Digital Commons Network^™

Seeing The Human Face: Refugee And Asylum Seeker Narratives And An Ethics Of Care In Recent Australian Picture Books, Debra Dudek

Research outputs 2014 to 2021

While working on the final stages of this essay, I went to a local children’s bookstore to look for a retelling of The Tempest to assist the eleven-year-old in my life with a drama audition. The audition required him to memorize the monologue in which Trinculo finds Caliban on the beach and asks, “What have we here? a man or a fish? dead or alive?” (2.2.24–25). The owner of the shop—who knows my field of research and advises me when new books arrive that she thinks would interest me—asked whether I had seen the latest Armin Greder book, The Mediterranean, …

The Influence Of Work-Integrated Learning And Paid Work During Studies On Graduate Employment And Underemployment, Denise Jackson, David Collings

Research outputs 2014 to 2021

To enhance employability and improve the career prospects of graduating students, this study explores the influence of practical experience on graduate employment outcomes in an Australian setting. To develop our understanding of the relative benefit of different forms of practical experience, the study evaluates the influence of both Work-Integrated Learning (WIL) and paid work in the final year of study on graduate employment and underemployment. Two samples are used, N = 628 and N = 237, to evaluate institutional data on practical experience combined with national data on graduate employment outcomes. Findings indicate that participating in WIL does not produce …

Survival Drivers Of Post-Incubated Start-Ups: The Effect Of Academic Governance, Simone Scagnelli, Lorenzo Vasile, Mico Apostolov

Research outputs 2014 to 2021

Incubators, spin-offs, industrial networks and consortiums are some of the examples to build-up university–industry links in fostering innovation. University incubators are well known for supporting the growth of start-ups by providing knowledge and research, as well as, sustaining entrepreneurship by the direct involvement of their faculty. In this regard, the aim of this paper is to examine the influence of faculty members on the financial performance of a sample of new technology based firms which have been previously incubated by different Italian University Incubators. Essentially, the results on the presence of academic governance in relation to the financial performance of …

Metabolic And Fatigue Profiles Are Comparable Between Prepubertal Children And Well-Trained Adult Endurance Athletes, Anthony Birat, Pierre Bourdier, Enzo Piponnier, Anthony J. Blazevich, Hugo Maciejewski, Pascale Duche, Sebastien Ratel

Research outputs 2014 to 2021

The aim of this study was to determine whether prepubertal children are metabolically comparable to well-trained adult endurance athletes and if this translates into similar fatigue rates during high-intensity exercise in both populations. On two different occasions, 12 prepubertal boys (10.5 ± 1.1 y), 12 untrained men (21.2 ± 1.5 y), and 13 endurance male athletes (21.5 ± 2.7 y) completed an incremental test to determine the power output at VO_2max (PVO_2max) and a Wingate test to evaluate the maximal anaerobic power (P_max) and relative decrement in power output (i.e., the fatigue index, FI). Furthermore, …

Efficiency And Risk In Sustaining China’S Food Production And Security: Evidence From Micro-Level Panel Data Analysis Of Japonica Rice Production, Chengjun Wang, Zhaoyong Zhang, Ximin Fei

Research outputs 2014 to 2021

Sustainable food production and food security are always challenging issues in China. This paper constructs a multi-element two-level constant-elasticity-of-substitution (CES) model to assess technological progress in, and its contribution to, japonica rice production in China. The results show that the speed of technological progress in the production of japonica rice on average was 0.44% per annum in 1985–2013, and technological progress has contributed significantly to the growth of japonica rice production in China. Robustness checks show that the results appear to be sensitive to which sub-sample is used. Labour and some other inputs are found to be significant but negative, …

Grey Wolf Optimization-Based Optimum Energy-Management And Battery-Sizing Method For Grid-Connected Microgrids, Kutaiba Sabah Nimma, Monaaf D. A. Al-Falahi, Hung Duc Nguyen, S. D. G. Jayasinghe, Thair Mahmoud, Michael Negnevitsky

Research outputs 2014 to 2021

In the revolution of green energy development, microgrids with renewable energy sources such as solar, wind and fuel cells are becoming a popular and effective way of controlling and managing these sources. On the other hand, owing to the intermittency and wide range of dynamic responses of renewable energy sources, battery energy-storage systems have become an integral feature of microgrids. Intelligent energy management and battery sizing are essential requirements in the microgrids to ensure the optimal use of the renewable sources and reduce conventional fuel utilization in such complex systems. This paper presents a novel approach to meet these requirements …

Measuring The Prevalence Of Intradialytic Hypotension In A Satellite Dialysis Clinic: Are We Too Complacent?, Ulrich Steinwandel, Nick Gibson, Mandy Towell-Barnard, Richard Parsons, James J. R. Rippey, Johan Rosman

Research outputs 2014 to 2021

Aims and objectives

To measure the prevalence of symptomatic (S‐IDH) and asymptomatic intradialytic hypotension (A‐IDH) or postdialysis overhydration in a satellite haemodialysis clinic in Western Australia.

Background

Intradialytic hypotension is one of the most common side effects of haemodialysis caused by ultrafiltration provoking a temporary volume depletion. The prevalence of asymptomatic hypotension during dialysis has been rarely reported, but is considered to have the same negative consequences as symptomatic hypotension on various end organs like the brain and the gastrointestinal tract.

Design

Observational study on a retrospective 3‐month period of nursing recorded fluid‐related adverse events.

Methods

Data collection on the …

Nitrate, The Oral Microbiome, And Cardiovascular Health: A Systematic Literature Review Of Human And Animal Studies, Lauren C. Blekkenhorst, Nicola P. Bondonno, Alex H. Liu, Natalie C. Ward, Richard L. Prince, Joshua R. Lewis, Amanda Devine, Kevin D. Croft, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2014 to 2021

Background

Dietary nitrate is an important source of nitric oxide (NO), a molecule critical for cardiovascular health. Nitrate is sequentially reduced to NO through an enterosalivary nitrate-nitrite-NO pathway that involves the oral microbiome. This pathway is considered an important adjunct pathway to the classical l-arginine–NO synthase pathway.

Objective

The objective of this study was to systematically assess the evidence for dietary nitrate intake and improved cardiovascular health from both human and animal studies.

Design

A systematic literature search was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines by using key search terms in Medline and …

Strengthening The Practice Of Exercise And Sport-Science Research, Israel Halperin, Andrew D. Vigotsky, Carl Foster, David B. Pyne

Research outputs 2014 to 2021

Exercise and sport sciences continue to grow as a collective set of disciplines investigating a broad array of basic and applied research questions. Despite the progress, there is room for improvement. A number of problems pertaining to reliability and validity of research practices hinder advancement and the potential impact of the field. These problems include inadequate validation of surrogate outcomes, too few longitudinal and replication studies, limited reporting of null or trivial results, and insufficient scientific transparency. The purpose of this review is to discuss these problems as they pertain to exercise and sport sciences based on their treatment in …

Revenge Pornography: The Influence Of Perpetrator-Victim Sex, Observer Sex And Observer Sexting Experience On Perceptions Of Seriousness And Responsibility, Adrian J. Scott, Jeff Gavin

Research outputs 2014 to 2021

Purpose: Drawing on gender-role stereotypes and defensive attribution theory, the purpose of this paper is to investigate the influence of perpetrator-victim sex, observer sex and observer sexting experience on perceptions of seriousness and responsibility in the context of revenge pornography.

Design/methodology/approach: In total, 239 university students read one of two versions of a hypothetical scenario, responded to items concerning their perceptions of the situation described, and responded to items concerning their sexting experience.

Findings: Men were more likely to believe the situation was serious when it involved a male perpetrator and a female victim rather than vice versa. However, perpetrator-victim …

Understanding Subterranean Variability: The First Genus Of Bathynellidae (Bathynellacea, Crustacea) From Western Australia Described Through A Morphological And Multigene Approach, Giulia Perina, A. I. Camacho, Joel Huey, Pierre Horwitz, Annette Koenders

Research outputs 2014 to 2021

The number of subterranean taxa discovered in the north of Western Australia has substantially increased due to the requirements for environmental surveys related to mining development. Challenges in estimating subterranean biodiversity and distributions are related to lack of knowledge of taxa with convergent morphological characters in a largely unobservable ecosystem setting. An integrated approach is warranted to understand such complexity.

Bathynellidae occur in most Australian aquifers, but only one species has been described so far, and the group lacks a reliable taxonomic framework. A new genus and one new species from the Pilbara region of Western Australia, Pilbaranella ethelensis, …

Application Of 3d Delaunay Triangulation In Fingerprint Authentication System, Wencheng Yang, Ahmed Ibrahim, Junaid Chaudhry, Song Wang, Jiankun Hu, Craig Valli

Research outputs 2014 to 2021

Biometric security has found many applications in Internet of Things (IoT) security. Many mobile devices including smart phones have supplied fingerprint authentication function. However, the authentication performance in such restricted environment has been downgraded significantly. A number of methods based on Delaunay triangulation have been proposed for minutiae-based fingerprint matching, due to some favorable properties of the Delaunay triangulation under image distortion. However, all existing methods are based on 2D pattern, of which each unit, a Delaunay triangle, can only provide limited discrimination ability and could cause low matching performance. In this paper, we propose a 3D Delaunay triangulation based …

Overwhelming Research And Clinical Evidence Of Exercise Medicine Efficacy In Cancer Management—Translation Into Practice Is The Challenge Before Us, Robert Newton

Research outputs 2014 to 2021

The paper “Connecting people with cancer to physical activity and exercise programs: a pathway to create accessibility and engagement”1 is very timely. As the authors have convincingly demonstrated, rigorous clinical and research evidence support something of which most medical and allied health professionals are cognizant: the benefit of physical activity and exercise for people with cancer.

Increased Fxyd1 And Pgc-1Α Mrna After Blood Flow-Restricted Running Is Related To Fibre Type-Specific Ampk Signalling And Oxidative Stress In Human Muscle, Danny Christiansen, Robyn M. Murphy, Christos G. Stathis, David Bishop

Research outputs 2014 to 2021

Aim: This study explored the effects of blood flow restriction (BFR) on mRNA responses of PGC-1α (total, 1α1, and 1α4) and Na+,K+-ATPase isoforms (NKA; α1-3, β1-3, and FXYD1) to an interval running session and determined whether these effects were related to increased oxidative stress, hypoxia, and fibre type-specific AMPK and CaMKII signalling, in human skeletal muscle. Methods: In a randomized, crossover fashion, 8 healthy men (26 ± 5 year and 57.4 ± 6.3 mL kg−1 min−1) completed 3 exercise sessions: without (CON) or with blood flow restriction (BFR), or in systemic hypoxia (HYP, ~3250 m). A muscle sample was collected …

Spectrum Of Antibacterial Activity And Mode Of Action Of A Novel Tris-Stilbene Bacteriostatic Compound, Nikki Y. Man, Daniel R. Knight, Scott G. Stewart, Allan J. Mckinley, Thomas V. Riley, Katherine A. Hammer

Research outputs 2014 to 2021

The spectrum of activity and mode of action of a novel antibacterial agent, 135C, was investigated using a range of microbiological and genomic approaches. Compound 135C was active against Gram-positive bacteria with MICs for Staphylococcus aureus ranging from 0.12-0.5 μg/ml. It was largely inactive against Gram-negative bacteria. The compound showed bacteriostatic activity in time-kill studies and did not elicit bacterial cell leakage or cell lysis. Checkerboard assays showed no synergy or antagonism when 135C was combined with a range of other antibacterials. Multi-step serial passage of four S. aureus isolates with increasing concentrations of 135C showed that resistance developed rapidly …

Impact Of Aging On The Auditory System And Related Cognitive Functions: A Narrative Review, Dona M.P. Jayakody, Pete L. Friedland, Ralph Martins, Hamid R. Sohrabi

Research outputs 2014 to 2021

Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia. Here we review the …

The Epidemiology Of Clostridium Difficile Infection In Japan: A Systematic Review, Thomas V. Riley, Tomomi Kimura

Research outputs 2014 to 2021

To increase understanding of the epidemiology, risks, consequences and resource utilization of Clostridium difficile infection (CDI) in Japan, a systematic literature review was undertaken of relevant publications from January 2006 to November 2017. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and methods, 55 articles met the criteria for full review. The majority (58%) of studies were from a single site, with the most recent data from 2015. The incidence, reported prevalence and recurrence rate of CDI in Japan were 0.8–4.71/10,000 patient-days, 0.3–5.5/1000 patients and 3.3–27.3%, respectively, and varied according to setting, population, CDI definition and …

Alzheimer's Disease: A Journey From Amyloid Peptides And Oxidative Stress, To Biomarker Technologies And Disease Prevention Strategies-Gains From Aibl And Dian Cohort Studies, Ralph Martins, Victor Villemagnen, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer Gupta, Stephanie Rainey-Smith, Eugene Hone, Steve Pedrini, Wei L. Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O’Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J. Fuller, Belinda Brown, Samantha Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon Laws, Anna M. Barron, Kathryn Goozee, Eka J. Wahjoepramono, Prita R. Asih, James D. Doecke, Olivier Salvado, Ashley I. Bush, Christopher C. Rowe, Samuel E. Gandy, Colin L. Masters

Research outputs 2014 to 2021

Worldwide there are over 46 million people living with dementia, and this number is expected to double every 20 years reaching about 131 million by 2050. The cost to the community and government health systems, as well as the stress on families and carers is incalculable. Over three decades of research into this disease have been undertaken by several research groups in Australia, including work by our original research group inWestern Australia which was involved in the discovery and sequencing of the amyloid-β peptide (also known as Aβ or A4 peptide) extracted from cerebral amyloid plaques. This review discusses the …

Guidelines And Considerations For The Use Of System Suitability And Quality Control Samples In Mass Spectrometry Assays Applied In Untargeted Clinical Metabolomic Studies, David Broadhurst, Royston Goodacre, Stacey N. Reinke, Julia Kuligowski, Ian Wilson, Matthew Lewis, Warwick Dunn

Research outputs 2014 to 2021

Background

Quality assurance (QA) and quality control (QC) are two quality management processes that are integral to the success of metabolomics including their application for the acquisition of high quality data in any high-throughput analytical chemistry laboratory. QA defines all the planned and systematic activities implemented before samples are collected, to provide confidence that a subsequent analytical process will fulfil predetermined requirements for quality. QC can be defined as the operational techniques and activities used to measure and report these quality requirements after data acquisition.

Aim of review

This tutorial review will guide the reader through the use of system …

Geographical Variations In The Clinical Management Of Colorectal Cancer In Australia: A Systematic Review, Fiona Crawford-Williams, Sonja March, Michael Ireland, Arlen Rowe, Belinda Goodwin, Melissa Hyde, Suzanne K. Chambers, Joanne Aitken, Jeff Dunn

Research outputs 2014 to 2021

Background: In Australia, cancer survival is significantly lower in non-metropolitan compared to metropolitan areas. Our objective was to evaluate the evidence on geographical variations in the clinical management and treatment of colorectal cancer (CRC).

Methods: A systematic review of published and gray literature was conducted. Five databases (CINAHL, PubMed, Embase, ProQuest, and Informit) were searched for articles published in English from 1990 to 2018. Studies were included if they assessed differences in clinical management according to geographical location; focused on CRC patients; and were conducted in Australia. Included studies were critically appraised using a modified Newcastle–Ottawa Scale. PRISMA systematic review …

Cardiovascular Health Benefits Of Specific Vegetable Types: A Narrative Review, Lauren C. Blekkenhorst, Marc Sim, Catherine P. Bondonno, Nicola Bondonno, Natalie Ward, Richard Prince, Amanda Devine, Joshua Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Adequate vegetable consumption is one of the cornerstones of a healthy diet. The recommendation to increase vegetable intake is part of most dietary guidelines. Despite widespread and long-running public health messages to increase vegetable intake, similar to other countries worldwide, less than 1 in 10 adult Australians manage to meet target advice. Dietary guidelines are predominantly based on studies linking diets high in vegetables with lower risk of chronic diseases. Identifying vegetables with the strongest health benefits and incorporating these into dietary recommendations may enhance public health initiatives around vegetable intake. These enhanced public health initiatives would be targeted at …

Active And Inactive Leg Hemodynamics During Sequential Single-Leg Interval Cycling, Nicole Gordon, Chris R. Abbiss, Mohammed Ihsan, Andrew J. Maiorana, Jeremiah J. Peiffer

Research outputs 2014 to 2021

Introduction Leg order during sequential single-leg cycling (i.e., exercising both legs independently within a single session) may affect local muscular responses potentially influencing adaptations. This study examined the cardiovascular and skeletal muscle hemodynamic responses during double-leg and sequential single-leg cycling. Methods Ten young healthy adults (28 ± 6 yr) completed six 1-min double-leg intervals interspersed with 1 min of passive recovery and, on a separate occasion, 12 (six with one leg followed by six with the other leg) 1-min single-leg intervals interspersed with 1 min of passive recovery. Oxygen consumption, heart rate, blood pressure, muscle oxygenation, muscle blood volume, and …

Identification Of The Cftr C.1666a > G Mutation In Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis, Yan Lu, Yuwei Da, Yong B. Zhang, Xingang Li, Min Wang, Li Di, Mi Pang, Lin Lei

Research outputs 2014 to 2021

Hereditary inclusion body myopathy (HIBM) is a rare autosomal recessive adult onset muscle disease which affects one to three individuals per million worldwide. This disease is autosomal dominant and occurs in adulthood. Our previous study reported a new subtype of HIBM linked to the susceptibility locus at 7q22.1-31.1. The present study is aimed to identify the candidate gene responsible for the phenotype in HIBM pedigree. After multipoint linkage analysis, we performed targeted capture sequencing on 16 members and whole-exome sequencing (WES) on 5 members. Bioinformatics filtering was performed to prioritize the candidate pathogenic gene variants, which were further genotyped by …

Lifestyle Health Behaviors Of Nurses And Midwives: The ‘Fit For The Future’ Study, Lin Perry, Xiaoyue Xu, Robyn Callagher, Rachel Nicholls, David Sibbritt, Christine Duffield

Research outputs 2014 to 2021

Nurses and midwives (nurses) are the principle role models and health educators for the wider population. This study sought to identify the health-related behaviors of the nursing workforce of New South Wales (NSW), Australia, compared to contemporary recommendations for healthy living and to the Australian general population, matched by gender and age. An electronic cross-sectional survey delivered in 2014–2015 recruited 5041 nurses through the NSW Nurses and Midwives Association and professional networks. Validated health behavior measures were collected and compared to Australian National Health Survey data. Compared with younger nurses, older nurses reported greater adherence to fruit and vegetable guideline …

Glucose Gel As A Potential Alternative Treatment To Infant Formula For Neonatal Hypoglycaemia In Australia, Raenee L. Barbe, Amy K. Ekin, Pushparani Sivakumar, Kay Howard, Therese O'Sullivan

Research outputs 2014 to 2021

Infant formula is often used as a treatment for neonatal hypoglycaemia in Australia; however, there are concerns that this may jeopardise mother-baby bonding and breastfeeding. Successful use of glucose gel as an alternative treatment for hypoglycaemia has been reported. We wanted to investigate in a pilot study whether the use of glucose gel has the potential to quickly and safely restore normoglycaemia in the infants of diabetic mothers in an Australian setting. Infants with asymptomatic hypoglycaemia were treated with glucose gel (n = 36) and compared to a historical group of infants which had been treated with infant formula …

White Matter Hyperintensities And The Mediating Role Of Cerebral Amyloid Angiopathy In Dominantly-Inherited Alzheimer’S Disease, Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L.S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, Bernardino Ghetti, Eric Mcdade, Ralph Martins, Andrew J. Saykin, Colin L. Masters, John M. Ringman, Stefan Fӧrster, Peter R. Schofield, Reisa A. Sperling, Keith A. Johnson, Jasmeer P. Chhatwal, Stephen Salloway, Stephen Correia, Clifford R. Jack, Jr, Michael Weiner, Randall J. Bateman, John C. Morris, Richard Mayeux, Adam M. Brickman

Research outputs 2014 to 2021

Introduction: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer’s disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebral amyloid angiopathy (CAA) and that increased WMH in this population is a manifestation of this vascular form of primary AD pathology. We examined whether the presence of cerebral microbleeds, a marker of CAA, mediates the relationship between WMH and estimated symptom onset in individuals with and without autosomal dominant mutations for AD.

Participants and methods: Participants (n = 175, …

The Psychometric Assessment Of Alexithymia: Development And Validation Of The Perth Alexithymia Questionnaire, David Preece, Rodrigo Becerra, Ken Robinson, Justine Dandy, Alfred Allan

Research outputs 2014 to 2021

Alexithymia is a trait comprising people's ability to focus attention on and accurately appraise their own emotions. Its assessment is of clinical interest because people who have difficulty processing their negative and positive emotions are more vulnerable to developing psychopathology symptoms, however, existing alexithymia measures cannot comprehensively assess the construct across both negative and positive emotions. In this paper, we attempt to remedy these measurement limitations by developing and validating a new 24-item self-report measure, the Perth Alexithymia Questionnaire (PAQ), which is based on the attention-appraisal model of alexithymia. In Study 1, our confirmatory factor analyses in a sample of …

Properties Of Ferrite Garnet (Bi, Lu, Y)3(Fe, Ga)5o12 Thin Film Materials Prepared By Rf Magnetron Sputtering, Mohammad Nur-E-Alam, Mikhail Vasiliev, Vladimir Belotelov, Kamal Alameh

Research outputs 2014 to 2021

This work is devoted to physical vapor deposition synthesis, and characterisation of bismuth and lutetium-substituted ferrite-garnet thin-film materials for magneto-optic (MO) applications. The properties of garnet thin films sputtered using a target of nominal composition type Bi_0.9Lu_1.85Y_0.25Fe_4.0Ga₁O₁₂ are studied. By measuring the optical transmission spectra at room temperature, the optical constants and the accurate film thicknesses can be evaluated using Swanepoel’s envelope method. The refractive index data are found to be matching very closely to these derived from Cauchy’s dispersion formula for the entire spectral range between 300 and …

Properties Of Traditional Bamboo Carrying Poles Have Implications For User Interactions, Ryan T. Schroeder, James L. Croft, Giang D. Ngo, John E. A. Bertram

Research outputs 2014 to 2021

Compliant bamboo poles have long been used for load carriage in Asian cultures. Although this custom differs from Western conventions of rigid body attachments (e.g. backpack), potential benefits include reduced peak shoulder forces as well as metabolic transport cost savings. Evidence that carrying a flexible pole benefits locomotion remains mixed, perhaps in part because the properties of pole design (e.g. bamboo material, structural geometry, etc.) have largely been neglected. These properties influence vibrational forces and consequently, the energy required by the user to manage the oscillations. We collected authentic bamboo poles from northern Vietnam and characterized their design parameters. Four …

Ischemic Stroke Is Associated With The Pro-Inflammatory Potential Of N-Glycosylated Immunoglobulin G, Di Liu, Zhongyao Zhao, Anxin Wang, Siqi Ge, Hao Wang, Xiaoyu Zhang, Qi Sun, Weijie Cao, Ming Sun, Lijuan Wu, Manshu Song, Yong Zhou, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

Background

Glycosylation significantly affects protein structure and function and thus participates in multiple physiologic and pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, and hypertension.

Methods

The study aimed to investigate the association between IgG N-glycosylation and IS in a Chinese population. IgG glycome composition in patients with IS (n = 78) and cerebral arterial stenosis (CAS) (n = 75) and controls (n = 77) were analyzed by ultra-performance liquid chromatography.

Results

Eleven initial glycans and 10 …