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Als Mutations Of Fus Suppress Protein Translation And Disrupt The Regulation Of Nonsense-Mediated Decay, Marisa Kamelgarn, Jing Chen, Lisha Kuang, Huan Jin, Edward J. Kasarskis, Haining Zhu

Toxicology and Cancer Biology Faculty Publications

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by preferential motor neuron death. Approximately 15% of ALS cases are familial, and mutations in the fused in sarcoma (FUS) gene contribute to a subset of familial ALS cases. FUS is a multifunctional protein participating in many RNA metabolism pathways. ALS-linked mutations cause a liquid–liquid phase separation of FUS protein in vitro, inducing the formation of cytoplasmic granules and inclusions. However, it remains elusive what other proteins are sequestered into the inclusions and how such a process leads to neuronal dysfunction and degeneration. In this study, we developed …

Stroke Outcomes With Vorapaxar Versus Placebo In Patients With Acute Coronary Syndromes: Insights From The Tracer Trial, Leo Ungar, Robert M. Clare, Fatima Rodriguez, Bradley J Kolls, Paul W. Armstrong, Philip Aylward, Claes Held, David J. Moliterno, John Strony, Frans Van De Werf, Lars Wallentin, Harvey D. White, Pierluigi Tricoci, Robert A. Harrington, Kenneth W. Mahaffey, Chiara Melloni

Gill Heart & Vascular Institute Faculty Publications

Background—Vorapaxar, a protease‐activated receptor‐1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage.

Methods and Results—TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) was a trial of vorapaxar versus placebo among patients with acute coronary syndrome. Strokes were adjudicated by a central events committee. Of 12 944 patients, 199 (1.5%) had ≥1 stroke during the study period (median follow‐up, 477 days). Four patients had a single stroke of unknown type; 195 patients had ≥1 stroke classified as hemorrhagic or nonhemorrhagic (165 nonhemorrhagic, 28 hemorrhagic, and 2 both). …

Tumor Cell-Released Autophagosomes (Traps) Promote Immunosuppression Through Induction Of M2-Like Macrophages With Increased Expression Of Pd-L1., Zhi-Fa Wen, Hongxiang Liu, Rong Gao, Meng Zhou, Jie Ma, Yue Zhang, Jinjin Zhao, Yongqiang Chen, Tianyu Zhang, Fang Huang, Ning Pan, Jinping Zhang, Bernard A Fox, Hong-Ming Hu, Li-Xin Wang

Articles, Abstracts, and Reports

BACKGROUND: Tumor-associated macrophages (TAMs) facilitate tumor progression via establishment of an immunosuppressive tumor microenvironment (TME). However, it is poorly understood how tumor cells could functionally modulate TAMs. Our previous work indicated that tumor cell-released autophagosomes (TRAPs), a type of LC3-II

METHODS: TRAPs isolated from multiple murine tumor cell lines and pleural effusions or ascites of cancer patients were incubated with bone marrow-derived macrophages (BMDMs) and monocytes, respectively. Cellular phenotypes were examined by flow cytometry, ELISA and quantitative PCR. TRAPs treated BMDMs were tested for the ability to suppress T-cell proliferation in vitro, and for promotion of tumor growth in vivo. …

Wave Energy In America, Chris Sukstorf

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The United States has an untapped energy goldmine: our shores. According to the National Oceanic and Atmospheric Administration (NOAA), the United States his home to over 95,000 miles of shoreline. This shoreline is home to beaches, homes, and wildlife, but it could be home to more: wave energy.

Wave energy comes in many forms: some use the bobbing up and down motion of waves to generate energy in a similar motion of a piston; others store water during high tide and then release it during low tide like a dam. All said and done, the United States has the ability …

Why Lincoln Needs To Get Ahead Of The Emerald Ash Borer Outbreak, Bryce Meyer

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The emerald ash borer was recently sighted in Lincoln, Nebraska this August. This was to be expected as they were also located in Douglas and Cass county. The emerald ash borer has been making its way west from Michigan and has also been detected in 61 counties in Iowa.

The emerald ash borer is a metallic green colored beetle that feeds on green ash, black ash, blue ash, and white ash trees. The insect can kill up to 99% of the ash trees that they come in contact with. The beetle is native to north-eastern Asia and is considered an …

“On-Bill Financing: A Bright Idea For Nebraska”, Lauren Taylor

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

In over 29 states, a program called On-Bill Financing (OBF) is being utilized to improve the energy efficiency of homes and livelihoods of the people living in them. These programs have been implemented all over the country for many years, in states like Colorado, Hawaii, Iowa, and Michigan. According to the Environmental and Energy Study Institute (EESI), OBF has been wildly successful, reducing energy inefficiency, cutting energy bills, and improving the comfort of homes across the country with no upfront costs.

But what exactly is this mysterious money-saving program, and why hasn’t Nebraska tapped into it yet?

The Department of …

Looking At The True Costs Of Environmental Degradation, Zachery Sehnert

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Progress is why we change, and innovation drives that progress. It is already very clear to scientists around the globe that our current framework for living is not sustainable. 97 percent of climate scientists are in consensus that there is a major threat to our ecosystem and action needs to be taken. Overpopulation, pollution, water scarcity, natural disasters, overfishing, deforestation are all issues that must be reevaluated with sustainability in mind. However only 49 percent of the general population share this belief, and even less, only 29 percent of CEOs are actively addressing climate change. The shortcoming for the general …

“Renewable Energy Implementation”, William Newcomb

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Finding and providing ways to produce energy in an environmentally clean way is becoming a major push for countries all around the world today. Renewable energy provides a clean way to produce energy efficiently without using our planets non-renewable resources. Renewable energy has been growing substantially in the United States in the last decade and is making its way towards becoming a major energy production method. So, what is stopping the United States from implementing renewable energy production into our country at a mass scale?

There are many barriers that are keeping renewable energy from becoming a main source of …

Nebraska’S Public Power Is Proof That Renewables Are (Literally) In The Public’S Best Interest, Jacob Monti

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Nebraska is the only state that has every electric utility publicly owned. This gives Nebraska a unique advantage of serving its customers rather than out-of-state shareholders. Since the goal is cheap power instead of profit margins and keeping shareholders happy, Nebraska rates are 16.8% below the national average. (EIA.gov)

So what does that mean for Renewable sources of electricity if cheap power is the main focus? Does cheap but dirty coal reign supreme?

Some might think that’d be a death blow for Renewables. Renewables (wind, solar, and hydro-electric power) are expensive and not profitable, right? WRONG.

Renewables make up just …

Lift On E15 Ban: Should Nebraskan Farmers Be Cheering?, Samantha Wattier

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The common gasoline-ethanol mixture available at gas station pumps is 10% ethanol (E10). The Environmental Protection Agency had a ban on 15% ethanol (E15) during summer months. The news has been covering the talks of President Trump to lifting this summer ban and supporters in Iowa are excited.

Should Nebraska shout Hoorah, too? It is common knowledge Nebraska is better than Iowa. We should be excited, too, right?! NO.

Iowa has been tracking Fuel Revenue sales including those from ethanol blends and has been pushing for the E15 ban lift. Considering Iowa produces MORE corn and MORE ethanol than …

Recycling Just Got More Expensive. Can It Be Done Better?, Zachery Homolka

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

There was a time in history that America led the world in recycling. In World War Two, Americans were asked to recycle tin, steel, paper, and rubber for the war effort. The University of Southern Carolina states that children were so eager to participate, they went door to door collecting recyclable scraps to turn in to be made into tanks, planes, and ammunition. Yet, in 2017 the National Geographic estimated about 91% of plastic produced globally has not been recycled and instead is landfilled or littered into the environment. America is no longer leading the recycling charge, the World Economic …

Social Change For A Global Problem, Isabella Catalano

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Recently, the United Nations' International Panel on Climate Change (IPCC) released a new report[1], warning us that storms are becoming more volatile, sea surface temperatures are getting higher, global environment as a whole growing less predictable: in other words, things are about to get a whole lot worse than we predicted.

Unless, of course, we do something about it. The IPCC recommends cutting CO₂ emissions by 45% in order to curb just the worst of climate change's many effects.

There are a plethora of articles on the topic of just what, exactly, we as individuals can do: …

Interference And Control Of The Nosocomial Transmission Of Methicillin-Resistant Staphylococcus Aureus, Sen Pei, Flaviano Morone, Fredrik Liljeros, Hernan Makse, Jeffrey L. Shaman

Publications and Research

Methicillin-resistant Staphylococcus aureus (MRSA) is a continued threat to human health in both community and healthcare settings. In hospitals, control efforts would benefit from accurate estimation of asymptomatic colonization and infection importation rates from the community. However, developing such estimates remains challenging due to limited observation of colonization and complicated transmission dynamics within hospitals and the community. Here, we develop an inference framework that can estimate these key quantities by combining statistical filtering techniques, an agent-based model, and real-world patient-to-patient contact networks, and use this framework to infer nosocomial transmission and infection importation over an outbreak spanning 6 years in …

Negev Bedouins And The State Of Israel: Social Conflict And Territorial Dispute, Tamar Arieli

California Western International Law Journal

No abstract provided.

Effects Of Urbanization On The Foraging Ecology And Microbiota Of The Generalist Seabird Larus Argentatus, Matthew Fuirst, Richard R. Veit, Megan Hahn, Nolwenn Dheilly, Lesley H. Thorne

Publications and Research

Larus gull species have proven adaptable to urbanization and due to their generalist feeding behaviors, they provide useful opportunities to study how urban environments impact foraging behavior and host-associated microbiota. We evaluated how urbanization influenced the foraging behavior and microbiome characteristics of breeding herring gulls (Larus argentatus) at three different colonies on the east coast of the United States. Study colonies represented high, medium and low degrees of urbanization, respectively. At all colonies, gulls frequently foraged at landfills and in other urban environments, but both the use of urban environments and gull foraging metrics differed with the degree of urbanization. …

Nurse Practitioner Knowledge, Attitudes, And Beliefs When Caring For Transgender People, Catherine Paradiso, Robin M. Lally

Publications and Research

Purpose: The aim of this study was to explore Nurse Practitioner (NP) knowledge, attitudes, and beliefs when working with transgender people and to inform about Practitioner education needs.

Methods: A qualitative descriptive design was used to explore (NP) experiences. Focused semistructured interviews were conducted in 2016 with 11 (N = 11) NPs in the northeastern United States who represent various years of experience and encounters with transgender patients. The interviews explored NP knowledge attitudes and beliefs when caring for transgender patients and described their overall experiences in rendering care in the clinical setting. The interviews were professionally transcribed and analyzed …

Esthétique Environnementale : Art, Écologie Et Politique, Alexandre Melay

The Goose

Loin de « l’idée » romantique de la nature, l’artiste Olafur Eliasson produit des « environnements environnés » à grande échelle mettant en scène les éléments naturels. L’être humain et l’expérience humaine sont au centre de ses installations, invitant le visiteur à expérimenter la spatialité et la temporalité. Eliasson utilise son art pour sensibiliser l’homme avec l’environnement et interroger sa position en tant que sujet phénoménologique. À l’activisme traditionnel, Eliasson propose une autre vision en rapport avec les mutations contemporaines et les enjeux écologiques liés au réchauffement de la planète, tout en préconisant un retour à la nature comme une …

Most Campus Offices To Close Dec. 22-Jan. 1, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Malassezia Vespertilionis Sp. Nov.: A New Cold-Tolerant Species Of Yeast Isolated From Bats, J. M. Lorch, J. M. Palmer, K. J. Vanderwolf, K.Z. Schmidt, M. L. Verant, T. J. Weller, D. S. Blehert

KIP Articles

Malassezia is a genus of medically-important, lipid-dependent yeasts that live on the skin of warmblooded animals. The 17 described species have been documented primarily on humans and domestic animals, but few studies have examined Malassezia species associated with more diverse host groups such as wildlife. While investigating the skin mycobiota of healthy bats, we isolated a Malassezia sp. that exhibited only up to 92 % identity with other known species in the genus for the portion of the DNA sequence of the internal transcribed spacer region that could be confidently aligned. The Malassezia sp. was cultured from the skin of …

Atwater, Barber Lead Gs Women's Basketball To Third Straight Win, Georgia Southern University

Athletics: News & Publications

• Atwater, Barber Lead GS Women's Basketball To Third Straight Win

Moral Philosophy: A Contemporary Introduction, Daniel R. Denicola

Gettysburg College Faculty Books

Moral Philosophy: A Contemporary Introduction is a compact yet comprehensive book offering an explication and critique of the major theories that have shaped philosophical ethics. Engaging with both historical and contemporary figures, this book explores the scope, limits, and requirements of morality. DeNicola traces our various attempts to ground morality: in nature, in religion, in culture, in social contracts, and in aspects of the human person such as reason, emotions, caring, and intuition.

Enabling Retrospective Application Of The Denial Of Benefits Clause: An Analysis Of Decisions Of Tribunals Under The Energy Charter Treaty, Ramya Ramachanderan

University of Miami International and Comparative Law Review

No abstract provided.

Raising The Bar: The Aba’S Pulling Of Accreditation And Its Oversight In Legal Education, Alex Gass

SLU Law Journal Online

The American Bar Association's role in accrediting and disciplining law schools has entered a new and contentious era: litigation. In this article, Alex Gass discusses the history of law school accreditation and the recent lawsuits against the ABA by law schools disciplined for their failure to adhere to ABA standards.

Trevo 2000: Results Of A Large Real-World Registry For Stent Retriever For Acute Ischemic Stroke., Mandy J Binning, Bruno Bartolini, Blaise Baxter, Ronald Budzik, Joey English, Rishi Gupta, Hirad Hedayat, Antonin Krajina, David Liebeskind, Raul G Nogueira, Ryan Shields, Erol Veznedaroglu

OhioHealth Research Institute Articles

Background Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real-world data aid in assessing reproducibility of outcomes outside of clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess outcomes in a large cohort of patients. Methods and Results The Trevo Registry is a prospective database of patients with large vessel occlusion treated with the Trevo device as the first device. The primary end point is revascularization based on modified Thrombolysis in Cerebral Infarction score and secondary end points include 90-day modified Rankin Scale, 90-day mortality, neurological deterioration at …

12-18-2018 Wright Family Scholarship Fund Established At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2018

Southwestern Oklahoma State University (SWOSU) with locations in Weatherford and Sayre has announced the creation of the Wright Family Scholarship Fund.

Lightweight Thermal Management Material For Enhancement Of Through-Thickness Thermal Conductivity, Matthew Collins Weisenberger

Center for Applied Energy Research Faculty Patents

A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes held in a polymer matrix material. The carbon nanotubes have an average length of between about 50 microns and about 500 microns. The polymer matrix has an average thickness of between about 10 microns and about 500 microns. The flexible sheet has a density of about 0.2 to about 1.0 glee and includes between about 98 to about 60 weight percent aligned carbon nanotubes and between about 2 and about 40 weight percent polymer. A tape of aligned carbon nanotubes, a method for producing a tape of …

Determination Of Chemical Speciation Of Arsenic And Selenium In High-As Coal Combustion Ash By X-Ray Photoelectron Spectroscopy: Examples From A Kentucky Stoker Ash, Biao Fu, James C. Hower, Shifeng Dai, Sarah M. Mardon, Guijian Liu

Center for Applied Energy Research Faculty and Staff Publications

Knowledge of the chemical speciation of arsenic and selenium in coal fly ash is essential in the evaluation of the environmental behavior of fly ash disposed in a landfill in a natural environment. In this study, a series of high-As coal fly ash from stoker boilers were collected to determine the chemical forms of arsenic and selenium. The ash surface chemical characteristics and the speciation of arsenic and selenium were characterized by X-ray photoelectron spectroscopy and X-ray-induced Auger electron spectroscopy. The results indicate that the surface enrichment ratio for selenium (63.3–309.5) is higher than that of arsenic (1.2–21.2). The Wagner …

Finding A Key Mechanism In Assembly Of Asv, A 100-Year-Old Virus Often Used To Study Hiv-1, Staff

Browse All News

No abstract provided.

"Bean Bags" Aim To Give Uab Hospital Families Basic Comforts, Necessities During Their Stay, Staff

Browse All News

No abstract provided.

Nidilrr Awards Five-Year Grant To Uab Researchers' Movement 2 Music Program, Staff

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No abstract provided.