Digital Commons Network^™

Identification Of The Kaposi's Sarcoma-Associated Herpesvirus (Kshv) Surface Glycoprotein Targets Of Human Kshv-Specific Neutralizing Antibody Responses, Yasaman Mortazavi

School of Biological Sciences: Dissertations, Theses, and Student Research

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the etiological agent of Kaposi’s sarcoma (KS), and is also associated with two B cell malignancies, primary effusion lymphoma and multicentric Castleman's disease. The distribution of KSHV varies globally with high prevalence in some areas of sub-Saharan Africa (SSA), where seroprevalence can be as high as 80%. It is estimated that nearly 44,000 new cases of KS emerge annually globally, with the highest incidents occurring in Africa, where KSHV is endemic. Currently, there is no prophylactic vaccine against KSHV, and efforts to develop prophylactic vaccines have been limited. …

Black Fatherhood In America Through The Lens Of Contemporary Memoir, Christian Allred

Criterion: A Journal of Literary Criticism

No abstract provided.

The New Woman In Embryo: Masculine Women In Victorian Novels, Kayla Merrick

Criterion: A Journal of Literary Criticism

No abstract provided.

The Gothic And The Gross: Frankenstein And His Friend's Attractiveness To Children, Rebecca Mckee

Criterion: A Journal of Literary Criticism

No abstract provided.

The Prairie Naturalist, Vol. 51, Issue 2, December 2019

The Prairie Naturalist

45 EDITOR’S NOTE: Final Thoughts as Editor-in-Chief, by Christopher N. Jacques

RESEARCH ARTICLES

47 Bats of the Loess Hills Ecoregion of Southeast Nebraska, by Virgil Brack, Jr., Dale W. Sparks, and Darwin C. Brack

58 Serological Survey and Pathogen Exposure of Adult Female White-tailed Deer in the Western Dakotas, by Katherine L. Moratz, Bailey S. Gullikson, Eric S. Michel, Daniel M. Grove, Jonathan A. Jenks, and William F. Jensen

68 Factors Limting Reintroduced Plains Topminnow, Fundulus sciadicus, Populations in Central Great Plains Streams, by Joseph D. Thiessen, Keith D. Koupal, and Casey W. Schoenebeck

NOTES

77 Recent Observations of Water …

Pay Now, Play Later?: Youth And Adolescent Collision Sports, Vivian E. Hamilton

Faculty Publications

The routine and repeated head impacts experienced by athletes in a range of sports can inflict microscopic brain injuries that accumulate over time, even in the absence of concussion. Indeed, cumulative exposure to head impacts—not number of concussions—is the strongest predictor of sports-related degenerative brain disease in later life. The observable symptoms of disease appear years or decades after initial injury and resemble those of other mental-health conditions such as depression and dementia. The years-long interval between earlier, seemingly minor, head impacts and later brain disease has long obscured the connection between the two.

Risk of injury differs across demographics, …

A Landscape-Scaled And Community Ecology Approach To Wildlife Corridor Design In South Texas, James A. Stilley

Theses and Dissertations

A formidable challenge in landscape ecology is developing a sound resolution to mitigate the impacts of habitat fragmentation and restore connectivity to a degraded landscape. The problem is worldwide landscapes are becoming primarily anthropogenic and areas set aside for wildlife are small and isolated. Researchers’ have developed the concept of the wildlife corridor to mediate this situation but a proper methodology to implement this concept is still in its infancy. This study aims to uncover a quantitative and repeatable wildlife corridor design methodology based on the least cost analysis strategy with both a singular focal taxa approach and a comprehensive …

Distribution And Risk Factors Of Clinical Caseous Lymphadenitis In Small-Holder Goat Herds In Northeastern Thailand, Suteekan Thongkwow, Natchanon Poosiripinyo, Nuttapon Pongkornkumpon, Sitang Saengsakchai, Nattakarn Klinkhiew, Tassapon Chalatan, Kwankate Kanistanon, Sawarin Lerk-U-Suke, Sarinya Rerkyusuke

The Thai Journal of Veterinary Medicine

Clinical caseouslymphadenitis was observed in 60 of 1,186 goats. A total of 34 small holder goat farms were investigated in 11 provinces in the northeastern part of Thailand. Approximately66.67%of clinical caseous lymphadenitis goats were infected with Corynebacterium pseudotuberculosis,as confirmed by an ELISA test or bacterial culture. The average prevalence of clinical caseous lymphadenitisin herds was 6.36+4.30%(4.86–7.86; 95%CI). The abscessation of a superficial lymph node was commonly found in proximal (46.67%), middle (38.33%), and distal (15%)parts of the body. The location of the lesion was significantly associated (p<0.05)with positivity either from ELISA or bacterial culture, as goats with lesionsinthe distal part of the body showed a higher positivity (90%)than at theproximal (75%)and middle parts(45%)(p=0.02), respectively. No significant difference was observed for goat gender, age, or breed in terms of infection prevalence or displays of clinical signs of caseous lymphadenitis(p>0.05). Controland prevention measures should incorporate client education on a number of factors, …

Thermoresponsive Switchable Solvents For Enhanced, Simultaneous Microalgae Oil Extraction Reaction For Biodiesel Production, Mukhtar Ahmed Ismail

Mechanical Engineering Theses

In this study, a thermo-responsive switchable solvent (TSS), with a tunable hydrophobicity by simply changing the temperature (between 25 to 45oC) was used for simultaneous lipids extraction from wet microalgae and biodiesel production. By manipulating the hydrophobicity of the solvent, the cell wall disruption, lipid extraction and transesterification, and product separation steps were all carried out in a single pot, while eliminating the need for the energy intensive and time-consuming drying step. To overcome the problems currently encountered by using conventional alkaline catalysts in the transesterification of lipids, immobilized enzyme has been used. The proposed TSS consisted of an ionic …

Integration Of Cover Crops Into Midwest Corn-Soybean Cropping Systems And Potential For Weed Suppression, Joshua S. Wehrbein

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Cover crops have potential to provide benefits to agricultural systems, such as improved soil productivity, nutrient scavenging, weed suppression, and livestock forage. There are several challenges associated with cover crop integration into traditional Midwest corn-soybean cropping systems. One of these challenges is timely establishment in the fall, which is limited by the relatively late harvest of corn and soybean. Cover crop effectiveness is related to the amount of biomass produced, thus maximizing the growth period in the fall is desired. To address this challenge, we evaluated the potential to utilize early-season soybean maturity groups (MGs) to allow for earlier soybean …

Benchmarking On-Farm Maize Nitrogen Balance In The Western U. S. Corn Belt, Fatima Amor Tenorio

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

A nitrogen (N) balance, calculated as the difference between N inputs and grain-N removal, provides an estimate of the potential N losses. We used N balance with other N-related metrics (partial factor productivity for N inputs, and yield-scaled N balance), to benchmark maize yields in relation with N input use in the US Corn Belt. We first used experimental data on grain-N concentration (GNC) to assess variation in this parameter due to biophysical and management factors. Subsequently, we used N balance and N-related metrics to benchmark yields in relation with N inputs in irrigated and rainfed fields in Nebraska using …

Exploration Of Ataxia Telangiectasia And Rad3-Related’S (Atr’S) Role In Cell Death Regulation: Implications In Development, Cancer, And Stroke, Brian Cartwright

Electronic Theses and Dissertations

From gametogenesis until death an organism’s genome is under constant bombardment from endogenous and exogenous sources of DNA damage. To maintain genomic integrity amid this damage, cells have evolved responses which allow them to either preserve viability for recovery or initiate self-destructive pathways depending on the severity of DNA damage. One protein involved in initiating and carrying out these responses is the protein kinase ataxia telangiectasia and Rad3-related (ATR). ATR is known primarily for its regulatory role in initiating the checkpoint-signaling cascade following DNA damage and replicative stress. These signaling events lead to cell cycle arrest, DNA repair, or apoptosis …

Tumors Of The Conjunctiva And Cornea., Carol L. Shields, Jerry A. Shields

Wills Eye Hospital Papers

Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Melanocytic lesions include nevus, racial melanosis, primary acquired melanosis, melanoma, and other ocular surface conditions like ocular melanocytosis and secondary pigmentary deposition. The most frequent nonmelanocytic neoplastic lesions include squamous cell carcinoma and lymphoma, both of which have typical features appreciated on clinical examination. …

Evaluation Of The Management Of The Laurentian Great Lakes - The Role Of Us Congressional Policymaking, Kelly Tzoumis, Kathleen Wruk

College of Liberal Arts and Social Sciences Faculty and Staff Works

This research examines the importance of tone and issue framing by the United States Congress, using the case of the Laurentian Great Lakes (Great Lakes) from 2000 to 2019. Researching the tone of United States congressional committees, subcommittees and their witnesses, it is determined that congressional committees conduct hearings reflecting their public policy tone instead of more open discussions of the policy issues confronting the Great Lakes today. There is a statistically significant weak to moderate relationship of the tone of the committee, reflecting the same tone as the hearing. Similar to the tone of the committees mimicking the tone …

Making The Case For The Use Of The Ksu Archives And Special Collections Through Interpretive Videos, Helen Thomas

Graduate Scholarly Works

One of the challenges faced by Kennesaw State University’s Museums, Archives and Rare Books Department is a lack of awareness of both the existence of our collections and the many potential research applications that archives and rare books provide. This series of short videos makes the case to potential users as to why we collect these materials and how they are useful and relevant to a variety of research interests. Each video pairs an item or collection from the KSU Archives and Special Collections (including the Bentley Rare Book Museum) with expert interpretation provided by a KSU faculty member in …

Generational Marketing: An Imc Approach To Increase Non-Profit Awareness And Giving In North Mississippi Status:, Anna Kate Joyce

Honors Theses

The number of Americans giving and advocating for non-profits has decreased from 2012 to 2019. While the amount of dollars donated has increased, money is coming from significantly fewer sources. Giving and awareness advocacy for non-profit organizations differ among generations. Non-profits are having to market to multiple generations in different ways to gain advocacy and support for their organizations. The historical, cultural, economic, and social experiences of people’s lifetimes shape the way individuals perceive the world and their place in it. Each American generation has different traits and characteristics that makes it unique, and non-profit organizations can target each generation …

Reproducibility Of Cognitive Endpoints In Clinical Trials: Lessons From Neurofibromatosis Type 1, Jonathan M Payne, David H Gutmann, Et Al

Open Access Publications

OBJECTIVE: Rapid developments in understanding the molecular mechanisms underlying cognitive deficits in neurodevelopmental disorders have increased expectations for targeted, mechanism-based treatments. However, translation from preclinical models to human clinical trials has proven challenging. Poor reproducibility of cognitive endpoints may provide one explanation for this finding. We examined the suitability of cognitive outcomes for clinical trials in children with neurofibromatosis type 1 (NF1) by examining test-retest reliability of the measures and the application of data reduction techniques to improve reproducibility.

METHODS: Data were analyzed from the STARS clinical trial (n = 146), a multi-center double-blind placebo-controlled phase II trial of lovastatin, …

Nonlinear Z-Score Modeling For Improved Detection Of Cognitive Abnormality, John Kornak, Nupur Ghoshal, Lynne Jones, Et Al

Open Access Publications

Introduction: Conventional Z-scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these "adjusted" Z-scores better represent whether an individual's cognitive performance is abnormal. Extreme negative Z-scores for individuals relative to this normative distribution are considered indicative of cognitive deficiency.

Methods: In this article, we consider nonlinear shape constrained additive models accounting for age, sex, and education (correcting for nonlinearity). Additional shape constrained additive models account for varying standard deviation of the cognitive scores with age (correcting for heterogeneity of variance).

Results: Corrected Z-scores based …

Signal Regulatory Protein Alpha Initiates Cachexia Through Muscle To Adipose Tissue Crosstalk, Jiao Wu, Jiangling Dong, Daniela Verzola, Keith Hruska, Giacomo Garibotto, Zhaoyong Hu, William E Mitch, Sandhya S Thomas

Open Access Publications

BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is associated with cachexia in patients with CKD.

METHODS: We assessed insulin signalling and mechanisms causing muscle atrophy plus white adipose tissue (WAT) metabolism in mouse models of CKD or acute diabetes (streptozotocin treatment). We then examined these factors in mice with global knockout (KO) of SIRPα and sought mediators of metabolic responses in muscle and adipose tissues of mice …

Linking The Effects Of Helminth Infection, Diet And The Gut Microbiota With Human Whole-Blood Signatures, Soo Ching Lee, Mei San Tang, Alice V. Easton, Joseph Cooper Devlin, Ling Ling Chua, Ilseung Cho, Foong Ming Moy, Tsung Fei Khang, Yvonne A. L. Lim, P'Ng Loke

Open Access Publications

Helminth infection and dietary intake can affect the intestinal microbiota, as well as the immune system. Here we analyzed the relationship between fecal microbiota and blood profiles of indigenous Malaysians, referred to locally as Orang Asli, in comparison to urban participants from the capital city of Malaysia, Kuala Lumpur. We found that helminth infections had a larger effect on gut microbial composition than did dietary intake or blood profiles. Trichuris trichiura infection intensity also had the strongest association with blood transcriptional profiles. By characterizing paired longitudinal samples collected before and after deworming treatment, we determined that changes in serum zinc …

Evaluating Urban Downtown One-Way To Two-Way Street Conversion Using Microscopic Traffic Simulation, Bernice Liu

Master's Theses

Located in the heart of Silicon Valley, Downtown San Jose is attracting new residents, visitors, and businesses. Clearly, the mobility of these residents, visitors, and businesses cannot be accommodated by streets that focus on the single-occupancy automobile mode. To increase the potential for individuals to use non-single-occupancy modes of travel, the downtown area must have a cohesive plan to integrate multimodal use and public life. Complete streets are an integral component of the multi-modal transport system and more livable communities. Complete streets refer to roads designed to accommodate multiple modes, users, and activities including walking, cycling, transit, automobile, and nearby …

Spatio-Temporal Assessment Of Headwater Streams In The San Bernardino National Forest, Jose Angel Mora

Electronic Theses, Projects, and Dissertations

As the demand for freshwater resources increases due to increasing human populations, degradation of available resources, and climatic changes it will become increasingly important to understand the factors that impact the physicochemical characteristics of surface water resources over space and time. This study assessed a headwater stream over the course of a year in the San Bernardino National Forest that serves as both surface and groundwater resources for the Santa Ana River Watershed region, the largest and most populated watershed in Southern California. Streams were monitored bi-weekly during dry periods and weekly during wet periods from April 2018 through April …

Researching The Legal History Of Santa Claus, Kurt Metzmeier

Faculty and Staff Scholarship

For most lawyers, the figure of Santa Claus in the law is an unpleasant memory of an establishment clause essay question on a Constitutional Law exam where they had to decide what combination of Christmas trees, electric menorahs and inflatable Santas a city-owned mall could display without being reprimanded by the U.S. Supreme Court. Alas, Lynch v. Donnelly (1984) and Allegheny County v. Greater Pittsburgh ACLU (1989) have been a lump of coal in the fall semester grades stocking of many a law student. But the white-bearded one made his first appearance in the law reports a hundred years before …

An Exploratory Study Of Duty-Related Stress Among Conservation Officers, Logan Ledford

Electronic Theses and Dissertations

Research relating to police stress has typically focused on officers working in urban areas, neglecting their rural counterparts. This is especially true of conservation officers, who are tasked with enforcing laws in state parks and other recreational areas. To date, only a handful of studies have sought to better understand their experiences and perceptions. The current study seeks to further our understanding of conservation officer stress in three unique ways: (1) via applying McCreary and Thompson’s (2006) operational police stress scale (PSQ-Op) to the population, (2) determining whether officer characteristics (e.g., age, education, length of service) affect perceived stress, and …

Preparation Of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles As Targeting Tumor Theranostics, Samson Dada

Electronic Theses and Dissertations

Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic agent Doxorubicin (Dox). All the NPs and their intermediates were characterized using ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR). The drug loading capacity (DLC) and drug loading efficiency (DLE) of two series of FA-CDs-Dox were assessed using UV-vis absorption spectroscopy at the wavelength of 485 nm. Both showed good DLE and DLC …

Death On The Horizon: Osteoethnography Of The People Of Akhetaten, Alissa Michelle Bandy

Graduate Theses and Dissertations

The purpose of this dissertation is to define and implement osteoethnography. Osteoethnography is the analysis and description of an ancient culture through the bioarchaeological and archaeological evidence, utilizing cultural anthropological theories and techniques. An osteoethnographic narrative is presented in this dissertation, which describes the embodied lives of the people of the 18th Dynasty Egyptian city of Akhetaten, now known as Amarna, founded in 1355 B.C.E. by the Pharaoh Akhenaten. Osteoethnography looks at how people are shaped by and shape their environment, how culture impacts health, and how culture informs the lives of its practioners. Osteoethnography employs life course theory, and …

An Application Of The Ising Model, Juliano A. Everett

Publications and Research

Understanding how the Ising model works,what it represents, and how it can be applied to neurology. Given that an Ising model is an Entropy model that could be representative of the firing of neurons, some assumptions of the system are made and then the process is simulated through Monte Carlo methods.

Animal Science E-Newsletter, December 2019, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

An Assessment Of Conceptual Understanding Of Metabolic Pathways, Amani Atiyalla Abdugadar

Dissertations

Researchers have previously studied misconceptions of biochemistry topics such as photosynthesis, protein structure, and ATP-production. However, no studies have reported on students’ misconceptions regarding major metabolic pathways. Since learning metabolism builds on students’ prior knowledge, new material being learned will be affected by the presence of any misconceptions. Some of these misconceptions will be robust and thus hard to be replaced by the correct concepts. Thus, if students are to learn new material, these misconceptions must be diminished. This dissertation focused on the origins of these misconceptions, investigated what misconceptions students had on metabolism, and why students developed misconceptions instead …

The Association Between Melanoma And Exposure To Arsenic Among U.S. Adults Using The National Health And Nutrition Examination Survey (Nhanes) From 2003 To 2016, Ahmed Bedaiwi

Capstone Experience: Master of Public Health

Background: Melanoma is a deadly skin cancer at late stages, and its incidence has been increasing significantly over the last ten years in the United States. Chronic exposure to arsenic has been associated in many studies as a risk factor for non-melanoma skin cancer, notably squamous cell carcinoma. However, current knowledge is limited regarding melanoma and long-term arsenic exposure.

Methods: We conducted a cross-sectional study using the 2003-2016 cycles of the National Health and Nutrition Examination Survey (NHANES), to investigate the association between arsenic exposure and self-reported melanoma and non-melanoma skin cancer diagnoses. Univariate and multivariate logistic regressions were conducted. …