Digital Commons Network^™

Transcriptome-Wide Analysis Of Vsv Strains With Varying Ability To Block Nf-Κb, Thomas M. Russell

Theses

Vesicular stomatitis virus (VSV) is a negative sense, single-stranded RNA (ssRNA) virus that is currently studied for its uses as a vaccine viral vector and its potential in oncolytic therapy. The M protein of VSV is the active participant in the virus’s abrogation of the host innate immune response. This activity is thought to be due to the M protein’s ability to downregulate overall host transcription by blocking nuclear transport. A VSV mutant containing a D52G mutation in the M protein (22-20) has been shown to block nuclear transport while being defective as a suppressor of NF-κB activation. It is …

Variations On A Theme: Using Amino Acid Sequences To Generate Music, Aaron Kosmatin

Master's Projects

In this project, we explore using a musical space to represent the properties of amino acids. We consider previous mappings and explore the limitations of these mappings. In this exploration, we will propose a new method of mapping into musical spaces that extends the properties that can be represented. For this work, we will use amino acid sequences as our example mapping. The amino acid properties we will use include mass, charge, structure, and hydrophobicity. Finally, we will show how the different musical properties can be compared for similarity.

Intra-Exchange Cryptocurrency Arbitrage Bot, Eric Han

Master's Projects

Cryptocurrencies are defined as a digital currency in which encryption techniques are utilized to regulate generation of units of currency and verify the transfer of funds, independent of a central governing body such as a bank. Due to the large number of cryptocurrencies currently available, there inherently exists many price discrepancies due to market inefficiencies. Market inefficiencies occur when the price of assets do not reflect their true value. In fact, these types of pricing discrepancies exist in other financial markets, including fiat currency exchanges and stock exchanges. However, these discrepancies are more significant in the cryptocurrency domain due to …

Gradubique: An Academic Transcript Database Using Blockchain Architecture, Thinh Nguyen

Master's Projects

Blockchain has been widely adopted in the last few years even though it is in its infancy. The first well-known application built on blockchain technology was Bitcoin, which is a decentralized and distributed ledger to record crypto-currency transactions. All of the transactions in Bitcoin are anonymously transferred and validated by participants in the network. Bitcoin protocol and its operations are so reliable that technologists have been inspired to enhance blockchain technologies and deploy it outside of the crypto-currency world. The demand for private and non-crypto-currency solutions have surged among consortiums because of the security and fault tolerant features of blockchain. …

Understanding Women´S Empowerment Through Indigenous Epistemologies: An Alternative Approach To Development?, Melissa Klara Vonimary Søvik

Master's Theses

Development projects that aim at empowering women have gained popularity among many actors and institutions in the field of development for their capacity to contribute in development and economic growth. Nevertheless, the concept of empowerment has also gained critics from various stands claiming it to be too technical, and not taking into account social relations in contexts where other epistemologies exist. It is necessary to adapt these kind of terms taking into account local world-views. This thesis explores the dynamics of women's empowerment in Tzeltal Mayan communities in Chiapas, Mexico. It aims at understanding the way empowerment is manifested in …

Boom And Bust: How Private Detention Centers Wreak Economic Havoc On The Counties That Turn To Them For Stability, Max W. Parrott, Reynaldo Leanos Jr.

Capstones

In 2015, a riot broke out at a federal prison in a small Texas town not far from the U.S.-Mexico border. Prisoners tore through the kevlar tents of their dorms and a fire broke out, rendering the private prison uninhabitable. The facility was an economic engine for the impoverished, Rio Grande Valley county, so when the facility closed, it left the county $2 million short of its estimated budget, with $78 million in unpaid bonds and 400 fewer jobs for a population of about 21,000 people. This summer, three years after experiencing near economic collapse, Willacy County rushed back into …

Overcoming Barriers For The Implementation Of Evidence-Based Practice Through Journal Clubs, Regina Thomas

Doctor of Nursing Practice Projects

Many barriers exist at a 134-bed rural hospital in southern Illinois that hinder generation, evaluation, and implementation of evidence-based research into practice. This DNP project was completed through a phase approach utilizing a modified version of Kotter’s Model of Change, the RNcEBP Survey to self-rate individual confidence in the EBP process, and the Iowa Model of Evidence-Based Practice to facilitate implementation of journal clubs. The RNcEBP survey revealed that nurses were familiar with the concept of EBP, have positive attitudes, and are confident that EBP changes can improve patient outcomes, but lack experience in evaluating literature to support implementing evidence-based …

Transitioning With Grace: Improving Quality Of Life For Comfort Care Patients In The Intensive Care Unit, Melissa Ashley

Doctor of Nursing Practice Projects

The primary aim of this project was to develop and execute a standard protocol of interventions for comfort care patients on a medical intensive care unit. Staff at a 15 bed MICU at a Midwest urban teaching hospital from June 1 until August 11, 2018 were trained to execute a standardized protocol of interventions for comfort care patients. Seventeen MICU patients who transitioned to comfort care were offered a standardized set of evidence-based interventions, after staff attended educational in-services on providing high quality end of life (EOL) care. Checklists were used to determine intervention compliance. Pre-project and post-project surveys were …

Implementation Of High Blood Pressure Guidelines In Clinical Practice, Jessica Walker

Doctor of Nursing Practice Projects

Abstract

This quality improvement project implemented 2017 Guidelines for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults. An in-service education session on the 2017 High Blood Pressure Guidelines was provided to clinical staff. In addition, the AHA/ACC pooled cohort 10-year risk calculator was installed to computer desktops or smart phones, for providers. “Seven simple tips to get an accurate blood pressure reading” (American Medical Association, 2016) was posted in exam rooms and proper measurement and documentation techniques were reviewed with clinical staff. Review of recommended non-pharmacological treatment methods with proper patient education documentation was also conducted. …

Strong Recommendation Towards Hpv Vaccination, Danielle Bogue

Doctor of Nursing Practice Projects

Risk of future HPV related cancers remains high in individuals unvaccinated against HPV, leading to too many people dying from this preventable cancer. However, primary care providers’ strong recommendation to vaccinate and family education about HPV and vaccine efficacy have a positive impact on a family’s decision to vaccinate. The setting for this project was a Midwest suburban family healthcare practice. This process was implemented by providing the guardian with a handout, a short video on HPV, a question and answer period with the provider, and ended with the provider giving a strong recommendation towards HPV vaccination. Of the 35 …

Science In The News, Ethan Trinh

CHEM151

Calderon, B. M.; Conn, G. L. A human cellular noncoding RNA activates the antiviral protein 2′–5′-oligoadenylate synthetase 1 J. Biol. Chem. 2018 293: 16115-. doi:10.1074/jbc.RA118.004747

Science In The News, Celine M. Chandler

CHEM151

Zimmer, C. Scientists Are Designing Artisanal Proteins for Your Body. New York Times, Dec 2017, pp D1.

Employing Natural History Collections In The Aid Of Conservation: Streamlining An Approach To Model Species Distributions En Masse For The Preservation Of Biodiversity, Alice Fornari

Master's Projects and Capstones

Using species distribution models (SDMs) in Natural History Collections (NHCs) can influence how humans implement conservation changes in flora and fauna communities and ecosystems. Through the use of legacy data (old NHCs and their associated locality/collection information), data correction (background data or pseudo absences added to presence-only data), and the SDM software, Maxent (and its associated geographic information systems or GIS projected models), it has been shown that it is feasible to create a low budget protocol/setup to project the past, present and future of species population changes. This has been done in the past few decades as more collections …

Emphasizing The Importance Of Cultural Identity Of Second Language Learners In Lesson Plans, Sreyasi De

Master's Projects and Capstones

A sky rocketing trend of one in three United States residents is estimated to be either an immigrant or the child of an immigrant by 2065. How well immigrants and second-generation immigrants are inhabiting in United States is of great significance to the state of being happy, healthy, prosperous, and full of energy and resonance of the United States in general. While economic, political, and social aspects of immigration are frequently contemplated for policy-making, comparatively small investigations have examined the cultural identity of the immigrants. In the review of literature, topics of intercultural competence, cultural competence, and culturally responsive teaching …

Would You Do Cognitive Trainings Again: A View From Participants With First Episode Of Schizophrenia, Mehgan Sierra

Master's Projects and Capstones

Purpose: The purpose of this project is to identify if individuals with first episode of schizophrenia would utilize computerized cognitive trainings after the study. Using this information, we can identify better ways to support individuals with first episode of schizophrenia in utilizing cost-effective interventions to improve cognition such as attention, memory, and problem solving among ages 18-35 individuals.

Methods: One-hour semi-structured interviews were conducted with twelve participants in community-based programs who completed cognitive trainings in the Prodromal Assessment Research and Treatment (PART) lab at UCSF. Fifteen participants who completed their post-testing or dropped out of the study were given …

Quarterly Meeting Agenda, Wku Board Of Regents

Board of Regents Documents

Quarterly meeting agenda.

Observation Of Medium-Induced Modifications Of Jet Fragmentation In Pb-Pb Collisions At √SNn =5.02 Tev Using Isolated Photon-Tagged Jets, A. M. Sirunyan

Department of Physics and Astronomy: Faculty Publications

Measurements of fragmentation functions for jets associated with an isolated photon are presented for the first time in pp and Pb-Pb collisions. The analysis uses data collected with the CMS detector at the CERN LHC at a nucleon-nucleon center-of-mass energy of 5.02 TeV. Fragmentation functions are obtained for jets with p^jet_T > 30 GeV/c in events containing an isolated photon with p^γ_T > 60 GeV/c, using charged tracks with transverse momentum p^trk_T > 1 GeV/c in a cone around the jet axis. The association with an isolated photon constrains the initial p_{T …}

Methanogens: Pushing The Boundaries Of Biology, Nicole R. Buan

Department of Biochemistry: Faculty Publications

Methanogens are anaerobic archaea that grow by producing methane gas. These microbes and their exotic metabolism have inspired decades of microbial physiology research that continues to push the boundary of what we know about how microbes conserve energy to grow. The study of methanogens has helped to elucidate the thermodynamic and bioenergetics basis of life, contributed our understanding of evolution and biodiversity, and has garnered an appreciation for the societal utility of studying trophic interactions between environmental microbes, as methanogens are important in microbial conversion of biogenic carbon into methane, a high-energy fuel. This review discusses the theoretical basis for …

Teaching Equity, Jennifer Saunders

UNH Today Archive

No abstract provided.

Action Collection Service Inc. V. Black Appellant's Brief Dckt. 46116

Not Reported

No abstract provided.

Fagus Sylvatica (European Beech) Id #1191, Alyssa Cuomo-Perriello

BIO 140 Arboretum Project

Location: Wakehurst

Condition: Fair

Age Class: Mature

Introductory Essay: Ejournal Of Public Affairs Special Issue On First-Generation College Students, Tracey Glaessgen, Mark Biggs, Rachelle Darabi, Kelly Wood

eJournal of Public Affairs

No abstract provided.

A New-Old Way To Explore Civic Engagement: Learning From The Past, Peter A. Nagler, Harry Basehart

eJournal of Public Affairs

No abstract provided.

Georgia Southern University Golf Course Newsletter, Georgia Southern University

Athletics: News & Publications

• Holiday Open House
• The Perfect Gift for your Golfer
• 10 Play Pass
• 50% off Annual Passes beginning January 1

A Bilinear Bogolyubov Theorem, Pierre‐Yves Bienvenu, Thái Hoàng Lê

Faculty and Student Publications (Open Access)

No abstract provided.

Observation Of Medium-Induced Modifications Of Jet Fragmentation In Pb-Pb Collisions At Snn=5.02 Tev Using Isolated Photon-Tagged Jets, Cms Collaboration, J. G. Acosta, S. Oliveros

Faculty and Student Publications (Open Access)

No abstract provided.

Short Sleep Duration And Obesity Among Children: A Meta-Analysis, Katherine Faye Real Villar

International Nursing Research Congress (INRC)

This meta-analytical study examined whether there is an association between lesser sleep duration and risk of childhood obesity and to determine which gender is more common in childhood obesity.

Understanding Cauda Equina Syndrome: Protocol For A Uk Multicentre Prospective Observational Cohort Study, Julie Woodfield, Ingrid Hoeritzauer, Aimun A.B. Jamjoom, Savva Pronin, Nisaharan Srikandarajah, Michael Poon, Holly Roy, Andreas K. Demetriades, Philip Sell, Niall Eames, Patrick F.X. Statham

Peninsula Medical School

IntroductionCauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. This study aims to identify and describe the presentation and management of patients with CES in the UK.Methods and analysisUnderstanding Cauda Equina Syndrome (UCES) is a prospective and collaborative multicentre cohort study of adult patients with confirmed CES managed at specialist spinal centres in the UK. Participants will be identified using neurosurgical and orthopaedic trainee …

Combination Therapy: Parp Inhibitor Synergizes The Therapeutic Efficacy Of Doxorubicin In The Treatment Of Prostate Cancer, Momin Ansare

Electronic Theses & Dissertations

Men are most susceptible to prostate cancer in the United States. The general treatment options include surgery, hormone therapy, chemotherapy, and radiation therapy. But in recent days, the nanoformulation have shown promising applications in overcoming the drawbacks of the currently available treatment options. To complement, we tried to enhance the capability of the nanoparticle formulation by loading them with a novel drug combination for the treatment of prostate cancer. Herein, we synthesized folate conjugated iron oxide nanoparticles encapsulated with doxorubicin and olaparib for imaging and targeted treatment of prostate cancer. Both drugs are approved by FDA for clinical cancer treatment. …

Synthesis Of Doxorubicin-Based Prodrug And Activatable Mr Nanoprobe For The Imaging And Treatment Of Cancer, Bayan Dous

Electronic Theses & Dissertations

Magnetic Resonance Imaging (MRI) is increasingly being used as a diagnostic tool for cancer. We propose a novel molecular probe, Gadolinium-DTPA disulfide-bonded Doxorubicin (Gd-DTPA-SS-Doxo) encapsulated in iron oxide which could provide a dual modality for detecting malignant growth while simultaneously targeting treatment options. We first synthesized Gd-DTPA-SS-Doxo followed by encapsulation within the poly (acrylic acid) (PAA) coating of iron oxide nanoparticle (IONP), producing a nanoprobe (IO-Gd-DTPA-SS-Doxo) with quenched longitudinal spin lattice magnetic relaxation (T1). After receptor-mediated internalization, Gd-DTPA-SS-Doxo is released from the nanoprobe’s polymeric coating due to the acidic microenvironment of the tumor. When the molecular probe is subjected to …