted to different hospitals in Erbil city/Kurdistan region of Iraq. Specimens were of urine, wounds swabs, burn swabs, vaginal swabs, ear swabs, eye swabs, and sputum. All isolates were identified depending on cultural, morphological, biochemical characteristics, and confirmatory VITEK 2 system. Furthermore, VITEK 2 (antibiotic susceptibility testing) panel was used to determine the antibiotic susceptibility of Proteus isolates, and the results showed that all isolates were entirely resistant to tetracycline and tigecycline (100%), but sensitive to meropenem. …

Spanish Food Duelos Y Quebrantos ‘Sorrows And Breakings’ In Light Of Hot Dog, Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

No abstract provided.

Novel Mechanistic Insight Into The Anticancer Activity Of Cucurbitacin D Against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer), Mohammed Sikander, Shabnam Malik, Sheema Khan, Sonam Kumari, Neeraj Chauhan, Parvez Khan, Fathi T. Halaweish, Bhavin Chauhan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is gemcitabine, but its success is poor due to the emergence of drug resistance. Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. However, there is no report on the therapeutic effect of Cuc D in PanCa. In the present study, we investigated the effects of the Cuc D on PanCa cells in vitro and in vivo. Cuc D inhibited …

Messina (Melilotus Siculus)–A New Pasture Legume For Saltland, Amanda L. Bonython, Andrew D. Craig, Ross A. Ballard, Nigel Charman, Philip G. H. Nichols, Clinton Revell, Natasha L. Teakle

IGC Proceedings (1977-2023)

Messina (Melilotus siculus ((Turra) Vitman ex B.D. Jacks)) is a new annual pasture legume for saltland in temperate Australia and regions of the world that experience Mediterranean climates. Messina has greater tolerance to the combined stresses of salinity and water-logging than existing commercial pasture legumes. Coupled with desirable agronomic traits these characteristics give messina the capacity to rehabilitate saltland and increase productivity on land where existing legumes fail. This paper reviews the agronomic perform-ance of messina in relation to top soil salinity levels.

Agronomic Traits In Tall Fescue Populations Under Irrigated And Rain-Fed Conditions, M. Anowarul Islam, Malay C. Saha

IGC Proceedings (1977-2023)

Grasslands and native rangelands are the predominant land-use all over the world. Tall fescue [Schedonorus arundinaceus (Schreb.) Dumort] is a cool-season perennial grass widely grown throughout the temperate regions of the world and an important component of the grasslands. Drought can have serious consequences on performance of agriculture, soil and plant health, and economics. Developing drought tolerant plants that can maintain productivity during drought, will have great environmental and economic benefits to farmers. A tall fescue population was developed by crossing a drought tolerant genotype to a susceptible genotype. The population was evaluated for different morphological and yield traits …

Advances In Improving Tolerance To Waterlogging In Brachiaria Grasses, Juan A. Cardoso, Juan Jiménez, Joisse Rincón, Edward Guevara, Rein Van Der Hoek, Andy Jarvis, Michael Peters, John Miles, Miguel Ayarza, Socorro Cajas, Alvaro Rincón, Henry Mateus, Jaime Quiceno, Wilson Barragán, Carlos Lascano, Pedro Argel, Martin Mena, Luis Hertentains, Idupulapati M. Rao

IGC Proceedings (1977-2023)

Poor drainage is found on about 11.3% of agricultural land in Latin America where physiography promotes flooding, high groundwater tables, or stagnant surface water (waterlogging). Waterlogging drastically reduces oxygen diffusion into the soil causing hypoxia which is the main limitation that reduces root aerobic respiration and the absorption of minerals and water. Under waterlogging conditions plants can adapt with traits and mechanisms that improve root aeration such as production of aerenchyma and development of adventitious roots. During the rainy season Brachiaria pastures are exposed to waterlogging conditions that can severely limit pasture productivity and hence animal production. The main objective …