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Pharmacy Newsletter : December 2019, Pharmacy Department

Department of Pharmacy Archives

Content:

• FDA Safety Alert | Ranitidine Recall & AKUH Approaches
• Truth About Patients with Penicillin Allergies
• House Hold Poisoning | How to Keep Your Child Safe
• Protective effect of Co-Enzyme Q10 administration on propofol infusion syndrome (PRIS)
• Antibiotic Prophylaxis in Animal Bite
• Role of Vitamin E In Non-Alcoholic Fatty Liver Disease

Unique New York: Examining The Impact Of Breed Labels, Phenotypic Variations, And Geography On Length Of Stay In A Multi-Location New York Limited Intake Animal Shelter, Nicole Passmore

Theses and Dissertations

New York City (NYC) is a unique area for a shelter welfare as it has limited dog-friendly housing and an abundance of dogs. A common barrier to entry for NYC dog adopters trying to rent apartments is the breed label the shelter assigned to their dog, despite the fact breed labelling is primarily based off intuition and physical appearance. Following research by Gunter, Barber and Wynne (2016) that saw adoption rates at a Florida animal shelter increase following the removal of breed labels from the shelter’s kennel cards, some shelters ceased using breed labels. One was Bideawee, a limited admission …

Electrodermal Activity During Dissonant Music In Musicians And Non-Musicians, Joshua Chapin

Masters Theses

The purpose of this study was to investigate the subjective emotional and physiological responses to consonant and dissonant music excerpts in musicians and non-musicians. Participants were assigned to one of two groups, high experience (HE) or low experience (LE) based on their level of music experience and education. Participants from both groups listened to the same set of randomized musical excerpts half of which were consonant and half of which were dissonant. Participants self-reported ratings of perceived pleasantness, as well as Electromyography (EMG) and Electrodermal Activity (EDA) data were collected. Average Skin Conductance Responses (SCR) were averaged over all trials …

Pcr Analysis On The Effects Of Alpha Synuclein Treatment On C6 Rat Glioma Cells, Michael John Helmus

Masters Theses

Multiple System Atrophy (MSA) is a rare neurological disease that mainly implicates the neuronal protein, alpha synuclein, as being centrally involved in MSA pathology. Despite synucleinopathy dogma, little is known about alpha synucleins role in MSA pathogenesis. The Ide laboratory previously conducted an Affymetrix gene expression study utilizing the post-mortem pons tissue from eight individuals with MSA and five individuals without any known neurological disorders. One conclusion from that study was that downregulation of numerous mitochondrial homeostasis related genes had occurred. It is hypothesized that alpha synuclein can perturb mitochondrial homeostasis through direct interaction with mitochondria. This study utilized Reverse …

Forest Management Influences On Northern Bobwhite (Colinus Virginianus) Habitat In The South Carolina Lowcountry And Range-Wide, James Garrett

All Theses

Northern bobwhite (Colinus virginianus) populations have steadily declined since at least the 1960s. There are numerous factors that contribute to this decline, such as lack of prescribed fire, cleaner farming practices, change in land use, and increased urbanization. These factors have all contributed to the deterioration and fragmentation of bobwhite habitat. Despite the expansive literature at the local level on bobwhite habitat and management, much fewer studies have observed the range-wide decline and its associated factors. Adding to both local and range-wide literature on bobwhites is essential to overturn the range-wide decline.

This thesis delves into both a …

Tricarboxylic Acid Cycle Enzyme Activities In A Mouse Model Of Methylmalonic Aciduria, Parith Wongkittichote, Gary Cunningham, Marshall L Summar, Elena Pumbo, Patrick Forny, Matthias R Baumgartner, Kimberly A Chapman

Open Access Publications

Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into the tricarboxylic acid (TCA) cycle. As part of the pathological mechanisms of MMA, previous studies have suggested there is decreased TCA activity due to a "toxic inhibition" of TCA cycle enzymes by MMA related metabolites, in addition to reduced anaplerosis. Here, we have utilized mitochondria isolated from livers of a mouse model of MMA (Mut-ko/ki) and their littermate controls (Ki/wt) to examine the amounts and enzyme functions of …

Is An Organic Diet Sustainable?, Cassidy Sturdevant, Brock Nahalka, Arline Camilo, Tessa Lagrou

Student Work

This poster explains the ecological and physical effects that an organic diet has on the environment and the human body.

Addiction-Informed Immigration Reform, Rebecca Sharpless

Articles

Immigration law fails to align with the contemporary understanding of substance addiction as a medical condition. The Immigration and Nationality Act regards noncitizens who suffer from drug or alcohol substance use disorder as immoral and undesirable. Addiction is a ground of exclusion and deportation and can prevent the finding of "good moral character" needed for certain immigration applications. Substance use disorder can lead to criminal behavior that lands noncitizens, including lawful permanent residents, in removal proceedings with no defense. The time has come for immigration law to catch up to today's understanding of addiction. The damage done by failing to …

Bioresorbable Composite Stents For Enhanced Response Of Vascular Smooth Muscle Cells, Hozhabr Mozafari

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Formation of arterial plaque and stenosis is one of the main cardiovascular disease risk factors. Stenting is a popular approach to increase the inner diameter of the artery and provide an acceptable lumen gain. This is achieved by applying internal pressure to the arterial wall. Despite the desirable outcomes of this procedure, there are complexities and challenges that are being discussed among scholars in this area. Restenosis is one of these complications, in which smooth muscles cell start proliferation and remodeling in response of induced mechanical stresses. Another important issue is the placement of the stent and possible migration due …

The History And Evolution Of The Market For ‘Delebs’ (Dead Celebrities), Denver D'Rozario, Guang Yang

Atlantic Marketing Journal

In this paper, we survey the history behind the growing market for dead celebrities (‘Delebs’) in their role of creating secondary brand associations. According to some estimates, this market is now worth $2.25 billion in annual licensing and royalty revenues (CBC 2013). We begin, by defining key terms that are used in this market. Next, we do a survey and analysis of the major events that have given rise (intentionally or unintentionally) to this market. For ease of discussion, we discuss these historical events grouped by era. We follow this with a summary of the major events and trends that …

Impact Of Customer Engagement, Brand Attitude And Brand Experience On Branded Apps Recommendation And Re-Use Intentions, Nusser Raajpoot, Beth Ghilni-Wage

Atlantic Marketing Journal

Abstract

This paper seeks to understand the impact of customer engagement, brand attitude, and brand experience on branded apps recommendation and re-use intentions. Using structural equation modeling we test a causal model to establish the direct and mediated paths between constructs under study. We found that contrary to popular perceptions, customer engagement does not load directly on the recommendation or re-use intention suggesting that engagement on its own may not be sufficient to elicit recommendation or re-use intention. Other factors and contexts will be necessary to elicit recommendation etc. We also found that recommendation mediates the relationship between brand attitude …

Ribbon Α-Conotoxin Ktm Exhibits Potent Inhibition Of Nicotinic Acetylcholine Receptors, Leanna A. Marquart, Matthew W. Turner, Lisa R. Warner, Matthew D. King, James R. Groome, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

KTM is a 16 amino acid peptide with the sequence WCCSYPGCYWSSSKWC. Here, we present the nuclear magnetic resonance (NMR) structure and bioactivity of this rationally designed α-conotoxin (α-CTx) that demonstrates potent inhibition of rat α3β2-nicotinic acetylcholine receptors (rα3β2-nAChRs). Two bioassays were used to test the efficacy of KTM. First, a qualitative PC12 cell-based assay confirmed that KTM acts as a nAChR antagonist. Second, bioactivity evaluation by two-electrode voltage clamp electrophysiology was used to measure the inhibition of rα3β2-nAChRs by KTM (IC₅₀ = 0.19 ± 0.02 nM), and inhibition of the same nAChR isoform by α-CTx MII (IC₅₀ = …

Comparison Of Morphological Traits In Cowpea Pod Length, Seed Number Per Pod, Seed Weight, Seed Color And Seed Density In Usda Germplasm Accessions And Arkansas Breeding Lines, Sora Imamura

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

The objective of the study was to compare and correlate the Arkansas cowpea breeding lines to the USDA cowpea germplasm accessions on the following morphological traits: seed color, pod length, number of seeds per pod, 100 seed weight, and seed density. The seed density is defined as the weight of seed in gram per centimeter of pod length. Three hundred seventeen cowpea genotypes were used in this experiment. Out of the 317, 285 germplasm accessions were from the USDA GRIN and 32 lines were from the Arkansas breeding program.

T-test between Arkansas breeding lines and USDA germplasm accessions were done …

A Survey Of Earthworm Communities Across Areas Of Varying Land Management In Northwest Arkansas, Alyssa M. Ferri

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Earthworms are an integral component of the soil ecosystem, impacting factors including soil formation, maintenance of soil structure, and nutrient recycling. Earthworm abundances and distributions are related to abiotic soil properties and can influence the community structure. The goal of this study was to survey earthworm populations across areas of different land management histories and soil characteristics to determine if a relationship between earthworm density and land management characteristics was present. Earthworm and soil samples were collected at irregular temporal intervals from September 2017 to March 2018. In total, five sites were sampled, three at the Botanical Garden of the …

Vol. 96, No. 2: Table Of Contents, Denver Law Review

Denver Law Review

No abstract provided.

Colorado Marijuana Regulation Five Years Later: Have We Learned Anything At All, Sam Kamin

Denver Law Review

No abstract provided.

Vol. 96, No. 2: Full Issue, Denver Law Review

Denver Law Review

No abstract provided.

Filipino Postmodernity: Quo Vadis?, Romualdo E. Abulad

Philosophy Department Faculty Publications

In this paper, Romualdo Abulad initially presents variations of postmodernity as distinct historical breaks which feature paradigmatic shifts that lead us to a new beginning. Postmodernity, as Abulad shows, is characterized by a radical openness; this leads him to argue that postmodernity as an event occurred in different moments in the history of thought, from ancient to contemporary. In what seems to be a dialectical description of history, he maintains that an opportunity for a break occurs when the inherent limitations and deficiencies of the prevailing status quo emerge, and as a result, ignite the tensions between the preservation of …

"I Dissent, Therefore, From This Legalization Of Racism:" A Legal Analysis Of Korematsu V. United States (1944), Madelyn Sadler

Undergraduate Honors Theses

The Japanese Pearl Harbor attack on December 7, 1941, marked the beginning of total war between the United States and Japan. On February 19, 1942, President Franklin Delano Roosevelt issued Executive Order 9066, giving the military broad abilities to exclude any person(s) from prescribed military areas. Less than one week later, U.S. Army Lieutenant General John DeWitt began the process of removing Japanese Americans from their West Coast homes. Within four months of the Executive Order, the United States government forced over 100,000 Japanese Americans to abandon their lives and relocate to internment camps. Fred Korematsu, a twenty-three-year-old, natural-born American …

Full Issue Fall 2019

Criterion: A Journal of Literary Criticism

No abstract provided.

Performing Self, Performing Community, Performing Care: A Polyphony, Lindsay M. Goldman, Musonda Mwango, Vicki Reitenauer

Women, Gender, and Sexuality Studies Faculty Publications and Presentations

This article traces a performative arc across time and distance, starting in the men's carceral setting in which the co-authors first met in a gender studies course called Writing as Activism; through their continued co-learning (and individual authorship of self) in a campus-based course, Women, Writing, and Memoir; to and through the co-construction of this essay. These co-authors are variously situated relative to the institutions in which they were positioned; embody difference related to race, ethnicity, gender, class, sexuality, religion, age, and national origin; and are co-committed both to creating learning communities in which a socially just pedagogy might be …

Baby Girl Z : A Novel, Kathryn Bradley

Legacy Theses & Dissertations (2009 - 2024)

The novel Baby Girl Z examines the worlds of fertility treatment, neonatal intensive care, and early motherhood. The critical introduction highlights the connections between Baby Girl Z and contemporary fiction, autofiction, and memoirs about motherhood while exploring how the traditional tools of literary analysis and creative writing, when paired with feminist rhetorical analysis, promote a new reading of these texts as the literature of lived, traumatic experience. The theoretical underpinnings of the novel can be found in works that explore the intersections of the fields of creative writing, feminist rhetorics and maternal theory, such as Leigh Gilmore’s Autobiographics. The novel’s …

Emergent Regulatory Systems And Their Challenges: The Case Of Combination Medical Products, George Horvath

Washington Law Review

Where regulatory systems overlap, courts and scholars often focus on the undesirable aspects of the overlap—the ways in which systems conflict. One such context involves the regulation of prescription drugs and medical devices by the FDA’s premarket evaluation processes and by state common-law tort and products liability actions. FDA regulation and state common law are often described as separate, conflicting regulatory systems. This Article challenges that description by proposing a model in which FDA premarket evaluation and state common law function as a single regulatory system. This model brings order to the Supreme Court’s seemingly inconsistent medical products preemption cases, …

Sagebrush Seeds Of Success: A Genetic Analysis Of Bureau Of Land Management Seeds Of Success Seeds And Of Eriogonum Umbellatum, Emily Katherine Schumacher

Master's Theses

Due to the increasing frequency of anthropogenic disturbances, greater effort needs to be put into identifying appropriate seed material for large scale restoration projects. The Bureau of Land Management created the Seeds of Success (SOS) project to increase stocks of native seeds for restoration projects following worsening disturbances. However, there is little known about the genetic composition of these seeds, so it is unclear if these seed accessions will be able to establish healthy and persistent native plant communities. This thesis identified that in 20 accessions of SOS seeds, inbreeding was low to moderate in 17 accessions, allelic richness was …

Musician Earplugs: Knowledge, Attitudes, Beliefs, Behaviors, And Experiences Among Small Music Venue Workers, Kathryn Hickey

Doctoral Scholarly Projects & Capstones

Hickey, Kathryn Michelle. Musician earplugs: Knowledge, attitudes, beliefs, behaviors, and experiences among small music venue workers. Unpublished Doctor of Audiology capstone, University of Northern Colorado, 2019. Music venue workers are frequently exposed to high levels of music without access to hi-fidelity (musician’s) hearing protection or hearing health education. The purpose of this study was to describe the changes in knowledge, attitudes, beliefs, behaviors, and experiences of small music venue workers before and after wearing high-fidelity musician’s earplugs at work for five work shifts. A modified pre-questionnaire and post-questionnaire were administered including the Youth Attitude to Noise Scale (YANS), the Beliefs …

Play Now, Pay Later?: Youth And Adolescent Collision Sports, Vivian E. Hamilton

UC Law Journal

The routine and repeated head impacts experienced by athletes in a range of sports can inflict microscopic brain injuries that accumulate over time, even in the absence of concussion. Indeed, cumulative exposure to head impacts—not number of concussions—is the strongest predictor of sports-related degenerative brain disease in later life. The observable symptoms of disease appear years or decades after initial injury and resemble those of other mental-health conditions such as depression and dementia. The years-long interval between earlier, seemingly minor, head impacts and later brain disease has long obscured the connection between the two.

Risk of injury differs across demographics, …

Qualitative Assay To Detect Dopamine Release By Ligand Action On Nicotinic Acetylcholine Receptors, Leanna A. Marquart, Matthew W. Turner, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

A pheochromocytoma of the rat adrenal medulla derived (a.k.a. PC12) cell-based assay for dopamine measurement by luminescence detection was customized for the qualitative evaluation of agonists and antagonists of nicotinic acetylcholine receptors (nAChRs). The assay mechanism begins with ligand binding to transmembrane nAChRs, altering ion flow into the cell and inducing dopamine release from the cell. Following release, dopamine is oxidized by monoamine oxidase generating hydrogen peroxide that catalyzes a chemiluminescence reaction involving luminol and horseradish peroxidase, thus producing a detectable response. Results are presented for the action of nAChR agonists (acetylcholine, nicotine, and cytisine), and antagonists (α-conotoxins (α-CTxs) MII, …

Natural Resource Condition Assessment, Homestead National Monument Of America, David S. Jones, Roy Cook, John Sovell, Christopher Herron, Jay Benner, Karin Decker, Andrew Beavers, Johannes Beebee, David Weinzimmer

United States National Park Service: Publications

Executive Summary

The National Park Service (NPS) Natural Resource Condition Assessment (NRCA) Program administered by the NPS Water Resources Division evaluates current conditions for important natural resources and resource indicators using primarily existing information and data. NRCAs also report on trends in resource condition when possible, identify critical data gaps, and characterize a general level of confidence for study findings. This NRCA complements historic resource assessments, is multi-disciplinary in scope, employs a hierarchical indicator framework, identifies and develops reference conditions/values for comparison against current conditions, and emphasizes spatial evaluation of conditions and GIS (map) products.

Congress established the Homestead National …

Plant Community Composition And Structure Monitoring At Agate Fossil Beds National Monument, 2019 Data Report, Molly B. Davis

United States National Park Service: Publications

Abstract

This report presents the results of vegetation monitoring efforts in 2019 at Agate Fossil Beds National Monument (AGFO) by the Northern Great Plains Inventory and Monitoring Network (NGPN) and the Northern Great Plains Fire Ecology Program (NGPFire). This was the ninth year of combined monitoring efforts.

In 2019, crew members from NGPN visited 6 long-term plant community monitoring (PCM) plots to collect data on the upland mixed-grass prairie plant communities at AGFO. This work is part of a long-term monitoring program established to better understand the condition of the vegetation community and how it changes over time. NGPN staff …

Hunters And Their Perceptions Of Public Access: A View From Afield, Joseph J. Fontaine, Alexis D. Fedele, Lyndsie S. Wszola, Lindsey N. Messinger, Christopher J. Chizinski, Jeffery J. Lusk, Karie L. Decker, J. Scott Taylor, Erica F. Stuber

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Declining hunter participation threatens cultural traditions and public support for conservation, warranting examination of the forces behind the downward trajectory. Access to lands for hunting, an often-cited reason for non participation, may play a critical role in the retention and recruitment of hunters. Meeting the access needs of a diverse hunting constituency requires understanding how hunters use and perceive access opportunities, particularly public-access sites. Given that perceptions of access are entirely place based and degrade with time, traditional postseason survey methods may fail to adequately quantify the value of public access to the hunting constituency. To overcome the potential limitations …