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2019

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Displays Of Medici Wealth And Authority: The Acts Of The Apostles And Valois Fêtes Tapestry Cycles, Madison L. Clyburn Jan 2019

Displays Of Medici Wealth And Authority: The Acts Of The Apostles And Valois Fêtes Tapestry Cycles, Madison L. Clyburn

Honors Undergraduate Theses

The objective of my research is to explore Medici extravagance, power, and wealth through the multifaceted artistic form of tapestries vis-à-vis two particular tapestry cycles; the Acts of the Apostles and the Valois Fêtes. The cycles were commissioned by Pope Leo X (1475-1521), the first Medici pope, and Catherine de' Medici (1519-1589), queen, queen regent, and queen mother of France. The motivation for such a project lies in analyzing what is traditionally considered as two independent tapestry cycles by revealing their social, religious, political, and artistic significance through the powerful dynastic influence of the Medici. As Leo and Catherine were …

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The Feminine Margin: The Re-Imagining Of One Professor's Rhetorical Pedagogy--A Curriculum Project, Camila Alvarez Jan 2019

The Feminine Margin: The Re-Imagining Of One Professor's Rhetorical Pedagogy--A Curriculum Project, Camila Alvarez

Electronic Theses and Dissertations

Writing pedagogy uses techniques that institutionalize dichotomous thinking rather than work against it. Cartesian duality has helped to create the marginalization of people, environments, and animals inherent in Western thought. Writing pedagogy based in current-traditional rhetoric uses a writing process that reinforces the hierarchical structure of Self/Other, Author/Reader, and Teacher/Student. This structure, in conjunction with capitalism, prioritizes the self and financial gain while diminishing and objectifying the other. The thought process behind the objectification and monetization of the other created the unsustainable business and life practices behind global warming, racism, sexism, and environmental destruction. A reframing of pedagogical writing practices …

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Collective Nobility: Spinoza And The Politics Of Emotion, Ethan K. Uhlig Jan 2019

Collective Nobility: Spinoza And The Politics Of Emotion, Ethan K. Uhlig

Honors Undergraduate Theses

The intent of this thesis is to examine Spinoza's philosophy of emotion as it relates to groups of individuals, or collectives. These groups, especially political collectives such as nation-states, are evaluated through Spinozist understandings of virtue, nobility, and blessedness. From this analysis, a novel concept of "collective nobility" is used to create philosophical guidance for the emotional dimensions of politics and state action. Drug policy is used as a case study to understand how emotion influences policymaking and vice versa, both negatively (as in the United States) and positively (as in Portugal).

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The Metaphysics Of The Collective Unconscious, Oscar B. Jablon Jan 2019

The Metaphysics Of The Collective Unconscious, Oscar B. Jablon

Honors Undergraduate Theses

This thesis shows how the metaphysical features of the Jungian collective unconscious can be demystified by viewing the collective unconscious through the lens of functionalism. The features of the collective unconscious that will be investigated in this thesis are the possibility of the collective unconscious being present in every person, the archetypes as being the formal feature of some of our modes of perception, psychic energy, and synchronicity. By admitting functionalism, Jung doesn't need to posit synchronicity to explain how it is possible for the archetypes to interact with the body. This is because functionalism can view mental states as …

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Women's Work: Materializing Feminist Thought In Lucy Lippard's C.7,500 Exhibition, Francesca Felicella Jan 2019

Women's Work: Materializing Feminist Thought In Lucy Lippard's C.7,500 Exhibition, Francesca Felicella

Honors Undergraduate Theses

This thesis aims to explore the c.7,500 exhibition curated by Lucy Lippard as a culminating point for Lippard's activism in the arts, and more specifically, women's representation in conceptualism. Understanding Lippard's political involvement within the arts and the networks established before c.7,500 further illuminates the activist approach of an all-women's art show. Throughout Lippard's career, she has advanced the exposure of women artists through her curatorial endeavors and written criticism. Her Numbers series is continuously referenced today though little documentation of each show has been easily accessible. By looking at ephemeral artifacts and artworks from c.7,500 I aim to establish …

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Latchkey: A Memoir In Essays, Nicole C. Pendleton Jan 2019

Latchkey: A Memoir In Essays, Nicole C. Pendleton

Honors Undergraduate Theses

"Latchkey: A Memoir in Essays" is an essay collection that follows the narrator through her childhood as it relates to being raised a latchkey kid in the 1980s. The lack of published academic studies that follow children through their experience as latchkey kids and into adulthood leaves personal exploration as the primary means through which a child, specifically a young girl, can seek understanding as to how her view of the world develops. Each of the five essays explores issues of autonomy, self-efficacy, sexuality, addiction, and familial bonds. It is through her reflection of specific events – the loss of …

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Of Martyrs And Minstrels, Trevon J. Coleman Jan 2019

Of Martyrs And Minstrels, Trevon J. Coleman

Honors Undergraduate Theses

"Our search for understanding in matters of race automatically incline us toward blackness, although that is not where these answers lie." – Nell Irvin Painter. Over the course of, and in partial fulfillment for, the degree of Bachelor of Fine Arts in Studio Art and the degree of Bachelor of Fine Arts in Film Production, I have produced a multimedia body of work. I made this body of work as a reflection and result of my processes and studies, and as a method to examine perception, and representation in relation to identity. This body of work combines drawing, painting, printmaking, …

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Open World Translation: Localizing Japanese Video Games For A Globalizing World, Emily Suvannasankha Jan 2019

Open World Translation: Localizing Japanese Video Games For A Globalizing World, Emily Suvannasankha

Honors Undergraduate Theses

This paper investigates the most effective ways of handling cultural differences in the Japanese-to-English game localization process. The thesis advocates for applying the Skopos theory of translation to game localization; analyzes how topics such as social issues, humor, fan translation, transcreation, and censorship have been handled in the past; and explores how international players react to developers' localization choices. It also includes interviews with three Japanese-to-English translators who have worked with major Japanese game companies to gain insight into how the industry operates today. Through the deconstruction of different aspects of Japanese-to-English localization, this analysis aims to help the game …

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Music And The Presidency: How Campaign Songs Sold The Image Of Presidential Candidates, Gary M. Bogers Jan 2019

Music And The Presidency: How Campaign Songs Sold The Image Of Presidential Candidates, Gary M. Bogers

Honors Undergraduate Theses

In this thesis, I will discuss the importance of campaign songs and how they were used throughout three distinctly different U.S. presidential elections: the 1960 campaign of Senator John Fitzgerald Kennedy against Vice President Richard Milhouse Nixon, the 1984 reelection campaign of President Ronald Wilson Reagan against Vice President Walter Frederick Mondale, and the 2008 campaign of Senator Barack Hussein Obama against Senator John Sidney McCain. In doing so, there will be an analysis of how music was used to sell the image of these presidential candidates through both its juxtaposition with other forms of mass media (television advertisements, radio, …

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An Ecofeminist Analysis Of The Ready-Made Garment Industry In Bangladesh, Yasmin Fakhoury Jan 2019

An Ecofeminist Analysis Of The Ready-Made Garment Industry In Bangladesh, Yasmin Fakhoury

Honors Undergraduate Theses

Bangladesh's ready-made garment industry and its harsh working conditions have been the center of intense scrutiny for the past decade, especially following the massive death tolls of the Tazreen Fashions factory fire in 2012 and the Rana Plaza building collapse in 2013. While lauded by many for its tremendous contributions to the Bangladeshi economy and its employment of primarily women, the garment industry is responsible for causing harm both to the women who work there and the local environment. Women workers are physically and verbally abused in the workplace for little pay, while the factories emit pollutants that contaminate the …

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The Present State Of Things: Class Struggle In The 21st Century, Lukas M. Desjardins Jan 2019

The Present State Of Things: Class Struggle In The 21st Century, Lukas M. Desjardins

USF St. Petersburg campus Honors Program Theses (Undergraduate)

No abstract provided.

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“But In A Story, I Can Steal [Its] Soul”: Vietnam War Veterans And The Literature Of Catharsis, Gina P. E. Marks Jan 2019

“But In A Story, I Can Steal [Its] Soul”: Vietnam War Veterans And The Literature Of Catharsis, Gina P. E. Marks

USF St. Petersburg campus Honors Program Theses (Undergraduate)

How does a returning veteran cope with the consequences of their experiences in a war they were drafted to fight? How do they face a society that sees that war only in statistics, only in the clips seen on the nightly news across the dinner table, only from what seems like another world? How do they explain how it felt to watch his friends get shot down with a sudden pop or step on a grenade and explode in the sky? How do they explain how it felt to kill someone, to take the life of a stranger because they …

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Buried Treasure: Excavating Foreign Law From Civil Pleadings Filed In U.S. Federal Courts, Loren Turner Jan 2019

Buried Treasure: Excavating Foreign Law From Civil Pleadings Filed In U.S. Federal Courts, Loren Turner

Articles

The Animal Science case is one of many cases in U.S. federal courts wherein parties rely in some measure on foreign law as part of a claim or defense. Yet, none of our legal research databases tracks and catalogs the foreign law and legal analysis filed in our courts. In fact, none of our legal research databases even provides an efficient way to find the foreign law and legal analysis filed in our courts. Despite the increasing frequency of cross-border litigation and the various types of cases that trigger a need to determine foreign law, access to foreign law as …

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Reducing Survey Hypothetical Bias Through Revealed Behavior Priming: A Case Of Student Preference For Beef Served By University Dining, Gaby De Nascimento Mandlhate Jan 2019

Reducing Survey Hypothetical Bias Through Revealed Behavior Priming: A Case Of Student Preference For Beef Served By University Dining, Gaby De Nascimento Mandlhate

Theses and Dissertations--Agricultural Economics

Economists are still searching for methods to reduce/eliminate Hypothetical Bias (HB). Different methods have been previously applied some with success and others without. In this study, we aimed to further test the cognitive dissonance approach (CD) through a learning design method to estimate the WTP for five beef attributes: Non-quality, Kentucky Proud, Appalachian, Grass Fed and a mix of 25% Non-quality and 75% Kentucky Proud, using a one and one half bounded model. To test the CD, 881 participants from the University of Kentucky, were randomly assigned to a real/hypothetical market for a battery recycling project at first and afterwards …

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Protecting The Nation From Honor Killings: The Construction Of A Problem, Leti Volpp Jan 2019

Protecting The Nation From Honor Killings: The Construction Of A Problem, Leti Volpp

Constitutional Commentary, Vols 1–36 (1984–2022)

Symposium: Constitutional Law in the Trump Era

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Phillis Wheatley And Carolina Maria De Jesus: Unexpected Voices Of Revolutionary Times, Tami L. Toms Jan 2019

Phillis Wheatley And Carolina Maria De Jesus: Unexpected Voices Of Revolutionary Times, Tami L. Toms

USF St. Petersburg campus Master's Theses (Graduate)

The works of Phillis Wheatley and Carolina Maria de Jesus are compared using the concept of jeitinho, a Portuguese word for a little way The creative and crafty method of jeitinho is identified in both writers’ work and gives a lens to see a different level of engagement in criticism. Both writers have been criticized for their lack of social commentary, but the introduction of jeitinho shows their subtle, yet clear assessment of their society. By re-evaluating the contributions made by each author, it is possible to reclaim their relevance as authors.

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Effects Of In Situ Incubation Temperatures On Hatchling Loggerhead Sea Turtle (Caretta Caretta) Morphology, Health Indices, And Locomotor Performance, Kelsey Alexandra Fleming Jan 2019

Effects Of In Situ Incubation Temperatures On Hatchling Loggerhead Sea Turtle (Caretta Caretta) Morphology, Health Indices, And Locomotor Performance, Kelsey Alexandra Fleming

USF St. Petersburg campus Master's Theses (Graduate)

Incubation temperatures, in addition to an embryo’s genetic makeup, play crucial roles in development and alter a variety of characteristics in sea turtle embryos. Atmospheric temperatures are currently predicted to rise at least 1.5°C above preindustrial levels by 2052, potentially impacting embryonic development. Most sea turtle temperature studies document the effects of “high” and “low” incubation temperatures in laboratory-reared nests. This study’s objective was to examine impacts of varying in situ incubation temperatures on loggerhead sea turtle (Caretta caretta) hatchling morphology, health, and locomotor performance. Temperature data loggers were deployed in 15 individual loggerhead nests on Juno Beach, Florida between …

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Comparing The Fertility Of Florida’S Eastern Mosquitofish, Gambusia Holbrooki, Based On Differences In Female Traits, Water Quality, And Habitat Type, Jordan David Miller Jan 2019

Comparing The Fertility Of Florida’S Eastern Mosquitofish, Gambusia Holbrooki, Based On Differences In Female Traits, Water Quality, And Habitat Type, Jordan David Miller

USF St. Petersburg campus Master's Theses (Graduate)

The eastern mosquitofish, Gambusia holbrooki, is a surface-dwelling guppy native to the southeastern United States. While resilient to poor water quality, the fish is a voracious predator of the epilimnion, with established populations in most subtropical/tropical regions with surficial freshwater. Eastern mosquitofish are farmed and collected for use as biocontrol agents against the spread of many infectious, often life-threatening, mosquito-borne illnesses. I compared the reproductive success (fertility) of 370 gravid mosquitofish among 32 sites across central Florida to test the hypothesis that fertility is influenced by maternal, ecological, and environmental factors. I found that fish fertility (clutch size) differed significantly …

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A Comparative Behavioral Analysis Of Time Budgets Of Sea Turtles At The Florida Aquarium Through The Application Of An Ethogram, Kate Rae Lowry Jan 2019

A Comparative Behavioral Analysis Of Time Budgets Of Sea Turtles At The Florida Aquarium Through The Application Of An Ethogram, Kate Rae Lowry

USF St. Petersburg campus Master's Theses (Graduate)

Sea turtles are a crucial component of many coastline habitats due to their roles as ecosystem engineers and their ability to raise awareness for conservation efforts. Despite the extensive amount of research conducted on nesting behaviors of wild sea turtles, there are few behavioral studies of turtles in managed care. Sea turtles were observed at The Florida Aquarium from February 2018 to May 2019 to examine possible variations among behavior for five Loggerhead (Caretta caretta), Green (Chelonia mydas), and Kemp’s Ridley turtles (Lepidochelys kempii). The first part of this study includes a baseline time budget for the five turtles using …

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Pah Exposure In Red Snapper (Lutjanus Campechanus) Collected At Natural And Artificial Reef Systems In The Northwestern Gulf Of Mexico, Tiffany Jane Nicholson Jan 2019

Pah Exposure In Red Snapper (Lutjanus Campechanus) Collected At Natural And Artificial Reef Systems In The Northwestern Gulf Of Mexico, Tiffany Jane Nicholson

USF St. Petersburg campus Master's Theses (Graduate)

Red Snapper are commonly recognized as an important fishery across the bordering states of the Gulf of Mexico (GoM) and are found in abundance around oil and gas platforms. A small, yet toxic and environmentally persistent component, of crude oil known as polycyclic aromatic hydrocarbons (PAHs), are released into Gulf waters through both anthropogenic (e.g., oil and gas activities) and natural (e.g., hydrocarbon seeps) sources. These pollutants are associated with a variety of negative health effects in fish including cardio-toxicity, reproductive and developmental impairment, and external skin lesions. The objectives of this study were to measure and to compare PAH …

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A Survey And Comparison Of Plant Communities In Crescent Lake Park, An Urban Lake In St. Petersburg, Florida, Hunter Hajaistron Jan 2019

A Survey And Comparison Of Plant Communities In Crescent Lake Park, An Urban Lake In St. Petersburg, Florida, Hunter Hajaistron

USF St. Petersburg campus Master's Theses (Graduate)

In Florida, urban lakes are challenged. Pollution from surrounding urban ecosystems is detrimental to the ecological health of these lakes. Planting and restoring native wetlands along the littoral zone of these lakes will reduce the effects of pollution. Crescent Lake is an urban lake in Pinellas County, Florida, USA, that has recently begun to restore its wetlands system. This study surveys and evaluates the plant species in the wetland, shoreline, and parkland habitats of Crescent Lake to determine the effectiveness of management. Transects and quadrats were used to determine the diversity and structure of native and non-native plant species. 58 …

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Novel Habitat Causes A Shift To Diurnal Activity In A Nocturnal Species, J. Sean Doody, Colin R. Mchenry, David Rhind, Simon Clulow Jan 2019

Novel Habitat Causes A Shift To Diurnal Activity In A Nocturnal Species, J. Sean Doody, Colin R. Mchenry, David Rhind, Simon Clulow

USF St. Petersburg Campus Faculty Publications

Plastic responses may allow individuals to survive and reproduce in novel environments, and can facilitate the establishment of viable populations. But can novel environments reveal plasticity by causing a shift in a behavior as fundamental and conspicuous as daily activity? We studied daily activity times near the invasion front of the cane toad (Rhinella marina), an invasive species that has colonized much of northern Australia. Cane toads in Australia are nocturnal, probably because diurnal activity would subject them to intolerably hot and dry conditions in the tropical savannah during the dry season. Our study can demonstrate, however, that upon reaching …

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Lipophagy And Alcohol-Induced Fatty Liver, Li Yang, Changqing Yang, Paul G. Thomes, Kusum K. Kharbanda, Carol A. Casey, Mark A. Mcniven, Terrence M. Donohue Jan 2019

Lipophagy And Alcohol-Induced Fatty Liver, Li Yang, Changqing Yang, Paul G. Thomes, Kusum K. Kharbanda, Carol A. Casey, Mark A. Mcniven, Terrence M. Donohue

Journal Articles: Internal Medicine

This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes. During classical autophagy, also known as macroautophagy, all forms of macromolecules and organelles are sequestered in autophagosomes, which, with their cargo, fuse with lysosomes, forming autolysosomes in which the cargo is degraded. It is well established that excessive drinking accelerates intrahepatic lipid biosynthesis, enhances uptake of fatty acids by the liver from the plasma and impairs hepatic secretion of lipoproteins. All the latter contribute to alcohol-induced fatty liver (steatosis). Here, our …

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Silent Takeover! Invasive Plants In Florida, Katherine Harris, Linda Walters, Samantha Yuan Jan 2019

Silent Takeover! Invasive Plants In Florida, Katherine Harris, Linda Walters, Samantha Yuan

CEELAB Children's Books

Native plants in Florida create the beautiful, wild world around us. But they are in danger! Hundreds of invasive plant species are silently taking over Florida's natural environment. These unwelcome plants grow aggressively and can overgrow native plants and animals in many different habitats. Invasive plants are so widespread that there may even be some growing in your backyard. Look inside to learn about Florida's invasive plant problem. Find out about some of the most harmful invasive plants, the problems they cause to natural ecosystems, and how you can help to manage invasive plants to help keep Florida native and …

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Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien Adriaenssens, Bas Dutilh, Eugene Koonin, Andrew Kropinski, Mart Krupovic, Mya Breitbart, Karyna Rosario Jan 2019

Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien Adriaenssens, Bas Dutilh, Eugene Koonin, Andrew Kropinski, Mart Krupovic, Mya Breitbart, Karyna Rosario

Marine Science Faculty Publications

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. In turn, this should enable more robust comparative …

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Pepper Mild Mottle Virus: Agricultural Menace Turned Effective Tool For Microbial Water Quality Monitoring And Assessing (Waste)Water Treatment Technologies, Erin Symonds, Karyna Rosario, Mya Breitbart Jan 2019

Pepper Mild Mottle Virus: Agricultural Menace Turned Effective Tool For Microbial Water Quality Monitoring And Assessing (Waste)Water Treatment Technologies, Erin Symonds, Karyna Rosario, Mya Breitbart

Marine Science Faculty Publications

No abstract provided.

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Developing High Resolution Baseline Coast Resource Maps Using World View 2 Imagery For A Coastal Village In Fiji, Ashneel Ajay Singh, Anish Maharaj, Michelle Kumar, Priyatma Singh, Sanjay Singh, Frank Muller-Karger, Matthew James Mccarthy, Lionel Joseph, Herve Damlamian, Zulfikar Begg Jan 2019

Developing High Resolution Baseline Coast Resource Maps Using World View 2 Imagery For A Coastal Village In Fiji, Ashneel Ajay Singh, Anish Maharaj, Michelle Kumar, Priyatma Singh, Sanjay Singh, Frank Muller-Karger, Matthew James Mccarthy, Lionel Joseph, Herve Damlamian, Zulfikar Begg

Marine Science Faculty Publications

In Fiji, like most Pacific Island countries, there have been numerous reports of degradation of coastal resources, including adverse changes in abundance and stock distribution of numerous aquatic species associated with the coastal habitat. To develop effective management plans, assessment of existing coastal resources is pertinent. High spatial resolution satellite imagery, combined with geographic information systems allow for efficient and synoptic mapping of coastal resources to provide a baseline for developing effective and improved management plans. The purpose of this study was to develop a baseline habitat map of the intertidal benthic cover in Komave Village, Coral Coast, Sigatoka, Fiji. …

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Cyclized Ndga Modifies Dynamic Α-Synuclein Monomers Preventing Aggregation And Toxicity, Malcolm J. Daniels, J. Brucker Nourse, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J. Ferrie, Conor M. Haney, Rani Moons, Neal S. Gould, Antonino Natalello, Rita Grandori, Frank Sobott, E. James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vladimir N. Uversky, Kim A. Caldwell, Guy A. Caldwell, Edward S. Krol, Harry Ischiropoulos Jan 2019

Cyclized Ndga Modifies Dynamic Α-Synuclein Monomers Preventing Aggregation And Toxicity, Malcolm J. Daniels, J. Brucker Nourse, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J. Ferrie, Conor M. Haney, Rani Moons, Neal S. Gould, Antonino Natalello, Rita Grandori, Frank Sobott, E. James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vladimir N. Uversky, Kim A. Caldwell, Guy A. Caldwell, Edward S. Krol, Harry Ischiropoulos

Molecular Medicine Faculty Publications

Growing evidence implicates α-synuclein aggregation as a key driver of neurodegeneration in Parkinson’s disease (PD) and other neurodegenerative disorders. Herein, the molecular and structural mechanisms of inhibiting α-synuclein aggregation by novel analogs of nordihydroguaiaretic acid (NDGA), a phenolic dibenzenediol lignan, were explored using an array of biochemical and biophysical methodologies. NDGA analogs induced modest, progressive compaction of monomeric α-synuclein, preventing aggregation into amyloid-like fibrils. This conformational remodeling preserved the dynamic adoption of α-helical conformations, which are essential for physiological membrane interactions. Oxidation-dependent NDGA cyclization was required for the interaction with monomeric α-synuclein. NDGA analog-pretreated α-synuclein did not aggregate even without …

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Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair Jan 2019

Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair

Molecular Medicine Faculty Publications

Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein-induced neurotoxicity and disease progression. Molecular chaperones have a wide range of functions from facilitating proper nascent folding and refolding to degradation or sequestration of misfolded substrates. In disease states, molecular chaperones can display protective or aberrant effects, including the promotion and stabilization of toxic protein aggregates. This seems to be dependent on the aggregating protein and discrete chaperone interaction. Small heat shock proteins (sHsps) are a class of molecular chaperones …

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Rational Discovery Of Antimetastatic Agents Targeting The Intrinsically Disordered Region Of Mbd2, Min Young Kim, Insung Na, Ji Sook Kim, Seung Han Son, Sungwoo Choi, Seol Eui Lee, Ji-Hun Kim, Kiseok Jang, Gil Alterovitz, Yu Chen, Arjant Van Der Vaar, Hyung-Sik Won, Vladimir N. Uversky, Chul Geun Kim Jan 2019

Rational Discovery Of Antimetastatic Agents Targeting The Intrinsically Disordered Region Of Mbd2, Min Young Kim, Insung Na, Ji Sook Kim, Seung Han Son, Sungwoo Choi, Seol Eui Lee, Ji-Hun Kim, Kiseok Jang, Gil Alterovitz, Yu Chen, Arjant Van Der Vaar, Hyung-Sik Won, Vladimir N. Uversky, Chul Geun Kim

Molecular Medicine Faculty Publications

Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging due to their extreme structural flexibility. We report a rational discovery of inhibitors targeting an IDPR of MBD2 that undergoes disorder-to-order transition upon PPI and is critical for the regulation of the Mi-2/NuRD chromatin remodeling complex (CRC). Computational biology was essential for identifying target site, searching for promising leads, and assessing their binding feasibility and off-target probability. Molecular action of selected leads inhibiting the targeted PPI of MBD2 was validated in vitro and in cell, followed by confirming their …

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